Figure 4
From: A Gain-of-Function Mutation in Nav1.6 in a Case of Trigeminal Neuralgia
Met136Val channels increase excitability in TRG neurons. (A) Representative responses of TRG neurons expressing WT or Met136Val channels to 500 ms sustained depolarizations in current steps one, two and three times (top, middle, bottom traces, respectively) the current threshold for action potential generation. (B) Comparison of repetitive action potential firing between TRG neurons expressing WT (black; n = 18) and Met136Val (red; n = 22) across a series of 500 ms current injections from 25–500 pA; p < 0.05.