Table 1 KRAS mutations reported to date. (Data obtained from https://mycancergenome.org on June 2, 2016.)
From: KRAS and the Reality of Personalized Medicine in Non-Small Cell Lung Cancer
Gene Level | Protein Level | Frequency in NSCLC |
|---|---|---|
34G > T | G12C | 42% |
35G > T | G12V | 20% |
35G > A | G12D | 17% |
35G > C | G12A | 7% |
34G > A | G12S | 5% |
37G > T | G13C | 3% |
38G > A | G13D | 2% |
34G > C | G12R | 2% |
37G > C | G13R | < 1% |
37G > A | G13S | < 1% |
38G > C | G13A | < 1% |
181C > A | Q61K | < 1% |
182A > T | Q61L | < 1% |
182A > G | Q61R | < 1% |
183A > C | Q61H | < 1% |
183A > T | Q61H | < 1% |