Figure 2

GLP-1 enhances MSC-mediated glucose tolerance in diabetic NOD mice. Following MSC infusion and GLP-1 treatment, the body weight and FGB levels of individual mice were measured weekly. The AUC and ≥G30 levels in individual mice at the indicated time points post treatment were determined. Data are expressed as the mean ± SEM of each group (n = 6 per group). (A) Body weight. (B) FBG levels. (C) AUC. (D) Plasma ≥G30 levels. *P < 0.05 versus diabetic controls. †P < 0.05 versus mice treated with MSCs alone. AUC: values of the area under the curve for the levels of blood glucose over the IPGTT period. ≥G30: net increase in the levels of blood glucose at 30 min post glucose challenge.