Skip to main content
Figure 5 | Molecular Medicine

Figure 5

From: Anti-LRP/LR-Specific Antibody IgG1-iS18 Significantly Impedes Adhesion and Invasion in Early- and Late-Stage Colorectal Carcinoma Cells

Figure 5

Adhesion of tumorigenic cells to laminin-1 investigated through adhesion assays. Each cell line’s untreated cells were compared with MCF-7 untreated control cells to determine adhesive potential. P values show all three cell lines had increased adhesive potential compared to MCF-7. After treatment with the anti-LRP/LR-specific antibody IgG1-iS18, P values showed significantly decreased adhesive potential compared to MCF-7 control cells; SW-480 by 59%, HT-29 by 56% and DLD-1 by 84%. The control antibody IgG1-HD37 shows a small effect on each colorectal cancer cell line; however, statistical analysis indicates that IgG1-iS18 has a significantly greater effect (***p = 0.001106 in SW-480, ***p = 2.97188E-05 for HT-29 and ***p = 0.000644 in DLD-1).

Back to article page

Molecular Medicine

ISSN: 1528-3658