Figure 5
From: Development of a Zebrafish Sepsis Model for High-Throughput Drug Discovery
LPS induces ROS production and increased proinflammatory and antiinflammatory cytokine expression in zebrafish. (A, B) LPS exposure leads to systemic production of ROS (n = 4/treatment) and an increase in the transcript levels of key proinflammatory cytokines (C) IL-1β, (D) IL-6, (E) TNFα and (F, G) IL-8 and (H) the antiinflammatory cytokine IL-10. For experiments on transcript abundance, an average of 3 trials was used, each with a pool of 20 larvae/treatment.