Figure 7

Effect of genetic deletion of MLCK on local bacterial burden and cytokines 24 h after CLP. (A) The number of bacteria in the peritoneal cavity was similar between MLCK^−/− and WT mice following CLP (n = 10/group, p = 0.82). (B) IL-6 levels in peritoneal fluid were lower in MLCK^−/− mice (n = 6–9/group, p = 0.03), but no differences were detected in (C) peritoneal TNF (n = 8–9/group, p = 0.17), (D) IL-10 (n = 10/group, p = 0.76), (E) IL-13 (n = 10/group, p = 0.46) and (F) IFN-y (n = 10/group, p = 0.65).