Figure 6From: IL-37 Suppresses MyD88-mediated Inflammatory Responses in Human Aortic Valve Interstitial CellsSchematic description of the suppression of human AVIC inflammatory responses to stimulation of TLR2 and TLR4. Both TLR2 and TLR4 utilize the MyD88 pathway to induce inflammatory mediator production in human AVICs. IL-37 inhibits NF-κB through an IL-18Rα-dependent mechanism to down-regulate inflammatory mediator production mediated by the MyD88 pathway.Back to article page