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  1. Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children and Glucocorticoids (GCs) form an essential component of the standard chemotherapy in most treatment regimens. The cat...

    Authors: Zaynab Mousavian, Abbas Nowzari-Dalini, Yasir Rahmatallah and Ali Masoudi-Nejad
    Citation: Molecular Medicine 2019 25:36
    Content type: Research article Published on:

  2. Following publication of the original article [1], the author reported an error in Figure 1. The correct version of Figure 1 is as follows:

    Authors: Vijay K. Sonkar, Paresh P. Kulkarni, Susheel N. Chaurasia, Ayusman Dash, Abhishek Jauhari, Devendra Parmar, Sanjay Yadav and Debabrata Dash
    Citation: Molecular Medicine 2019 25:34
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2016 22:Art22

  3. The beneficial effects of angiotensin II type 1 receptor blockers (ARBs) on atherosclerosis have been demonstrated in numerous studies. We investigated the effects of fimasartan on reducing neointimal formatio...

    Authors: Jong-Ho Kim, I-Rang Lim, Hyung Joon Joo, Chi-Yeon Park, Seung-Cheol Choi, Han Saem Jeong and Soon Jun Hong
    Citation: Molecular Medicine 2019 25:33
    Content type: Research article Published on:

  5. Delocalization of neuronal nitric oxide synthase (nNOS) from the sarcolemma leads to functional muscle ischemia. This contributes to the pathogenesis in cachexia, aging and muscular dystrophy. Mutations in the...

    Authors: Junling Zhao, Hsiao Tung Yang, Lakmini Wasala, Keqing Zhang, Yongping Yue, Dongsheng Duan and Yi Lai
    Citation: Molecular Medicine 2019 25:31
    Content type: Research article Published on:

  6. Drug repurposing is a swift, safe, and cheap drug discovery method. Melanoma disorders present low survival and high mortality rates and are challenging to diagnose and treat. Moreover, there is a high volume ...

    Authors: Ali Khosravi, B. Jayaram, Bahram Goliaei and Ali Masoudi-Nejad
    Citation: Molecular Medicine 2019 25:30
    Content type: Research article Published on:

  7. Late-onset Alzheimer’s disease (LOAD), the most common form of dementia, results from complicated interactions among multiple environmental and genetic factors. Despite recent advances in genetic analysis of L...

    Authors: Yuya Asanomi, Daichi Shigemizu, Akinori Miyashita, Risa Mitsumori, Taiki Mori, Norikazu Hara, Kaoru Ito, Shumpei Niida, Takeshi Ikeuchi and Kouichi Ozaki
    Citation: Molecular Medicine 2019 25:20
    Content type: Research article Published on:

  8. Innate immune dysfunction contributes to the development and progression of nonalcoholic fatty liver disease (NAFLD), however, its pathogenesis is still incompletely understood. Identifying the key innate immu...

    Authors: Cheng Zhang, Feng Chen, Li Feng, Qun Shan, Gui-Hong Zheng, Yong-Jian Wang, Jun Lu, Shao-Hua Fan, Chun-Hui Sun, Dong-Mei Wu, Meng-Qiu Li, Bin Hu, Qing-Qing Wang, Zi-Feng Zhang and Yuan-Lin Zheng
    Citation: Molecular Medicine 2019 25:29
    Content type: Research article Published on:

  10. Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease of unknown etiology with only two federally approved drug options. Given the complex molecular pathogenesis of IPF involving multiple cell types and ...

    Authors: L. R. Rodriguez, S. N. Bui, R. T. Beuschel, E. Ellis, E. M. Liberti, M. K. Chhina, B. Cannon, M. Lemma, S. D. Nathan and G. M. Grant
    Citation: Molecular Medicine 2019 25:27
    Content type: Research article Published on:

  11. Non-alcoholic fatty liver disease (NAFLD) is a common hepatic disease with an increasing prevalence but an unclear aetiology. This study aimed to investigate the functional implications of microRNA-122 (miR-12...

    Authors: Jun-Ke Long, Wen Dai, Ya-Wen Zheng and Shui-Ping Zhao
    Citation: Molecular Medicine 2019 25:26
    Content type: Research article Published on:

  12. Tumor necrosis factor (TNF) blockers have a high efficacy in treating Ankylosing Spondylitis (AS), yet up to 40% of AS patients show poor or even no response to this treatment. In this paper, we aim to build a...

    Authors: Jing Liu, Qi Zhu, Jing Han, Hui Zhang, Yuan Li, Yanyun Ma, Dongyi He, Jianxin Gu, Xiaodong Zhou, John D. Reveille, Li Jin, Hejian Zou, Shifang Ren and Jiucun Wang
    Citation: Molecular Medicine 2019 25:25
    Content type: Short report Published on:

  13. Alcohol abuse affects the brain regions responsible for memory, coordination and emotional processing. Binge alcohol drinking has shown reductions in brain activity, but the molecular targets have not been com...

    Authors: Asha Jacob, Yilong Ma, Elham Nasiri, Mahendar Ochani, Joseph Carrion, Shichun Peng, Max Brenner, Patricio T. Huerta and Ping Wang
    Citation: Molecular Medicine 2019 25:24
    Content type: Research article Published on:

  14. Cervical cancer is the third most common gynecological malignancy. Conventional treatment options are known to be ineffective for the majority of patients with advanced or recurrent cervical cancer. Therefore,...

    Authors: Sungha Lee, Jung Yoon Ho, Jing Jing Liu, Hyewon Lee, Jae Young Park, Minwha Baik, Minji Ko, Seon Ui Lee, Youn Jin Choi and Soo Young Hur
    Citation: Molecular Medicine 2019 25:23
    Content type: Research article Published on:

  15. Our previous research confirmed that electroacupuncture (EA) stimulus elicits neuroprotective effects against cerebral ischemic injury through α7 nicotinic acetylcholine receptor (α7nAChR)-mediated inhibition ...

    Authors: Tao Jiang, Meiyan Wu, Zhanqin Zhang, Chaoying Yan, Zhi Ma, Shan He, Wei Yuan, Kairui Pu and Qiang Wang
    Citation: Molecular Medicine 2019 25:22
    Content type: Research article Published on:

  16. Metabolic memory contributes to the development of diabetic retinopathy (DR), which is the complication of diabetes. But it’s still unknown how to prevent the metabolic memory to treat the DR. In our study, we...

    Authors: Ping Liu, Qing-Hua Peng, Ping Tong and Wen-Jie Li
    Citation: Molecular Medicine 2019 25:21
    Content type: Research article Published on:

  17. The immune response of the critically ill after severe trauma is sex-specific and may explain the different progression of the disease. This may be explained by a different gene regulatory program of their per...

    Authors: Amol Kolte and Rainer König
    Citation: Molecular Medicine 2019 25:19
    Content type: Research article Published on:

  18. Acute myocardial infarction (AMI) was considered to be one of the major causes of morbidity and mortality worldwide. In order to manage the acute myocardial infarction outbreaks, accurate biomarkers for risk p...

    Authors: Sheng Xue, Wenjie Zhu, Dacheng Liu, Zhe Su, Liwei Zhang, Qing Chang and Peifeng Li
    Citation: Molecular Medicine 2019 25:18
    Content type: Research article Published on:

  19. Obesity is one of the leading causes of insulin resistance. Accumulating reports have highlighted that serum amyloid A-1 (SAA1) is a potential candidate that is capable of attenuating insulin resistance. Hence...

    Authors: Yong Wang, Feng Cao, Yang Wang, Gang Yu and Ben-Li Jia
    Citation: Molecular Medicine 2019 25:17
    Content type: Research article Published on:

  20. Non-alcoholic fatty liver disease (NAFLD) is becoming a major health problem worldwide. Inflammation plays an important role in disease pathogenesis and recent studies have shown a potential role for the neutr...

    Authors: Andreea-Manuela Mirea, Erik J. M. Toonen, Inge van den Munckhof, Isabelle D. Munsterman, Eric T. T. L. Tjwa, Martin Jaeger, Marije Oosting, Kiki Schraa, Joost H. W. Rutten, Marinette van der Graaf, Niels P. Riksen, Jacqueline de Graaf, Mihai G. Netea, Cees J. Tack, Triantafyllos Chavakis and Leo A. B. Joosten
    Citation: Molecular Medicine 2019 25:16
    Content type: Research article Published on:

  21. The demonstration of EGFR T790M gene mutation in plasma is crucial to assess the eligibility of Non Small Cell Lung Cancer (NSCLC) patients, who have acquired resistance to first or second generation Tyrosine Kin...

    Authors: Mariella Dono, Giuseppa De Luca, Sonia Lastraioli, Giorgia Anselmi, Maria Giovanna Dal Bello, Simona Coco, Irene Vanni, Francesco Grossi, Antonella Vigani, Carlo Genova, Manlio Ferrarini, Jean Louis Ravetti and Simona Zupo
    Citation: Molecular Medicine 2019 25:15
    Content type: Research article Published on:

  22. Chronic Fatigue Syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a complex multifactorial disorder of unknown cause having multi-system manifestations. Although the aetiology of CFS/ME remains elusive, immunolo...

    Authors: H. Cabanas, K. Muraki, C. Balinas, N. Eaton-Fitch, D. Staines and S. Marshall-Gradisnik
    Citation: Molecular Medicine 2019 25:14
    Content type: Research article Published on:

  23. Extracellular high mobility group box 1 protein  (HMGB1) serves a central role in inflammation as a transporter protein, which binds other immune-activating molecules that are endocytosed via the receptor for ...

    Authors: Huan Yang, Hui Liu, Qiong Zeng, Gavin H. Imperato, Meghan E. Addorisio, Jianhua Li, Mingzhu He, Kai Fan Cheng, Yousef Al-Abed, Helena E. Harris, Sangeeta S. Chavan, Ulf Andersson and Kevin J. Tracey
    Citation: Molecular Medicine 2019 25:13
    Content type: Research article Published on:

  24. The polymeric immunoglobulin receptor (pIgR) maintains the integrity of epithelial barriers by transporting polymeric antibodies and antigens through the epithelial mucosa into the lumen. In this study, we exa...

    Authors: Kim R. Simpfendorfer, Nancy Wang, Dedreia L. Tull, David P. De Souza, Amsha Nahid, Andre Mu, Dianna M. Hocking, John S. Pedersen, Odilia L. C. Wijburg, Malcolm J. McConville and Richard A. Strugnell
    Citation: Molecular Medicine 2019 25:12
    Content type: Research article Published on:

  25. Endometrial carcinoma represents one of the most common cancer types of the female reproductive tract. If diagnosed at an early stage, the 5-year survival rate is promising. However, recurrence and chemoresist...

    Authors: Jing-Wei Zhou, Juan-Juan Tang, Wei Sun and Hui Wang
    Citation: Molecular Medicine 2019 25:11
    Content type: Research article Published on:

  26. The pathological features of aortic dissection (AD) include vascular smooth muscle cell (VSMC) loss, elastic fiber fraction, and inflammatory responses in the aorta. However, little is known about the post-tra...

    Authors: Xian Guo, Ze-Min Fang, Xiang Wei, Bo Huo, Xin Yi, Cai Cheng, Jun Chen, Xue-Hai Zhu, Anas Omar Khalil Abu Bokha and Ding-Sheng Jiang
    Citation: Molecular Medicine 2019 25:10
    Content type: Research article Published on:

  27. Cell therapy is proposed to be a potential treatment for Parkinson’s disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has bee...

    Authors: Sha Li, Han Zhang, Aifang Wang, Yan Liu, Houqi Liu, Feng Yue, Xianmixinuer Abulaiti, Caiqiao Zhang and Lingsong Li
    Citation: Molecular Medicine 2019 25:9
    Content type: Research article Published on:

  28. 2-oxoglutarate (2OG), an intermediate metabolite in the tricarboxylic acid cycle, has been found to associate with chronic heart failure (HF), but its effect on short-term adverse outcomes in patients with acu...

    Authors: Zhengliang Peng, Qiong Zhan, Xiangkun Xie, Hanlin Li, Yan Tu, Yujia Bai, Xingfu Huang, Wenyan Lai, Boxin Zhao, Qingchun Zeng and Dingli Xu
    Citation: Molecular Medicine 2019 25:8
    Content type: Research article Published on:

  29. Long non-coding RNAs (lncRNA) plasmacytoma variant translocation 1 (PVT1) has been shown to be associated with liver fibrosis. Nevertheless, the role of PVT1 in atrial fibrosis remains undefined. This study ai...

    Authors: Feng Cao, Zhe Li, Wen-mao Ding, Ling Yan and Qing-yan Zhao
    Citation: Molecular Medicine 2019 25:7
    Content type: Research article Published on:

  30. Deleterious variants in the voltage-gated sodium channel type 2 (Nav1.2) lead to a broad spectrum of phenotypes ranging from benign familial neonatal-infantile epilepsy (BFNIE), severe developmental and epileptic...

    Authors: Anaïs Begemann, Mario A. Acuña, Markus Zweier, Marie Vincent, Katharina Steindl, Ruxandra Bachmann-Gagescu, Annette Hackenberg, Lucia Abela, Barbara Plecko, Judith Kroell-Seger, Alessandra Baumer, Kazuhiro Yamakawa, Yushi Inoue, Reza Asadollahi, Heinrich Sticht, Hanns Ulrich Zeilhofer…
    Citation: Molecular Medicine 2019 25:6
    Content type: Research article Published on:

  31. Damage to the endothelium due to ischemia reperfusion injury (IRI) leads to a disruption of the microvasculature, which could be influenced by angiopoietin 1 via its effects on endothelium. We investigated the...

    Authors: Wen-Chih Chiang, Yu-Chin Huang, Ten-I Fu, Ping-Min Chen, Fan-Chi Chang, Chun-Fu Lai, Vin-Cent Wu, Shuei-Liong Lin and Yung-Ming Chen
    Citation: Molecular Medicine 2019 25:5
    Content type: Research article Published on:

  33. Streptococcus pneumoniae is a major causative agent in community-acquired pneumonia and sepsis. Overwhelming lung inflammation during pneumococcal pneumonia may hamper lung function. Ibrutinib is an irreversible ...

    Authors: Alexander P. de Porto, Zhe Liu, Regina de Beer, Sandrine Florquin, Onno J. de Boer, Rudi W. Hendriks, Tom van der Poll and Alex F. de Vos
    Citation: Molecular Medicine 2019 25:3
    Content type: Research article Published on:

  34. Sulfonylurea receptor 1 (SUR1) is primarily responsible for glucose regulation in normal conditions. Here, we sought to investigate the glucose metabolism characteristics of SUR1−/− rats.

    Authors: Xiaojun Zhou, Chunmei Xu, Zhiwei Zou, Xue Shen, Tianyue Xie, Rui Zhang, Lin Liao and Jianjun Dong
    Citation: Molecular Medicine 2019 25:2
    Content type: Research article Published on:

  35. Both the parasympathetic and sympathetic nervous system exert control over innate immune responses. In inflammatory bowel disease, sympathetic innervation in intestinal mucosa is reduced. Our aim was to invest...

    Authors: Rose A. Willemze, Olaf Welting, Patricia van Hamersveld, Caroline Verseijden, Laurens E. Nijhuis, Francisca W. Hilbers, Sybren L. Meijer, Balthasar A. Heesters, Joost H. A. Folgering, Harold Darwinkel, Philippe Blancou, Margriet J. Vervoordeldonk, Jurgen Seppen, Sigrid E. M. Heinsbroek and Wouter J. de Jonge
    Citation: Molecular Medicine 2019 25:1
    Content type: Research article Published on:

  36. Caspase-11, a cytosolic receptor of bacterial endotoxin (lipopolysaccharide: LPS), mediates immune responses and lethality in endotoxemia and experimental sepsis. However, the upstream pathways that regulate c...

    Authors: Yiting Tang, Rui Zhang, Qianqian Xue, Ran Meng, Xiangyu Wang, Yanliang Yang, Lingli Xie, Xianzhong Xiao, Timothy R. Billiar and Ben Lu
    Citation: Molecular Medicine 2018 24:66
    Content type: Research Published on:

  37. Numerous host cellular factors are exploited by viruses to facilitate infection. Our previous studies and those of others have shown heat-shock protein 90 (Hsp90), a cellular molecular chaperone, is involved i...

    Authors: Yiliang Wang, Rongze Wang, Feng Li, Yun Wang, Zhen Zhang, Qiaoli Wang, Zhe Ren, Fujun Jin, Kaio Kitazato and Yifei Wang
    Citation: Molecular Medicine 2018 24:65
    Content type: Research article Published on:

  38. The multiple biological effects of vitamin D and its novel activities on inflammation and redox homeostasis have raised high expectations on its use as a therapeutic agent for multiple fibrogenic conditions. W...

    Authors: Trinidad Guijarro, Esmeralda Magro-Lopez, Joana Manso, Ricardo Garcia-Martinez, Maria Jesus Fernandez-Aceñero, Isabel Liste and Alberto Zambrano
    Citation: Molecular Medicine 2018 24:64
    Content type: Research article Published on:

  39. Imbalanced autonomic nervous system (ANS) activity is associated with poor cardiovascular outcome. However, clinically validated biomarkers to assess parasympathetic function are not yet available. We sought t...

    Authors: Rafael Y. Brzezinski, Eyal Fisher, Noa Cohen, Etti Zwang, Gabi Shefer, Naftali Stern, David Zeltser, Itzhak Shapira, Shlomo Berliner, Ori Rogowski and Shani Shenhar-Tsarfaty
    Citation: Molecular Medicine 2018 24:63
    Content type: Research article Published on:

  40. Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuN...

    Authors: Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu and Jeffrey A. Keelan
    Citation: Molecular Medicine 2018 24:62
    Content type: Research article Published on:

  41. There have been a number of reports implicating the association of microRNAs (miRs) and the MAPK signaling pathway with the dopaminergic neuron, which is involved in the development of Parkinson’s disease (PD)...

    Authors: Yue Dong, Li-Li Han and Zhong-Xin Xu
    Citation: Molecular Medicine 2018 24:61
    Content type: Research article Published on:

  42. We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor ...

    Authors: Yi-Ling Chen, Yuan-Ping Lin, Cheuk-Kwan Sun, Tien-Hung Huang, Hon-Kan Yip and Yen-Ta Chen
    Citation: Molecular Medicine 2018 24:60
    Content type: Research article Published on:

  43. Traditional risk factors are insufficient to explain all cases of coronary artery disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products (AGEs) and their receptors may play impo...

    Authors: Sarah Louise Fishman, Halis Sonmez, Craig Basman, Varinder Singh and Leonid Poretsky
    Citation: Molecular Medicine 2018 24:59
    Content type: Review Published on:

  44. The neuroprotective role of propofol (PPF) in cerebral ischemia-reperfusion (I/R) has recently been highlighted. This study aimed to explore whether the neuroprotective mechanisms of PPF were linked to its reg...

    Authors: Bei Sun, Hao Ou, Fei Ren, Ye Huan, Tao Zhong, Min Gao and Hongwei Cai
    Citation: Molecular Medicine 2018 24:58
    Content type: Research article Published on:

  45. Gene expression profiles of normal and tumor tissue reflect both differences in biological processes taking place in vivo and differences in response to stress during surgery and sample handling. The effect of...

    Authors: Inge Søkilde Pedersen, Mads Thomassen, Qihua Tan, Torben Kruse, Ole Thorlacius-Ussing, Jens Peter Garne and Henrik Bygum Krarup
    Citation: Molecular Medicine 2018 24:57
    Content type: Research article Published on:

  46. Exposure of rodents to chronic high-fat diet (HFD) results in upregulation of inflammatory markers and proliferation of microglia within the mediobasal hypothalamus. Such hypothalamic inflammation is associate...

    Authors: Mary K. Herrick, Kristin M. Favela, Richard B. Simerly, Naji N. Abumrad and Nathan C. Bingham
    Citation: Molecular Medicine 2018 24:56
    Content type: Research article Published on:

  47. Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we evaluate the effect of microRNA-31 (miR-31) on intesti...

    Authors: Cheng-Ye Zhan, Di Chen, Jin-Long Luo, Ying-Hua Shi and You-Ping Zhang
    Citation: Molecular Medicine 2018 24:55
    Content type: Research article Published on:

  48. Currently, no suitable clinical marker for detection of septic immunosuppression is available. We aimed at identifying microRNAs that could serve as biomarkers of T-cell mediated immunoparalysis in sepsis.

    Authors: P Möhnle, S Hirschberger, L C Hinske, J Briegel, M Hübner, S Weis, G Dimopoulos, M Bauer, E J Giamarellos-Bourboulis and S Kreth
    Citation: Molecular Medicine 2018 24:54
    Content type: Research article Published on:

  49. Vitamin D is a key immune-modulator that plays a role in the innate and adaptive immune systems. Certain pathogens impair the immune defense by downregulating the vitamin D receptor (VDR) pathway. Low serum level...

    Authors: Neta Gotlieb, Irena Tachlytski, Yelena Lapidot, Maya Sultan, Michal Safran and Ziv Ben-Ari
    Citation: Molecular Medicine 2018 24:53
    Content type: Research article Published on:

  50. For the study, we determine the potential biomarkers and uncover the regulatory mechanisms of lncRNA MALAT1 / miR-145 / SOX9 axis on the abilities of cell growth and cell metastasis of colorectal cancer.

    Authors: Yuanlin Xu, Xihong Zhang, Xiufeng Hu, Wenping Zhou, Peipei Zhang, Jiuyang Zhang, Shujun Yang and Yanyan Liu
    Citation: Molecular Medicine 2018 24:52
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658