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  1. Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a red...

    Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck and Gary D. Lopaschuk
    Citation: Molecular Medicine 2018 24:3
    Content type: Research article Published on:

  2. Epidemiological studies have suggested a link between cumulative diabetic exposure and cancer. The interaction of advanced glycation end products (AGEs) with their receptor (RAGE) may contribute to the phenome...

    Authors: Nobutaka Nakamara, Takanori Matsui, Yuji Ishibashi, Ami Sotokawauchi, Kei Fukami, Yuichiro Higashimoto and Sho-ichi Yamagishi
    Citation: Molecular Medicine 2017 23:2301295
    Content type: Research Article Published on:

  3. Sirtuin-6 (Sirt6) is a critical epigenetic regulator, but its function in the gut is unknown. Here, we studied the role of intestinal epithelial Sirt6 in colitis-associated intestinal epithelial injury. We fou...

    Authors: Fangyi Liu, Heng-Fu Bu, Hua Geng, Isabelle G. De Plaen, Chao Gao, Peng Wang, Xiao Wang, Jacob A. Kurowski, Hong Yang, Jiaming Qian and Xiao-Di Tan
    Citation: Molecular Medicine 2017 23:2301272
    Content type: Research Article Published on:

  4. The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation. MicroRNA-210 (miR-210) is ...

    Authors: Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu and Ming Fan
    Citation: Molecular Medicine 2017 23:2301258
    Content type: Research Article Published on:

  5. BD750, a novel JAK3/STAT5 inhibitor, can inhibit T cell proliferation. This study aims to evaluate whether BD750 can induce tolerogenic dendritic cells (tolDC) and their function in experimental autoimmune enc...

    Authors: Yan Zhou, Xiao Leng, Hua Li, Shuxia Yang, Tai Yang, Limei Li, Ying Xiong, Qiang Zou, Yang Liu and Yantang Wang
    Citation: Molecular Medicine 2017 23:2301204
    Content type: Research Article Published on:

  6. Biobanks and national registries represent a powerful tool for genomic discovery, but rely on diagnostic codes that can be unreliable and fail to capture relationships between related diagnoses. We developed a...

    Authors: Thomas H. McCoy Jr, Victor M. Castro, Leslie A. Snapper, Kamber L. Hart and Roy H. Perlis
    Citation: Molecular Medicine 2017 23:2301285
    Content type: Research Article Published on:

  7. Interleukin (IL)-26 is abundant in human airways and this cytokine is involved in the local immune response to a bacterial stimulus in vivo. Specifically, local exposure to the toll-like receptor (TLR) 4 agoni...

    Authors: Karlhans Fru Che, Riitta Kaarteenaho, Elisa Lappi-Blanco, Bettina Levänen, Jitong Sun, Åsa Wheelock, Lena Palmberg, C. Magnus Sköld and Anders Lindén
    Citation: Molecular Medicine 2017 23:2301247
    Content type: Research Article Published on:

  8. Coiled-coil domain-containing 80 (CCDC80) is an adipocyte-secreted protein that modulates glucose homeostasis in response to diet-induced obesity in mice. The objective of this study was to analyze the link be...

    Authors: Óscar Osorio-Conles, María Guitart, José María Moreno-Navarrete, Xavier Escoté, Xavier Duran, José Manuel Fernandez-Real, Anna María Gómez-Foix, Sonia Fernández-Veledo and Joan Vendrell
    Citation: Molecular Medicine 2017 23:2301225
    Content type: Research Article Published on:

  9. Adoptive immunotherapy with cytokine induced killer (CIK) cells has shown antitumor activity against several kinds of cancer in preclinical models and clinical trials. CIK cells are a subset of ex vivo expanded T...

    Authors: Giulia Mesiano, Roberta Zini, Giulia Montagner, Nicoletta Bianchi, Rossella Manfredini, Antonella Chillemi, Massimo Aglietta, Giovanni Grignani, Ilaria Lampronti, Erika Fiorino, Fabio Malavasi, Dario Sangiolo, Roberto Gambari and Davide Ferrari
    Citation: Molecular Medicine 2017 23:2301235
    Content type: Research Article Published on:

  10. Heme oxygenase-1 (HO-1) is reported to protect against liver injury, but little Is known about its effect on the intestinal barrier in cholestatic liver injury. In this study, we investigated the effects of HO...

    Authors: Lijing Zhang, Zhenling Zhang, Bojia Liu, Yanling Jin, Yan Tian, Yi Xin and Zhijun Duan
    Citation: Molecular Medicine 2017 23:2301215
    Content type: Research Article Published on:

  11. Histone modifications play a critical role In the pathological processes of dilated cardiomyopathy (DCM), while the role and expression pattern of histone methyltransferases (HMTs), especially mixed lineage le...

    Authors: Ding-Sheng Jiang, Xin Yi, Rui Li, Yun-Shu Su, Jing Wang, Min-Lai Chen, Li-Gang Liu, Min Hu, Cai Cheng, Ping Zheng, Xue-Hai Zhu and Xiang Wei
    Citation: Molecular Medicine 2017 23:2301196
    Content type: Research Article Published on:

  12. Inflammation plays a significant role in protecting hosts against pathogens. Inflammation induced by noninfectious endogenous agents can be detrimental and, if excessive, can result in organ and tissue damage....

    Authors: Qian Sun, Jie Fan, Timothy R. Billiar and Melanie J. Scott
    Citation: Molecular Medicine 2017 23:2301188
    Content type: Research Article Published on:

  13. More than 100 risk loci for rheumatoid arthritis (RA) have been identified in individuals of European and Asian descent, but the genetic basis for RA in African Americans is less well understood. We genotyped ...

    Authors: Maria I. Danila, Vincent A. Laufer, Richard J. Reynolds, Qi Yan, Nianjun Liu, Peter K. Gregersen, Annette Lee, Marlena Kern, Carl D. Langefeld, Donna K. Arnett and S. Louis Bridges Jr.
    Citation: Molecular Medicine 2017 23:2301177
    Content type: Research Article Published on:

  14. Previously, we showed that an oligodeoxynucleotide (ODN) with AAAG repeats (AAAG ODN) rescued mice from fatal acute lung injury (ALI) induced by influenza virus and inhibited production of tumor necrosis facto...

    Authors: Yue Xiao, Wenting Lu, Xin Li, Peiyan Zhao, Yun Yao, Xiaohong Wang, Ying Wang, Zhipeng Lin, Yongli Yu, Shucheng Hua and Liying Wang
    Citation: Molecular Medicine 2017 23:2301166
    Content type: Research Article Published on:

  15. Reperfusion injury following acute myocardial infarction is associated with significant morbidity. Activation of neuronal or non-neuronal cholinergic pathways in the heart has been shown to reduce ischemic inj...

    Authors: Spyros A. Mavropoulos, Nayaab S. Khan, Asaph C. J. Levy, Bradley T. Faliks, Cristina P. Sison, Valentin A. Pavlov, Youhua Zhang and Kaie Ojamaa
    Citation: Molecular Medicine 2017 23:2301120
    Content type: Research Article Published on:

  16. Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the perijunctional actin-myosin ring. Myosin light chain kinase (MLCK) p...

    Authors: C. Adam Lorentz, Zhe Liang, Mei Meng, Ching-Wen Chen, Benyam P. Yoseph, Elise R. Breed, Rohit Mittal, Nathan J. Klingensmith, Alton B. Farris, Eileen M. Burd, Michael Koval, Mandy L. Ford and Craig M. Coopersmith
    Citation: Molecular Medicine 2017 23:2301155
    Content type: Research Article Published on:

  17. Sepsis is a leading cause of death worldwide. Current treatment modalities remain largely supportive. Intervention strategies focused on inhibiting specific mediators of the inflammatory host response have bee...

    Authors: Anju M. Philip, Youdong Wang, Antonio Mauro, Suzan El-Rass, John C. Marshall, Warren L. Lee, Arthur S. Slutsky, Claudia C. dos Santos and Xiao-Yan Wen
    Citation: Molecular Medicine 2017 23:2301134
    Content type: Research Article Published on:

  18. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Paul Nurse
    Citation: Molecular Medicine 2017 23:2301112
    Content type: Anthony Cerami Award in Translational Medicine Published on:

  19. Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer tumors. Comparisons between TNBC and non-triple-negative breast cancer (nTNBC) may help to differentiate key components involved i...

    Authors: Sandra K. Santuario-Facio, Servando Cardona-Huerta, Yadira X. Perez-Paramo, Victor Trevino, Francisco Hernandez-Cabrera, Augusto Rojas-Martinez, Grecia Uscanga-Perales, Jorge L. Martinez-Rodriguez, Lizeth Martinez-Jacobo, Gerardo Padilla-Rivas, Gerardo Muñoz-Maldonado, Juan Francisco Gonzalez-Guerrero, Javier Valero-Gomez, Ana L. Vazquez-Guerrero, Herminia G. Martinez-Rodriguez, Alvaro Barboza-Quintana…
    Citation: Molecular Medicine 2017 23:2301101
    Content type: Research Article Published on:

  20. Congenital lipoid adrenal hyperplasia (CLAH) is the most severe form of congenital adrenal hyperplasia, caused by defects in the steroidogenic acute regulatory protein (STAR). The STAR p.Q258* mutation is the mos...

    Authors: Eungu Kang, Yoon-Myung Kim, Gu-Hwan Kim, Beom Hee Lee, Han-Wook Yoo and Jin-Ho Choi
    Citation: Molecular Medicine 2017 23:2301149
    Content type: Research Article Published on:

  21. The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain...

    Authors: Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri and Marc Symons
    Citation: Molecular Medicine 2017 23:2301050
    Content type: Research Article Published on:

  22. Calcific aortic valve disease (CAVD) is common among the elderly, and aortic valve interstitial cells (AVICs) exhibit unique inflammatory and osteogenic responses to proinflammatory stimulation, which plays an...

    Authors: Qiong Zhan, Qingchun Zeng, Rui Song, Yufeng Zhai, Dingli Xu, David A. Fullerton, Charles A. Dinarello and Xianzhong Meng
    Citation: Molecular Medicine 2017 23:2301083
    Content type: Research Article Published on:

  23. Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are hepatic manifestations of the metabolic syndrome. Many currently used animal models of NAFLD/NASH lack clinical features of ...

    Authors: Janin Henkel, Charles Dominic Coleman, Anne Schraplau, Korinna Jöhrens, Daniela Weber, José Pedro Castro, Martin Hugo, Tim Julius Schulz, Stephanie Krämer, Annette Schürmann and Gerhard Paul Püschel
    Citation: Molecular Medicine 2017 23:2301070
    Content type: Research Article Published on:

  24. Osteoporosis is a global public health problem affecting more than 200 million people worldwide. We previously showed that treatment with α-1 antitrypsin (AAT), a multifunctional protein with antiinflammatory ...

    Authors: Mohammad Ahsanul Akbar, David Nardo, Mong-Jen Chen, Ahmed S. Elshikha, Rubina Ahamed, Eslam M. Elsayed, Claire Bigot, L. Shannon Holliday and Sihong Song
    Citation: Molecular Medicine 2017 23:2301057
    Content type: Research Article Published on:

  25. The inflammatory pathways that drive the development of intimai hyperplasia (IH) following arterial injury are not fully understood. We hypothesized that the lysosomal cysteine protease cathepsin L activates p...

    Authors: Jingjing Cai, Hua Zhong, Jinze Wu, Rui-Fang Chen, Huan Yang, Yousef Al-Abed, Ying Li, Xiaohui Li, Weihong Jiang, Marcelo F. Montenegro, Hong Yuan, Timothy R. Billiar and Alex F. Chen
    Citation: Molecular Medicine 2017 23:2301092
    Content type: Research Article Published on:

  26. α7 nicotinic acetylcholine receptor (α7 nAChR, coded by Chrna7) is indispensable in dampening proinflammatory responses. However, whether α7 nAChR plays a role in regulating bleomycin (BLM)-induced lung fibrosis ...

    Authors: Peiyu Sun, Ling Li, Caiqi Zhao, Mengyao Pan, Zhikang Qian and Xiao Su
    Citation: Molecular Medicine 2017 23:2301034
    Content type: Research Article Published on:

  27. Pancreatic cancer is one of the most lethal solid malignancies, with few treatment options. We have recently shown that expression of protease activated receptor (PAR)-1 in the tumor microenvironment drives th...

    Authors: Kun Shi, Helene Damhofer, Joost Daalhuisen, Marieke ten Brink, Dick J. Richel and C. Arnold Spek
    Citation: Molecular Medicine 2017 23:2301013
    Content type: Research Article Published on:

  28. miR-155 has been shown to participate in host response to infection and neuroinflammation via negative regulation of blood-brain barrier (BBB) integrity and T cell function. We hypothesized that miR-155 may co...

    Authors: Kevin R. Barker, Ziyue Lu, Hani Kim, Ying Zheng, Junmei Chen, Andrea L. Conroy, Michael Hawkes, Henry S. Cheng, Makon-Sébastien Njock, Jason E. Fish, John M. Harlan, Jose A. López, W. Conrad Liles and Kevin C. Kain
    Citation: Molecular Medicine 2017 23:2301024
    Content type: Research Article Published on:

  29. Amino acid replacement mutations in certain chronic lymphocytic leukemia (CLL) stereotyped B cell receptor (BCR) immunoglobulins (IGs) at defined positions within antigen-binding sites strongly imply antigen s...

    Authors: Rosa Catera, Yun Liu, Chao Gao, Xiao-Jie Yan, Amanda Magli, Steven L. Allen, Jonathan E. Kolitz, Kanti R. Rai, Charles C. Chu, Ten Feizi, Kostas Stamatopoulos and Nicholas Chiorazzi
    Citation: Molecular Medicine 2017 23:2301001
    Content type: Research Article Published on:

  30. Sepsis survivors suffer from additional morbidities, including higher risk of readmissions, nervous system disturbances and cognitive dysfunction, and increased mortality, even several years after the initial ...

    Authors: Naara Mendes Oliveira, Ester C S Rios, Thais Martins de Lima, Vanessa Jacob Victorino, Hermes Barbeiro, Fabiano Pinheiro da Silva, Csaba Szabo and Francisco Garcia Soriano
    Citation: Molecular Medicine 2016 22:2201886
    Content type: Research Article Published on:

  31. Strategies aimed at reducing cerebral accumulation of the amyloid-β (Aβ) peptides have therapeutic potential in Alzheimer’s disease (AD). Aβ immunization has proven to be effective at promoting Aβ clearance in...

    Authors: Valérie Vingtdeux, Haitian Zhao, Pallavi Chandakkar, Christopher M Acker, Peter Davies and Philippe Marambaud
    Citation: Molecular Medicine 2016 22:2201841
    Content type: Research Article Published on:

  32. The absence of early outcome biomarkers for pediatric acute liver failure (PALF) hinders medical and liver transplant decisions. We sought to define dynamic interactions among circulating inflammatory mediator...

    Authors: Ruben Zamora, Yoram Vodovotz, Qi Mi, Derek Barclay, Jinling Yin, Simon Horslen, David Rudnick, Kathleen M Loomes and Robert H Squires
    Citation: Molecular Medicine 2016 22:2201821
    Content type: Research Article Published on:

  33. After several decades of Alzheimer’s disease (AD) research and failed clinical trials, one can speculate that targeting a single pathway is not sufficient. However, a cocktail of novel therapeutics will consti...

    Authors: Roman Sankowski, Arne Herring, Kathy Keyvani, Kathrin Frenzel, Jinyu Wu, Stephan Röskam, Carmen Noelker, Michael Bacher and Yousef Al-Abed
    Citation: Molecular Medicine 2016 22:2201776
    Content type: Research Article Published on:

  34. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Tak Mak
    Citation: Molecular Medicine 2016 22:2201675
    Content type: Research Article Published on:

  35. Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R Tannemaat, Anthony Cerami, and Michael Brines. (2013) ARA 290 Im...

    Authors: Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L. Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R. Tannemaat, Anthony Cerami and Michael Brines
    Citation: Molecular Medicine 2016 22:2201674
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2013 19:Art43

  36. OBJECTIVE: In rheumatoid arthritis (RA) several recent efforts have sought to discover means of predicting which patients would benefit from treatment. However, results have been discrepant with few successful...

    Authors: Lasse Folkersen, Boel Brynedal, Lina Marcela Diaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky, Helga Westerlind, Yvonne Sundström, Danika Schepis, Aase Hensvold, Nancy Vivar, Maija-Leena Eloranta, Lars Rönnblom, Søren Brunak, Vivianne Malmström, Anca Catrina, Ulrik G W Moerch…
    Citation: Molecular Medicine 2016 22:2201322
    Content type: Research Article Published on:

  38. During exercise, cardiac oxygen consumption increases and the resulting low oxygen level in the myocardium triggers coronary vasodilation. This response to hypoxia is controlled notably by the vasodilator aden...

    Authors: Jean Ruf, Franck Paganelli, Laurent Bonello, Nathalie Kipson, Giovanna Mottola, Julien Fromonot, Jocelyne Condo, Alain Boussuges, Laurie Bruzzese, François Kerbaul, Yves Jammes, Vlad Gariboldi, Frédéric Franceschi, Emmanuel Fenouillet and Régis Guieu
    Citation: Molecular Medicine 2016 22:2201530
    Content type: Research Article Published on:

  39. Although current vaccination strategies have been successful at preventing a variety of human diseases, attempts at vaccinating against some pathogens such as AIDS and tuberculosis (TB) have been more problema...

    Authors: Rui Li, Nan Zhang, Miaomiao Tian, Zihan Ran, Mingjun Zhu, Haiyan Zhu, Fangting Han, Juan Yin and Jiang Zhong
    Citation: Molecular Medicine 2016 22:2201497
    Content type: Research Article Published on:

  40. The ratio of the longer (Aβ42/Aβ43) to shorter (Aβ40) species is a critical factor determining amyloid fibril formation, neurotoxicity and progression of the amyloid pathology in Alzheimer’s disease. The relat...

    Authors: Katarzyna Marta Zoltowska, Masato Maesako and Oksana Berezovska
    Citation: Molecular Medicine 2016 22:2201329
    Content type: Research Article Published on:

  41. Previous in vivo work showed that resveratrol has beneficial effects in Alzheimer’s disease (AD) pathology, resulting in increased expression of transthyretin (TTR). TTR binds amyloid-beta (Aβ) peptide, avoiding ...

    Authors: Luís Miguel Santos, Daniela Rodrigues, Mobina Alemi, Sara Costa Silva, Carlos Alexandre Ribeiro and Isabel Cardoso
    Citation: Molecular Medicine 2016 22:2201597
    Content type: Research Article Published on:

  42. A 55–200 expansion of the CGG nucleotide repeat in the 5′-UTR of the fragile X mental retardation 1 gene (FMR1) is the hallmark of the triplet nucleotide disease known as the “premutation” as opposed to those ...

    Authors: Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone and Cecilia Giulivi
    Citation: Molecular Medicine 2016 22:2201548
    Content type: Original Articles Published on:

  43. Methicillin-resistant Staphylococcus aureus (MRSA) is an important pathogen in pneumonia associated with severe lung damage. Tissue injury causes release of damage-associated molecular patterns (DAMPs), which may...

    Authors: Anne Jan van der Meer, Achmed Achouiti, Arie van der Ende, Aicha Ait Soussan, Sandrine Florquin, Alex de Vos, Sacha S Zeerleder and Tom van der Poll
    Citation: Molecular Medicine 2016 22:2201292
    Content type: Research Article Published on:

  44. Esophageal adenocarcinoma (EAC) has a poor prognosis and is increasing in incidence in many Western populations. Neoadjuvant chemoradiation therapy (CRT) followed by surgery is increasingly the standard of car...

    Authors: Niamh Lynam-Lennon, Becky A S Bibby, Ann Marie Mongan, Laure Marignol, Christian N Paxton, Katherine Geiersbach, Mary P Bronner, Jacintha O’Sullivan, John V Reynolds and Stephen G Maher
    Citation: Molecular Medicine 2016 22:2201388
    Content type: Research Article Published on:

  45. Acute emotionally reactive mental stress (MS) can provoke prognostically relevant deficits in cardiac function and myocardial perfusion, and chronic inflammation increases risk for this ischemic phenomenon. We...

    Authors: Robert Soufer, Antonio B Fernandez, Judith Meadows, Dorothea Collins and Matthew M Burg
    Citation: Molecular Medicine 2016 22:2201286
    Content type: Research Article Published on:

  46. The tumor-node-metastasis (TNM) system fails to accurately predict disease recurrence in a considerable number of patients. Although node-negative (stage II) colon cancer is considered to have an overall good ...

    Authors: Martin M Watson and Kjetil Søreide
    Citation: Molecular Medicine 2016 22:2201271
    Content type: Invited Commentary Published on:

  48. Emerging evidence demonstrates association of depression with both immune malfunctioning and worsened course of diverse aging-related diseases, but there is no explanation for the pathway(s) controlling this d...

    Authors: Shani Shenhar-Tsarfaty, Sharon Joker, Itzhak Shapira, Ori Rogowski, Shlomo Berliner, Yaacov Ritov and Hermona Soreq
    Citation: Molecular Medicine 2016 22:2201156
    Content type: Invited Research Article Published on:

  49. Endothelial cell (EC) dysfunction is a critical mediator of the acute respiratory distress syndrome (ARDS). Recent studies have demonstrated that stromal cell-derived factor 1α (SDF-1α) promotes EC barrier int...

    Authors: Changrun Guo, Andrew Goodwin, Joy N Jones Buie, James Cook, Perry Halushka, Kelley Argraves, Basilia Zingarelli, Xian Zhang, Liping Wang and Hongkuan Fan
    Citation: Molecular Medicine 2016 22:2201115
    Content type: Research Article Published on:

  50. Sepsis is a major healthcare concern, especially in the elderly population. The use of an animal model closely resembling clinical conditions in this population may provide a better prediction in translating b...

    Authors: Weng-Lang Yang, Gaifeng Ma, Mian Zhou, Monowar Aziz, Hao-Ting Yen, Spyros A Marvropoulos, Kaie Ojamaa and Ping Wang
    Citation: Molecular Medicine 2016 22:2201124
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658