Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 22 of 37

  1. Although the molecular links underlying the causative relationship between chronic low-grade inflammation and insulin resistance are not completely understood, compelling evidence suggests a pivotal role of th...

    Authors: Fausto Chiazza, Aurélie Couturier-Maillard, Elisa Benetti, Raffaella Mastrocola, Debora Nigro, Juan C. Cutrin, Loredana Serpe, Manuela Aragno, Roberto Fantozzi, Bernard Ryffel, Christoph Thiemermann and Massimo Collino
    Citation: Molecular Medicine 2015 21:21011025
    Content type: Research Article Published on:

  2. Aloperine is a quinolizidine alkaloid extracted from the leaves of Sophora plants. It has been recognized with the potential to treat inflammatory and allergic diseases as well as tumors. In this report, we de...

    Authors: Shuang Hu, Yuxing Zhang, Meng Zhang, Yanchao Guo, Ping Yang, Shu Zhang, Sakine Simsekyilmaz, Jun-Fa Xu, Jinxiu Li, Xudong Xiang, Qilin Yu and Cong-Yi Wang
    Citation: Molecular Medicine 2015 21:2101912
    Content type: Research Article Published on:

  3. Hepatic ischemia/reperfusion (I/R) injury is a side effect of major liver surgery that often cannot be avoided. Prolonged periods of ischemia put a metabolic strain on hepatocytes and limit the tolerable ische...

    Authors: Pim B. Olthof, Megan J. Reiniers, Marcel C. Dirkes, Thomas M. van Gulik, Michal Heger and Rowan F. van Golen
    Citation: Molecular Medicine 2015 21:2101833
    Content type: Review Article Published on:

  4. Extracellular high-mobility group box 1 (HMGB1) (disulfide form), via activation of toll-like receptor 4 (TLR4)-dependent signaling, is a strong driver of pathologic inflammation in both acute and chronic cond...

    Authors: John P. Pribis, Yousef Al-Abed, Huan Yang, Domokos Gero, Hongbo Xu, Marcelo F. Montenegro, Eileen M. Bauer, Sodam Kim, Sangeeta S. Chavan, Changchun Cai, Tunliang Li, Petra Szoleczky, Csaba Szabo, Kevin J. Tracey and Timothy R. Billiar
    Citation: Molecular Medicine 2015 21:2101749
    Content type: Research Article Published on:

  5. The receptor type protein tyrosine phosphatase D (PTPRD) gene encodes a cell adhesion molecule likely to influence development and connections of addiction-, locomotion- and sleep-related brain circuits in which ...

    Authors: Jana Drgonova, Donna Walther, Katherine J. Wang, G. Luke Hartstein, Bryson Lochte, Juan Troncoso, Noriko Uetani, Yoichiro Iwakura and George R. Uhl
    Citation: Molecular Medicine 2015 21:2101717
    Content type: Research Article Published on:

  6. Toll-like receptors (TLRs) play an important role in regulating muscle regeneration and angiogenesis in response to ischemia. TLR2 knockout mice exhibit pronounced skeletal muscle necrosis and abnormal vessel ...

    Authors: Jia Xu, Kelly Benabou, Xiangdong Cui, Marissa Madia, Edith Tzeng, Timothy Billiar, Simon Watkins and Ulka Sachdev
    Citation: Molecular Medicine 2015 21:2101605
    Content type: Research Article Published on:

  7. Somatic DNA alterations are known to occur in atherosclerotic carotid artery lesions; however, their significance is unknown. The accumulation of microsatellite mutations in coding DNA regions may reflect a de...

    Authors: Carolin Kurz, Maani Hakimi, Matthias Kloor, Caspar Grond-Ginsbach, Marie-Luise Gross-Weissmann, Dittmar Böckler, Magnus von Knebel Doeberitz and Susanne Dihlmann
    Citation: Molecular Medicine 2015 21:2101479
    Content type: Research Article Published on:

  8. Tumor-specific metabolic changes can reveal new therapeutic targets. Our findings implicate a supporting role for fatty acid metabolism in chronic lymphocytic leukemia (CLL) cell survival. Peroxisome prolifera...

    Authors: Davorka Messmer, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock, Geraldine Cabrera, Lucia Correa, Austin Chen, Jason Jacintho, Nicholas Chiorazzi, Xiao Jie Yan, David Spaner, Peppi Prasit and Daniel Lorrain
    Citation: Molecular Medicine 2015 21:2101410
    Content type: Research Article Published on:

  9. Acute intermittent porphyria (AIP) is an autosomal-dominant hepatic disorder caused by the half-normal activity of hydroxymethylbilane (HMB) synthase. Symptomatic individuals experience life-threatening acute ...

    Authors: Makiko Yasuda, Angelika L. Erwin, Lawrence U. Liu, Manisha Balwani, Brenden Chen, Senkottuvelan Kadirvel, Lin Gan, M. Isabel Fiel, Ronald E. Gordon, Chunli Yu, Sonia Clavero, Antonios Arvelakis, Hetanshi Naik, L. David Martin, John D. Phillips, Karl E. Anderson…
    Citation: Molecular Medicine 2015 21:2101487
    Content type: Research Article Published on:

  10. Epidemiological studies indicate that vitamin D exerts a protective effect on the development of various solid cancers. However, concerns have been raised regarding the potential deleterious role of high vitam...

    Authors: Vincent T. Janmaat, Anouk van de Winkel, Maikel P. Peppelenbosch, Manon C. W. Spaander, André G. Uitterlinden, Farzin Pourfarzad, Hugo W. Tilanus, Agnieszka M. Rygiel, Leon M. G. Moons, Pascal P. Arp, Kausilia K. Krishnadath, Ernst J. Kuipers and Luc J. W. van der Laan
    Citation: Molecular Medicine 2015 21:2101346
    Content type: Research Article Published on:

  11. Cystic fibrosis (CF) is a monogenic disease caused by mutations of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The genotype-phenotype relationship in this disease is still unclear, and di...

    Authors: Marco Lucarelli, Sabina Maria Bruno, Silvia Pierandrei, Giampiero Ferraguti, Antonella Stamato, Fabiana Narzi, Annalisa Amato, Giuseppe Cimino, Serenella Bertasi, Serena Quattrucci and Roberto Strom
    Citation: Molecular Medicine 2015 21:2101257
    Content type: Research Article Published on:

  12. Interleukin-37 (IL-37) is a recently identified cytokine with potent antiinflammatory and immunosuppressive functions. The objective of this study was to compare levels of IL-37 mRNA in immunological subgroups...

    Authors: Jesper F. Højen, Thomas A. Rasmussen, Karen Lise D. Andersen, Anni A. Winckelmann, Rune R. Laursen, Jesper D. Gunst, Holger J. Møller, Mayumi Fujita, Lars Østergaard, Ole S. Søgaard, Charles A. Dinarello and Martin Tolstrup
    Citation: Molecular Medicine 2015 21:2101337
    Content type: Research Article Published on:

  13. Chronic, nonhealing wounds result in patient morbidity and disability. Reactive oxygen species (ROS) and nitric oxide (NO) are both required for normal wound repair, and derangements of these result in impaire...

    Authors: Michael C. Madigan, Ryan M. McEnaney, Ankur J. Shukla, Guiying Hong, Eric E. Kelley, Margaret M. Tarpey, Mark Gladwin, Brian S. Zuckerbraun and Edith Tzeng
    Citation: Molecular Medicine 2015 21:2101313
    Content type: Research Article Published on:

  15. In sepsis, the severity-dependent decrease of von Willebrand factor (VWF)-inactivating protease, a disintegrin and metalloproteinase with thrombospondin motifs 13 (ADAMTS13), results in platelet aggregation an...

    Authors: Michael L. Ekaney, Clemens L. Bockmeyer, Maik Sossdorf, Philipp A. Reuken, Florian Conradi, Tobias Schuerholz, Markus F. Blaess, Scott L. Friedman, Wolfgang Lösche, Michael Bauer and Ralf A. Claus
    Citation: Molecular Medicine 2015 21:2101355
    Content type: Research Article Published on:

  16. Inflammatory responses play a critical role in ischemic brain injury. MicroRNA-155 (miR-155) induces the expression of inflammatory cytokines, and acetylbritannilactone (ABL) exerts potent antiinflammatory act...

    Authors: Ya Wen, Xiangjian Zhang, Lipeng Dong, Jingru Zhao, Cong Zhang and Chunhua Zhu
    Citation: Molecular Medicine 2015 21:2101197
    Content type: Research Article Published on:

  17. In a first genome-wide association study (GWAS) approach to anti-Borrelia seropositivity, we identified two significant single nucleotide polymorphisms (SNPs) (rs17850869, P = 4.17E-09; rs41289586, P = 7.18E-08)....

    Authors: Christian Hammer, Podchanart Wanitchakool, Lalida Sirianant, Sergi Papiol, Mathieu Monnheimer, Diana Faria, Jiraporn Ousingsawat, Natalie Schramek, Corinna Schmitt, Gabriele Margos, Angelika Michel, Peter Kraiczy, Michael Pawlita, Rainer Schreiber, Thomas F. Schulz, Volker Fingerle…
    Citation: Molecular Medicine 2015 21:2101026
    Content type: Research Article Published on:

  18. Double-stranded RNA-dependent protein kinase (PKR), an intracellular pathogen recognition receptor, is involved both in insulin resistance in peripheral tissues and in downregulation of pancreatic β-cell funct...

    Authors: LiLi Gao, Wei Tang, ZhengZheng Ding, DingYu Wang, XiaoQiang Qi, HuiWen Wu and Jun Guo
    Citation: Molecular Medicine 2015 21:2101154
    Content type: Research Article Published on:

  19. Hydrogen sulfide (H2S), as a reducing agent and an antioxidant molecule, exerts protective effects against hyperglycemic stress in the vascular endothelium. The mitochondrial enzyme 3-mercaptopyruvate sulfurtrans...

    Authors: Ciro Coletta, Katalin Módis, Bartosz Szczesny, Attila Brunyánszki, Gábor Oláh, Ester C. S. Rios, Kazunori Yanagi, Akbar Ahmad, Andreas Papapetropoulos and Csaba Szabo
    Citation: Molecular Medicine 2015 21:2101011
    Content type: Research Article Published on:

  20. Nonclassical protein secretion is of major importance as a number of cytokines and inflammatory mediators are secreted via this route. Current evidence indicates that there are several mechanistically distinct...

    Authors: Lisa Mullen, Eva-Maria Hanschmann, Christopher Horst Lillig, Leonore A. Herzenberg and Pietro Ghezzi
    Citation: Molecular Medicine 2015 21:2101098
    Content type: Research Article Published on:

  21. Valsartan has a protective effect against hypertension and atherosclerosis in humans and experimental animal models. This study aimed to determine the effect of prolonged treatment with angiotensin II (Ang II)...

    Authors: Kai Meng, Qiutang Zeng, Qinghua Lu, Yingzhong Lin, Bangwei Wu, Kunwu Yu, Zhaoqiang Dong, Jianwei Zhang, Meng Chai, Yuyang Liu, Qingwei Ji and Yujie Zhou
    Citation: Molecular Medicine 2015 21:2101143
    Content type: Research Article Published on:

  22. Sperm DNA fragmentation (sDF) represents a threat to male fertility, human reproduction and the health of the offspring. The causes of sDF are still unclear, even if apoptosis, oxidative assault and defects in...

    Authors: Monica Muratori, Lara Tamburrino, Sara Marchiani, Marta Cambi, Biagio Olivito, Chiara Azzari, Gianni Forti and Elisabetta Baldi
    Citation: Molecular Medicine 2015 21:2101109
    Content type: Research Article Published on:

  23. The host tolerance mechanisms to avian influenza virus (H5N1) infection that limit tissue injury remain unknown. Emerging evidence indicates that cystic fibrosis transmembrane conductance regulator (CFTR), a c...

    Authors: Ke Cao, Minhui Chen, Xiang Jie, Yansheng Wang, Qiasheng Li and Jun Xu
    Citation: Molecular Medicine 2015 21:2101134
    Content type: Research Article Published on:

  24. Experimental autoimmune encephalomyelitis (EAE), an animal model of human multiple sclerosis (MS), is mediated by myelinspecific autoreactive T cells that cause inflammation and demyelination in the central ne...

    Authors: Prameladevi Chinnasamy, Sarah E. Lutz, Dario F. Riascos-Bernal, Venkatesh Jeganathan, Isabel Casimiro, Celia F. Brosnan and Nicholas E. S. Sibinga
    Citation: Molecular Medicine 2015 21:2101233
    Content type: Research Article Published on:

  25. We previously reported that atrial natriuretic factor (ANF) stimulates secretin-evoked cAMP efflux through multidrug resistance-associated protein 4 (MRP4) in the exocrine pancreas. Here we sought to establish in...

    Authors: María Silvia Ventimiglia, Ana Clara Najenson, Juan Carlos Perazzo, Alejandro Carozzo, Marcelo S. Vatta, Carlos A. Davio and Liliana G. Bianciotti
    Citation: Molecular Medicine 2015 21:2101058
    Content type: Research Article Published on:

  26. The cytokine macrophage migration inhibitory factor (MIF) possesses unique tautomerase enzymatic activity, which contributes to the biological functional activity of MIF. In this study, we investigated the eff...

    Authors: Leona Mawhinney, Michelle E. Armstrong, Ciaran O’Reilly, Richard Bucala, Lin Leng, Gunter Fingerle-Rowson, Darren Fayne, Michael P. Keane, Aisling Tynan, Lewena Maher, Gordon Cooke, David Lloyd, Helen Conroy and Seamas C. Donnelly
    Citation: Molecular Medicine 2014 20:2001729
    Content type: Research Article Published on:

  27. In the hydroxyurea era, insights into mechanisms downstream of erythrocyte sickling have led to new therapeutic approaches for patients with sickle cell disease (SCD). Therapies have been developed that target...

    Authors: Joshua J. Field and David G. Nathan
    Citation: Molecular Medicine 2014 20(Suppl 1):20001037
    Content type: Retrospective Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  32. Disease processes provoke a balancing act between tissue damage and repair. In the 1980s, the discovery that tumor necrosis factor (TNF)-α is a general mediator of disease-related injury led to the development...

    Authors: Michael Brines
    Citation: Molecular Medicine 2014 20(Suppl 1):20001010
    Content type: Retrospective Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  33. Rheumatoid arthritis (RA) is an autoimmune disease resulting from a largely unknown interaction between genetically determined and environmental factors. Progress in the understanding of this chronic inflammat...

    Authors: Ferry Breedveld
    Citation: Molecular Medicine 2014 20(Suppl 1):20001007
    Content type: Retrospective Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  36. In volume 19, the Journal made an error in pagination for the two papers below (both begin with the same page number and share eight pages with the same page numbers):

    Authors: Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d’Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman and Peter Davies
    Citation: Molecular Medicine 2014 20:2001037
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2013 20:Art4

  37. Anakinra, the recombinant form of the human interleukin (IL)-1 receptor antagonist, blunts the acute systemic inflammatory response in patients with ST-segment elevation myocardial infarction (STEMI), by deter...

    Authors: Chiara Sonnino, Sanah Christopher, Claudia Oddi, Stefano Toldo, Raquel Appa Falcao, Ryan D. Melchior, George H. Mueller, Nayef A. Abouzaki, Amit Varma, Michael L. Gambill, Benjamin W. Van Tassell, Charles A. Dinarello and Antonio Abbate
    Citation: Molecular Medicine 2014 20:2001486
    Content type: Research Article Published on:

  40. Macrophages are instrumental in the pathophysiology of liver ischemia/reperfusion injury (IRI). Although Nrf2 regulates macrophage-specific heme oxygenase-1 (HO-1) antioxidant defense, it remains unknown whether ...

    Authors: Jing Huang, Xiu-Da Shen, Shi Yue, Jianjun Zhu, Feng Gao, Yuan Zhai, Ronald W. Busuttil, Bibo Ke and Jerzy W. Kupiec-Weglinski
    Citation: Molecular Medicine 2014 20:2001448
    Content type: Research Article Published on:

  41. High mobility group box 1 (HMGB1) is an evolutionarily ancient protein that is present in one form or another in all eukaryotes. It fundamentally resides in the nucleus but translocates to the cytosol with str...

    Authors: Daolin Tang, Rui Kang, Bennett Van Houten, Herbert J. Zeh, Timothy R. Billiar and Michael T. Lotze
    Citation: Molecular Medicine 2014 20:2001359
    Content type: Commentary Published on:

  42. Accumulating evidence shows that protease-activated receptor-1 (PAR-1) plays an important role in the development of fibrosis, including lung fibrosis. However, whether PAR-1 also plays a role in the developme...

    Authors: Jan Willem Duitman, Roberta R. Ruela-de-Sousa, Kun Shi, Onno J. de Boer, Keren S. Borensztajn, Sandrine Florquin, Maikel P. Peppelenbosch and C. Arnold Spek
    Citation: Molecular Medicine 2014 20:2001410
    Content type: Research Article Published on:

  43. The mammalian immune system and the nervous system coevolved under the influence of cellular and environmental stress. Cellular stress is associated with changes in immunity and activation of the NACHT, LRR an...

    Authors: Ben Lu, Kevin Kwan, Yaakov A. Levine, Peder S. Olofsson, Huan Yang, Jianhua Li, Sonia Joshi, Haichao Wang, Ulf Andersson, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Molecular Medicine 2014 20:2001350
    Content type: Research Article Published on:

  45. Chronic vascular inflammation is a key hallmark in the pathogenesis of abdominal aortic aneurysm (AAA). Recent investigations have suggested that the inflammasome, a cytosolic multiprotein complex that recogni...

    Authors: Susanne Dihlmann, Philipp Erhart, Arianeb Mehrabi, Arash Nickkholgh, Felix Lasitschka, Dittmar Böckler and Maani Hakimi
    Citation: Molecular Medicine 2014 20:2001230
    Content type: Research Article Published on:

  47. High mobility group box 1 (HMGB1) is a central mediator in inflammation and immunity. Recently, it was shown that different redox states of the three cysteines of HMGB1 endow it with mutually exclusive activit...

    Authors: Daniel J. Antoine, Helena Erlandsson Harris, Ulf Andersson, Kevin J. Tracey and Marco E. Bianchi
    Citation: Molecular Medicine 2014 20:2001135
    Content type: Commentary Published on:

  48. Vascular endothelial growth factor (VEGF)-D, a member of the VEGF family, induces both angiogenesis and lymphangiogenesis by activating VEGF receptor-2 (VEGFR-2) and VEGFR-3 on the surface of endothelial cells...

    Authors: Ye Cui, Juan C. Osorio, Cristobal Risquez, Hao Wang, Ying Shi, Bernadette R. Gochuico, Danielle Morse, Ivan O. Rosas and Souheil El-Chemaly
    Citation: Molecular Medicine 2014 20:2001120
    Content type: Research Article Published on:

  49. Parasympathetic activity influences long-term outcome in patients with cardiovascular disease, but the underlying mechanism(s) linking parasympathetic activity and the occurrence of major adverse cardiovascula...

    Authors: Yaron Arbel, Shani Shenhar-Tsarfaty, Nir Waiskopf, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Itzhak Herz, Itzhak Shapira, Gad Keren, Hermona Soreq and Shmuel Banai
    Citation: Molecular Medicine 2013 20:2001038
    Content type: Research Article Published on:

  50. Severe hemorrhage leads to decreased blood flow to tissues resulting in decreased oxygen and nutrient availability affecting mitochondrial function. A mitoscriptome profiling study demonstrated alteration in s...

    Authors: Bixi Jian, Shaolong Yang, Irshad H. Chaudry and Raghavan Raju
    Citation: Molecular Medicine 2013 20:2001010
    Content type: Research Article Published on:
Submit manuscript

Annual Journal Metrics

  • Annual Journal Metrics

    2022 Citation Impact
    5.7 - 2-year Impact Factor
    6.3 - 5-year Impact Factor
    1.026 - SNIP (Source Normalized Impact per Paper)
    1.245 - SJR (SCImago Journal Rank)

    2023 Speed
    6 days submission to first editorial decision for all manuscripts (Median)
    132 days submission to accept (Median)

    2023 Usage
    1,105,866 downloads
    1,878 Altmetric mentions

Follow

Molecular Medicine

ISSN: 1528-3658