Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 24 of 37

  1. A single nucleotide polymorphism of PRDM1, the gene encoding Blimp-1, is strongly associated with inflammatory bowel disease. Here, we demonstrate that Blimp-1 in CD103+ dendritic cells (DCs) critically contribut...

    Authors: Sun Jung Kim, Jordan Goldstein, Kimberly Dorso, Miriam Merad, Lloyd Mayer, James M. Crawford, Peter K. Gregersen and Betty Diamond
    Citation: Molecular Medicine 2014 20:2001707
    Content type: Research Article Published on:

  2. Glycine N-methyltransferase (GNMT) is known for its function as a tumor suppressor gene. Since 100% of female Gnmt−/− mice developed hepatocellular carcinoma, we hypothesized that Gnmt−/− mice may have defective ...

    Authors: Chung-Hsien Li, Ming-Hong Lin, Shih-Han Chu, Pang-Hsien Tu, Cheng-Chieh Fang, Chia-Hung Yen, Peir-In Liang, Jason C. Huang, Yu-Chia Su, Huey-Kang Sytwu and Yi-Ming Arthur Chen
    Citation: Molecular Medicine 2014 20:2001684
    Content type: Research Article Published on:

  3. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: David J. Weatherall
    Citation: Molecular Medicine 2014 20:2001478
    Content type: Anthony Cerami Award in Translational Medicine Published on:

  4. The autonomic nervous system is an important modulator of cardiac signaling in both health and disease. In fact, the significance of altered parasympathetic tone in cardiac disease has recently come to the for...

    Authors: Ashbeel Roy, Silvia Guatimosim, Vania F. Prado, Robert Gros and Marco A. M. Prado
    Citation: Molecular Medicine 2014 20:2001527
    Content type: Review Article Published on:

  5. The pathogenesis of nonalcoholic steatohepatitis (NASH) is a two-stage process in which steatosis is the “first hit” and an unknown “second hit.” We hypothesized that “a binge” could be a “second hit” to devel...

    Authors: Takahiro Minato, Mikihiro Tsutsumi, Mutsumi Tsuchishima, Nobuhiko Hayashi, Takashi Saito, Yasuhiro Matsue, Nobuyuki Toshikuni, Tomiyasu Arisawa and Joseph George
    Citation: Molecular Medicine 2014 20:2001490
    Content type: Research Article Published on:

  6. Autophagy is involved in both the cell protective and the cell death process but its mechanism is largely unknown. The present work unravels a novel intracellular mechanism by which the serpin α1-antitrypsin (AAT...

    Authors: Michal G. Shapira, Boris Khalfin, Eli C. Lewis, Abraham H. Parola and Ilana Nathan
    Citation: Molecular Medicine 2014 20:2001417
    Content type: Research Article Published on:

  7. The aim of this study was to identify genetic variants associated with rheumatoid arthritis (RA) risk in black South Africans. Black South African RA patients (n = 263) were compared with healthy controls (n =...

    Authors: Nimmisha Govind, Ananyo Choudhury, Bridget Hodkinson, Claudia Ickinger, Jacqueline Frost, Annette Lee, Peter K. Gregersen, Richard J. Reynolds, S. Louis Bridges Jr., Scott Hazelhurst, Michèle Ramsay and Mohammed Tikly
    Citation: Molecular Medicine 2014 20:2001341
    Content type: Research Article Published on:

  8. The myocardial inflammatory response contributes to cardiac functional injury associated with heart surgery obligating global ischemia/reperfusion (I/R). Toll-like receptors (TLRs) play an important role in th...

    Authors: Chunhua Jin, Joseph C. Cleveland, Lihua Ao, Jilin Li, Qingchun Zeng, David A. Fullerton and Xianzhong Meng
    Citation: Molecular Medicine 2014 20:2001280
    Content type: Research Article Published on:

  9. The role of interleukin-22 (IL-22) in intracellular bacterial infections is a controversial issue, although the contribution of this cytokine to host defense against extracellular bacterial pathogens has been ...

    Authors: Ying Peng, Xiaoling Gao, Jie Yang, Sudhanshu Shekhar, Shuhe Wang, Yijun Fan, Weiming Zhao and Xi Yang
    Citation: Molecular Medicine 2014 20:2001109
    Content type: Research Article Published on:

  11. Abnormalities of lipid metabolism through overexpression of fatty acid synthase (FASN), which catalyzes the formation of long-chain fatty acids, are associated with the development of inflammatory bowel diseas...

    Authors: Shingo Matsuo, Weng-Lang Yang, Monowar Aziz, Shingo Kameoka and Ping Wang
    Citation: Molecular Medicine 2013 20:2001001
    Content type: Research Article Published on:

  12. Iodine supplementation exerts antitumor effects in several types of cancer. Iodide (I−) and Iodine (I2) reduce cell proliferation and induce apoptosis in human prostate cancer cells (LNCaP and DU-145). Both chemi...

    Authors: Paloma Olvera-Caltzontzin, Guadalupe Delgado, Carmen Aceves and Brenda Anguiano
    Citation: Molecular Medicine 2013 19:1901409
    Content type: Research Article Published on:

  13. Induced cell fate changes by reprogramming of somatic cells offers an efficient strategy to generate autologous pluripotent stem (iPS) cells from any adult cell type. The potential of iPS cells to differentiat...

    Authors: Nils Offen, Johannes Flemming, Hares Kamawal, Ruhel Ahmad, Wanja Wolber, Christian Geis, Holm Zaehres, Hans R. Schöler, Hannelore Ehrenreich, Albrecht M. Müller and Anna-Leena Sirén
    Citation: Molecular Medicine 2013 19:1901399
    Content type: Research Article Published on:

  14. Damage-associated molecular pattern (DAMP) molecules are essential for the initiation of innate inflammatory responses to infection and injury. The prototypic DAMP molecule, high-mobility group box 1 (HMGB1), ...

    Authors: Ruochan Chen, Wen Hou, Qiuhong Zhang, Rui Kang, Xue-Gong Fan and Daolin Tang
    Citation: Molecular Medicine 2013 19:1901357
    Content type: Review Article Published on:

  15. Antiangiogenesis is a promising antitumor strategy that inhibits tumor vascular formation to suppress tumor growth. DNAzymes are synthetic single-strand deoxyribonucleic acid (DNA) molecules that can cleave ri...

    Authors: Liangfang Shen, Qin Zhou, Ying Wang, Weihua Liao, Yan Chen, Zhijie Xu, Lifang Yang and Lun-Quan Sun
    Citation: Molecular Medicine 2013 19:1901377
    Content type: Research Article Published on:

  16. Members of the human epidermal growth factor receptor (HER) family play a significant role in bladder cancer progression and may underlie the development of chemotherapy resistance. Dacomitinib is an irreversi...

    Authors: Petros D. Grivas, Kathleen C. Day, Andreas Karatsinides, Alyssa Paul, Nazia Shakir, Iya Owainati, Monica Liebert, Lakshmi P. Kunju, Dafydd Thomas, Maha Hussain and Mark L. Day
    Citation: Molecular Medicine 2013 19:1901367
    Content type: Research Article Published on:

  18. Small nerve fiber loss and damage (SNFLD) is a frequent complication of sarcoidosis that is associated with autonomic dysfunction and sensory abnormalities, including pain syndromes that severely degrade the q...

    Authors: Albert Dahan, Ann Dunne, Maarten Swartjes, Paolo L. Proto, Lara Heij, Oscar Vogels, Monique van Velzen, Elise Sarton, Marieke Niesters, Martijn R. Tannemaat, Anthony Cerami and Michael Brines
    Citation: Molecular Medicine 2013 19:1901334
    Content type: Research Article Published on:

  20. An inability of neutrophils to eliminate invading microorganisms is frequently associated with severe infection and may contribute to the high mortality rates associated with sepsis. In the present studies, we...

    Authors: Dae Won Park, Shaoning Jiang, Jean-Marc Tadie, William S. Stigler, Yong Gao, Jessy Deshane, Edward Abraham and Jaroslaw W. Zmijewski
    Citation: Molecular Medicine 2013 19:1901387
    Content type: Research Article Published on:

  21. An association between inducible costimulator ligand (ICOS-L) expression and interleukin (IL)-10 production by dendritic cells (DCs) has been commonly found in infectious disease. DCs with higher ICOS-L expres...

    Authors: Xiaoling Gao, Lei Zhao, Shuhe Wang, Jie Yang and Xi Yang
    Citation: Molecular Medicine 2013 19:1901346
    Content type: Research Article Published on:

  23. Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Maria Chatzouli, Tatjana Smilevska, George Bourikas, Helene Merle-Beral, Eleni Manioudaki-Kavallieratou, Achilles Anagn...

    Authors: Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Maria Chatzouli, Tatjana Smilevska, George Bourikas, Helene Merle-Beral, Eleni Manioudaki-Kavallieratou, Achilles Anagnostopoulos, Monika Brüggemann, Frederic Davi, Kostas Stamatopoulos and Chrysoula Belessi
    Citation: Molecular Medicine 2013 19:1901332
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2011 18:Art14

  24. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Carl Nathan
    Citation: Molecular Medicine 2013 19:1901305
    Content type: Anthony Cerami Award in Translational Medicine Published on:

  25. Sylvain Doré, Kenji Sampei, Shozo Goto, Nabil J Alkayed, Daniel Guastella, Seth Blackshaw, Michela Gallagher, Richard J Traystman, Patricia D Hurn, Raymond C Koehler, and Solomon H Snyder. (1999) Heme Oxygenas...

    Authors: Sylvain Doré, Kenji Sampei, Shozo Goto, Nabil J. Alkayed, Daniel Guastella, Seth Blackshaw, Michela Gallagher, Richard J. Traystman, Patricia D. Hurn, Raymond C. Koehler and Solomon H. Snyder
    Citation: Molecular Medicine 2013 19:1901160
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 1999 5:Art2

  26. Staphylococcus aureus is sometimes isolated from the airways during acute exacerbations of chronic obstructive pulmonary disease (COPD) but more commonly recognized as a cause of ventilator-associated pneumonia (...

    Authors: Helena M. Linge, Cecilia Andersson, Sara L. Nordin, Anders I. Olin, Ann-Cathrine Petersson, Matthias Mörgelin, Amanda Welin, Johan Bylund, Leif Bjermer, Jonas Erjefält and Arne Egesten
    Citation: Molecular Medicine 2013 19:1901314
    Content type: Research Article Published on:

  27. Lymph node (LN) harvest is influenced by several factors, including tumor genetics. Microsatellite instability (MSI) is associated with improved node harvest, but the association to other genetic factors is la...

    Authors: Marianne Berg, Marianne Guriby, Oddmund Nordgård, Bjørn S. Nedrebø, Terje C. Ahlquist, Rune Smaaland, Satu Oltedal, Jon Arne Søreide, Hartwig Kørner, Ragnhild A. Lothe and Kjetil Søreide
    Citation: Molecular Medicine 2013 19:1901286
    Content type: Research Article Published on:

  28. Chemokines facilitate the recruitment of inflammatory cells into tissues, contributing to target organ injury in a wide range of inflammatory and autoimmune diseases. Targeting either single chemokines or chem...

    Authors: Zheng Liu, Ramalingam Bethunaickan, Ranjit Sahu, Max Brenner, Teresina Laragione, Percio S. Gulko and Anne Davidson
    Citation: Molecular Medicine 2013 19:1901276
    Content type: Research Article Published on:

  29. Chronic lymphocytic leukemia (CLL) is a clonal disease of a subset of human B lymphocytes. Although the cause of the disease is unknown, its development and evolution appear to be promoted by signals delivered...

    Authors: Yun Liu, Chelsea D Higgins, Cathie M Overstreet, Kanti R Rai, Nicholas Chiorazzi and Jonathan R Lai
    Citation: Molecular Medicine 2013 19:1901245
    Content type: Research Article Published on:

  30. Chronic lymphocytic leukemia (CLL) patients assigned to stereotyped subset 4 possess distinctive patterns of intraclonal diversification (ID) within their immunoglobulin (IG) genes. Although highly indicative ...

    Authors: Lesley-Ann Sutton, Efterpi Kostareli, Evangelia Stalika, Athanasios Tsaftaris, Achilles Anagnostopoulos, Nikos Darzentas, Richard Rosenquist and Kostas Stamatopoulos
    Citation: Molecular Medicine 2013 19:1901230
    Content type: Research Article Published on:

  31. Liver regeneration can be impaired by permanent oxidative stress and activation of nuclear factor erythroid 2-related factor 2 (Nrf2), known to regulate the cellular antioxidant response, and has been shown to...

    Authors: Rania Dayoub, Arndt Vogel, Jutta Schuett, Madeleine Lupke, Susannah M. Spieker, Nadja Kettern, Eberhard Hildt, Michael Melter and Thomas S. Weiss
    Citation: Molecular Medicine 2013 19:1901237
    Content type: Research Article Published on:

  32. The pathogen- and damage-associated molecular patterns (for example, bacterial endotoxin and adenosine 5′-triphosphate (ATP)) activate the double-stranded RNA-activated protein kinase R (PKR) to trigger the in...

    Authors: Wei Li, Jianhua Li, Andrew E. Sama and Haichao Wang
    Citation: Molecular Medicine 2013 19:1901203
    Content type: Research Article Published on:

  33. Erythropoietin (EPO) has protective effects in neurodegenerative and neuroinflammatory diseases, including in animal models of multiple sclerosis, where EPO decreases disease severity. EPO also promotes neurog...

    Authors: Ilaria Cervellini, Alexander Annenkov, Thomas Brenton, Yuti Chernajovsky, Pietro Ghezzi and Manuela Mengozzi
    Citation: Molecular Medicine 2013 19:1901223
    Content type: Research Article Published on:

  34. Although a relationship between PDZK1 expression and estrogen receptor (ER)-α stimulation has been suggested, the nature of such a connection and the function of PDZK1 in breast cancer remain unknown. Human tissu...

    Authors: Hogyoung Kim, Zakaria Y Abd Elmageed, Jihang Ju, Amarjit S Nauru, Asim B Abdel-Mageed, Shibu Varughese, Dennis Paul, Suresh Alahari, Andrew Catling, Jong G Kim and A Hamid Boulares
    Citation: Molecular Medicine 2013 19:1901253
    Content type: Research Article Published on:

  35. Autoantibodies to components of chromatin, which include double-stranded DNA (dsDNA), histones and nucleosomes, are central in the pathogenesis of lupus nephritis. How anti-chromatin autoantibodies exert their...

    Authors: Natalya Seredkina, Johan van der Vlag, Jo Berden, Elin Mortensen and Ole Petter Rekvig
    Citation: Molecular Medicine 2013 19:1901161
    Content type: Review Article Published on:

  36. Anxiety disorders and substance abuse, including benzodiazepine use disorder, frequently occur together. Unfortunately, treatment of anxiety disorders still includes benzodiazepines, and patients with an exist...

    Authors: Sonja M. Wojcik, Martesa Tantra, Beata Stepniak, Kwun-nok M. Man, Katja Müller-Ribbe, Martin Begemann, Anes Ju, Sergi Papiol, Anja Ronnenberg, Artem Gurvich, Yong Shin, Iris Augustin, Nils Brose and Hannelore Ehrenreich
    Citation: Molecular Medicine 2013 19:1901135
    Content type: Research Article Published on:

  37. Multiple sclerosis (MS) is a chronic progressive, demyelinating condition whose therapeutic needs are unmet, and whose pathoetiology is elusive. We report that transient receptor potential vanilloid-1 (TRPV1) ...

    Authors: Geoffrey Paltser, Xue Jun Liu, Jason Yantha, Shawn Winer, Hubert Tsui, Ping Wu, Yuko Maezawa, Lindsay S. Cahill, Christine L. Laliberté, Sreeram V. Ramagopalan, Gabriele C. DeLuca, A. Dessa Sadovnick, Igor Astsaturov, George C. Ebers, R. Mark Henkelman, Michael W. Salter…
    Citation: Molecular Medicine 2013 19:1901149
    Content type: Research Article Published on:

  38. Disorders of the oxidative phosphorylation (OXPHOS) system frequently result in a severe multisystem disease with the consequence of early childhood death. Among these disorders, isolated complex I deficiency ...

    Authors: Dana Marcus, Michal Lichtenstein, Ann Saada and Haya Lorberboum-Galski
    Citation: Molecular Medicine 2013 19:1901124
    Content type: Research Article Published on:

  39. Erythropoietin (EPO), a type I cytokine originally identified for its critical role in hematopoiesis, has been shown to have non-hematopoietic, tissue-protective effects, including suppression of atheroscleros...

    Authors: Hiroto Ueba, Masashi Shiomi, Michael Brines, Michael Yamin, Tsutomu Kobayashi, Junya Ako, Shin-ichi Momomura, Anthony Cerami and Masanobu Kawakami
    Citation: Molecular Medicine 2013 19:1901195
    Content type: Research Article Published on:

  41. Trifunctional bispecific antibodies (trAbs) used in tumor immunotherapy have the unique ability to recruit T cells toward antigens on the tumor cell surface and, moreover, to activate accessory cells through t...

    Authors: Nina Eissler, Josef Mysliwietz, Nina Deppisch, Peter Ruf, Horst Lindhofer and Ralph Mocikat
    Citation: Molecular Medicine 2013 19:1901054
    Content type: Research Article Published on:

  42. Efferocytosis is a unique phagocytic process for macrophages to remove apoptotic cells in inflammatory loci. This event is maintained by milk fat globule-EGF factor 8 (MFG-E8), but attenuated by high mobility ...

    Authors: Xiao Wang, Heng-Fu Bu, Wei Zhong, Akihiro Asai, Zhanxiang Zhou and Xiao-Di Tan
    Citation: Molecular Medicine 2013 19:1901170
    Content type: Research Article Published on:

  43. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine known to be released from lymphocytes, macrophages and endothelial cells and also in animal models shown to be inducible with glucocor...

    Authors: Mårten Wendt, Ola Börjesson, Aune Avik, Johan Bratt, Björn Anderstam, Abdul R. Qureshi, Edmund J. Miller, Iva Gunnarsson and Annette Bruchfeld
    Citation: Molecular Medicine 2013 19:1901109
    Content type: Research Article Published on:

  44. α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.....

    Authors: Siyoung Lee, Youngmin Lee, Kwangwon Hong, Jaewoo Hong, Suyoung Bae, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Charles A. Dinarello and Soohyun Kim
    Citation: Molecular Medicine 2013 19:1901065
    Content type: Research Article Published on:

  45. The first 24 h following burn injury is known as the ebb phase and is characterized by a depressed metabolic rate. While the postburn ebb phase has been well described, the molecular mechanisms underlying this...

    Authors: Natasha C. Brooks, Alexandra H. Marshall, Nour Qa’aty, Yaeko Hiyama, Darren Boehning and Marc G. Jeschke
    Citation: Molecular Medicine 2013 19:1901072
    Content type: Research Article Published on:

  46. High mobility group box 1 (HMGB1) is a DNA-binding protein that possesses cytokinelike, proinflammatory properties when released extracellularly in the C23–C45 disulfide form. HMGB1 also plays a key role as a ...

    Authors: Sodam Kim, Sun Young Kim, John P. Pribis, Michael Lotze, Kevin P. Mollen, Richard Shapiro, Patricia Loughran, Melanie J. Scott and Timothy R. Billiar
    Citation: Molecular Medicine 2013 19:1901088
    Content type: Research Article Published on:

  47. Bone has a high capacity for self-renewal and repair. Prolonged local secretion of interleukin 1β (IL-1β), however, is known to be associated with severe bone loss and delayed fracture healing. Since induction...

    Authors: Nina-Emily Hengartner, Jörg Fiedler, Anita Ignatius and Rolf E. Brenner
    Citation: Molecular Medicine 2013 19:1901036
    Content type: Research Article Published on:

  48. Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are inborn errors of heme biosynthesis with the same phenotype but resulting from autosomal recessive loss-of-function mutations in the fer...

    Authors: Manisha Balwani, Dana Doheny, David F. Bishop, Irina Nazarenko, Makiko Yasuda, Harry A. Dailey, Karl E. Anderson, D. Montgomery Bissell, Joseph Bloomer, Herbert L. Bonkovsky, John D. Phillips, Lawrence Liu and Robert J. Desnick
    Citation: Molecular Medicine 2013 19:1901026
    Content type: Research Article Published on:

  49. It is well known that genotypic differences can account for the subject-specific responses to opiate administration. In this regard, the basal activity of the endogenous system (either at the receptor or ligan...

    Authors: Veronica Gonzalez-Nunez, Ada Jimenez González, Katherine Barreto-Valer and Raquel E. Rodríguez
    Citation: Molecular Medicine 2013 19:1901007
    Content type: Research Article Published on:

  50. Severe burn injury causes hepatic dysfunction that results in major metabolic derangements including insulin resistance and hyperglycemia and is associated with hepatic endoplasmic reticulum (ER) stress. We ha...

    Authors: Yaeko Hiyama, Alexandra H. Marshall, Robert Kraft, Nour Qa’aty, Anna Arno, David N. Herndon and Marc G. Jeschke
    Citation: Molecular Medicine 2013 19:1901001
    Content type: Research Article Published on:
Submit manuscript

Annual Journal Metrics

  • Annual Journal Metrics

    2022 Citation Impact
    5.7 - 2-year Impact Factor
    6.3 - 5-year Impact Factor
    1.026 - SNIP (Source Normalized Impact per Paper)
    1.245 - SJR (SCImago Journal Rank)

    2023 Speed
    6 days submission to first editorial decision for all manuscripts (Median)
    132 days submission to accept (Median)

    2023 Usage
    1,105,866 downloads
    1,878 Altmetric mentions

Follow

Molecular Medicine

ISSN: 1528-3658