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  1. The endocannabinoid CB2 receptor system has been implicated in the neuropathology of Alzheimer’s disease (AD). In order to investigate the impact of the CB2 receptor system on AD pathology, a colony of mice with ...

    Authors: Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d’Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman and Peter Davies
    Citation: Molecular Medicine 2013 19:1901029
    Content type: Research Article Published on:

  2. Synovial fibroblast proliferation Is a hallmark of the Invasive pannus in the rheumatoid joint. Activated protein C (APC) is a natural anticoagulant that exerts antiinflammatory and cyto-protective effects in ...

    Authors: Sohel M. Julovi, Kaitlin Shen, Kelly McKelvey, Nikita Minhas, Lyn March and Christopher J. Jackson
    Citation: Molecular Medicine 2013 19:1901324
    Content type: Research Article Published on:

  3. Cystatin 9 (CST9) is a member of the type 2 cysteine protease inhibitor family, which has been shown to have immunomodulatory effects that restrain inflammation, but its functions against bacterial infections ...

    Authors: Tonyia Eaves-Pyles, Jignesh Patel, Emma Arigi, Yingzi Cong, Anthony Cao, Nisha Garg, Monisha Dhiman, Richard B. Pyles, Bernard Arulanandam, Aaron L. Miller, Vsevolod L. Popov, Lynn Soong, Eric D. Carlsen, Ciro Coletta, Csaba Szabo and Igor C. Almeida
    Citation: Molecular Medicine 2013 19:1901263
    Content type: Research Article Published on:

  4. Marginal zone (MZ) B cells, identified as surface (s)IgMhighsIgDlowCD23low/−CD21+CD38− B cells, were purified from human spleens, and the features of their V(D)J gene rearrangements were investigated and compared...

    Authors: Monica Colombo, Giovanna Cutrona, Daniele Reverberi, Silvia Bruno, Fabio Ghiotto, Claudya Tenca, Kostas Stamatopoulos, Anastasia Hadzidimitriou, Jenny Ceccarelli, Sandra Salvi, Simona Boccardo, Maria Grazia Calevo, Amleto De Santanna, Mauro Truini, Franco Fais and Manlio Ferrarini
    Citation: Molecular Medicine 2013 19:1901294
    Content type: Research Article Published on:

  5. Although females suffer twice as much as males from stress-related disorders, sex-specific participating and pathogenic cellular stress mechanisms remain uncharacterized. Using corticotropin-releasing factor r...

    Authors: Eric Kubat, Shilpi Mahajan, Min Liao, Larry Ackerman, Peter T. Ohara, Eileen F. Grady and Aditi Bhargava
    Citation: Molecular Medicine 2013 19:1901212
    Content type: Research Article Published on:

  6. Rheumatoid arthritis (RA) is a chronic inflammatory synovitis that leads to the destruction of bone and cartilage. The receptor for advanced glycation end products (RAGE) is a multiligand membrane-bound recept...

    Authors: Tatsuo Takahashi, Sayaka Katsuta, Yusuke Tamura, Nozomi Nagase, Keita Suzuki, Masaaki Nomura, Shunji Tomatsu, Ken-ichi Miyamoto and Shinjiro Kobayashi
    Citation: Molecular Medicine 2013 19:1901183
    Content type: Research Article Published on:

  7. In vivo use of monoclonal antibodies (mAbs) has become a mainstay of routine clinical practice in the treatment of various human diseases. A number of molecules can serve as targets, according to the condition be...

    Authors: Antonella Chillemi, Gianluca Zaccarello, Valeria Quarona, Manuela Ferracin, Chiara Ghimenti, Massimo Massaia, Alberto L. Horenstein and Fabio Malavasi
    Citation: Molecular Medicine 2013 19:1901099
    Content type: Review Article Published on:

  8. Critical processes of B-cell physiology, including immune signaling through the B-cell receptor (BcR) and/or Toll-like receptors (TLRs), are targeted by microRNAs. With this in mind and also given the importan...

    Authors: Nikos Papakonstantinou, Stavroula Ntoufa, Elisavet Chartomatsidou, Giorgio Papadopoulos, Artemis Hatzigeorgiou, Achiles Anagnostopoulos, Katerina Chlichlia, Paolo Ghia, Marta Muzio, Chrysoula Belessi and Kostas Stamatopoulos
    Citation: Molecular Medicine 2013 19:1901115
    Content type: Research Article Published on:

  9. Previous work has established the existence of dystrophin-nitric oxide (NO) signaling to histone deacetylases (HDACs) that is deregulated in dystrophic muscles. As such, pharmacological interventions that targ...

    Authors: Silvia Consalvi, Chiara Mozzetta, Paolo Bettica, Massimiliano Germani, Francesco Fiorentini, Francesca Del Bene, Maurizio Rocchetti, Flavio Leoni, Valmen Monzani, Paolo Mascagni, Pier Lorenzo Puri and Valentina Saccone
    Citation: Molecular Medicine 2013 19:1901079
    Content type: Research Article Published on:

  10. We recently found that S100A4, a member of the multifunctional S100 protein family, protects neurons in the injured brain and identified two sequence motifs in S100A4 mediating its neurotrophic effect. Synthet...

    Authors: Mihai Moldovan, Volodymyr Pinchenko, Oksana Dmytriyeva, Stanislava Pankratova, Kåre Fugleholm, Jorg Klingelhofer, Elisabeth Bock, Vladimir Berezin, Christian Krarup and Darya Kiryushko
    Citation: Molecular Medicine 2013 19:1901043
    Content type: Research Article Published on:

  11. X-linked protoporphyria (XLP) (MIM 300752) is a recently recognized erythropoietic porphyria due to gain-of-function mutations in the erythroid-specific aminolevulinate synthase gene (ALAS2). Previously, two exon...

    Authors: David F. Bishop, Vassili Tchaikovskii, Irina Nazarenko and Robert J. Desnick
    Citation: Molecular Medicine 2013 19:1901018
    Content type: Research Article Published on:

  12. The cholinergic antiinflammatory pathway (CAP), which terminates in the spleen, attenuates postoperative cognitive decline (PCD) in rodents. Surgical patients with metabolic syndrome exhibit exaggerated and pe...

    Authors: Xiao Su, Xiaomei Feng, Niccolo Terrando, Yan Yan, Ajay Chawla, Lauren G Koch, Steven L Britton, Michael A Matthay and Mervyn Maze
    Citation: Molecular Medicine 2013 18:18121481
    Content type: Research Article Published on:

  13. Metastatic colorectal cancer (mCRC) is frequently characterized by the presence of mutations of the KRAS oncogene, which are generally associated with a poor response to treatment with anti-epidermal growth facto...

    Authors: Mariella Dono, Carlotta Massucco, Silvana Chiara, Claudia Sonaglio, Marco Mora, Anna Truini, Giannamaria Cerruti, Gabriele Zoppoli, Alberto Ballestrero, Mauro Truini, Manlio Ferrarini and Simona Zupo
    Citation: Molecular Medicine 2012 18:18121519
    Content type: Research Article Published on:

  14. Survival rates for patients with pulmonary hypertension (PH) remain low, and our understanding of the mechanisms involved are incomplete. Here we show in a mouse model of chronic hypoxia (CH)-induced PH that t...

    Authors: Eileen M Bauer, Richard Shapiro, Han Zheng, Ferhaan Ahmad, David Ishizawar, Suzy A Comhair, Serpil C Erzurum, Timothy R Billiar and Philip M Bauer
    Citation: Molecular Medicine 2012 18:18121509
    Content type: Research Article Published on:

  15. Our previously reported phase I clinical trial with the allogeneic gene-modified tumor cell line RCC-26/CD80/IL-2 showed that vaccination was well tolerated and feasible in metastatic renal cell carcinoma (RCC...

    Authors: Heike Pohla, Alexander Buchner, Birgit Stadlbauer, Bernhard Frankenberger, Stefan Stevanovic, Steffen Walter, Ronald Frank, Tim Schwachula, Sven Olek, Joachim Kopp, Gerald Willimsky, Christian G Stief, Alfons Hofstetter, Antonio Pezzutto, Thomas Blankenstein, Ralph Oberneder…
    Citation: Molecular Medicine 2012 18:18121499
    Content type: Research Article Published on:

  16. Deregulated miRNAs participate in colorectal carcinogenesis. In this study, miR-218 was found to be downregulated in human colorectal cancer (CRC) by miRNA profile assay. miR-218 was silenced or downregulated ...

    Authors: Xinqi He, Yujuan Dong, Chung Wah Wu, Zengren Zhao, Simon S M Ng, Francis K L Chan, Joseph J Y Sung and Jun Yu
    Citation: Molecular Medicine 2012 18:18121491
    Content type: Research Article Published on:

  17. Yin-Hsiu Chien, Ni-Chung Lee, Shu-Chuan Chiang, Robert J Desnick, and Wuh-Liang Hwu. (2012) Fabry Disease: Incidence of the Common Later-Onset α-Galactosidase A IVS4+919G→A Mutation in Taiwanese Newborns—Superior...

    Authors: Yin-Hsiu Chien, Ni-Chung Lee, Shu-Chuan Chiang, Robert J. Desnick and Wuh-Liang Hwu
    Citation: Molecular Medicine 2012 18:18121537
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2012 18:Art6

  18. Trastuzumab is a monoclonal antibody targeted against the HER2 tyrosine kinase receptor. Although trastuzumab is a very active agent in HER2-overexpressing breast cancer, the majority of patients with metastat...

    Authors: Myra F. Barginear, Veena John and Daniel R. Budman
    Citation: Molecular Medicine 2012 18:18111473
    Content type: Invited Review Article Published on:

  19. Glucocorticoid (GC) sensitivity depends on glucocorticoid receptor (GR) and heat shock proteins (Hsps). We investigated whether common GR genes (ER22/23EK N363S, Bcl I, and 9β) and adrenocorticotropin receptor pr...

    Authors: Svetozar S. Damjanovic, Jadranka A. Antic, Bojana B. Ilic, Bojana Beleslin Cokic, Miomira Ivovic, Sanja I. Ognjanovic, Tatjana V. Isailovic, Bojana M. Popovic, Ivana B. Bozic, Svetislav Tatic, Gordana Matic, Vera N. Todorovic and Ivan Paunovic
    Citation: Molecular Medicine 2012 18:18111456
    Content type: Research Article Published on:

  20. Current endocrine treatment for advanced prostate cancer does not result in a complete ablation of adrenal androgens. Adrenal androgens can be metabolized by prostate cancer cells, which is one of the mechanis...

    Authors: Agus Rizal A. H. Hamid, Minja J. Pfeiffer, Gerald W. Verhaegh, Ewout Schaafsma, Andre Brandt, Fred C. G. J. Sweep, John P. M. Sedelaar and Jack A. Schalken
    Citation: Molecular Medicine 2012 18:18111449
    Content type: Research Article Published on:

  21. Sepsis is a complex, multifactorial, rapidly progressive disease characterized by an overwhelming activation of the immune system and the countervailing antiinflammatory response. In the current study in murin...

    Authors: Chan-Ho Lee, Seong-Jin Yoon and Sun-Mee Lee
    Citation: Molecular Medicine 2012 18:18111437
    Content type: Research Article Published on:

  22. ARA 290 (a peptide designed to activate the innate repair receptor that arrests injury and initiates cytoprotection, antiinflammation and healing) reduces allodynia in preclinical neuropathy models. We studied...

    Authors: Lara Heij, Marieke Niesters, Maarten Swartjes, Elske Hoitsma, Marjolein Drent, Ann Dunne, Jan C. Grutters, Oscar Vogels, Michael Brines, Anthony Cerami and Albert Dahan
    Citation: Molecular Medicine 2012 18:18111430
    Content type: Research Article Published on:

  23. Duchenne muscular dystrophy (DMD) is a genetic muscle disease caused by the absence of a functional dystrophin protein. Lack of dystrophin protein disrupts the dystrophin-glycoprotein complex causing muscle me...

    Authors: Rakshita A Charan, Gabriela Niizawa, Hiroyuki Nakai and Paula R Clemens
    Citation: Molecular Medicine 2012 18:18121527
    Content type: Research Article Published on:

  24. Regulation of key proteins by microRNAs (miRNAs) is an emergent field in biomedicine. Vitamin K 2,3-epoxide reductase complex subunit 1 (VKORC1) is a relevant molecule for cardiovascular diseases, since it is ...

    Authors: Virginia Pérez-Andreu, Raúl Teruel, Javier Corral, Vanessa Roldán, Nuria García-Barberá, Salam Salloum-Asfar, María José Gómez-Lechón, Stephane Bourgeois, Panos Deloukas, Mia Wadelius, Vicente Vicente, Rocío González-Conejero and Constantino Martínez
    Citation: Molecular Medicine 2012 18:18111466
    Content type: Research Article Published on:

  25. Ulcerative colitis (UC) is a chronic disease associated with long periods of quiescent disease followed by fulminant exacerbation. Imminent relapse in UC is associated with high mucosal expression of suppresso...

    Authors: Yi Li, Jasper Deuring, Maikel P. Peppelenbosch, Ernst J. Kuipers, Colin de Haar and C. Janneke van der Woude
    Citation: Molecular Medicine 2012 18:18101412
    Content type: Research Article Published on:

  26. Psychosocial stress has been shown to be a contributing factor in the development of atherosclerosis. Although the underlying mechanisms have not been elucidated entirely, it has been shown previously that the...

    Authors: Zdenka Djuric, Muhammed Kashif, Thomas Fleming, Sajjad Muhammad, David Piel, Rüdiger von Bauer, Florian Bea, Stephan Herzig, Martin Zeier, Marina Pizzi, Berend Isermann, Markus Hecker, Markus Schwaninger, Angelika Bierhaus and Peter P. Nawroth
    Citation: Molecular Medicine 2012 18:18101375
    Content type: Research Article Published on:

  30. The liver is a central organ involved in inflammatory processes, including the elaboration of acute-phase proteins. Augmenter of liver regeneration (ALR) protein, expressed and secreted by hepatocytes, promote...

    Authors: Yoram Vodovotz, John Prelich, Claudio Lagoa, Derek Barclay, Ruben Zamora, Noriko Murase and Chandrashekhar R. Gandhi
    Citation: Molecular Medicine 2012 18:18111421
    Content type: Research Article Published on:

  31. Dapper homolog 1 (DACT1) is a disheveled partner in the planar cell polarity pathway. By using genome-wide promoter methylation screening, dapper homolog 1 (DACT1) was found to be frequently methylated in gastric...

    Authors: Shiyan Wang, Wei Kang, Minnie Y. Y. Go, Joanna H. M. Tong, Lili Li, Ning Zhang, Qian Tao, Xiaoxing Li, Ka Fai To, Joseph J. Y. Sung and Jun Yu
    Citation: Molecular Medicine 2012 18:18101402
    Content type: Research Article Published on:

  32. For almost three decades, researchers have invested in strategies that involved removal of excess inflammatory mediators from the circulation (that is, the “cytotoxic” approach). Blood purification techniques ...

    Authors: Patrick M. Honore, Rita Jacobs, Olivier Joannes-Boyau, Willem Boer, Elisabeth De Waele, Viola Van Gorp, Jouke De Regt and Herbert D. Spapen
    Citation: Molecular Medicine 2012 18:18101363
    Content type: Commentary Published on:

  33. Inflammation, neurodegeneration and microvascular irregularities are included in the spectrum of defects associated with diabetic retinopathy. Here, we evaluated intraocular deliverability features of two pigm...

    Authors: Yanling Liu, Lan Franco Leo, Corban McGregor, Anzor Grivitishvili, Colin J. Barnstable and Joyce Tombran-Tink
    Citation: Molecular Medicine 2012 18:18101387
    Content type: Research Article Published on:

  34. Recurrent respiratory papillomatosis (RRP), characterized by the recurrent growth of benign tumors of the respiratory tract, is caused by infection with human papillomavirus (HPV), predominantly types 6 and 11...

    Authors: David W. Rosenthal, James A. DeVoti, Bettie M. Steinberg, Allan L. Abramson and Vincent R. Bonagura
    Citation: Molecular Medicine 2012 18:18091338
    Content type: Research Article Published on:

  35. Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to under...

    Authors: Maarten Swartjes, René A. G. Mooren, Amanda R. Waxman, Caroline Arout, Koen van de Wetering, Jan den Hartigh, Jos H. Beijnen, Benjamin Kest and Albert Dahan
    Citation: Molecular Medicine 2012 18:18091320
    Content type: Research Article Published on:

  36. Inheriting a BRCA1 or BRCA2 gene mutation can cause a deficiency in repairing complex DNA damage. This step leads to genomic instability and probably contributes to an inherited predisposition to breast and ovari...

    Authors: Bess Levin, Denise Lech and Bernard Friedenson
    Citation: Molecular Medicine 2012 18:18091327
    Content type: Research Article Published on:

  37. The April 2012 issue of Molecular Medicine contained a report from Yan et al.: Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidative Stress, Increase Nitric Oxide and Improve Blo...

    Authors: Jinglian Yan, Guodong Tie and Louis M. Messina
    Citation: Molecular Medicine 2012 18:18080001
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2012 18:Art14

  38. As significant differences between sexes were found in the susceptibility to alcoholic liver disease in human and animal models, it was the aim of the present study to investigate whether female mice also are ...

    Authors: Astrid Spruss, Janin Henkel, Giridhar Kanuri, Daniela Blank, Gerhard P. Püschel, Stephan C. Bischoff and Ina Bergheim
    Citation: Molecular Medicine 2012 18:18091346
    Content type: Research Article Published on:

  39. Lipopolysaccharide (LPS) is ubiquitous in the environment. Inhalation of LPS has been implicated in the pathogenesis and/or severity of several lung diseases, including pneumonia, chronic obstructive pulmonary...

    Authors: Frederic Reynier, Alex F. de Vos, Jacobien J. Hoogerwerf, Paul Bresser, Jaring S. van der Zee, Malick Paye, Alexandre Pachot, Bruno Mougin and Tom van der Poll
    Citation: Molecular Medicine 2012 18:18091303
    Content type: Research Article Published on:

  40. Despite recent advances in understanding the biological basis of prostate cancer, management of the disease, especially in the phase resistant to androgen ablation, remains a significant challenge. The long la...

    Authors: Roberta Venè, Roberto Benelli, Simona Minghelli, Simonetta Astigiano, Francesca Tosetti and Nicoletta Ferrari
    Citation: Molecular Medicine 2012 18:18091292
    Content type: Research Article Published on:

  41. Tumor-derived microvesicles are rich in metastasis-related proteases and play a role in the interactions between tumor cells and tumor microenvironment in tumor metastasis. Because shed microvesicles may remai...

    Authors: Ching-Fong Liao, Shu-Hui Lin, Hung-Chang Chen, Cheng-Jeng Tai, Chun-Chao Chang, Li-Tzu Li, Chung-Min Yeh, Kun-Tu Yeh, Ying-Chun Chen, Tsu-Han Hsu, Shing-Chuan Shen, Woan-Ruoh Lee, Jeng-Fong Chiou, Shue-Fen Luo and Ming-Chung Jiang
    Citation: Molecular Medicine 2012 18:18091269
    Content type: Research Article Published on:

  42. Spinal and bulbar muscular atrophy is an X-linked motor neuron disease caused by polyglutamine expansion in the androgen receptor. Patients develop slowly progressive proximal muscle weakness, muscle atrophy a...

    Authors: Carlo Rinaldi, Laura C. Bott, Ke-lian Chen, George G. Harmison, Masahisa Katsuno, Gen Sobue, Maria Pennuto and Kenneth H. Fischbeck
    Citation: Molecular Medicine 2012 18:18091261
    Content type: Research Article Published on:

  43. The U.S. Food and Drug Administration recently approved phase I/II clinical trials for embryonic stem (ES) cell-based retinal pigmented epithelium (RPE) transplantation, but this allograft transplantation requ...

    Authors: Yao Li, Yi-Ting Tsai, Chun-Wei Hsu, Deniz Erol, Jin Yang, Wen-Hsuan Wu, Richard J. Davis, Dieter Egli and Stephen H. Tsang
    Citation: Molecular Medicine 2012 18:18091312
    Content type: Research Article Published on:

  44. Glyoxalase detoxification system composed of glyoxalase (GLO)-I and GLO-II is ubiquitously expressed and implicated in the protection against cellular damage because of cytotoxic metabolites such as advanced g...

    Authors: Eleni Kandaraki, Antonis Chatzigeorgiou, Christina Piperi, Eleni Palioura, Sotiria Palimeri, Penelope Korkolopoulou, Michael Koutsilieris and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2012 18:18081183
    Content type: Research Article Published on:

  45. The tissue destruction that characterizes periodontitis is driven by the host response to bacterial pathogens. Inhibition of glycogen synthase kinase 3β (GSK3β) in innate cells leads to suppression of Toll-lik...

    Authors: Karina Adamowicz, Huizhi Wang, Ravi Jotwani, Iris Zeller, Jan Potempa and David A. Scott
    Citation: Molecular Medicine 2012 18:18081190
    Content type: Research Article Published on:

  46. Circadian rhythms show universally a 24-h oscillation pattern in metabolic, physiological and behavioral functions of almost all species. This pattern is due to a fundamental adaptation to the rotation of Eart...

    Authors: Christos Savvidis and Michael Koutsilieris
    Citation: Molecular Medicine 2012 18:18091249
    Content type: Review Article Published on:

  47. Improper compartmentalization of the inflammatory response leads to systemic inflammation in sepsis. Hemoadsorption (HA) is an emerging approach to modulate sepsis-induced inflammation. We sought to define the...

    Authors: Rami A. Namas, Rajaie Namas, Claudio Lagoa, Derek Barclay, Qi Mi, Ruben Zamora, Zhiyong Peng, Xiaoyan Wen, Morgan V. Fedorchak, Isabella E. Valenti, William J. Federspiel, John A. Kellum and Yoram Vodovotz
    Citation: Molecular Medicine 2012 18:18101366
    Content type: Research Article Published on:

  48. In sepsis, toll-like receptor (TLR)-4 modulates the migration of neutrophils to infectious foci, favoring bacteremia and mortality. In experimental sepsis, organ dysfunction and cytokines released by activated...

    Authors: Fabricia Petronilho, Francieli Vuolo, Letícia Selinger Galant, Larissa Constantino, Cristiane Damiani Tomasi, Vinicius Renne Giombelli, Cláudio Teodoro de Souza, Sabrina da Silva, Denise Frediani Barbeiro, Francisco Garcia Soriano, Emílio Luiz Streck, Cristiane Ritter, Alfeu Zanotto-Filho, Matheus Augusto Pasquali, Daniel Pens Gelain, José Luiz Rybarczyk-Filho…
    Citation: Molecular Medicine 2012 18:18081209
    Content type: Research Article Published on:

  49. Obesity is a major risk factor for insulin resistance, type 2 diabetes mellitus and cardiovascular disease. The pathophysiology of obesity is associated with chronic low-grade inflammation. Adipose tissue in o...

    Authors: Sangeeta S. Chavan, LaQueta K. Hudson, Jian Hua Li, Mahendar Ochani, Yael Harris, Nirav B. Patel, David Katz, Joshua A. Scheinerman, Valentin A. Pavlov and Kevin J. Tracey
    Citation: Molecular Medicine 2012 18:18081161
    Content type: Research Article Published on:

  50. Subgroups of patients with chronic lymphocytic leukemia (CLL) have distinct expression profiles of Toll-like receptor (TLR) pathway-associated genes. To test the hypothesis that signaling through innate immuni...

    Authors: Stavroula Ntoufa, Anna Vardi, Nikos Papakonstantinou, Achilles Anagnostopoulos, Vassiliki Aleporou-Marinou, Chrysoula Belessi, Paolo Ghia, Federico Caligaris-Cappio, Marta Muzio and Kostas Stamatopoulos
    Citation: Molecular Medicine 2012 18:18091281
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658