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  1. An infectious etiology has been proposed for many human cancers, but rarely have specific agents been identified. One difficulty has been the need to propagate cancer cells in vitro to produce the infectious agen...

    Authors: Charles C. Chu, Lu Zhang, Arjun Dhayalan, Briana M. Agagnina, Amanda R. Magli, Gia Fraher, Sebastien Didier, Linda P. Johnson, William J. Kennedy, Rajendra N. Damle, Xiao-Jie Yan, Piers E. M. Patten, Saul Teichberg, Prasad Koduru, Jonathan E. Kolitz, Steven L. Allen…
    Citation: Molecular Medicine 2011 17:17111338
    Content type: Research Article Published on:

  2. Robust biomarkers are needed to identify donor kidneys with poor quality associated with inferior early and longer-term outcome. The occurrence of delayed graft function (DGF) is most often used as a clinical ...

    Authors: Valeria R. Mas, Mariano J. Scian, Kellie J. Archer, Jihee L. Suh, Krystle G. David, Qing Ren, Todd W. B. Gehr, Anne L. King, Marc P. Posner, Thomas F. Mueller and Daniel G. Maluf
    Citation: Molecular Medicine 2011 17:17111311
    Content type: Research Article Published on:

  3. In the margin of page 742 of the following article, a red arrow was left from the production process; it has no meaning with respect to the figure or figure legend:

    Authors: Arie J Hoogendijk, Sander H Diks, Maikel P Peppelenbosch, Tom van der Poll and Catharina W Wieland
    Citation: Molecular Medicine 2011 17:17911292
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2011 17:Art18

  4. The title of the following article was incorrectly published:

    Authors: Cheng-Che E. Lan, Ching-Shuang Wu, Shu-Mei Huang, Hsuan-Yu Kuo, I.-Hui Wu, Chien-Hui Wen, Chee-Yin Chai, Ai-Hui Fang and Gwo-Shing Chen
    Citation: Molecular Medicine 2011 17:17911291
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2011 17:Art22

  5. The cannabinoid system (CS) is implicated in the regulation of hepatic fibrosis, steatosis and inflammation, with cannabinoid receptors 1 and 2 (CB1 and CB2) being involved in regulation of pro- and antifibrog...

    Authors: Eleonora Patsenker, Matthias Stoll, Gunda Millonig, Abbas Agaimy, Till Wissniowski, Vreni Schneider, Sebastian Mueller, Rudolf Brenneisen, Helmut K. Seitz, Matthias Ocker and Felix Stickel
    Citation: Molecular Medicine 2011 17:17111285
    Content type: Research Article Published on:

  7. Aberrant fibroblast migration in response to fibrogenic peptides plays a significant role in keloid pathogenesis. Angiotensin II (Ang II) is an octapeptide hormone recently implicated as a mediator of organ fi...

    Authors: Jennifer E. Bond, Andrew Bergeron, Peter Thurlow, M. Angelica Selim, Edith V. Bowers, Anna Kuang and Howard Levinson
    Citation: Molecular Medicine 2011 17:17111196
    Content type: Research Article Published on:

  8. Liraglutide is a glucagonlike peptide (GLP)-1 analog that reduces blood glucose levels, increases insulin secretion and improves insulin sensitivity through mechanisms that are not completely understood. There...

    Authors: Ling Li, Zongyu Miao, Rui Liu, Mengliu Yang, Hua Liu and Gangyi Yang
    Citation: Molecular Medicine 2011 17:17111168
    Content type: Research Article Published on:

  9. Early reperfusion after myocardial ischemia that is essential for tissue salvage also causes myocardial and vascular injury. Cardioprotection during reperfusion therapy is an essential aspect of treating myoca...

    Authors: Sae-Won Lee, Joo-Yun Won, Hae-Young Lee, Ho-Jae Lee, Seock-Won Youn, Ji-Young Lee, Chung-Hyun Cho, Hyun-Jai Cho, Seil Oh, In-Ho Chae and Hyo-Soo Kim
    Citation: Molecular Medicine 2011 17:1791095
    Content type: Research Article Published on:

  10. Obesity, a serious and growing health threat, is associated with low-grade inflammation that plays a role in mediating its adverse consequences. Previously, we have discovered a role for neural cholinergic sig...

    Authors: Sanjaya K Satapathy, Mahendar Ochani, Meghan Dancho, LaQueta K Hudson, Mauricio Rosas-Ballina, Sergio I Valdes-Ferrer, Peder S Olofsson, Yael Tobi Harris, Jesse Roth, Sangeeta Chavan, Kevin J Tracey and Valentin A Pavlov
    Citation: Molecular Medicine 2011 17:1707599
    Content type: Research Article Published on:

  11. Tissue factor (TF) is traditionally known as the initiator of blood coagulation, but TF also plays an Important role In inflammatory processes. Considering the pivotal role of coagulation in inflammatory bowel...

    Authors: Karla C. S. Queiroz, Cornelis van’t Veer, Yascha van den Berg, JanWillem Duitman, Henri H. Versteeg, Hella L. Aberson, Angelique P. Groot, Marleen I. Verstege, Joris J. T. H. Roelofs, Anje A. te Velde and C. Arnold Spek
    Citation: Molecular Medicine 2011 17:1791119
    Content type: Research Article Published on:

  12. Lipid rafts are cholesterol- and sphingomyelin-enriched microdomains that provide a highly saturated and viscous physico-chemical microenvironment to promote protein-lipid and protein-protein interactions. We ...

    Authors: Noemí Fabelo, Virginia Martín, Gabriel Santpere, Raquel Marín, Laia Torrent, Isidre Ferrer and Mario Díaz
    Citation: Molecular Medicine 2011 17:1791107
    Content type: Research Article Published on:

  13. We investigated the antitumorogenic effects of progesterone (P4) in a human neuroblastoma (SK-N-AS) cell line in vitro and in a mouse xenograft model of neuroblastoma. The safety of P4 was tested in rat primary c...

    Authors: Fahim Atif, Iqbal Sayeed, Seema Yousuf, Tauheed Ishrat, Fang Hua, Jun Wang, Daniel J. Brat and Donald G. Stein
    Citation: Molecular Medicine 2011 17:1791084
    Content type: Research Article Published on:

  14. Stroke is a leading cause of death and the primary medical cause of acquired adult disability worldwide. The progressive brain injury after acute stroke is partly mediated by ischemia-elicited inflammatory res...

    Authors: Wayne W. Chaung, Rongqian Wu, Youxin Ji, Zhimin Wang, Weifeng Dong, Cletus Cheyuo, Lei Qi, Xiaoling Qiang, Haichao Wang and Ping Wang
    Citation: Molecular Medicine 2011 17:1791075
    Content type: Research Article Published on:

  15. Atherogenesis is a long-term process that involves inflammatory response coupled with metabolic dysfunction. Foam cell formation and macrophage inflammatory response are two key events in atherogenesis. Adipoc...

    Authors: Oleg Bogachev, Amin Majdalawieh, Xuefang Pan, Lei Zhang and Hyo-Sung Ro
    Citation: Molecular Medicine 2011 17:1791056
    Content type: Research Article Published on:

  16. The BRCA-1 associated protein gene (BRAP) was recently identified as a susceptibility gene for myocardial infarction (MI). In the present study we aimed to decipher the association between the BRAP polymorphism a...

    Authors: Yi-Chu Liao, Yung-Song Wang, Yuh-Cherng Guo, Kouichi Ozaki, Toshihiro Tanaka, Hsiu-Fen Lin, Ming-Hong Chang, Ku-Chung Chen, Ming-Lung Yu, Sheng-Hsiung Sheu and Suh-Hang Hank Juo
    Citation: Molecular Medicine 2011 17:1791065
    Content type: Research Article Published on:

  17. Endothelial progenitor cells (EPCs) promote angiogenesis, and clinical trials have shown such cell therapy to be feasible for treating ischemic disease. However, clinical outcomes have been contradictory owing...

    Authors: Reinhold J. Medina, Christina L. O’Neill, T. Michelle O’Doherty, Henry Knott, Jasenka Guduric-Fuchs, Tom A. Gardiner and Alan W. Stitt
    Citation: Molecular Medicine 2011 17:1791045
    Content type: Research Article Published on:

  18. Antiinflammatory clinical-grade, plasma-derived human α-1 antitrypsin (hAAT) protects islets from allorejection as well as from autoimmune destruction. hAAT also interferes with disease progression in experime...

    Authors: Galit Shahaf, Hadas Moser, Eyal Ozeri, Mark Mizrahi, Avishag Abecassis and Eli C. Lewis
    Citation: Molecular Medicine 2011 17:1791000
    Content type: Research Article Published on:

  19. High mobility group box chromosomal protein 1 (HMGB1) is a DNA-binding nuclear protein that can be released from dying cells and activated myeloid cells. Extracellularly, HMGB1 promotes inflammation. Experimen...

    Authors: Hanna Schierbeck, Peter Lundbäck, Karin Palmblad, Lena Klevenvall, Helena Erlandsson-Harris, Ulf Andersson and Lars Ottosson
    Citation: Molecular Medicine 2011 17:1791039
    Content type: Research Article Published on:

  20. Adaptive immune responses are induced in liver after major stresses such as hemorrhagic shock (HS) and trauma. There is emerging evidence that the inflammasome, the multiprotein platform that induces caspase-1...

    Authors: Christoph L. Menzel, Qian Sun, Patricia A. Loughran, Hans-Christoph Pape, Timothy R. Billiar and Melanie J. Scott
    Citation: Molecular Medicine 2011 17:1791031
    Content type: Research Article Published on:

  21. AMP-activated protein kinase (AMPK) is a sensor and regulator of cellular energy metabolism potentially Implicated In a broad range of conditions, including obesity and Alzheimer’s disease. Its role in the con...

    Authors: Valérie Vingtdeux, Pallavi Chandakkar, Haitian Zhao, Peter Davies and Philippe Marambaud
    Citation: Molecular Medicine 2011 17:1791022
    Content type: Research Article Published on:

  22. Dendritic cell (DC)-based adoptive tumor immunotherapy approaches have shown promising results, but the incidence of tumor regression is low and there is an evident call for identifying culture conditions that...

    Authors: Diahnn Futalan, Chien-Tze Huang, Ingo G. H. Schmidt-Wolf, Marie Larsson and Davorka Messmer
    Citation: Molecular Medicine 2011 17:1709910
    Content type: Research Article Published on:

  23. Diabetes is associated with an increased risk of heart failure, in part explained by endoplasmic reticulum stress and apoptosis. Protein disulfide isomerase (PDI) prevents stressed cardiomyocytes apoptosis. We...

    Authors: Stefano Toldo, Mariarosaria Boccellino, Barbara Rinaldi, Ignacio M. Seropian, Eleonora Mezzaroma, Anna Severino, Lucio Quagliuolo, Benjamin W. Van Tassell, Raffaele Marfella, Giuseppe Paolisso, Francesco Rossi, Ramesh Natarajan, Norbert Voelkel, Antonio Abbate, Filippo Crea and Alfonso Baldi
    Citation: Molecular Medicine 2011 17:1791012
    Content type: Research Article Published on:

  24. Atherosclerosis begins as local inflammation of arterial walls at sites of disturbed flow, such as vessel curvatures and bifurcations with low shear stress. c-Jun NH2-terminal kinase (JNK) is a major regulator of...

    Authors: Juan Wang, Feng Shuang An, Wei Zhang, Lei Gong, Shu Jian Wei, Wei Dong Qin, Xu Ping Wang, Yu Xia Zhao, Yun Zhang, Cheng Zhang and Ming-Xiang Zhang
    Citation: Molecular Medicine 2011 17:1709990
    Content type: Research Article Published on:

    The Correction to this article has been published in Molecular Medicine 2022 28:110

  25. The plasma fluorescence related to the standard fluorescence of advanced glycation end products (AGEs) is a simple measurable blood parameter for distinct diseases but its importance in human cancer, including...

    Authors: Babett Bartling, Hans-Stefan Hofmann, Antonia Sohst, Yvonne Hatzky, Veronika Somoza, Rolf-Edgar Silber and Andreas Simm
    Citation: Molecular Medicine 2011 17:1709980
    Content type: Research Article Published on:

  26. The calcium homeostasis modulator 1 (CALHM1) gene codes for a novel cerebral calcium channel controlling Intracellular calcium homeostasis and amyloid-β (Aβ) peptide metabolism, a key event in the etiology of Alz...

    Authors: Jeremy Koppel, Fabien Campagne, Valérie Vingtdeux, Ute Dreses-Werringloer, Michael Ewers, Dan Rujescu, Harald Hampel, Marc L. Gordon, Erica Christen, Julien Chapuis, Blaine S. Greenwald, Peter Davies and Philippe Marambaud
    Citation: Molecular Medicine 2011 17:1709974
    Content type: Research Article Published on:

  27. Effective manipulation of human disease processes may be achieved by understanding transcriptional, posttranscriptional and epigenetic events that orchestrate cellular events. The levels of activation of speci...

    Authors: Prithi Rajan
    Citation: Molecular Medicine 2011 17:1709965
    Content type: Review Article Published on:

  28. Recent gene expression profiling analyses and gain- and loss-of-function studies performed with distinct prostate cancer (PC) cell models indicated that the alterations in specific gene products and molecular ...

    Authors: Murielle Mimeault and Surinder K. Batra
    Citation: Molecular Medicine 2011 17:1709949
    Content type: Review Article Published on:

  29. The immunomodulatory effect of the autonomic nervous system has raised considerable interest over the last decades. Studying the influence on the immune system and the role in inflammation of the sympathetic a...

    Authors: Frieda A. Koopman, Susanne P. Stoof, Rainer H. Straub, Marjolein A. van Maanen, Margriet J. Vervoordeldonk and Paul P. Tak
    Citation: Molecular Medicine 2011 17:1709937
    Content type: Review Article Published on:

  30. Duchenne muscular dystrophy (DMD) Is an X-linked, lethal, degenerative disease that results from mutations In the dystrophin gene, causing necrosis and inflammation in skeletal muscle tissue. Treatments that r...

    Authors: Saman Eghtesad, Siddharth Jhunjhunwala, Steven R. Little and Paula R. Clemens
    Citation: Molecular Medicine 2011 17:1709917
    Content type: Research Article Published on:

  31. Deptor is an mTOR binding protein that affects cell metabolism. We hypothesized that knockdown (KD) of Deptor in C2C12 myocytes will increase protein synthesis via stimulating mTOR-S6K1 signaling. Deptor KD wa...

    Authors: Abid A. Kazi, Ly Hong-Brown, Susan M. Lang and Charles H. Lang
    Citation: Molecular Medicine 2011 17:1709925
    Content type: Research Article Published on:

  32. The aim of the present study was to determine whether different subsets of B cells characterize synovial fluid (SF) or synovial tissue (ST) of seropositive or seronegative rheumatoid arthritis (RA) with respec...

    Authors: Alessandro Michelutti, Elisa Gremese, Francesca Morassi, Luca Petricca, Vincenzo Arena, Barbara Tolusso, Stefano Alivernini, Giusy Peluso, Silvia Laura Bosello and Gianfranco Ferraccioli
    Citation: Molecular Medicine 2011 17:1709901
    Content type: Research Article Published on:

  33. Cordycepin has been shown to interfere with a myriad of molecular processes from RNA elongation to kinase activity, and prevents numerous inflammatory processes in animal models. Here we show in a mouse model ...

    Authors: Hogyoung Kim, Amarjit S. Naura, Youssef Errami, Jihang Ju and A. Hamid Boulares
    Citation: Molecular Medicine 2011 17:1709893
    Content type: Research Article Published on:

  34. Recent studies have shown that erythropoietin, critical for the differentiation and survival of erythrocytes, has cytoprotective effects in a wide variety of tissues, including the kidney and lung. However, er...

    Authors: Nimesh S. A. Patel, Kiran K. Nandra, Michael Brines, Massimo Collino, W. S. Fred Wong, Amar Kapoor, Elisa Benetti, Fera Y. Goh, Roberto Fantozzi, Anthony Cerami and Christoph Thiemermann
    Citation: Molecular Medicine 2011 17:1709883
    Content type: Research Article Published on:

  35. Dysferlinopathies are autosomal recessive disorders caused by mutations in the dysferlin (DYSF) gene, encoding the dysferlin protein. DYSF mutations lead to a wide range of muscular phenotypes, with the most prom...

    Authors: Florian Barthélémy, Nicolas Wein, Martin Krahn, Nicolas Lévy and Marc Bartoli
    Citation: Molecular Medicine 2011 17:1709875
    Content type: Review Article Published on:

  36. The mutational status of the immunoglobulin heavy-chain variable region (IGHV) genes utilized by chronic lymphocytic leukemia (CLL) clones defines two disease subgroups. Patients with unmutated IGHV have a mor...

    Authors: Monica Colombo, Giovanna Cutrona, Daniele Reverberi, Sonia Fabris, Antonino Neri, Marina Fabbi, Giovanni Quintana, Giovanni Quarta, Fabio Ghiotto, Franco Fais and Manlio Ferrarini
    Citation: Molecular Medicine 2011 17:1707834
    Content type: Research Article Published on:

  37. A significant association between a polymorphism in the D repeat of the gene encoding asporin and osteoarthritis, the most frequent of articular diseases, has been recently reported. The goal of the present st...

    Authors: Elise Duval, Nicolas Bigot, Magalie Hervieu, Ikuyo Kou, Sylvain Leclercq, Philippe Galéra, Karim Boumediene and Catherine Baugé
    Citation: Molecular Medicine 2011 17:1707816
    Content type: Research Article Published on:

  38. A rapid recruitment of neutrophils to sites of injury or infection is a hallmark of the inflammatory response and is required for effective host defense against pathogenic stimuli. However, neutrophil-mediated...

    Authors: Mariam Al-Omari, Elena Korenbaum, Matthias Ballmaier, Ulrich Lehmann, Danny Jonigk, Dietmar J. Manstein, Tobias Welte, Ravi Mahadeva and Sabina Janciauskiene
    Citation: Molecular Medicine 2011 17:1709865
    Content type: Invited Research Article Published on:

  39. Cytological analysis of body fluids is currently used for detecting cancer. The objective of this study was to determine if the herpes virus carrying an enhanced green fluorescent protein (EGFP) could detect r...

    Authors: Prasad S. Adusumilli, Sepideh Gholami, Yun Shin Chun, Michael Mullerad, Mei Ki Chan, Zhenkun Yu, Leah Ben-Porat, Valerie W Rusch and Yuman Fong
    Citation: Molecular Medicine 2011 17:1707628
    Content type: Research Article Published on:

  40. Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of fatty acids, has been shown to be deregulated in several cancers, including epithelial ovarian carcinoma (EOC). In this study, we invest...

    Authors: Shahab Uddin, Zeenath Jehan, Maqbool Ahmed, Aisha Alyan, Fouad Al-Dayel, Azhar Hussain, Prashant Bavi and Khawla S Al-Kuraya
    Citation: Molecular Medicine 2011 17:1707635
    Content type: Research Article Published on:

  41. Pneumonia is a severe disease with high morbidity and mortality. A major causative pathogen is the Gram-negative bacterium Klebsiella (K.) pneumoniae. Kinases play an integral role in the transduction of intracel...

    Authors: Arie J Hoogendijk, Sander H Diks, Maikel P Peppelenbosch, Tom van der Poll and Catharina W Wieland
    Citation: Molecular Medicine 2011 17:1707741
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2011 17:Art29

  42. The hereditary forms of breast cancer identified by BRCA1 and BRCA2 genes have a defect in homologous DNA repair and demonstrate a dependence on alternate DNA repair processes by base excision repair, which requi...

    Authors: Mary Leung, David Rosen, Scott Fields, Alessandra Cesano and Daniel R Budman
    Citation: Molecular Medicine 2011 17:1707854
    Content type: Research Article Published on:

  43. Interleukin (IL)-12 and IL-23 both share the p40 subunit and are key cytokines in the pathogenesis of Crohn’s disease. Previously, we have developed and identified three mouse p40 peptide-based and virus-like ...

    Authors: Qingdong Guan, Yanbing Ma, China-Li Hillman, Gefei Qing, Allan G Ma, Carolyn R Weiss, Gang Zhou, Aiping Bai, Richard J Warrington, Charles N Bernstein and Zhikang Peng
    Citation: Molecular Medicine 2011 17:1707646
    Content type: Research Article Published on:

  44. High mobility group protein B1 (HMGB1) has been implicated as an important mediator in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). However, the expression of HMGB1 in plasma an...

    Authors: Changchun Hou, Haijin Zhao, Laiyu Liu, Wenjun Li, Xiaoting Zhou, Yanhua Lv, Xiangbo Shen, Zhenyu Liang, Shaoxi Cai and Fei Zou
    Citation: Molecular Medicine 2011 17:1707807
    Content type: Research Article Published on:

  45. Morbid obesity is associated with a state of chronic inflammation. Interleukin-1 family (IL-1F) cytokine members are produced by human adipose tissue in obesity. Whereas certain IL-1F members such as IL-1β or ...

    Authors: Alexander R Moschen, Clemens Molnar, Barbara Enrich, Sabine Geiger, Christoph F Ebenbichler and Herbert Tilg
    Citation: Molecular Medicine 2011 17:1707840
    Content type: Research Article Published on:

  46. Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in glucose, lipid metabolism and energy homeostasis, with main tissues of expression being the liver and adipose tissue. Brown adipose tiss...

    Authors: Dionysius V Chartoumpekis, Ioannis G Habeos, Panos G Ziros, Agathoklis I Psyrogiannis, Venetsana E Kyriazopoulou and Athanasios G Papavassiliou
    Citation: Molecular Medicine 2011 17:1707736
    Content type: Research Article Published on:

  47. Mesenchymal stem cells (MSCs) are suggested to be immune modulators because of their therapeutic potential in transplantation. In the present study, we evaluated the therapeutic potential of autologous MSCs fo...

    Authors: Yang-Hee Kim, Yu-Mee Wee, Monica-Y Choi, Dong-Gyun Lim, Song-Cheol Kim and Duck-Jong Han
    Citation: Molecular Medicine 2011 17:1707697
    Content type: Research Article Published on:

  48. Considerable levels of testosterone and dihydrotestosterone (DHT) are found In prostate cancer (PCa) tissue after androgen deprivation therapy. Treatment of surviving cancer-initiating cells and the ability to...

    Authors: Minja J Pfeiffer, Frank P Smit, John P M Sedelaar and Jack A Schalken
    Citation: Molecular Medicine 2011 17:1707657
    Content type: Research Article Published on:

  50. S100P was recently found to be overexpressed In a variety of cancers and Is considered a potential target for cancer therapy, but the functional role or mechanism of action of S100P in colon cancer is not full...

    Authors: Lei Jiang, Yiu-Kay Lai, Jinfang Zhang, Hua Wang, Marie C M Lin, Ming-liang He and Hsiang-fu Kung
    Citation: Molecular Medicine 2011 17:1707709
    Content type: Research Article Published on:
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