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Page 40 of 44

  1. The Btk (Bruton’s tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinas...

    Authors: Bratin K. Saha, Sherill K. Curtis, Larry B. Vogler and Mauno Vihinen
    Citation: Molecular Medicine 1997 3:BF03401694
  2. Several plasmid DNA-based mammalian expression systems have recently been developed which make it possible to manipulate gene expression via the administration of exogenous agents. In order to extend the appli...

    Authors: Dirk Lindemann, Edward Patriquin, Sandy Feng and Richard C. Mulligan
    Citation: Molecular Medicine 1997 3:BF03401693
  3. The synovial T cell infiltrate in rheumatoid arthritis (RA) is diverse but contains clonally expanded CD4+ populations. Recent reports have emphasized that RA patients have a tendency to develop CD4+ T cell oligo...

    Authors: Heike L. Rittner, Andreas Zettl, Michael C. Jendro, Peter Bartz-Bazzanella, Jörg J. Goronzy and Cornelia M. Weyand
    Citation: Molecular Medicine 1997 3:BF03401692
  4. DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the exp...

    Authors: Lin Wu and Arnold J. Levine
    Citation: Molecular Medicine 1997 3:BF03401691
  5. Cystic fibrosis (CF) is characterized by pancreatic destruction following the gradual obstruction of small pancreatic ducts, from the mid-trimester of gestation onwards. To date, the material causing the obstr...

    Authors: Golm J. Reid, Karen Hyde, Samuel B. Ho, Ann Harris and D. Weatherall
    Citation: Molecular Medicine 1997 3:BF03401687
  6. The 845A(C282Y) mutation in the HLA-H gene accounts for most cases of hereditary hemochromatosis in patients who are of European origin. Some lack this mutation, however, and it is not present in Asian patients. ...

    Authors: Ernest Beutler, Carol West and Terri Gelbart
    Citation: Molecular Medicine 1997 3:BF03401686
  7. A correct balance between protease and inhibitor activity is critical in the maintenance of homoeostasis; excessive activation of enzyme pathways is frequently associated with inflammatory disorders. Plasmin i...

    Authors: Eleanor M. Wallace, Stephen J. Perkins, Robert B. Sim, Anthony C. Willis, Con Feighery and John Jackson
    Citation: Molecular Medicine 1997 3:BF03401685
  8. Mutations of the murine limb deformity (ld) locus are responsible for a pleiotropic phenotype of completely penetrant limb malformations and incompletely penetrant renal agenesis and/or dysgenesis. The ld locus e...

    Authors: Anthony Wynshaw-Boris, Gabriella Ryan, Chu-Xia Deng, David C. Chan, Laurie Jackson-Grusby, Denise Larson, Judy H. Dunmore and Philip Leder
    Citation: Molecular Medicine 1997 3:BF03401684
  9. MHC class I molecule-restricted cytotoxic T-lymphocyte (CTL) responses are induced following either intramuscular (i.m.) injection of a DNA plasmid encoding influenza virus nucleoprotein (NP) or transplantatio...

    Authors: Tong-Ming Fu, Jeffrey B. Ulmer, Michael J. Caulfield, R. Randall Deck, Arthur Friedman, Su Wang, Xu Liu, John J. Donnelly, Margaret A. Liu and H. Wigzell
    Citation: Molecular Medicine 1997 3:BF03401683
  10. Replication of HIV-1 in human T lymphocytes requires the activation of host cellular proteins. This study identifies p38 mitogen-activated protein kinase (MAPK) as one such kinase necessary for HIV-1 replicati...

    Authors: Pamela S. Cohen, Helena Schmidtmayerova, Jameel Dennis, Larisa Dubrovsky, Barbara Sherry, Haichao Wang, Michael Bukrinsky and Kevin J. Tracey
    Citation: Molecular Medicine 1997 3:BF03401812
  11. AIDS-associated Kaposi’s sarcoma (AIDS-KS) represents one of the most common malignancies associated with human immunodeficiency virus infection. To target effective therapeutic agents to AIDS-KS, we have iden...

    Authors: Syed R. Husain, Parkash Gill, Robert J. Kreitman, Ira Pastan and Raj K. Puri
    Citation: Molecular Medicine 1997 3:BF03401811
  12. The production of nitric oxide by type II inducible nitric oxide synthase (type II NOS) gene is controlled at least in part by transcriptional activation. Although the murine and human type II NOS genes share ...

    Authors: Sergei V. Spitsin, John L. Farber, Michael Bertovich, Gisela Moehren, Hilary Koprowski and Frank H. Michaels
    Citation: Molecular Medicine 1997 3:BF03401810
  13. Resistance to thyroid hormone (RTH) is a syndrome characterized by refractoriness of the pituitary and/or peripheral tissues to the action of thyroid hormone. Mutations in the thyroid hormone receptor β (TRβ) gen...

    Authors: Rosemary Wong, Vyacheslav V. Vasilyev, Yuan-Tsang Ting, David I. Kutler, Mark C. Willingham, Bruce D. Weintraub and Sheue-yann Cheng
    Citation: Molecular Medicine 1997 3:BF03401809
  14. The overexpression or amplification of tumor suppressor and proto-oncogenes are important factors in the progression of breast cancer. Recent attention has focused on the cyclin genes, whose involvement in sig...

    Authors: G. Wani, I. Noyes, G. E. Milo and S. M. D’Ambrosio
    Citation: Molecular Medicine 1997 3:BF03401680
  15. Reactive arthritis (ReA) can develop as a consequence of a bacterial infection with organisms such as Chlamydia trachomata, Shigella flexneri, or Yersinia enterocolitica. Although the mechanism underlying the ind...

    Authors: Anja E. Schröder, Jochen Sieper and Claudia Berek
    Citation: Molecular Medicine 1997 3:BF03401679
  16. Based on the hypothesis that IgGs are potent tolerogens and that immature lymphohematopoietic antigen-presenting cells (APC), and even mature peripheral B cells, may be effective APC for tolerance induction, w...

    Authors: Elias T. Zambidis, Anupama Kurup and David W. Scott
    Citation: Molecular Medicine 1997 3:BF03401674
  17. Amyloid β-protein (Aβ), the major constituent of amyloid deposits found in Alzheimer’s disease, is derived from the β-amyloid precursor protein (βPP). Constitutive proteolysis by α-secretase and secretion of solu...

    Authors: Edward H. Koo and P. Greengard
    Citation: Molecular Medicine 1997 3:BF03401673
  18. Although γδ T cells are a major component of the human intestinal mucosa, it is not clear what role they play in mucosal immunity or if they are involved in the disease process of inflammatory bowel disease (IBD)...

    Authors: Laila D. McVay, Baiqing Li, Renée Biancaniello, Mary Anne Creighton, Dale Bachwich, Gary Lichtenstein, John L. Rombeau and Simon R. Carding
    Citation: Molecular Medicine 1997 3:BF03401672
  19. Fabry disease, an X-linked inborn error of glycosphingolipid catabolism, results from mutations in the α-galactosidase A (α-Gal A) gene located at Xq22.1. To determine the nature and frequency of the molecular le...

    Authors: Christine M. Eng, Grace A. Ashley, Tania S. Burgert, Annette L. Enriquez, Marcus D’Souza, Robert J. Desnick and E. Beutler
    Citation: Molecular Medicine 1997 3:BF03401671
  20. We sought to identify novel islet-cell autoantigens to better understand the pathogenesis, prediction, and immunotherapy of type 1 diabetes.

    Authors: James LaGasse, Laura Jelinek, Shannon Sexson, Cathy Lofton-Day, John Breininger, Paul Sheppard, Wayne Kindsvogel and William A. Hagopian
    Citation: Molecular Medicine 1997 3:BF03401670
  21. The so-called antikeratin antibodies and the antiperinuclear factor are the most specific serological markers of rheumatoid arthritis (RA). They were recently shown to be largely the same autoantibodies and to...

    Authors: Elisabeth Girbal-Neuhauser, Martine Montézin, Françoise Croute, Mireille Sebbag, Michel Simon, Jean-Jacques Durieux and Guy Serre
    Citation: Molecular Medicine 1997 3:BF03401806
  22. Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that participates in the pathogenesis of endotoxemia and experimental crescentic glomerulonephritis. However, very little is kn...

    Authors: Hui Y. Lan, Niansheng Yang, Christine Metz, Wei Mu, Qing Song, David J. Nikolic-Paterson, Michael Bacher, Richard Bucala and Robert C. Atkins
    Citation: Molecular Medicine 1997 3:BF03401805
  23. Laminin 5, an anchoring filament attachment protein within the lamina lucida of the basement membrane zone involved in the pathogenesis of junctional epidermolysis bullosa (JEB), consists of three polypeptide ...

    Authors: Leena Pulkkinen, John McGrath, Tomi Airenne, Heli Haakana, Karl Tryggvason, Sirpa Kivirikko, Guerrino Meneguzzi, Jean-Paul Ortonne, Angela M. Christiano and Jouni Uitto
    Citation: Molecular Medicine 1997 3:BF03401804
  24. The cytoplasmic domain of the Alzheimer’s disease amyloid precursor protein (APP) is phosphorylated in vitro at Thr654 and Ser655, and both in vitro and in intact cells at Thr668 (numbering for APP695 isoform).

    Authors: Masaki Oishi, Angus C. Nairn, Andrew J. Czernik, Gloria S. Lim, Toshio Isohara, Samuel E. Gandy, Paul Greengard and Toshiharu Suzuki
    Citation: Molecular Medicine 1997 3:BF03401803
  25. The HIV-1 matrix (MA) protein, p17, contains two subcellular localization signals that facilitate both nuclear import of the viral preintegration complex early during infection and virus particle assembly late...

    Authors: Reuven Levin, Abner M. Mhashilkar, Tatyana Dorfman, Anatoly Bukovsky, Christy Zani, Jessamyn Bagley, Jorma Hinkula, Mattias Niedrig, Jan Albert, Britta Wahren, Heinrich G. Göttlinger and Wayne A. Marasco
    Citation: Molecular Medicine 1997 3:BF03401802
  26. Upon engagement of the T cell receptor for antigen, its associated CD3 proteins recruit signal transduction molecules, which in turn regulate T lymphocyte proliferation, apoptosis, and thymocyte development. B...

    Authors: Baoping Wang, Jian She, Mariolina Salio, Deborah Allen, Elizabeth Lacy, Nils Lonberg and Cox Terhorst
    Citation: Molecular Medicine 1997 3:BF03401669
  27. Antiviral cellular immune responses may influence immunological homeostasis in HIV-infected persons. Recent data indicate that Vγ9/Vδ2 T lymphocytes display potent cytotoxic activities against human cells infecte...

    Authors: Marianne Wallace, Alexander M. Scharko, C. David Pauza, Paul Fisch, Koichi Imaoka, Shigetada Kawabata, Kohtaro Fujihashi, Hiroshi Kiyono, Yoshimasa Tanaka, Barry R. Bloom and Miroslav Malkovsky
    Citation: Molecular Medicine 1997 3:BF03401668
  28. The human maspin gene encodes a protein in the serine proteinase inhibitor (serpin) family with tumor-suppressing functions in cell culture and in nude mice. In order to examine the role of maspin in an intact...

    Authors: Ming Zhang, Shijie Sheng, Nicolai Maass and Ruth Sager
    Citation: Molecular Medicine 1997 3:BF03401667
  29. Tumor necrosis factor-α (TNF-α) is chronically elevated in the adipose tissue from obese humans and mice. This increase in TNF-α contributes to the insulin resistance, elevated plasminogen activator inhibitor-1 (...

    Authors: Fahumiya Samad, Koji Yamamoto, Manjula Pandey and David J. Loskutoff
    Citation: Molecular Medicine 1997 3:BF03401666
  30. CC chemokine receptor 5 (CCR5) is a cell entry cofactor for macrophage-tropic isolates of human immunodeficiency virus-1 (HIV-1). Recently, an inactive CCR5 allele (designated here as CCR5-2) was identified th...

    Authors: Peter A. Zimmerman, Alicia Buckler-White, Ghalib Alkhatib, Todd Spalding, Joseph Kubofcik, Christophe Combadiere, Drew Weissman, Oren Cohen, Andrea Rubbert, Gordon Lam, Mauro Vaccarezza, Paul E. Kennedy, V. Kumaraswami, Janis V. Giorgi, Roger Detels, Jay Hunter…
    Citation: Molecular Medicine 1997 3:BF03401665
  31. CDKN2A, the gene encoding the cell-cycle inhibitor p16CDKN2A, was first identified in 1994. Since then, somatic mutations have been observed in many cancers and germline alterations have been found in kindreds wi...

    Authors: William D. Foulkes, Tamar Y. Flanders, Pamela M. Pollock and Nicholas K. Hayward
    Citation: Molecular Medicine 1997 3:BF03401664
  32. In a majority of cases, autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations within a putative open reading frame of the PKD1 gene. The encoded protein, polycystin, is predicted to span ...

    Authors: Runolfur Palsson, Chander P. Sharma, Keetae Kim, Margaret McLaughlin, Dennis Brown and M. Amin Arnaout
    Citation: Molecular Medicine 1996 2:BF03401654

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