Articles

A Mutation Unique in Serine Protease Inhibitors (Serpins) Identified in a Family with Type II Hereditary Angioneurotic Edema

Hereditary angioneurotic edema (HANE) is an autosomal dominant disease due to genetic alterations at the C1 inhibitor gene. Mutations within the C1 inhibitor gene are responsible for the molecular defect in ty...

Authors: Javier G. Ocejo-Vinyals, Francisco Leyva-Cobián and José L. Fernández-Luna

Interleukin 12: A Potential Link between Nerve Cells and the Immune Response in Inflammatory Disorders

The nervous system has been implicated in several inflammatory skin disorders based on evidence such as the role of stress in inducing lesions, symmetry of lesions, and sparing of denervated skin. Interleukin ...

Authors: Laurence A. Turka, Richard E. Goodman, J. Lynn Rutkowski, Anders A. F. Sima, Andrew Merry, Raj S. Mitra, Tamara Wrone-Smith, Galen Toews, Robert M. Strieter and Brian J. Nickoloff

δ Opioidmimetic Antagonists: Prototypes for Designing a New Generation of Ultraselective Opioid Peptides

Tyr-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) and Tyr-Tic-Ala were the first peptides with δ opioid antagonist activity lacking Phe, considered essential for opioid activity based on the N-terminal t...

Authors: Severo Salvadori, Martti Attila, Giofranco Balboni, Clementina Bianchi, Sharon D. Bryant, Orlando Crescenzi, Remo Guerrini, Delia Picone, Teodorico Tancredi, Piero A. Temussi and Lawrence H. Lazarus

Interleukin 1 Induces HIV-1 Expression in Chronically Infected U1 Cells: Blockade by Interleukin 1 Receptor Antagonist and Tumor Necrosis Factor Binding Protein Type 1

Cytokines and cytokine antagonists modulate human immunodeficiency virus (HIV) replication in vitro and may be involved in HIV disease pathogenesis. An understanding of these cytokine networks may suggest nove...

Authors: Eric V. Granowitz, Bradford M. Saget, Monica Z. Wang, Charles A. Dinarello, Paul R. Skolnik and A. S. Fauci

Association of Elevated Protein Kinase CK2 Activity with Aggressive Behavior of Squamous Cell Carcinoma of the Head and Neck

Protein kinase CK2 (also known as casein kinase 2) is a messenger-independent protein serine/threonine kinase ubiquitously distributed in eukaryotes. CK2 has been found to phosphorylate a wide variety of cytos...

Authors: Markus Gapany, Russell A. Faust, Sherif Tawfic, Alan Davis, George L. Adams, P. Leder and Khalil Ahmed

Prevention of Tumor Formation in a Mouse Model of Burkitt’s Lymphoma by 6 Weeks of Treatment with Anti-c-myc DNA Phosphorothioate

Transgenic mice bearing a murine immunoglobulin enhancer/c-myc fusion transgene (Eµ-myc) provide a useful model for Burkitt’s lymphoma.

Authors: Ye Huang, Ruthanne Snyder, Michael Kligshteyn and Eric Wickstrom

Identification of Galectin-3 As a High-Affinity Binding Protein for Advanced Glycation End Products (AGE): A New Member of the AGE-Receptor Complex

Advanced glycation end products (AGE), the reactive derivatives of nonenzymatic glucose-protein condensation reactions, are implicated in the multiorgan complications of diabetes and aging. An AGE-specific cel...

Authors: Helen Vlassara, Yong Ming Li, Farhad Imani, Donald Wojciechowicz, Zhi Yang, Fu-Tong Liu and Anthony Cerami

Similar Peptides from Two β Cell Autoantigens, Proinsulin and Glutamic Acid Decarboxylase, Stimulate T Cells of Individuals at Risk for Insulin-Dependent Diabetes

Insulin (1) and glutamic acid decarboxylase (GAD) (2) are both autoantigens in insulin-dependent diabetes mellitus (IDDM), but no molecular mechanism has been proposed for their association. We have identified a ...

Authors: George Rudy, Natalie Stone, Leonard C. Harrison, Peter G. Colman, Peter McNair, Vladimir Brusic, Michelle B. French, Margo C. Honeyman, Brian Tait and Andrew M. Lew

Oligoclonality in the Human CD8⁺ T Cell Repertoire in Normal Subjects and Monozygotic Twins: Implications for Studies of Infectious and Autoimmune Diseases

We have previously demonstrated CD8⁺ T cell clonal dominance using a PCR assay for the CDR3 length of T cell receptors belonging to a limited number of TCRBV segments/families. In this study, we have modified thi...

Authors: Joanita Monteiro, Ravi Hingorani, In-Hong Choi, Jack Silver, Robert Pergolizzi and Peter K. Gregersen

Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein Gene

Creutzfeldt-Jakob disease (CJD) is a prion disease which is manifest as a sporadic, inherited, and transmissible neurodegenerative disorder. The mean age at onset of CJD is ∼60 years, and as such, many people ...

Authors: Serena Spudich, James A. Mastrianni, Margaret Wrensch, Ruth Gabizon, Zeev Meiner, Irit Kahana, Hana Rosenmann, Esther Kahana and Stanley B. Prusiner

Report on the Lactic Acid Fermentation (Author’s abstract)

Authors: Thomas D. Brock

Mémoire sur la fermentation appelée lactique (Extrait par l’auteur)

Authors:

Institut Pasteur

Authors: Maxime Schwartz

Louis Pasteur and Molecular Medicine: A Centennial Celebration

Authors: Maxime Schwartz

Analysis of Families at Risk for Insulin-Dependent Diabetes Mellitus Reveals that HLA Antigens Influence Progression to Clinical Disease

Individuals at risk for insulin-dependent diabetes mellitus (IDDM), with an affected first-degree relative, can be identified by the presence of islet cell antibodies (ICA). ICA-positive relatives progress at ...

Authors: Margo C. Honeyman, Leonard C. Harrison, Bruce Drummond, Peter G. Colman and Brian D. Tait

Ciliary Neurotrophic Factor Inhibits Brain and Peripheral Tumor Necrosis Factor Production and, When Coadministered with Its Soluble Receptor, Protects Mice From Lipopolysaccharide Toxicity

The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor...

Authors: Fabio Benigni, Pia Villa, Maria Teresa Demitri, Silvano Sacco, Jean D. Sipe, Laura Lagunowich, Nikos Panayotatos and Pietro Ghezzi

Variable Response to a Candidate Cancer Vaccine Antigen: MHC Control of the Antibody Response in the Rat to Avian Erythroblastosis Virus (AEV)-Encoded Epithelial Growth Factor Receptor but Not AEV-Encoded Thyroid Hormones Receptor

A problem likely to be encountered in any cancer immunotherapy based on vaccination with a single protein or peptide is variation in the host response. A particularly informative example is provided by the two...

Authors: Nance Nardi and Nicholas A. Mitchison

γδ T Cell Receptor Analysis Supports a Role for HSP 70 Selection of Lymphocytes in Multiple Sclerosis Lesions

Interactions between γδ T cells and heat shock proteins (HSP) have been proposed as contributing factors in a number of diseases of possible autoimmune etiology but definitive evidence to support this hypothesis ...

Authors: Luca Battistini, Marco Salvetti, Giovanni Ristori, Marika Falcone, Cedric S. Raine and Celia F. Brosnan

Amyloid Formation in Response to β Cell Stress Occurs In Vitro, but Not In Vivo, in Islets of Transgenic Mice Expressing Human Islet Amyloid Polypeptide

Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the β cells of the islets of Langerhans should be useful in identifying factors important for ...

Authors: Gunilla Westermark, Michelle Benig Arora, Niles Fox, Raymond Carroll, Shu Jin Chan, Per Westermark and Donald F. Steiner

Inhibition of Protein Phosphatase 1 Stimulates Secretion of Alzheimer Amyloid Precursor Protein

Aberrant metabolism of the Alzheimer amyloid precursor protein (APP) or its amyloidogenic Aβ fragment is thought to be centrally involved in Alzheimer’s disease. Nonamyloidogenic processing of APP involves its cl...

Authors: Edgar F. da Cruz e Silva, Odete A. B. da Cruz e Silva, Cássia Thais B. V. Zaia and Paul Greengard

Nerve Growth Factor Prevents Both Neuroretinal Programmed Cell Death and Capillary Pathology in Experimental Diabetes

Chronic diabetes causes structural changes in the retinal capillaries of nearly all patients with a disease duration of more than 15 years. Acellular occluded vessels cause hypoxia, which stimulates sight-thre...

Authors: Hans-Peter Hammes, Howard J. Federoff and Michael Brownlee

Taxol-Induced Mitotic Block Triggers Rapid Onset of a p53-Independent Apoptotic Pathway

At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induce...

Authors: Catherine M. Woods, Jian Zhu, Patricia A. McQueney, Daniel Bollag and Elias Lazarides

Burkitt’s Lymphoma Is a Malignancy of Mature B Cells Expressing Somatically Mutated V Region Genes

The developmental stage from which stems the malignant B cell population in Burkitt’s lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rearranged immunog...

Authors: Ulf Klein, George Klein, Barbro Ehlin-Henriksson, Klaus Rajewsky and Ralf Küppers

A Role for T Cells in the Pathogenesis of Treatment-Resistant Lyme Arthritis

Authors: Thomas Kamradt, Andreas Krause and Gerd-Rüdiger Burmester

HIV Accessory Proteins: Emerging Therapeutic Targets

Authors: Roger H. Miller and Nava Sarver

Yale’s Boyer Center for Molecular Medicine

Authors: Vincent T. Marchesi

Expression of the Von Hippel-Lindau Tumor Suppressor Gene, VHL, in Human Fetal Kidney and During Mouse Embryogenesis

Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors are hemangioblastomas...

Authors: Patricia M. Kessler, Sandip P. Vasavada, Raymond R. Rackley, Thomas Stackhouse, Fuh-Mei Duh, Farida Latif, Michael I. Lerman, Berton Zbar and Bryan R. G. Williams

Advanced Glycation Endproducts Promote Adhesion Molecule (VCAM-1, ICAM-1) Expression and Atheroma Formation in Normal Rabbits

Reactive glucose-protein intermediates and advanced glycation endproducts (AGEs) are shown to colocalize with atheromatous lesions and to trigger complex chemical and biological responses through interaction w...

Authors: Helen Vlassara, Hubert Fuh, Thomas Donnelly and Myron Cybulsky

The MarR Repressor of the Multiple Antibiotic Resistance (mar) Operon in Escherichia coli: Prototypic Member of a Family of Bacterial Regulatory Proteins Involved in Sensing Phenolic Compounds

The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of

Authors: Mark C. Sulavik, Laura F. Gambino and Paul F. Miller

LPS and Taxol Activate Lyn Kinase Autophosphorylation in Lpsⁿ, but Not in Lps^d, Macrophages

The anti-tumor agent, Taxol, has been shown in murine macrophages to stimulate tumor necrosis factor (TNF), modulate TNF receptors, induce a large panel of immediate-early genes, and induce protein tyrosine ph...

Authors: Beth E. Henricson, Joan M. Carboni, Anne L. Burkhardt and Stefanie N. Vogel

The Tissue Inhibitor of Metalloproteinases-3 Gene in Breast Carcinoma: Identification of Multiple Polyadenylation Sites and a Stromal Pattern of Expression

Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling.

Authors: Jennifer A. Byrne, Catherine Tomasetto, Nicolas Rouyer, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset

Antiviral Drugs from the Nucleoside Analog Family Block Volume-Activated Chloride Channels

The antiviral drugs AZT and acyclovir are generally used in the treatment of infections with human immunodeficiency virus (HIV) and herpes simplex virus (HSV). These substances are known to impede virus replic...

Authors: Martin Gschwentner, Alex Susanna, Ewald Wöll, Markus Ritter, Ulrich O. Nagl, Andreas Schmarda, Andreas Laich, Germar M. Pinggera, Helmut Ellemunter, Hartwig Huemer, Peter Deetjen and Markus Paulmichl

Clozapine: Selective Labeling of Sites Resembling 5HT₆ Serotonin Receptors May Reflect Psychoactive Profile

Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective ...

Authors: Charles E. Glatt, Adele M. Snowman, David R. Sibley and Solomon H. Snyder

Thalidomide Treatment Reduces Tumor Necrosis Factor α Production and Enhances Weight Gain in Patients with Pulmonary Tuberculosis

The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for host immunity, but overproduction of this cytokine may have serious pathologic consequences. Excess TNFα produced in pulmonary tu...

Authors: Jane M. Tramontana, Utaiwan Utaipat, Anthony Molloy, Pasakorn Akarasewi, Margaret Burroughs, Sanit Makonkawkeyoon, Barbara Johnson, Jeffrey D. Klausner, William Rom and Gilla Kaplan

Normal and Expanded Huntington’s Disease Gene Alleles Produce Distinguishable Proteins Due to Translation Across the CAG Repeat

An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG re...

Authors: Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella…

The MD PhD Physician Scientist—Endangered Species or the Next Generation?

Authors: Gary J. Nabel

The Institute of Molecular Medicine, University of Oxford

Authors: David Weatherall

Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types

Authors: Oswald T. Avery, Colin M. MacLeod and Maclyn McCarty

Transforming Biology

Authors: Maclyn McCarty

The McCarty Award in Molecular Medicine

Authors: Anthony Cerami

Immunogenicity and In Vivo Efficacy of Recombinant Plasmodium falciparum Merozoite Surface Protein-1 in Aotus Monkeys

The carboxy-terminus of the merozoite surface protein-1 (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.

Authors: Sanjai Kumar, Anjali Yadava, David B. Keister, Jing Hui Tian, Michael Ohl, Kathy A. Perdue-Greenfield, Louis H. Miller and David C. Kaslow

Failure of Alglucerase Infused into Gaucher Disease Patients to Localize in Marrow Macrophages

Gaucher disease is a common glycolipid storage disease, caused by a deficiency of lysosomal β-glucosidase (glucocerebrosidase). Alglucerase is a form of glucocerebrosidase enriched with terminal mannose moieties,...

Authors: Ernest Beutler, Wanda Kuhl and Luke M. Vaughan

Hemoglobin Switching in Humans Is Accompanied by Changes in the Ratio of the Transcription Factors, GATA-1 and SP1

Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the cl...

Authors: E. Rena Bacon, Nava Dalyot, Dvora Filon, Letizia Schreiber, Eliezer A. Rachmilewitz and Arieila Oppenheim

Restricted Usage of T Cell Receptor V_α/J_α Gene Segments with Different Nucleotide but Identical Amino Acid Sequences in HLA-DR3⁺ Sarcoidosis Patients

Sarcoidosis is a granulomatous disease characterized by the accumulation of activated T cells in the lungs. We previously showed that sarcoidosis patients expressing the HLA haplotype DR3(17), DQ2 had increased n...

Authors: Johan Grunewald, Thomas Hultman, Anders Bucht, Anders Eklund and Hans Wigzell

Construction of a Novel Bifunctional Biogenic Amine Receptor by Two Point Mutations of the H2-Histamine Receptor

H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously cloned the H2-...

Authors: John DelValle, Ira Gantz, Lidong Wang, Yi-Jun Guo, Gerd Munzert, Takao Tashiro, Yoshitaka Konda and Tadataka Yamada

Nramp Transfection Transfers Ity/Lsh/Bcg-Related Pleiotropic Effects on Macrophage Activation: Influence on Oxidative Burst and Nitric Oxide Pathways

The Ity/Lsh/Bcg gene on mouse chromosome 1 regulates priming/activation of macrophages for antimicrobial and tumouricidal activity. A candidate gene expressed in macrophages has been identified by positional clon...

Authors: C. Howard Barton, Simon H. Whitehead and Jenefer M. Blackwell

An Inhibitor of Macrophage Arginine Transport and Nitric Oxide Production (CNI-1493) Prevents Acute Inflammation and Endotoxin Lethality

Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissu...

Authors: Marina Bianchi, Peter Ulrich, Ona Bloom, Malcolm Meistrell III, Gary A. Zimmerman, Helena Schmidtmayerova, Michael Bukrinsky, Thomas Donnelley, Richard Bucala, Barbara Sherry, Kirk R. Manogue, Anthony J. Tortolani, Anthony Cerami and Kevin J. Tracey

Autoantibodies to Neuronal Glutamate Receptors in Patients with Paraneoplastic Neurodegenerative Syndrome Enhance Receptor Activation

Paraneoplastic syndromes are “remote” complications of cancer characterized clinically by neurological disease. The sera and cerebrospinal fluid (CSF) from patients with paraneoplastic neurological syndromes (...

Authors: Lorise C. Gahring, Roy E. Twyman, John E. Greenlee and Scott W. Rogers

Bernard N. Fields 1938–1995

Authors:

A Molecular Medicine Database

Authors: Kenneth S. Warren