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Page 42 of 44

  1. Lipopolysaccharides (LPS), widely used to study the mechanisms of gram-negative sepsis, increase airway resistance by constriction of terminal bronchioles. The role of the cyclooxygenase (COX) isoenzymes and t...

    Authors: Stefan Uhlig, Rolf Nüsing, Alexander von Bethmann, Roland Lewis Featherstone, Thomas Klein, Frank Brasch, Klaus-Michael Müller, Volker Ullrich and Albrecht Wendel
    Citation: Molecular Medicine 1996 2:BF03401635
  2. We recently showed that acquired immunodeficiency syndrome (AIDS) dementia is associated with activated infection of microglia, neurons, and astrocytes by HIV-1. However, it is doubtful whether infection per s...

    Authors: Gerard J. Nuovo, Maria Lynn Alfieri and A. Cerami
    Citation: Molecular Medicine 1996 2:BF03401633
  3. Thrombin is a serine protease that elicits a variety of cellular responses. Molecular cloning of a thrombin receptor revealed a G protein-coupled receptor that is activated by a novel proteolytic mechanism. Re...

    Authors: Mark Kahn, Kenji Ishii, Wen-Lin Kuo, Michael Piper, Andrew Connolly, Yu-Ping Shi, Richard Wu, C. C. Lin and Shaun R. Coughlin
    Citation: Molecular Medicine 1996 2:BF03401632
  4. Understanding the processes that control selective eosinophilia is of fundamental importance in a variety of human diseases (e.g., allergies, parasitic infections, malignancy). Interleukin 5, an eosinophil-spe...

    Authors: Marc E. Rothenberg, Robert Ownbey, Paul D. Mehlhop, Paul M. Loiselle, Matthijs van de Rijn, Joseph V. Bonventre, Hans C. Oettgen, Philip Leder and Andrew D. Luster
    Citation: Molecular Medicine 1996 2:BF03401631
  5. The immunophilins are proteins that mediate actions of immunosuppressant drugs such as FK-506 and cyclosporin A by binding to calcineurin, inhibiting its phosphatase activity, and increasing the phosphorylatio...

    Authors: Joseph P. Steiner, Ted M. Dawson, Majid Fotuhi and Solomon H. Snyder
    Citation: Molecular Medicine 1996 2:BF03401630
  6. The genetic factors involved in determining bone mineral density (BMD) have not been fully elucidated. We have begun genetic linkage analysis of seven families in which many members are osteopenic, in order to...

    Authors: Loretta D. Spotila, John Caminis, Marcella Devoto, Koichiro Shimoya, Larisa Sereda, Jürg Ott, Michael P. Whyte, Alan Tenenhouse and Darwin J. Prockop
    Citation: Molecular Medicine 1996 2:BF03401629
  7. CSF-1 expression precedes renal injury in autoimmune MRL-lpr mice and is responsible for macrophage () proliferation and survival in the kidney. By comparison, C3H-lpr mice do not express CSF-1 in the kidney, a...

    Authors: Takero Naito, Hitoshi Yokoyama, Kathryn J. Moore, Glenn Dranoff, Richard C. Mulligan and Vicki Rubin Kelley
    Citation: Molecular Medicine 1996 2:BF03401628
  8. Nitric oxide (NO) has been implicated as a mediator of penile erection, because the neuronal isoform of NO synthase (NOS) is localized to the penile innervation and NOS inhibitors selectively block erections. ...

    Authors: Arthur L. Burnett, Randy J. Nelson, David C. Calvin, Jian-Xiang Liu, Gregory E. Demas, Sabra L. Klein, Lance J. Kriegsfeld, Valina L. Dawso, Ted M. Dawson and Solomon H. Snyder
    Citation: Molecular Medicine 1996 2:BF03401627
  9. Mice with inactivated tumor necrosis factor (TNF) and lymphotoxin α (LTα) genes have profound abnormalities of the immune system including lymphocytosis, lack of lymph nodes, undifferentiated spleen, hypoimmunogl...

    Authors: Matthias Müller, Hans-Pietro Eugster, Michel Le Hir, Alexander Shakhov, Franco Di Padova, Claudine Maurer, Valerie F. J. Quesniaux and Bernhard Ryffel
    Citation: Molecular Medicine 1996 2:BF03401621
  10. Human falciparum malaria, caused by the intracellular protozoa Plasmodium falciparum, results in 1–2 million deaths per year. P. falciparum digests host erythrocyte hemoglobin within its food vacuole, resulting i...

    Authors: James A. Martiney, Anthony Cerami and Andrew F. G. Slater
    Citation: Molecular Medicine 1996 2:BF03401620
  11. Nitric oxide has a wide variety of homeostatic and pathological effects. Control of the production of nitric oxide by the inducible form of the enzyme resides in the 5′ promoter region of the gene. Although co...

    Authors: Sergei V. Spitsin, Hilary Koprowski and Frank H. Michaels
    Citation: Molecular Medicine 1996 2:BF03401619
  12. Nitric oxide (NO) has been shown to decrease myointimal hyperplasia in injured blood vessels. We hypothesize inducible NO synthase (iNOS) gene transfer even at low efficiency will provide adequate local NO pro...

    Authors: Edith Tzeng, Larry L. Shears II, Paul D. Robbins, Bruce R. Pitt, David A. Geller, Simon C. Watkins, Richard L. Simmons and Timothy R. Billiar
    Citation: Molecular Medicine 1996 2:BF03401618
  13. Parathyroid hormone-related protein (PTHrP) is a ubiquitous and highly conserved vasoactive peptide whose role and regulation in normal physiology remain an enigma. Recently, we demonstrated that low-dose endo...

    Authors: Janet L. Funk, Arthur H. Moser, Gordon J. Strewler, Kenneth R. Feingold and Carl Grünfeld
    Citation: Molecular Medicine 1996 2:BF03401617
  14. Protein tyrosine kinases play an imporH-RYK, an Unusual Receptor Kinase: Isolation and Analysis of Expression in Ovarian Cancertant role in cellular metabolism as key components of signal transduction pathways...

    Authors: Xiao C. Wang, Roy Katso, Robin Butler, Andrew M. Hanby, Richard Poulsom, Tania Jones, Denise Sheer and Trivadi S. Ganesan
    Citation: Molecular Medicine 1996 2:BF03401616
  15. An important issue in autoimmune diseases mediated by T cells, such as experimental allergic encephalomyelitis (EAE), is the affinity of the disease-inducing determinants for MHC class II proteins. Tolerance, ...

    Authors: Lars Fugger, James Liang, Anand Gautam, Jonathan B. Rothbard and Hugh O. McDevitt
    Citation: Molecular Medicine 1996 2:BF03401615
  16. The apolipoprotein E (apoE) type ε4 isoform specifies increased cerebral and cerebrovascular accumulation of amyloid-β protein (Aβ) and contributes to the genetic susceptibility underlying a large proportion (~60...

    Authors: Zhongmin Zhou, Jonathan D. Smith, Paul Greengard and Sam Gandy
    Citation: Molecular Medicine 1996 2:BF03401614
  17. Recent studies of melanin biosynthesis have uncovered an unusual enzymatic activity which converts the non-naturally occurring D-isomer of 2-carboxy-2,3-dihydroindole-5,6-quinone (dopachrome) into 5,6-dihydroxyin...

    Authors: Evald Rosengren, Richard Bucala, Pierre Åman, Lars Jacobsson, Gerd Odh, Christine N. Metz and Hans Rorsman
    Citation: Molecular Medicine 1996 2:BF03402210
  18. The main difficulty in providing effective treatment of patients with cancer is distinguishing between tumor and normal cells. The chimeric molecules created by cancer-associated chromosomal abnormalities (suc...

    Authors: B. García-Hernández and I. Sánchez-García
    Citation: Molecular Medicine 1996 2:BF03402208
  19. Activation of either the 55-kD tumor necrosis factor receptor (TNF-R1) or CD95 (Fas/Apo-1) causes apoptosis of cells and liver failure in mice, and has been associated with human liver disorders. The aim of th...

    Authors: Marcel Leist, Florian Gantner, Gerald Künstle, Ines Bohlinger, Gisa Tiegs, Horst Bluethmann and Albrecht Wendel
    Citation: Molecular Medicine 1996 2:BF03402207
  20. The gene encoding the hepatotrophic factor Augmenter of Liver Regeneration (ALR) has recently been cloned in the rat. The availability of the mouse form of ALR would allow the analysis of the role of this fact...

    Authors: Roberto Giorda, Michio Hagiya, Tatsuya Seki, Manabu Shimonishi, Harumi Sakai, James Michaelson, Antonio Francavilla, Thomas E. Starzl and Massimo Trucco
    Citation: Molecular Medicine 1996 2:BF03402206
  21. Csx/Nkx2.5, a murine nonclustered homeobox gene expressed primarily in the heart, has significant sequence similarity to the Drosophila tinman gene. Tinman is essential for heart and gut formation in Drosophila. ...

    Authors: David Turbay, Stephanie Burns Wechsler, Kristina McQuate Blanchard and Seigo Izumo
    Citation: Molecular Medicine 1996 2:BF03402205
  22. Several neurological disorders have recently been explained through the discovery of expanded DNA repeat sequences. Among these is Machado-Joseph disease, one of the most common spinocerebellar ataxias (MJD/SC...

    Authors: Kerstin Lindblad, Astrid Lunkes, Patricia Maciel, Giovanni Stevanin, Cecilia Zander, Thomas Klockgether, Tim Ratzlaff, Alexis Brice, Guy A. Rouleau, Tom Hudson, Georg Auburger and Martin Schalling
    Citation: Molecular Medicine 1996 2:BF03402204
  23. Epidermolysis bullosa (EB) is a group of heritable diseases that manifest as blistering and erosions of the skin and mucous membranes. In the dystrophic forms of EB (DEB), the diagnostic hallmark is abnormalit...

    Authors: Angela M. Christiano, Sal LaForgia, Amy S. Paller, Joseph McGuire, Hiroshi Shimizu and Jouni Uitto
    Citation: Molecular Medicine 1996 2:BF03402203
  24. Obesity, the condition of excessive accumulation of fat is a poorly understood disorder and is a risk factor for type II diabetes, hypertension, and hyperlipidaemia. Recently, a putative mouse obese gene was c...

    Authors: Klaus Giese, Wendy J. Fantl, Charles Vitt, James C. Stephans, Lawrence Cousens, Matthew Wachowicz and Lewis T. Williams
    Citation: Molecular Medicine 1996 2:BF03402202
  25. IgE/anti-IgE immune complexes (IgE-IC) induce the release of multiple mediators from monocytes/macrophages and the monocytic cell line U937 following the ligation of the low-affinity Fcε receptors (FcεRII/CD23). ...

    Authors: Fateh Ouaaz, Francis W. Ruscetti, Bernard Dugas, Judy Mikovits, Henri Agut, Patrice Debr and M. Djavad Mossalayi
    Citation: Molecular Medicine 1996 2:BF03402201
  26. Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to severe impairments in cognition, behavior, and motor skills. The mechanism(s) by which HIV-1 induces CNS di...

    Authors: Thomas E. Lane, Michael J. Buchmeier, Debbie D. Watry and Howard S. Fox
    Citation: Molecular Medicine 1996 2:BF03402200
  27. Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to bilirubin. Since bilirubin is a potent antioxidant and heme a pro-oxidant, HO may protect cel...

    Authors: Tory Prestera, Paul Talalay, Jawed Alam, Young I. Ahn, Patty J. Lee and Augustine M. K. Choi
    Citation: Molecular Medicine 1995 1:BF03401897
  28. T lymphocytes infiltrating airways during the allergic immune response play a fundamental role in recruiting other specialized cells, such as eosinophils, by secreting interleukin 5 (IL-5), and promoting local...

    Authors: Fabrizio Spinozzi, Elisabetta Agea, Onelia Bistoni, Nicola Forenza, Alessandro Monaco, Brunangelo Falini, Gabrio Bassotti, Fernando De Benedictis, Fausto Grignani and Alberto Bertotto
    Citation: Molecular Medicine 1995 1:BF03401896
  29. It has previously been observed that the insulin-producing cells of human pancreatic islets are more resistant to alloxan-, streptozotocin-, nitroprusside-, or cytokine-induced injury than those of mouse and r...

    Authors: Nils Welsh, Boris Margulis, L. A. Håkan Borg, Helena Jernberg Wiklund, Johan Saldeen, Malin Flodström, Maria Alice Mello, Arne Andersson, Daniel G. Pipeleers, Claes Hellerström and Decio L. Eizirik
    Citation: Molecular Medicine 1995 1:BF03401895
  30. Recurrent and metastatic carcinoma of the colorectum remains a major problem, with survival at 5 years post curative resection still only about 50%. Moreover, up to 30% of patients who present with early stage...

    Authors: Jennifer E. Hardingham, Dusan Kotasek, Robert E. Sage, Michael C. Eaton, Vivienne H. Pascoe and Alexander Dobrovic
    Citation: Molecular Medicine 1995 1:BF03401893
  31. Macrophage migration inhibitory factor (MIF) was one of the first lymphokine activities to be discovered and was described almost 30 years ago to be a soluble factor(s) produced by activated T lymphocytes. In ...

    Authors: Toshihiko Nishino, Jürgen Bernhagen, Hideo Shiiki, Thierry Calandra, Kazuhiro Dohi and Richard Bucala
    Citation: Molecular Medicine 1995 1:BF03401892
  32. Rheumatoid factor (RF) is a characteristic but not pathognomic feature in patients with rheumatoid arthritis (RA). It is unknown whether the repertoire of immunoglobulin genes utilized by RF+ B cells of RA patien...

    Authors: Xiaowen He, Jörg J. Goronzy, Wanyun Zhong, Congping Xie and Cornelia M. Weyand
    Citation: Molecular Medicine 1995 1:BF03401891
  33. Therapeutic intervention designed to block expression of human immunodeficiency virus (HIV) at a cellular level may slow the clinical progression of HIV-1 disease.

    Authors: Salvatore T. Butera, Beverly D. Roberts, J. William Critchfield, Guofu Fang, Thomas McQuade, Stephen J. Gracheck and Thomas M. Folks
    Citation: Molecular Medicine 1995 1:BF03401890
  34. We investigated the human immunodeficiency virus (HIV) proviral DNA sequence and copy number in alveolar macrophages (AM) and peripheral blood monocytes (PBM) from 10 HIV-positive patients without any active c...

    Authors: Koh Nakata, Michael Weiden, Timothy Harkin, David Ho and William N. Rom
    Citation: Molecular Medicine 1995 1:BF03401889
  35. The histopathology of multiple sclerosis (MS) is characterized by a loss of myelin and oligodendrocytes, relative preservation of axons, and a modest inflammatory response. The reasons for this selective oligo...

    Authors: Timothy Vartanian, You Li, Meijuan Zhao and Kari Stefansson
    Citation: Molecular Medicine 1995 1:BF03401888

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