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Page 42 of 47

  1. The receptor (ER) for estrogen (E2) is routinely assayed as a marker to determine the feasibility of anti-hormone therapy against breast cancer because ER-positive (ER+) tumors are much more likely to respond ...

    Authors: Debajit K. Biswas, Lidia Averboukh, Shijie Sheng, Kathy Martin, Darren S. Ewaniuk, Teddy F. Jawde, Feilan Wang and Arthur B. Pardee
    Citation: Molecular Medicine 1998 4:BF03401751
    Content type: Original Articles Published on:

  3. Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine that also counter-regulates glucocorticoid action. We investigated whether immunoneutralization of MIF could reverse establish...

    Authors: Niansheng Yang, David J. Nikolic-Paterson, Yee-Yung Ng, Wei Mu, Christine Metz, Michael Bacher, Andreas Meinhardt, Richard Bucala, Robert C. Atkins and Hui Y. Lan
    Citation: Molecular Medicine 1998 4:BF03401748
    Content type: Original Articles Published on:

  4. Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes a 442 amino acid polypeptide-desig-nated viral interferon regulatory factor (vIRF) that displays homology to members of the interferon regulatory factor (...

    Authors: C. Clay Flowers, Scarlett P. Flowers and Gary J. Nabel
    Citation: Molecular Medicine 1998 4:BF03401747
    Content type: Original Articles Published on:

  5. Members of the Ets family of winged helix-loop-helix transcription factors play important roles in the development and function of multiple mammalian cell lineages. Elf-1 is an Ets-related transcription factor...

    Authors: Alexander G. Bassuk, Kevin P. Barton, Roshani T. Anandappa, Min M. Lu and Jeffrey M. Leiden
    Citation: Molecular Medicine 1998 4:BF03401746
    Content type: Original Articles Published on:

  6. 3B3 is a high-affinity anti-gp120 antibody that neutralizes a wide range of primary and laboratory isolates of HIV-1. The parental antibody was isolated from a combinatorial phage display library constructed f...

    Authors: Tapan K. Bera, Paul E. Kennedy, Edward A. Berger, Carlos F. Barbas and Ira Pastan
    Citation: Molecular Medicine 1998 4:BF03401745
    Content type: Original Articles Published on:

  7. Curcumin is a small-molecular-weight compound that is isolated from the commonly used spice turmeric. In animal models, curcumin and its derivatives have been shown to inhibit the progression of chemically ind...

    Authors: Jack L. Arbiser, Nancy Klauber, Richard Rohan, Robert van Leeuwen, Mou-Tuan Huang, Carolyn Fisher, Evelyn Flynn and H. Randolph Byers
    Citation: Molecular Medicine 1998 4:BF03401744
    Content type: Original Articles Published on:

  9. Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective i...

    Authors: Robert G. Phelps, Chihiro Murai, Shinichiro Saito, Akira Hatakeyama, Konstantinos Andrikopoulos, Kuppuswamy N. Kasturi and Constantin A. Bona
    Citation: Molecular Medicine 1998 4:BF03401742
    Content type: Original Articles Published on:

  10. The pathogenesis of asthma is believed to reflect antigen-induced airway inflammation leading to the recruitment of eosinophils and activation of mast cells through cell-associated IgE. Controversies persist h...

    Authors: David B. Corry, Gabriele Grünig, Husein Hadeiba, Viswanath P. Kurup, Martha L. Warnock, Dean Sheppard, Donna M. Rennick, Richard M. Locksley and R. Locksley
    Citation: Molecular Medicine 1998 4:BF03401741
    Content type: Original Articles Published on:

  11. HIV-1-infected patients are in chronic oxidative stress and clastogenic factors (CFs) are present in their plasma. CFs from patients with HIV are formed via superoxide anion radical and stimulate further super...

    Authors: Jürgen Fuchs, Nicole Oelke, Matthias Imhof, Falk Ochsendorf, Helmut Schöfer, Gerhard Oromek, Amina Alaoui-Youssefi and Ingrid Emerit
    Citation: Molecular Medicine 1998 4:BF03401740
    Content type: Original Articles Published on:

  12. Massive neurofilament conglomeration in motor neurons has been described to occur in the early stages of both familial and sporadic amyotrophic lateral sclerosis (ALS). Previously, neurofilament conglomerates ...

    Authors: Samuel M. Chou, Helen S. Wang, Akira Taniguchi and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401739
    Content type: Original Articles Published on:

  13. Phosphoinositolglycan molecules isolated from insulin-sensitive mammalian tissues have been demonstrated in numerous in vitro studies to exert partial insulin-mimetic activity on glucose and lipid metabolism i...

    Authors: Günter Müller, Susanne Wied, Christine Piossek, Andrea Bauer, Jochen Bauer and Wendelin Frick
    Citation: Molecular Medicine 1998 4:BF03401738
    Content type: Original Articles Published on:

  16. Lung surfactant protein A (SP-A) is a complex molecule composed of up to 18 polypeptide chains. In vivo, SP-A probably binds to a wide range of inhaled materials via the interaction of surface carbohydrates wi...

    Authors: Timothy P. Hickling, Rajneesh Malhotra and Robert B. Sim
    Citation: Molecular Medicine 1998 4:BF03401923
    Content type: Original Articles Published on:

  17. The ion pump Na+,K+-ATPase is responsible for the secretion of cerebrospinal fluid from the choroid plexus. In this tissue, the activity of Na+,K+-ATPase is inhibited by serotonin via stimulation of protein kinas...

    Authors: Gilberto Fisone, Gretchen L. Snyder, Anita Aperia and Paul Greengard
    Citation: Molecular Medicine 1998 4:BF03401922
    Content type: Original Articles Published on:

  18. Synovia of patients with long-standing rheumatoid arthritis (RA) are typically infiltrated with B lymphocytes and plasma cells that secrete large amounts of immunoglobulin. The CDR3 of an immunoglobulin heavy ...

    Authors: Björn E. Clausen, S. Louis Bridges Jr., John C. Lavelle, Priscilla G. Fowler, Steffen Gay, William J. Koopman and Harry W. Schroeder Jr.
    Citation: Molecular Medicine 1998 4:BF03401921
    Content type: Original Articles Published on:

  19. The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type 1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeutic applications, and they...

    Authors: Margo C. Honeyman, Natalie L. Stone and Leonard C. Harrison
    Citation: Molecular Medicine 1998 4:BF03401920
    Content type: Original Articles Published on:

  20. The mediator known historically as macrophage migration inhibitory factor (MIF) has been identified recently as being released into the circulation by the anterior pituitary gland as a consequence of stress or...

    Authors: Michael Bacher, Andreas Meinhardt, Hui Y. Lan, Firdaus S. Dhabhar, Wei Mu, Christine N. Metz, Jason A. Chesney, Diethard Gemsa, Thomas Donnelly, Robert C. Atkins and Richard Bucala
    Citation: Molecular Medicine 1998 4:BF03401919
    Content type: Original Articles Published on:

  23. Patients with recessive dystrophic epidermolysis bullosa (RDEB) have deficiencies of collagen type VII and have elevated levels of fibroblast collagenase, and a greatly increased risk of cutaneous squamous cel...

    Authors: Jack L. Arbiser, Jo-David Fine, Dedee Murrell, Amy Paller, Susan Connors, Karen Keough, Elizabeth Marsh and Judah Folkman
    Citation: Molecular Medicine 1998 4:BF03401916
    Content type: Original Articles Published on:

  24. Nitric oxide (NO) is cytostatic for proliferating cells, inhibits microbial growth, and down-regulates the synthesis of specific proteins. Studies were undertaken to determine the mechanism by which NO inhibit...

    Authors: Young-Myeong Kim, Kyonghee Son, Sun-Joo Hong, Angela Green, Jane-Jane Chen, Edith Tzeng, Christian Hierholzer and Timothy R. Billiar
    Citation: Molecular Medicine 1998 4:BF03401915
    Content type: Original Articles Published on:

  25. The hydrophilic bile salt ursodeoxycholate (UDCA) inhibits injury by hydrophobic bile acids and is used to treat cholestatic liver diseases. Interestingly, hepatocyte cell death from bile acid-induced toxicity...

    Authors: Cecilia M. P. Rodrigues, Guangsheng Fan, Phillip Y. Wong, Betsy T. Kren and Clifford J. Steer
    Citation: Molecular Medicine 1998 4:BF03401914
    Content type: Original Articles Published on:

  26. Acute myeloid leukemia (AML) is a heterogeneous collection of leukemic disorders ranging from chemotherapy-sensitive subsets [inversion 16 and t(8;21)], which often can be cured with cytosine arabinoside alone...

    Authors: G. Deng, C. Lane, S. Kornblau, A. Goodacre, V. Snell, M. Andreeff and Albert B. Deisseroth
    Citation: Molecular Medicine 1998 4:BF03401913
    Content type: Original Articles Published on:

  27. Several lines of evidence suggest that most of the early-onset forms of familial Alzheimer’s disease (FAD) are due to inherited mutations borne by a chromosome 14–encoded protein, presenilin 1 (PS1). This is l...

    Authors: Philippe Marambaud, Karine Ancolio, Elvira Lopez-Perez and Frédéric Checler
    Citation: Molecular Medicine 1998 4:BF03401912
    Content type: Original Articles Published on:

  30. Acquired CI-inhibitor (C1-inh) deficiency is usually associated with the presence of circulating C1 -inh autoantibodies. These autoantibodies have been shown previously to bind to two synthetic peptides corres...

    Authors: Shiping He, Robert B. Sim, Keith Whaley and K. Austen
    Citation: Molecular Medicine 1998 4:BF03401735
    Content type: Original Articles Published on:

  31. Attempts to optimize DNA vaccines in mice include using different routes of administration and different formulations. It may be more relevant to human use to carry such studies out in nonhuman primates. Here ...

    Authors: Robert A. Gramzinski, Cynthia L. Brazolot Millan, Nicanor Obaldia, Stephen L. Hoffman and Heather L. Davis
    Citation: Molecular Medicine 1998 4:BF03401734
    Content type: Original Articles Published on:

  32. The molecular recognition theory (MRT) provides a conceptual framework that could explain the evolution of intermolecular and intramolecular interaction of peptides and proteins. As such, it predicts that bind...

    Authors: Nelson Ruiz-Opazo, Kenji Hirayama, Kaoru Akimoto and Victoria L. M. Herrera
    Citation: Molecular Medicine 1998 4:BF03401733
    Content type: Original Articles Published on:

  33. Anthrax toxin, secreted by Bacillus anthracis, consists of protective antigen (PA) and either lethal factor (LF) or edema factor (EF). PA, the receptor-binding component of the toxin, translocates LF or EF into t...

    Authors: Mini Varughese, Angela Chi, Avelino V. Teixeira, Peter J. Nicholls, Jerry M. Keith and Stephen H. Leppla
    Citation: Molecular Medicine 1998 4:BF03401732
    Content type: Original Articles Published on:

  34. A common genetic basis for IgA deficiency (IgAD) and common variable immunodeficiency (CVID) is suggested by their occurrence in members of the same family and the similarity of the underlying B cell different...

    Authors: Harry W. Schroeder Jr., Zeng-Bian Zhu, Ruth E. March, R. Duncan Campbell, Seth Mark Berney, Sergei A. Nedospasov, Regina L. Turetskaya, T. Prescott Atkinson, Rodney C. P. Go, Max D. Cooper and John E. Volanakis
    Citation: Molecular Medicine 1998 4:BF03401731
    Content type: Original Articles Published on:

  36. Advanced glycation end products (AGEs) are the reactive derivatives of nonenzymatic glucose-macromolecule condensation products. Aging human tissues accumulate AGEs in an age-dependent manner and contribute to...

    Authors: Jenny J. Li, Dennis Dickson, Patrick R. Hof and Helen Vlassara
    Citation: Molecular Medicine 1998 4:BF03401729
    Content type: Original Articles Published on:

  37. Photodynamic therapy employs photosensitive agents such as porphyrins to treat a variety of tumors accessible to light-emitting probes. This approach capitalizes on the selective retention of porphyrins by can...

    Authors: Ajay Verma, Stephen L. Facchina, David J. Hirsch, Shi-Yu Song, Larry F. Dillahey, Jerry R. Williams and Solomon H. Snyder
    Citation: Molecular Medicine 1998 4:BF03401728
    Content type: Original Articles Published on:

  38. Amphiphysin I is a 128 kD protein highly concentrated in nerve terminals, where it has a putative role in endocytosis. It is a dominant autoantigen in patients with stiff-man syndrome associated with breast ca...

    Authors: Scott Floyd, Margaret Husta Butler, Ottavio Cremona, Carol David, Zachary Freyberg, Xiaomei Zhang, Michele Solimena, Akira Tokunaga, Hideki Ishizu, Kimiko Tsutsui and Pietro De Camilli
    Citation: Molecular Medicine 1998 4:BF03401727
    Content type: Original Articles Published on:

  39. The synapsins are a family of neuron-specific proteins, associated with the cytoplasmic surface of synaptic vesicles, which have been shown to regulate neurotransmitter release in mature synapses and to accele...

    Authors: Adriana Ferreira, Lih-Shen Chin, Lian Li, Lorene M. Lanier, Kenneth S. Kosik and Paul Greengard
    Citation: Molecular Medicine 1998 4:BF03401726
    Content type: Original Articles Published on:

  43. Tumor necrosis factor α (TNF-α) is often considered the main proinflammatory cytokine induced by lipopolysaccharide (LPS) and consequently the critical mediator of the lethality associated with septic shock.

    Authors: Franck Amiot, Catherine Fitting, Kevin J. Tracey, Jean-Marc Cavaillon and François Dautry
    Citation: Molecular Medicine 1997 3:BF03401722
    Content type: Original Articles Published on:

  45. Substantial evidence has suggested that T cells play an important role in antitumor immunity. T cells with cytotoxic activity against tumors have been isolated from in vitro culture of tumor-infiltrated lympho...

    Authors: Koichi Ito, James Fetten, Houman Khalili, Steven Hajdu, Erna Busch, Robert Pergolizzi, Vincent Vinciguerra and Ming-der Y. Chang
    Citation: Molecular Medicine 1997 3:BF03401720
    Content type: Original Articles Published on:

  46. GLI is an oncodevelopmental gene in the vertebrate hedgehog/patched signaling pathway that is spatiotemporally regulated during development and is amplified in a subset of human cancers. GLI is the prototype for ...

    Authors: Jian Tao Yang, Cheng Zheng Liu, Elisabeth H. Villavicencio, Joon Won Yoon, David Walterhouse and Philip M. Iannaccone
    Citation: Molecular Medicine 1997 3:BF03401719
    Content type: Original Articles Published on:

  47. Vectors based on herpes simplex virus type 1 (HSV-1) can efficiently transduce hepatocytes in the mouse liver, and vector genomes can persist for at least 2 months. However, 24 hr after gene transfer, the numb...

    Authors: Cornel Fraefel, David R. Jacoby, Christopher Lage, Harold Hilderbrand, Janice Y. Chou, Fred W. Alt, Xandra O. Breakefield and Joseph A. Majzoub
    Citation: Molecular Medicine 1997 3:BF03401718
    Content type: Original Articles Published on:

  50. Brucelosis is a severe acute febrile disease caused by bacteria of the genus Brucella. Its current diagnosis is based on clinical observations that may be complemented by serology and microbiological culture test...

    Authors: Ana M. Sifuentes-Rincón, Agnès Revol and Hugo A. Barrera-Saldaña
    Citation: Molecular Medicine 1997 3:BF03401711
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658