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  2. The present work describes a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Rev protein and the cellular lens epithelium-derived growth factor p75 (LEDGF/p75) protein in vitro and in vi...

    Authors: Aviad Levin, Joseph Rosenbluh, Zvi Hayouka, Assaf Friedler and Abraham Loyter
    Citation: Molecular Medicine 2009 16:16010034
    Content type: Research Article Published on:

  3. In the terrorist radiation exposure scenario, radiation victims are likely to suffer from additional injuries such as sepsis. Our previous studies have shown that ghrelin is protective in sepsis. However, it r...

    Authors: Kavin G. Shah, Rongqian Wu, Asha Jacob, Steven A. Blau, Youxin Ji, Weifeng Dong, Corrado P. Marini, Thanjavur S. Ravikumar, Gene F. Coppa and Ping Wang
    Citation: Molecular Medicine 2009 15:1511407
    Content type: Research Article Published on:

  4. Coagulation abnormalities are common in severe pneumonia and sepsis, yet little is known about the presence of coagulopathy or its significance in patients with lesser illness severity. We examined coagulation...

    Authors: Eric B. Milbrandt, Michael C. Reade, MinJae Lee, Stephanie L. Shook, Derek C. Angus, Lan Kong, Melinda Carter, Donald M. Yealy and John A. Kellum
    Citation: Molecular Medicine 2009 15:1511438
    Content type: Research Article Published on:

  6. Dendritic cells (DCs) represent an important linkage between the innate and adaptive immune system and express proinflammatory transcriptomic products early after trauma. The use of a genomic approach recently...

    Authors: Marcus Maier, Emanuel V. Geiger, Dirk Henrich, Carolyn Bendt, Sebastian Wutzler, Mark Lehnert and Ingo Marzi
    Citation: Molecular Medicine 2009 15:1511384
    Content type: Research Article Published on:

  7. The definition of European population genetic substructure and its application to understanding complex phenotypes is becoming increasingly important. In the current study using over 4,000 subjects genotyped f...

    Authors: Chao Tian, Roman Kosoy, Rami Nassir, Annette Lee, Pablo Villoslada, Lars Klareskog, Lennart Hammarström, Henri-Jean Garchon, Ann E. Pulver, Michael Ransom, Peter K. Gregersen and Michael F. Seldin
    Citation: Molecular Medicine 2009 15:1511371
    Content type: Research Article Published on:

  8. Recent evidence suggests an association of β-amyloid (Aβ) with vascular risk factors and the medications to treat them, which could potentially obfuscate the usefulness of Aβ for prediction of mild cognitive impa...

    Authors: Laila Abdullah, Cheryl Luis, Daniel Paris, Benoit Mouzon, Ghania Ait-Ghezala, Andrew P. Keegan, Duolao Wang, Fiona Crawford and Michael Mullan
    Citation: Molecular Medicine 2009 15:1511432
    Content type: Research Article Published on:

  9. Overexpression of elongation factor-1α (EF-1α) has been reported to contribute to the development and progression of various cancers. However, its role in prostate cancer (PCa) still remains poorly understood....

    Authors: Gang Zhu, Wei Yan, Hui-chan He, Xue-cheng Bi, Zhao-dong Han, Qi-shan Dai, Yong-kang Ye, Yu-xiang Liang, Jianye Wang and Weide Zhong
    Citation: Molecular Medicine 2009 15:1511363
    Content type: Research Article Published on:

  10. Erythropoietic protoporphyria (EPP) is an inherited disorder of porphyrin metabolism in which decreased activity of ferrochelatase (FECH) leads to accumulation of protoporphyrin IX (PP IX) in red blood cells, ...

    Authors: Victoria E. Parera, Rita H. Koole, Gardi Minderman, Annie Edixhoven, Maria V. Rossetti, Alcira Batlle and Felix W. M. de Rooij
    Citation: Molecular Medicine 2009 15:1511425
    Content type: Research Article Published on:

  11. Natural deletions of the human γ-globin gene cluster lead to specific syndromes characterized by increased production of fetal hemoglobin in adult life and provide a useful model to delineate novel cis-acting ele...

    Authors: Maria Gazouli, Eleni Katsantoni, Theodoros Kosteas and Nicholas P. Anagnou
    Citation: Molecular Medicine 2009 15:1511415
    Content type: Research Article Published on:

  12. Endometriosis is a chronic disease characterized by the presence of ectopic endometrial tissue outside of the uterus with mixed traits of benign and malignant pathology. In this study we analyzed in endometria...

    Authors: Amalia Forte, Maria Teresa Schettino, Mauro Finicelli, Marilena Cipollaro, Nicola Colacurci, Luigi Cobellis and Umberto Galderisi
    Citation: Molecular Medicine 2009 15:1511392
    Content type: Research Article Published on:

  13. Although studies have shown an inverse association between cardiorespiratory fitness (CRF) and C-reactive protein (CRP) levels, the underlying mechanisms are not fully understood. There is emerging evidence th...

    Authors: Sae Young Jae, Kevin S. Heffernan, Eun Sun Yoon, Moon-Kyu Lee, Bo Fernhall and Won Hah Park
    Citation: Molecular Medicine 2009 15:1509291
    Content type: Research Article Published on:

  14. Because the complex heterogeneity of traumatic brain injury (TBI) is believed by many to be a major reason for the failed clinical trials of monotherapies, combining two (or more) drugs with some potentially d...

    Authors: Fahim Atif, Iqbal Sayeed, Tauheed Ishrat and Donald G. Stein
    Citation: Molecular Medicine 2009 15:1509328
    Content type: Research Article Published on:

  15. Aberrant coronary vascular smooth muscle cell (CSMC) proliferation is a pivotal event underlying intimal hyperplasia, a phenomenon impairing the long-term efficacy of bypass surgery and angioplasty procedures....

    Authors: Barbara Dapas, Rossella Farra, Mario Grassi, Carlo Giansante, Nicola Fiotti, Laura Uxa, Giuseppe Rainaldi, Alberto Mercatanti, Alfonso Colombatti, Paola Spessotto, Valentina Lacovich, Gianfranco Guarnieri and Gabriele Grassi
    Citation: Molecular Medicine 2009 15:1509297
    Content type: Research Article Published on:

  16. Severe burn injury results in liver dysfunction and damage, with subsequent metabolic derangements contributing to patient morbidity and mortality. On a cellular level, significant postburn hepatocyte apoptosi...

    Authors: Juquan Song, Celeste C. Finnerty, David N. Herndon, Darren Boehning and Marc G. Jeschke
    Citation: Molecular Medicine 2009 15:1509316
    Content type: Research Article Published on:

  17. Rheumatoid arthritis (RA) patients are characterized by increased arterial stiffness, an independent predictor of cardiovascular risk. It has been suggested that osteopontin (OPN), a cytokine involved in RA pa...

    Authors: Laura Bazzichi, Lorenzo Ghiadoni, Alessandra Rossi, Melania Bernardini, Mario Lanza, Francesca De Feo, Camillo Giacomelli, Ilaria Mencaroni, Katia Raimo, Marco Rossi, Anna Maria Mazzone, Stefano Taddei and Stefano Bombardieri
    Citation: Molecular Medicine 2009 15:1511402
    Content type: Research Article Published on:

  18. The lung is one of the organs to which cancers from solid tumors frequently metastasize. Multiple tumors in the lung are usually treated by systemic chemotherapy because of the lack of efficient methods of tar...

    Authors: Hong Xin, Ruowen Sun, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Hiroyuki Mizuguchi and Yasuo Saijo
    Citation: Molecular Medicine 2009 15:1509321
    Content type: Research Article Published on:

  19. Our previous studies showed that tetraspanin CD151 promotes neovascularization in rat hindlimb and myocardial ischemia models. This study is to assess whether CD151 induces arteriogenesis and promotes functional ...

    Authors: Houjuan Zuo, Zhengxiang Liu, Xiaochun Liu, Jun Yang, Tao Liu, Sha Wen, Xin A. Zhang, Katherine Cianflone and Daowen Wang
    Citation: Molecular Medicine 2009 15:1509307
    Content type: Research Article Published on:

  20. Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiat...

    Authors: Anna Lünemann, Jan D. Lünemann and Christian Münz
    Citation: Molecular Medicine 2009 15:1509352
    Content type: Review Article Published on:

  21. Conventional treatment options, including corticosteroids, intravenous immunoglobulin, or plasma exchange, often fail to treat dysimmune neuropathies, such as chronic inflammatory demyelinating polyneuropathy,...

    Authors: Andreas A. Argyriou
    Citation: Molecular Medicine 2009 15:15070283
    Content type: Review Article Published on:

  22. The pathogenesis of sepsis is partly attributable to dysregulated inflammatory response mediated by pathogen-associated molecular patterns (PAMPs) (for example, endotoxin) and damage-associated molecular patte...

    Authors: Shu Zhu, Mala Ashok, Jianhua Li, Wei Li, Huan Yang, Ping Wang, Kevin J. Tracey, Andrew E. Sama and Haichao Wang
    Citation: Molecular Medicine 2009 15:15070275
    Content type: Research Article Published on:

  25. Exposure to ricin, either by accident through ingestion of castor oil plant seeds or intentionally through its use as a bioweapon, invariably leads to multiple organ damage and death. Currently there is only a...

    Authors: Jon G. Mabley, Pal Packer and Csaba Szabo
    Citation: Molecular Medicine 2009 15:15050166
    Content type: Research Article Published on:

  26. The aim of this study was to determine the existence of association between the genetic polymorphisms of metabolizing genes GSTM-1, GSTT-1, and NAT-2, and the presence of mitochondrial genome instability (mtGI) i...

    Authors: Walter H. Pavicic, Martin Laguens and Silvina M. Richard
    Citation: Molecular Medicine 2009 15:15050160
    Content type: Research Article Published on:

  27. Bone marrow (BM)-derived endothelial progenitor cells (EPC) contribute to vascular maintenance by participating in angiogenesis, re-endothelialization, and remodeling. Myeloid progenitor cells in the BM are fu...

    Authors: Cindy J. M. Loomans, Rien van Haperen, Jacques M. Duijs, Caroline Verseyden, Rini de Crom, Pieter J. M. Leenen, Hemmo A. Drexhage, Hetty C. de Boer, Eelco J. P. de Koning, Ton J. Rabelink, Frank J. T. Staal and Anton Jan van Zonneveld
    Citation: Molecular Medicine 2009 15:15050152
    Content type: Research Article Published on:

  28. Noninvasive and repetitive monitoring of a virus in target tissues and/or specific organs of the body is highly desirable for the development of safe and efficient cancer virotherapeutics. We have previously s...

    Authors: Nanhai Chen, Qian Zhang, Yong A. Yu, Jochen Stritzker, Peter Brader, Andreas Schirbel, Samuel Samnick, Inna Serganova, Ronald Blasberg, Yuman Fong and Aladar A. Szalay
    Citation: Molecular Medicine 2009 15:15050144
    Content type: Research Article Published on:

  29. We carried out a genome-wide association study of genetic predictors of anti-cyclic citrullinated peptide antibody (anti-CCP) level in 531 self-reported non-Hispanic Caucasian Rheumatoid Arthritis (RA) patient...

    Authors: Jing Cui, Kimberly E. Taylor, Anita L. DeStefano, Lindsey A. Criswell, Elena S. Izmailova, Alex Parker, Ronenn Roubenoff, Robert M. Plenge, Michael E. Weinblatt, Nancy A. Shadick and Elizabeth W. Karlson
    Citation: Molecular Medicine 2009 15:15050136
    Content type: Research Article Published on:

  30. Insulinlike growth factor-1 (IGF-1) expression is implicated in myocardial pathophysiology, and two IGF-1 mRNA splice variants have been detected in rodents, IGF-1Ea and mechano-growth factor (MGF). We investi...

    Authors: Anastasia Stavropoulou, Antonios Halapas, Antigone Sourla, Anastassios Philippou, Efstathia Papageorgiou, Apostolos Papalois and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15050127
    Content type: Research Article Published on:

  32. To investigate a possible common environmental exposure that may partially explain the observed decrease in human semen quality, we correlated seminal plasma and blood cadmium levels with sperm concentration a...

    Authors: Susan Benoff, Russ Hauser, Joel L. Marmar, Ian R. Hurley, Barbara Napolitano and Grace M. Centola
    Citation: Molecular Medicine 2009 15:15070248
    Content type: Research Article Published on:

  33. Insulin resistance and type 2 diabetes (T2D) are closely linked to obesity. Numerous prospective studies have reported on weight gain, insulin resistance, and insulin signaling in experimental animals, but not...

    Authors: Anna Danielsson, Siri Fagerholm, Anita Öst, Niclas Franck, Preben Kjolhede, Fredrik H. Nystrom and Peter Strålfors
    Citation: Molecular Medicine 2009 15:15070228
    Content type: Research Article Published on:

  34. The ability to quit smoking successfully displays substantial heritability in classical and molecular genetic studies. Twin studies suggest that some of the genetics for the ability to quit overlap with geneti...

    Authors: Tomas Drgon, Catherine Johnson, Donna Walther, Anthony P. Albino, Jed E. Rose and George R. Uhl
    Citation: Molecular Medicine 2009 15:15070268
    Content type: Research Article Published on:

  35. The cholinergic antiinflammatory pathway modulates Inflammatory cytokine production through a mechanism dependent on the vagus nerve and the α7 subunit of the nicotinic acetylcholine receptor. GTS-21 [3-(2,4-d...

    Authors: Mauricio Rosas-Ballina, Richard S. Goldstein, Margot Gallowitsch-Puerta, Lihong Yang, Sergio Iván Valdés-Ferrer, Nirav B. Patel, Sangeeta Chavan, Yousef Al-Abed, Huan Yang and Kevin J. Tracey
    Citation: Molecular Medicine 2009 15:15070195
    Content type: Research Article Published on:

  36. Erythropoietin (EPO) is a type I cytokine that utilizes different receptor isoforms either to maintain hematopoiesis or protect against injuries that arise from widely diverse etiologies. EPO also facilitates ...

    Authors: Zübeyde Erbayraktar, Serhat Erbayraktar, Osman Yilmaz, Anthony Cerami, Thomas Coleman and Michael Brines
    Citation: Molecular Medicine 2009 15:15070235
    Content type: Research Article Published on:

  37. Hypothalamic growth hormone (GH)-releasing hormone (GHRH) regulates the release of GH from the pituitary gland. The receptors for GHRH (GHRH-R) are expressed predominantly in the pituitary. Recent evidence dem...

    Authors: Elena Theophanous, Constantina Petraki, Andreas Scorilas, Vassilios Komborozos, George Veloudis, Jozsef L. Varga, Marta Zarandi, Andrew V. Schally and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15070242
    Content type: Research Article Published on:

  38. Traumatic injuries frequently lead to infection, organ failure, and death. Health care providers rely on several Injury scoring systems to quantify the extent of injury and to help predict clinical outcome. Ph...

    Authors: H. Shaw Warren, Constance M. Elson, Douglas L. Hayden, David A. Schoenfeld, J. Perren Cobb, Ronald V. Maier, Lyle L. Moldawer, Ernest E. Moore, Brian G. Harbrecht, Kimberly Pelak, Joseph Cuschieri, David N. Herndon, Marc G. Jeschke, Celeste C. Finnerty, Bernard H. Brownstein, Laura Hennessy…
    Citation: Molecular Medicine 2009 15:15070220
    Content type: Research Article Published on:

  41. Nuclear factor erythroid 2-related factor 2 (Nrf2) is an oxidant-responsive transcription factor known to induce detoxifying and antioxidant genes. Cigarette smoke, with its large oxidant content, is a major s...

    Authors: Ralf-Harto Hübner, Jamie D. Schwartz, Bishnu P. De, Barbara Ferris, Larsson Omberg, Jason G. Mezey, Neil R. Hackett and Ronald G. Crystal
    Citation: Molecular Medicine 2009 15:15070203
    Content type: Research Article Published on:

  42. This review critically evaluates current knowledge of molecularly targeted therapies of malignant gliomas. Various molecularly targeted single-agent therapies, including targeted therapies of growth and surviv...

    Authors: Andreas A. Argyriou and Haralabos P. Kalofonos
    Citation: Molecular Medicine 2009 15:15030115
    Content type: Review Article Published on:

  43. Disseminated malignancy is the major cause of prostate cancer-related mortality. Circulating tumor cells (CTCs) are essential for the establishment of metastasis. Various contemporary and molecular methods usi...

    Authors: Zacharoula Panteleakou, Peter Lembessis, Antigone Sourla, Nikolaos Pissimissis, Aristides Polyzos, Charalambos Deliveliotis and Michael Koutsilieris
    Citation: Molecular Medicine 2009 15:15030101
    Content type: Review Article Published on:

  44. The main objective of this study was to determine whether elevated blood β-amyloid (Aβ) levels among the first-degree relatives of patients with Alzheimer’s Disease (AD) are associated with vascular risk facto...

    Authors: Laila Abdullah, Cheryl Luis, Daniel Paris, Ghania Ait-ghezala, Benoit Mouzon, Elizabeth Allen, Julia Parrish, Myles A. Mullan, Scott Ferguson, Marcie Wood, Fiona Crawford and Michael Mullan
    Citation: Molecular Medicine 2009 15:15030095
    Content type: Research Article Published on:

  45. The role of chronic hepatitis C virus (HCV) in the pathogenesis of HCV-associated hepatocellular carcinoma (HCC) remains controversial. To understand the transition from benign to malignant, we studied the gen...

    Authors: Valeria R. Mas, Daniel G. Maluf, Kellie J. Archer, Kenneth Yanek, Xiangrong Kong, Laura Kulik, Chris E. Freise, Kim M. Olthoff, Rafik M. Ghobrial, Paula McIver and Robert Fisher
    Citation: Molecular Medicine 2009 15:15030085
    Content type: Research Article Published on:

  46. Nicotinamide adenine dinucleotide (NAD+), a precursor of molecules involved in cell regulatory processes, is released in extracellular compartments after stress or inflammation. This study investigates the exp...

    Authors: Alberto L. Horenstein, Federico Sizzano, Riccardo Lusso, Federico Genzano Besso, Enza Ferrero, Silvia Deaglio, Franco Corno and Fabio Malavasi
    Citation: Molecular Medicine 2009 15:15030076
    Content type: Research Article Published on:

  47. Chronic kidney disease (CKD) carries an increased risk of cardiovascular disease (CVD). Macrophage migration inhibiting factor (MIF) is a proinflammatory cytokine implicated in the pathogenesis of sepsis, auto...

    Authors: Annette Bruchfeld, Juan J. Carrero, Abdul R. Qureshi, Bengt Lindholm, Peter Barany, Olof Heimburger, Maowen Hu, Xinchun Lin, Peter Stenvinkel and Edmund J. Miller
    Citation: Molecular Medicine 2009 15:15030070
    Content type: Research Article Published on:

  49. Molecular medicine is transforming everyday clinical practice from an empirical art to a rational ortho-molecular science. The prevailing concept in this emerging framework of molecular medicine is a personali...

    Authors: Panagiotis A. Konstantinopoulos, Michalis V. Karamouzis and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2009 15:15010060
    Content type: Mini-Review Published on:

  50. We recently demonstrated that early administration of rat adrenomedullin (AM), a vasoactive peptide, in combination with its binding protein (human AMBP-1) produces various beneficial effects in sepsis. Human ...

    Authors: Rongqian Wu, Shinya Higuchi, Weifeng Dong, Youxin Ji, Mian Zhou, Corrado P. Marini, Thanjavur S. Ravikumar and Ping Wang
    Citation: Molecular Medicine 2009 15:15010028
    Content type: Research Article Published on:
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ISSN: 1528-3658