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  1. Tyr-Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) and Tyr-Tic-Ala were the first peptides with δ opioid antagonist activity lacking Phe, considered essential for opioid activity based on the N-terminal t...

    Authors: Severo Salvadori, Martti Attila, Giofranco Balboni, Clementina Bianchi, Sharon D. Bryant, Orlando Crescenzi, Remo Guerrini, Delia Picone, Teodorico Tancredi, Piero A. Temussi and Lawrence H. Lazarus
    Citation: Molecular Medicine 1995 1:BF03401608
    Content type: Original Articles Published on:

  2. Advanced glycation end products (AGE), the reactive derivatives of nonenzymatic glucose-protein condensation reactions, are implicated in the multiorgan complications of diabetes and aging. An AGE-specific cel...

    Authors: Helen Vlassara, Yong Ming Li, Farhad Imani, Donald Wojciechowicz, Zhi Yang, Fu-Tong Liu and Anthony Cerami
    Citation: Molecular Medicine 1995 1:BF03401604
    Content type: Original Articles Published on:

  3. Individuals at risk for insulin-dependent diabetes mellitus (IDDM), with an affected first-degree relative, can be identified by the presence of islet cell antibodies (ICA). ICA-positive relatives progress at ...

    Authors: Margo C. Honeyman, Leonard C. Harrison, Bruce Drummond, Peter G. Colman and Brian D. Tait
    Citation: Molecular Medicine 1995 1:BF03401595
    Content type: Original Articles Published on:

  4. The receptor of ciliary neurotrophic factor (CNTF) contains the signal transduction protein gp130, which is also a component of the receptors of cytokines such as interleukin (IL)-6, leukemia-inhibitory factor...

    Authors: Fabio Benigni, Pia Villa, Maria Teresa Demitri, Silvano Sacco, Jean D. Sipe, Laura Lagunowich, Nikos Panayotatos and Pietro Ghezzi
    Citation: Molecular Medicine 1995 1:BF03401594
    Content type: Original Articles Published on:

  5. A problem likely to be encountered in any cancer immunotherapy based on vaccination with a single protein or peptide is variation in the host response. A particularly informative example is provided by the two...

    Authors: Nance Nardi and Nicholas A. Mitchison
    Citation: Molecular Medicine 1995 1:BF03401593
    Content type: Original Articles Published on:

  6. Interactions between γδ T cells and heat shock proteins (HSP) have been proposed as contributing factors in a number of diseases of possible autoimmune etiology but definitive evidence to support this hypothesis ...

    Authors: Luca Battistini, Marco Salvetti, Giovanni Ristori, Marika Falcone, Cedric S. Raine and Celia F. Brosnan
    Citation: Molecular Medicine 1995 1:BF03401592
    Content type: Original Articles Published on:

  7. Human, but not mouse, islet amyloid polypeptide (IAPP) is amyloidogenic. Transgenic mice overexpressing human IAPP in the β cells of the islets of Langerhans should be useful in identifying factors important for ...

    Authors: Gunilla Westermark, Michelle Benig Arora, Niles Fox, Raymond Carroll, Shu Jin Chan, Per Westermark and Donald F. Steiner
    Citation: Molecular Medicine 1995 1:BF03401591
    Content type: Original Articles Published on:

  8. Aberrant metabolism of the Alzheimer amyloid precursor protein (APP) or its amyloidogenic Aβ fragment is thought to be centrally involved in Alzheimer’s disease. Nonamyloidogenic processing of APP involves its cl...

    Authors: Edgar F. da Cruz e Silva, Odete A. B. da Cruz e Silva, Cássia Thais B. V. Zaia and Paul Greengard
    Citation: Molecular Medicine 1995 1:BF03401590
    Content type: Original Articles Published on:

  9. Chronic diabetes causes structural changes in the retinal capillaries of nearly all patients with a disease duration of more than 15 years. Acellular occluded vessels cause hypoxia, which stimulates sight-thre...

    Authors: Hans-Peter Hammes, Howard J. Federoff and Michael Brownlee
    Citation: Molecular Medicine 1995 1:BF03401589
    Content type: Original Articles Published on:

  10. At therapeutic concentrations, the antineoplastic agent taxol selectively perturbs mitotic spindle microtubules. Taxol has recently been shown to induce apoptosis, similar to the mechanism of cell death induce...

    Authors: Catherine M. Woods, Jian Zhu, Patricia A. McQueney, Daniel Bollag and Elias Lazarides
    Citation: Molecular Medicine 1995 1:BF03401588
    Content type: Original Articles Published on:

  11. The developmental stage from which stems the malignant B cell population in Burkitt’s lymphoma (BL) is unclear. An approach to answering this question is provided by the sequence analysis of rearranged immunog...

    Authors: Ulf Klein, George Klein, Barbro Ehlin-Henriksson, Klaus Rajewsky and Ralf Küppers
    Citation: Molecular Medicine 1995 1:BF03401587
    Content type: Original Articles Published on:

  15. Von Hippel-Lindau (VHL) disease is a familial cancer syndrome that has a dominant inherited pattern which predisposes affected individuals to a variety of tumors. The most frequent tumors are hemangioblastomas...

    Authors: Patricia M. Kessler, Sandip P. Vasavada, Raymond R. Rackley, Thomas Stackhouse, Fuh-Mei Duh, Farida Latif, Michael I. Lerman, Berton Zbar and Bryan R. G. Williams
    Citation: Molecular Medicine 1995 1:BF03401583
    Content type: OriginalPaper Published on:

  16. Reactive glucose-protein intermediates and advanced glycation endproducts (AGEs) are shown to colocalize with atheromatous lesions and to trigger complex chemical and biological responses through interaction w...

    Authors: Helen Vlassara, Hubert Fuh, Thomas Donnelly and Myron Cybulsky
    Citation: Molecular Medicine 1995 1:BF03401582
    Content type: OriginalPaper Published on:

  17. The marR gene of Escherichia coli encodes a repressor of the marRAB operon, a regulatory locus controlling multiple antibiotic resistance in this organism. Inactivation of marR results in increased expression of

    Authors: Mark C. Sulavik, Laura F. Gambino and Paul F. Miller
    Citation: Molecular Medicine 1995 1:BF03401581
    Content type: OriginalPaper Published on:

  18. The anti-tumor agent, Taxol, has been shown in murine macrophages to stimulate tumor necrosis factor (TNF), modulate TNF receptors, induce a large panel of immediate-early genes, and induce protein tyrosine ph...

    Authors: Beth E. Henricson, Joan M. Carboni, Anne L. Burkhardt and Stefanie N. Vogel
    Citation: Molecular Medicine 1995 1:BF03401580
    Content type: OriginalPaper Published on:

  19. Tissue inhibitor of metalloproteinases-3 (TIMP3) is the third member of the TIMP family of proteins, believed to play a significant role in controlling extracellular matrix remodeling.

    Authors: Jennifer A. Byrne, Catherine Tomasetto, Nicolas Rouyer, Jean-Pierre Bellocq, Marie-Christine Rio and Paul Basset
    Citation: Molecular Medicine 1995 1:BF03401579
    Content type: OriginalPaper Published on:

  20. The antiviral drugs AZT and acyclovir are generally used in the treatment of infections with human immunodeficiency virus (HIV) and herpes simplex virus (HSV). These substances are known to impede virus replic...

    Authors: Martin Gschwentner, Alex Susanna, Ewald Wöll, Markus Ritter, Ulrich O. Nagl, Andreas Schmarda, Andreas Laich, Germar M. Pinggera, Helmut Ellemunter, Hartwig Huemer, Peter Deetjen and Markus Paulmichl
    Citation: Molecular Medicine 1995 1:BF03401578
    Content type: OriginalPaper Published on:

  21. Clozapine, the classic atypical neuroleptic, exerts therapeutic actions in schizophrenic patients unresponsive to most neuroleptics. Clozapine interacts with numerous neurotransmitter receptors, and selective ...

    Authors: Charles E. Glatt, Adele M. Snowman, David R. Sibley and Solomon H. Snyder
    Citation: Molecular Medicine 1995 1:BF03401577
    Content type: OriginalPaper Published on:

  22. The monocyte-derived cytokine, tumor necrosis factor α (TNFα), is essential for host immunity, but overproduction of this cytokine may have serious pathologic consequences. Excess TNFα produced in pulmonary tu...

    Authors: Jane M. Tramontana, Utaiwan Utaipat, Anthony Molloy, Pasakorn Akarasewi, Margaret Burroughs, Sanit Makonkawkeyoon, Barbara Johnson, Jeffrey D. Klausner, William Rom and Gilla Kaplan
    Citation: Molecular Medicine 1995 1:BF03401576
    Content type: OriginalPaper Published on:

  23. An expanded CAG trinucleotide repeat is the genetic trigger of neuronal degeneration in Huntington’s disease (HD), but its mode of action has yet to be discovered. The sequence of the HD gene places the CAG re...

    Authors: Francesca Persichetti, Christine M. Ambrose, Pei Ge, Sandra M. McNeil, Jayalakshmi Srinidhi, Mary Anne Anderson, Barbara Jenkins, Glenn T. Barnes, Mabel P. Duyao, Lisa Kanaley, Nancy S. Wexler, Richard H. Myers, Edward D. Bird, Jean-Paul Vonsattel, Marcy E. MacDonald, James F. Gusella…
    Citation: Molecular Medicine 1995 1:BF03401575
    Content type: OriginalPaper Published on:

  29. The carboxy-terminus of the merozoite surface protein-1 (MSP1) of Plasmodium falciparum has been implicated as a target of protective immunity.

    Authors: Sanjai Kumar, Anjali Yadava, David B. Keister, Jing Hui Tian, Michael Ohl, Kathy A. Perdue-Greenfield, Louis H. Miller and David C. Kaslow
    Citation: Molecular Medicine 1995 1:BF03401557
    Content type: Original Articles Published on:

  31. Mutations in the ligand-binding domain of the thyroid hormone receptor β (TRβ) gene cause the syndrome of resistance to thyroid hormone (RTH). The clinical phenotype results from the antagonism of the normal TRα ...

    Authors: Rosemary Wong, Xu-Guang Zhu, Mark A. Pineda, Sheue-yann Cheng and Bruce D. Weintraub
    Citation: Molecular Medicine 1995 1:BF03401555
    Content type: Original Articles Published on:

  32. Understanding the mechanism of developmental regulation of hemoglobin switching has scientific as well as clinical relevance because of the influence of fetal hemoglobin (HbF) production in adulthood on the cl...

    Authors: E. Rena Bacon, Nava Dalyot, Dvora Filon, Letizia Schreiber, Eliezer A. Rachmilewitz and Arieila Oppenheim
    Citation: Molecular Medicine 1995 1:BF03401554
    Content type: Original Articles Published on:

  33. Sarcoidosis is a granulomatous disease characterized by the accumulation of activated T cells in the lungs. We previously showed that sarcoidosis patients expressing the HLA haplotype DR3(17), DQ2 had increased n...

    Authors: Johan Grunewald, Thomas Hultman, Anders Bucht, Anders Eklund and Hans Wigzell
    Citation: Molecular Medicine 1995 1:BF03401553
    Content type: Original Articles Published on:

  34. H2-histamine receptors mediate a wide range of physiological functions extending from stimulation of gastric acid secretion to induction of human promyelocyte differentiation. We have previously cloned the H2-...

    Authors: John DelValle, Ira Gantz, Lidong Wang, Yi-Jun Guo, Gerd Munzert, Takao Tashiro, Yoshitaka Konda and Tadataka Yamada
    Citation: Molecular Medicine 1995 1:BF03401552
    Content type: Original Articles Published on:

  35. The Ity/Lsh/Bcg gene on mouse chromosome 1 regulates priming/activation of macrophages for antimicrobial and tumouricidal activity. A candidate gene expressed in macrophages has been identified by positional clon...

    Authors: C. Howard Barton, Simon H. Whitehead and Jenefer M. Blackwell
    Citation: Molecular Medicine 1995 1:BF03401551
    Content type: Original Articles Published on:

  36. Nitric oxide (NO), a small effector molecule produced enzymatically from L-arginine by nitric oxide synthase (NOS), is a mediator not only of important homeostatic mechanisms (e.g., blood vessel tone and tissu...

    Authors: Marina Bianchi, Peter Ulrich, Ona Bloom, Malcolm Meistrell III, Gary A. Zimmerman, Helena Schmidtmayerova, Michael Bukrinsky, Thomas Donnelley, Richard Bucala, Barbara Sherry, Kirk R. Manogue, Anthony J. Tortolani, Anthony Cerami and Kevin J. Tracey
    Citation: Molecular Medicine 1995 1:BF03401550
    Content type: Original Articles Published on:

  37. Paraneoplastic syndromes are “remote” complications of cancer characterized clinically by neurological disease. The sera and cerebrospinal fluid (CSF) from patients with paraneoplastic neurological syndromes (...

    Authors: Lorise C. Gahring, Roy E. Twyman, John E. Greenlee and Scott W. Rogers
    Citation: Molecular Medicine 1995 1:BF03401549
    Content type: Original Articles Published on:

  40. Human immunodeficiency virus type 1 (HIV-1) is a lentivirus and shares with other members of this retroviral subfamily the ability to replicate in nondividing cells, in particular, cells of the monocyte/macrop...

    Authors: Larisa Dubrovsky, Peter Ulrich, Gerard J. Nuovo, Kirk R. Manogue, Anthony Cerami and Michael Bukrinsky
    Citation: Molecular Medicine 1995 1:BF03401569
    Content type: Original Articles Published on:

  41. Several immunotoxins in which antibodies are coupled to plant or bacterial toxins are now in clinical trials for the treatment of cancer. One of these is B3-LysPE38 in which MAb B3 which reacts with many human...

    Authors: Ulrich Brinkmann, Elisabeth Brinkmann and Ira Pastan
    Citation: Molecular Medicine 1995 1:BF03401568
    Content type: Original Articles Published on:

  42. Murine Nramp is a candidate for the macrophage resistance gene Ity/Lsh/Bcg. Sequence analysis of human NRAMP was undertaken to determine its role in man.

    Authors: Jenefer M. Blackwell, C. Howard Barton, Jacqueline K. White, Susan Searle, Anne-Marie Baker, Hazel Williams and Marie-Anne Shaw
    Citation: Molecular Medicine 1995 1:BF03401567
    Content type: Original Articles Published on:

  43. Vascular smooth muscle cell (VSMC) proliferation following arterial injury plays a critical role in a variety of vascular proliferative disorders, including atherosclerosis and restenosis after balloon angiopl...

    Authors: Mark W. Chang, Takeshi Ohno, David Gordon, Min Min Lu, Gary J. Nabel, Elizabeth G. Nabel and Jeffrey M. Leiden
    Citation: Molecular Medicine 1995 1:BF03401565
    Content type: Original Articles Published on:

  44. Cervical intraepithelial neoplasia (CIN) and cervical cancer have been shown to be strongly associated with infection by human papillomavirus (HPV). However, other factors may be contributory in the progressio...

    Authors: Kunle Odunsi, George Terry, Linda Ho, John Bell, Jack Cuzick and Trivadi S. Ganesan
    Citation: Molecular Medicine 1995 1:BF03401564
    Content type: Original Articles Published on:

  47. The identification of transcripts encoding putative olfactory receptors in mammalian germ cells (1) has generated the hypothesis that olfactory receptors may serve a chemosensory role in sperm Chemotaxis during f...

    Authors: Loren D. Walensky, A. Jane Roskams, Robert J. Lefkowitz, Solomon H. Snyder and Gabriele V. Ronnett
    Citation: Molecular Medicine 1995 1:BF03401561
    Content type: Original Articles Published on:
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Molecular Medicine

ISSN: 1528-3658