Skip to main content

Table 1 Summary of studies on CIN, cervical cancer, and HLA

From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia

Study Patients Controls Population HLA Typing Method HPV Typing Results
Wank and Thomssen (1991) (1) 66 (SCC) 109 (local panel) German Serology Not done 1. DQW3: RR = 7.1 2. DR5: Increased risk 3. DR6: Decreased RR 12.7
Wank et al. (1992) (32) 66 (SCC) 109 (local panel) German PCR-SSO Not done Increased risk of SCC for DQB1 * 0301 & 0303
Heiland et al. (1992) (26) 213 (SCC) 181 (local panel) Norwegian PCR-SSO Not done DQW3: RR = 2.0
Vandenvelde et al. (1993) (32) 71 (CIN) 323 (CINO, not typed for HPV) Belgian PCR-ASO Method and HPV types not stated DQB1 * 03: RR = 2.647 for HPV-associated CIN
David et al. (1993) (29) 50 (CIN) 99 (CINO, blood donors) British PCR-SSO Not done DQB1 * 03: RR = 2.5 for CIN III
Glew et al. (1993) (30) 65 (SCC) 857 (organ donors) British PCR-SSO & Serology Southern blotting, HPV 16 only No HLA association
Apple et al. (1994) (27) 98 (SCC) 220 (CINO, includes HPV-positive women) Hispanic PCR-SSO PCR consensus primers and oligonucleotide probing 1. DRB1 * 1501-DQB1 * 0602 OR = 4.78 for HPV 16 +ve cases 2. DRB1 * 0407-DQB1 * 0302 OR = 2.19 3. DR13: OR = 0.29 (−ve) 4. DQB1 * 03: No association
Gregoire et al. (1994) (31) 66 (SCC) 214 (local panel, not typed for HPV) African-American PCR-SSO PCR consensus primers and oligonucleotide probing 1. DQB1 * 03: RR = 2.3 2. DQB1 * 0303: RR = 5.2 3. DQB1 * 0604: RR = 5.2
  1. RR = relative risk; OR = odds ratio; SCC = squamous cell carinoma.