From: Association Between HLA DQBl * 03 and Cervical Intra-epithelial Neoplasia
Study | Patients | Controls | Population | HLA Typing Method | HPV Typing | Results |
---|---|---|---|---|---|---|
Wank and Thomssen (1991) (1) | 66 (SCC) | 109 (local panel) | German | Serology | Not done | 1. DQW3: RR = 7.1 2. DR5: Increased risk 3. DR6: Decreased RR 12.7 |
Wank et al. (1992) (32) | 66 (SCC) | 109 (local panel) | German | PCR-SSO | Not done | Increased risk of SCC for DQB1 * 0301 & 0303 |
Heiland et al. (1992) (26) | 213 (SCC) | 181 (local panel) | Norwegian | PCR-SSO | Not done | DQW3: RR = 2.0 |
Vandenvelde et al. (1993) (32) | 71 (CIN) | 323 (CINO, not typed for HPV) | Belgian | PCR-ASO | Method and HPV types not stated | DQB1 * 03: RR = 2.647 for HPV-associated CIN |
David et al. (1993) (29) | 50 (CIN) | 99 (CINO, blood donors) | British | PCR-SSO | Not done | DQB1 * 03: RR = 2.5 for CIN III |
Glew et al. (1993) (30) | 65 (SCC) | 857 (organ donors) | British | PCR-SSO & Serology | Southern blotting, HPV 16 only | No HLA association |
Apple et al. (1994) (27) | 98 (SCC) | 220 (CINO, includes HPV-positive women) | Hispanic | PCR-SSO | PCR consensus primers and oligonucleotide probing | 1. DRB1 * 1501-DQB1 * 0602 OR = 4.78 for HPV 16 +ve cases 2. DRB1 * 0407-DQB1 * 0302 OR = 2.19 3. DR13: OR = 0.29 (−ve) 4. DQB1 * 03: No association |
Gregoire et al. (1994) (31) | 66 (SCC) | 214 (local panel, not typed for HPV) | African-American | PCR-SSO | PCR consensus primers and oligonucleotide probing | 1. DQB1 * 03: RR = 2.3 2. DQB1 * 0303: RR = 5.2 3. DQB1 * 0604: RR = 5.2 |