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Table 1 Binding parameters of wild-type and mutant ET-1/AngII receptors for AngII and ET-1 expressed in permanent Cosl cell transfectants

From: Molecular Characterization of a Dual Endothelin-1/Angiotensin II Receptor

ET-1/AngII Receptor KH ET-1 (nmol/L) KH AngII (nmol/L) Bmax for AngII (fmols 10−6 cells)
Wild type 0.28 ± 0.07 1.30 ± 0.30 5.03 ± 0.99
R64G No binding 1.20 ± 0.13 0.95 ± 0.07
W65G No binding 7.36 ± 1.50 4.69 ± 0.84
  1. Scatchard analysis (RADLIG, Version 4 Program, McPherson) of the 125I-AngII and 125I-ET-1 saturation curves (Fig. 5) was done. KH, high affinity was stated as nmol/L ± error.