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Fig. 5 | Molecular Medicine

Fig. 5

From: Functional Characterization of Three Mutations of the Endothelin B Receptor Gene in Patients With Hirschsprung’s Disease: Evidence for Selective Loss of Gi Coupling

Fig. 5

Measurement of AP-1 pathway induced by activation of WT and mutant hETB receptors. CHO cells bearing WT (d), or mutant G57S (□) and R319W (δ) hETB receptors were transiently transfected with the 6xTRE-Coll-LUC plasmid. The AP-1 pathway was induced by various concentrations of ET-1 or specific ETB agonist: IRL 1620 (inset). Luciferase activity is expressed as a percentage of the luminescence of 102 6M agonist. Results are the means 6 SEM of three independent experiments.

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Molecular Medicine

ISSN: 1528-3658