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Correction: Angiotensin-Converting Enzyme (ACE) 2 Overexpression Ameliorates Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition

The Original Article was published on 14 September 2010

Correction: Molecular Medicine 17, (2011) 59-69 https://doi.org/10.2119/molmed.2010.00111

Following publication of the original article [1], the authors found an error in Fig. 1B: the immunohistochemical images in the ACEI and AD-ACE2 + ACEI groups were mistakenly used, which were partially overlapped with the correct image in the Ad-ACE2 group. They went back to their raw data and found the original immunohistochemical images in the ACEI and AD-ACE2 + ACEI groups (n = 10 in each group). The corrected Fig. 1B is given in this correction article.

Fig. 1
figure 1

Efficiency of gene transfer 4 wks after gene delivery. A Fluorescence microscopic images of frozen sections of the kidneys in the normal, no treatment, Ad-GFP, Ad-ACE2, ACE1 and Ad-ACE2 + ACEI groups, respectively (bar = 50 μm). G indicates glomeruli and T indicates tubules. B Immunochemical staining showing the localization of ACE2 protein in cortical sections from each group. Weak ACE2 staining was observed in tubules from rats in the no treatment and Ad-GFP groups, whereas marked ACE2 staining was depicted in both tubules and glomeruli from rats in the normal, Ad-ACE2, ACEI and Ad-ACE2 + ACEI groups (bar = 50 μm). C, D, E Quantitative analysis of ACE2 mRNA levels, protein levels and activities. *P < 0.05, #P < 0.01 versus normal group; P < 0.05, §P < 0.01 versus no treatment group

The authors apologise for this error.

Reference

  1. Liu CX, Hu Q, Wang Y, Zhang W, Ma ZY, Feng JB, Wang R, Wang XP, Dong B, Gao F, Zhang MX. Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition. Mol Med. 2011;17:59–69. https://doi.org/10.2119/molmed.2010.00111.

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Correspondence to Yun Zhang.

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Liu, C.X., Hu, Q., Wang, Y. et al. Correction: Angiotensin-Converting Enzyme (ACE) 2 Overexpression Ameliorates Glomerular Injury in a Rat Model of Diabetic Nephropathy: A Comparison with ACE Inhibition. Mol Med 28, 53 (2022). https://doi.org/10.1186/s10020-022-00482-9

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