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  1. L-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the cardioprotective effects and mechanisms of L-theanine in myocardial ischemia-reperfusion in...

    Authors: Qi Li, Jiaqi Ding, Boyu Xia, Kun Liu, Koulong Zheng, Jingjing Wu, Chao Huang, Xiaomei Yuan and Qingsheng You
    Citation: Molecular Medicine 2024 30:98
    Content type: Research article Published on:

  2. Ubiquitin-specific protease 38 (USP38), belonging to the USP family, is recognized for its role in controlling protein degradation and diverse biological processes. Ventricular arrhythmias (VAs) following hear...

    Authors: Yucheng Pan, Zheng Xiao, Hongjie Yang, Bin Kong, Hong Meng, Wei Shuai and He Huang
    Citation: Molecular Medicine 2024 30:97
    Content type: Research article Published on:

  3. Lupus nephritis (LN) is a severe and common manifestation of systemic lupus erythematosus (SLE) that is frequently identified with a poor prognosis. Macrophages play an important role in its pathogenesis. Diff...

    Authors: Limei Zhao, Shuqin Tang, Fahui Chen, Xiya Ren, Xiutao Han and Xiaoshuang Zhou
    Citation: Molecular Medicine 2024 30:96
    Content type: Review Published on:

  4. Ketone β-hydroxybutyrate (BHB) has been reported to prevent tumor cell proliferation and improve drug resistance. However, the effectiveness of BHB in oxaliplatin (Oxa)-resistant colorectal cancer (CRC) and th...

    Authors: Meng Deng, Peijie Yan, Hui Gong, Guiqiu Li and Jianjie Wang
    Citation: Molecular Medicine 2024 30:95
    Content type: Research article Published on:

  5. Despite recent advances in tumor diagnosis and treatment technologies, the number of cancer cases and deaths worldwide continues to increase yearly, creating an urgent need to find new methods to prevent or tr...

    Authors: Pengtao Liu, Bo Zhang, Yuanqiang Li and Qipeng Yuan
    Citation: Molecular Medicine 2024 30:94
    Content type: Review Published on:

  6. The epithelial-mesenchymal transition (EMT) of human bronchial epithelial cells (HBECs) is essential for airway remodeling during asthma. Wnt5a has been implicated in various lung diseases, while its role in t...

    Authors: Yu-Biao Liu, Xiao-Hua Tan, Hui-Hui Yang, Jin-Tong Yang, Chen-Yu Zhang, Ling Jin, Nan-Shi-Yu Yang, Cha-Xiang Guan, Yong Zhou, Shao-Kun Liu and Jian-Bing Xiong
    Citation: Molecular Medicine 2024 30:93
    Content type: Research article Published on:

  7. COVID-19 is a new infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS CoV-2). Since the outbreak in December 2019, it has caused an unprecedented world pandemic, leading to a...

    Authors: Hong-Hua Shao and Rui-Xing Yin
    Citation: Molecular Medicine 2024 30:92
    Content type: Review Published on:

  8. Glioma is the most common malignant tumor of the central nervous system, with EZH2 playing a crucial regulatory role. This study further explores the abnormal expression of EZH2 and its mechanisms in regulatin...

    Authors: Hongwei Zhang, Zixuan Wang, Xiaolong Qiao, Nan Peng, Jiaxing Wu, Yinan Chen and Chuandong Cheng
    Citation: Molecular Medicine 2024 30:91
    Content type: Research article Published on:

  9. Aortic dissection (AD) is a macrovascular disease which is pathologically characterized by aortic media degeneration.This experiment aims to explore how iron deficiency (ID) affects the function of vascular sm...

    Authors: Yuanyang Chen, Xu Li, Zhiwei Wang, Shun Yuan, Xiaoyan Shen, Xiaoping Xie, Kai Xing and Qingyi Zhu
    Citation: Molecular Medicine 2024 30:90
    Content type: Research article Published on:

  10. Myocardial infarction (MI) leads to enhanced activity of cardiac fibroblasts (CFs) and abnormal deposition of extracellular matrix proteins, resulting in cardiac fibrosis. Tartrate-resistant acid phosphatase 5...

    Authors: Shujun Yang, Liying Pei, Zijie Huang, Yinsheng Zhong, Jun Li, Yinghui Hong, Huibao Long, Xuxiang Chen, Changqing Zhou, Guanghui Zheng, Chaotao Zeng, Haidong Wu and Tong Wang
    Citation: Molecular Medicine 2024 30:89
    Content type: Research article Published on:

  11. Macrophages play a crucial role in the development of cardiac fibrosis (CF). Although our previous studies have shown that glycogen metabolism plays an important role in macrophage inflammatory phenotype, the ...

    Authors: Shiqi Chen, Kan Wang, Zhengfeng Fan, Tingwen Zhou, Rui Li, Bingxia Zhang, Jie Chen, Jiangyang Chi, Keke Wei, Jincheng Liu, Zongtao Liu, Jingwei Ma, Nianguo Dong and Junwei Liu
    Citation: Molecular Medicine 2024 30:88
    Content type: Research article Published on:

  12. Intervertebral disc degeneration (IDD) is a common musculoskeletal degenerative disease, which often leads to low back pain and even disability, resulting in loss of labor ability and decreased quality of life...

    Authors: Fengguang Yang, Yanni Duan, Yanhu Li, Daxue Zhu, Zhaoheng Wang, Zhangbin Luo, Yizhi Zhang, Guangzhi Zhang, Xuegang He and Xuewen Kang
    Citation: Molecular Medicine 2024 30:87
    Content type: Research article Published on:

  13. Despite the advances of therapies, multiple myeloma (MM) remains an incurable hematological cancer that most patients experience relapse. Tumor angiogenesis is strongly correlated with cancer relapse. Human le...

    Authors: Chi Wang, Nai-Wen Su, Kate Hsu, Chen-Wei Kao, Ming-Chih Chang, Yi-Fang Chang, Ken-Hong Lim, Yi-Hao Chiang, Yu-Cheng Chang, Meng-Ta Sung, Hsueh-Hsia Wu and Caleb G. Chen
    Citation: Molecular Medicine 2024 30:86
    Content type: Research article Published on:

  14. Immunotherapies effectively treat human malignancies, but the low response and resistance are major obstacles. Neoantigen is an emerging target for tumor immunotherapy that can enhance anti-tumor immunity and ...

    Authors: Yaoqi Sun, Bing Xiong, Xueqian Shuai, Jiale Li, Chunyan Wang, Jing Guo, Zhongping Cheng and Shupeng Liu
    Citation: Molecular Medicine 2024 30:85
    Content type: Research article Published on:

  15. Deep vein thrombosis (DVT) is a common vascular surgical disease caused by the coagulation of blood in the deep veins, and predominantly occur in the lower limbs. Endothelial progenitor cells (EPCs) are multi-...

    Authors: Zhang Xiujin, Guo Lili, Fan Jing, Ye Wenhai, Liu Sikai and Shi Wan-yin
    Citation: Molecular Medicine 2024 30:84
    Content type: Research article Published on:

  16. The terminal stage of ischemic heart disease develops into heart failure (HF), which is characterized by hypoxia and metabolic disturbances in cardiomyocytes. The hypoxic failing heart triggers hypoxia-inducib...

    Authors: Longfei Xu, Miaomiao Yang, Aili Wei, Zilin Wei, Yingkai Qin, Kun Wang, Bin Li, Kang Chen, Chen Liu, Chao Li and Tianhui Wang
    Citation: Molecular Medicine 2024 30:83
    Content type: Research article Published on:

  17. Programmed cell death is an important mechanism for the development of hepatic ischemia and reperfusion (IR) injury, and multiple novel forms of programmed cell death are involved in the pathological process o...

    Authors: Hang Zhao and Huizi Mao
    Citation: Molecular Medicine 2024 30:82
    Content type: Research article Published on:

  18. Studies have highlighted a possible crosstalk between the pathogeneses of COVID-19 and systemic lupus erythematosus (SLE); however, the interactive mechanisms remain unclear. We aimed to elucidate the impact o...

    Authors: Zekai Nian, Yicheng Mao, Zexia Xu, Ming Deng, Yixi Xu, Hanlu Xu, Ruoyao Chen, Yiliu Xu, Nan Huang, Feiyang Mao, Chenyu Xu, Yulin Wang, Mengyuan Niu, Aqiong Chen, Xiangyang Xue, Huidi Zhang…
    Citation: Molecular Medicine 2024 30:81
    Content type: Research article Published on:

  19. Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that commonly results from a high-calorie diet and sedentary lifestyle, leading to insulin resistance and glucose homeostasis perturbation. Physic...

    Authors: Elias Abi Akar, Laure Weill, Mirella El Khoury, Cédric Caradeuc, Gildas Bertho, Suzan Boutary, Cynthia Bezier, Zoé Clerc, Delphine Sapaly, Sabrina Bendris, Flore Cheguillaume, Nicolas Giraud, Assaad A. Eid, Frédéric Charbonnier and Olivier Biondi
    Citation: Molecular Medicine 2024 30:80
    Content type: Research article Published on:

  20. Increased level of serum cholic acid (CA) is often accompanied with decreased CYP2E1 expression in hepatocellular carcinoma (HCC) patients. However, the roles of CA and CYP2E1 in hepatocarcinogenesis have not ...

    Authors: Zhiwei Hao, Xuemin Liu, Huanhuan He, Zhixuan Wei, Xiji Shu, Jianzhi Wang, Binlian Sun, Hongyan Zhou, Jiucheng Wang, Ying Niu, Zhiyong Hu, Shaobo Hu, Yuchen Liu and Zhengqi Fu
    Citation: Molecular Medicine 2024 30:79
    Content type: Research article Published on:

  21. Diabetic nephropathy (DN) is a life-threatening renal disease and needs urgent therapies. Wogonin is renoprotective in DN. This study aimed to explore the mechanism of how wogonin regulated high glucose (HG)-i...

    Authors: Yufeng Liu, Mengbi Zhang, Lu Zeng, Yanhong Lai, Songzhao Wu and Xiaoyan Su
    Citation: Molecular Medicine 2024 30:78
    Content type: Research article Published on:

  22. Ischemic stroke presents a significant threat to human health due to its high disability rate and mortality. Currently, the clinical treatment drug, rt-PA, has a narrow therapeutic window and carries a high ri...

    Authors: Zhiyong Zhou, Weili Li, Lu Ni, Tianlun Wang, Yan Huang, Yuanqi Yu, Mingxin Hu, Yinling Liu, Jin’e Wang, Xiaofei Huang and Yanyan Wang
    Citation: Molecular Medicine 2024 30:77
    Content type: Research article Published on:

  23. Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced gl...

    Authors: Xi Yang, Jingxin Zeng, Kaiji Xie, Shuwen Su, Yuyang Guo, Hao Zhang, Jun Chen, Zhuang Ma, Zezhou Xiao, Peng Zhu, Shaoyi Zheng, Dingli Xu and Qingchun Zeng
    Citation: Molecular Medicine 2024 30:76
    Content type: Research article Published on:

  25. Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage destruction and inflammation. CC chemokine receptor 1 (CCR1), a member of the chemokine family and its receptor family, plays a ro...

    Authors: Hanqing Xu, Sheng Chen, Cheng Meng, Yi He, Xiao-jian Huang and Hong-bo You
    Citation: Molecular Medicine 2024 30:74
    Content type: Research article Published on:

  26. Human malignant pleural mesothelioma (hMPM) is an aggressive, rare disease with a poor prognosis. Histologically, MPM is categorized into epithelioid, biphasic, and sarcomatoid subtypes, with the epithelioid s...

    Authors: James Mei-Lin Chan, Yuan-Ching Chang, Hua-Chen Chan, Hsiu-Chuan Chan, Wei-Chin Chang, Liu-Fang Wang, Tung-Hu Tsai, Yu-Jen Chen and Wen-Chien Huang
    Citation: Molecular Medicine 2024 30:73
    Content type: Research article Published on:

  27. 8-Oxoguanine DNA glycosylase (OGG1), a well-known DNA repair enzyme, has been demonstrated to promote lung fibrosis, while the specific regulatory mechanism of OGG1 during pulmonary fibrosis remains unclarified.

    Authors: Wenjuan Wu, Hongxia Jia, Song Chen, Xinran Ma, Shuai Zhou, Lingxiao Qiu, Xinhui Wu, Ping Li, Heying Chu and Guojun Zhang
    Citation: Molecular Medicine 2024 30:72
    Content type: Research article Published on:

  28. Diabetes mellitus, a chronic metabolic disease, often leads to numerous chronic complications, significantly contributing to global morbidity and mortality rates. High glucose levels trigger epigenetic modific...

    Authors: Tongyue Yang, Feng Qi, Feng Guo, Mingwei Shao, Yi Song, Gaofei Ren, Zhao Linlin, Guijun Qin and Yanyan Zhao
    Citation: Molecular Medicine 2024 30:71
    Content type: Review Published on:

  29. The development of pulmonary fibrosis involves a cascade of events, in which inflammation mediated by immune cells plays a pivotal role. Chemotherapeutic drugs have been shown to have dual effects on fibrosis,...

    Authors: Ting Zhou, Lan lin, Yawen Zhan, Ziyao Zhang, Ying Jiang, Mi Wu, Dan Xue, Limin Chen, Xiufang Weng and Zhenghui Huang
    Citation: Molecular Medicine 2024 30:70
    Content type: Research article Published on:

  30. The Enoyl-CoA hydratase/isomerase family plays a crucial role in the metabolism of tumors, being crucial for maintaining the energy balance and biosynthetic needs of cancer cells. However, the enzymes within t...

    Authors: Jiancheng He, Jianfeng Yi, Li Ji, Lingchen Dai, Yu Chen and Wanjiang Xue
    Citation: Molecular Medicine 2024 30:69
    Content type: Research article Published on:

  31. Acute respiratory distress syndrome (ARDS) is characterized by alveolar edema that can progress to septal fibrosis. Mechanical ventilation can augment lung injury, termed ventilator-induced lung injury (VILI)....

    Authors: Charissa E. van den Brom, Caitlin Bozic, Chantal A. Polet, Annabel Bongers, Anita M. Tuip-de Boer, Roselique Ibelings, Joris J. T. H. Roelofs and Nicole P. Juffermans
    Citation: Molecular Medicine 2024 30:68
    Content type: Research article Published on:

  34. Catalpol (CAT) has various pharmacological activities and plays a protective role in cerebral ischemia. It has been reported that CAT played a protective role in cerebral ischemia by upregulaing NRF1 expressio...

    Authors: Kan Liu, Xinyan Yao, Jun Gao, Jinxi Wang and Jing Qi
    Citation: Molecular Medicine 2024 30:65
    Content type: Research article Published on:

  35. Insulin like growth factor II mRNA binding protein 3 (IGF2BP3) has been implicated in numerous inflammatory and cancerous conditions. However, its precise molecular mechanisms in endometriosis (EMs) remains un...

    Authors: Honglin Wang, Yingying Cao, Yanling Gou, Hao Wang, Zongwen Liang, Qiong Wu, Jiahuan Tan, Jinming Liu, Zhi Li, Jing Cui, Huiyan Zhang and Zongfeng Zhang
    Citation: Molecular Medicine 2024 30:64
    Content type: Research article Published on:

  36. Diabetic wounds are one of the long-term complications of diabetes, with a disordered microenvironment, diabetic wounds can easily develop into chronic non-healing wounds, which can impose a significant burden...

    Authors: Mengqian Liu, Xuerong Wei, Zijun Zheng, Erlian Xie, Qiuyi Yu, Yanbin Gao, Jun Ma and Lei Yang
    Citation: Molecular Medicine 2024 30:63
    Content type: Research article Published on:

  38. Triple negative breast cancer (TNBC) is a heterogeneous and aggressive disease characterized by a high risk of mortality and poor prognosis. It has been reported that Laminin γ2 (LAMC2) is highly expressed in ...

    Authors: Ding Wang, Kailibinuer Keyoumu, Rongji Yu, Doudou Wen, Hao Jiang, Xinchun Liu, Xiaotang Di and Shubing Zhang
    Citation: Molecular Medicine 2024 30:61
    Content type: Research article Published on:

  39. Severe acute pancreatitis (SAP) begins with premature activation of enzymes, promoted by the immune system, triggering a potential systemic inflammatory response that leads to organ failure with increased mort...

    Authors: Hongli Yang, Ruofan Cao, Feifei Zhou, Ben Wang, Qianqian Xu, Rui Li, ChunHua Zhang and Hongwei Xu
    Citation: Molecular Medicine 2024 30:60
    Content type: Review Published on:

  40. Microglial activation and polarization play a central role in poststroke inflammation and neuronal damage. Modulating microglial polarization from pro-inflammatory to anti-inflammatory phenotype is a promising...

    Authors: Chunyang Kang, Qiuling Sang, Dingxi Liu, Libo Wang, Jia Li and Xiaoyang Liu
    Citation: Molecular Medicine 2024 30:59
    Content type: Research article Published on:

  41. Vascular calcification (VC) is a complication in diabetes mellitus (DM) patients. Osteogenic phenotype switching of vascular smooth muscle cells (VSMCs) plays a critical role in diabetes-related VC. Mitophagy ...

    Authors: Kui Chen, Hao-jie Jin, Zi-heng Wu, Bao-fu Zhang, Jun Wu, Zi-yi Huang, Ying-peng Huang, Xin-wu Lu and Xiang-tao Zheng
    Citation: Molecular Medicine 2024 30:58
    Content type: Research article Published on:

  42. Ossification of the posterior longitudinal ligament (OPLL), an emerging heterotopic ossification disease, causes spinal cord compression, resulting in motor and sensory dysfunction. The etiology of OPLL remain...

    Authors: Xiangwu Geng, Yifan Tang, Changjiang Gu, Junkai Zeng, Yin Zhao, Quanwei Zhou, Lianshun Jia, Shengyuan Zhou and Xiongsheng Chen
    Citation: Molecular Medicine 2024 30:57
    Content type: Research article Published on:

  43. Ginsenoside Rh2 (G-Rh2), a steroidal compound extracted from roots of ginseng, has been extensively studied in tumor therapy. However, its specific regulatory mechanism in non-small cell lung cancer (NSCLC) is...

    Authors: Xiyu Liu, Jingjing Li, Qingqing Huang, Mingming Jin and Gang Huang
    Citation: Molecular Medicine 2024 30:56
    Content type: Research article Published on:

  44. Osteoarthritis (OA), the most common joint disease, is linked with chondrocyte apoptosis and extracellular matrix (ECM) degradation. Charged multivesicular body protein 5 (CHMP5), a member of the multivesicula...

    Authors: Weilu Gao, Rui Liu, Keke Huang, Wenhan Fu, Anquan Wang, Gongwen Du, Hao Tang, Li Yin and Zongsheng S. Yin
    Citation: Molecular Medicine 2024 30:55
    Content type: Research article Published on:

  45. Bleomycin, a potent antitumor agent, is limited in clinical use due to the potential for fatal pulmonary toxicity. The accelerated DNA damage and senescence in alveolar epithelial cells (AECs) is considered a ...

    Authors: Fuqiang Chen, Wenna Zhao, Chenghong Du, Zihan Chen, Jie Du and Meijuan Zhou
    Citation: Molecular Medicine 2024 30:54
    Content type: Research article Published on:

  47. Skin fibrosis affects the normal function of the skin. TGF-β1 is a key cytokine that affects organ fibrosis. The latency-associated peptide (LAP) is essential for TGF-β1 activation. We previously constructed a...

    Authors: Zhiqin Cao, Keke Zhang, Jingruo Liu, Yu Pan, Jiayi Shi, Luxin Li, Xiaocan Sun, Shiqi Li, Xiaohuan Yuan and Dan Wu
    Citation: Molecular Medicine 2024 30:52
    Content type: Research article Published on:

  48. The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis ...

    Authors: Maitray A. Patel, Douglas D. Fraser, Mark Daley, Gediminas Cepinskas, Noemi Veraldi and Serge Grazioli
    Citation: Molecular Medicine 2024 30:51
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658