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Page 26 of 37

  1. Gabriela A Kulp, Ronald G Tilton, David N Herndon, and Marc G Jeschke. (2012) Hyperglycemia Exacerbates Burn-Induced Liver Inflammation via Noncanonical Nuclear Factor-κB Pathway Activation. Mol. Med. 18(6):94...

    Authors: Gabriela A Kulp, Ronald G. Tilton, David N Herndon and Marc G Jeschke
    Citation: Molecular Medicine 2012 18:18610423
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2012 18:Art5

  2. George C Bobustuc, Joshua S Smith, Sreeram Maddipatla, Sheila Jeudy, Arati Limaye, Beth Isley, Maria-Lourdes M Caparas, Susan M Constantino, Nikita Shah, Cheryl H Baker, Kalkunte S Srivenugopal, Said Baidas, a...

    Authors: George C Bobustuc, Joshua S Smith, Sreeram Maddipatla, Sheila Jeudy, Arati Limaye, Beth Isley, Maria-Lourdes M Caparas, Susan M Constantino, Nikita Shah, Cheryl H Baker, Kalkunte S Srivenugopal, Said Baidas and Santhi D Konduri
    Citation: Molecular Medicine 2012 18:18610422
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2012 18:Art2

  3. Eleni A Karavia, Dionysius J Papachristou, Kassiani Liopeta, Irene-Eva Triantaphyllidou, Odyssefs Dimitrakopoulos, and Kyriakos E Kypreos. (2012) Apolipoprotein A-I Modulates Processes Associated with Diet-Ind...

    Authors: Eleni A Karavia, Dionysios J Papachristou, Kassiani Liopeta, Irene-Eva Triantaphyllidou, Odyssefs Dimitrakopoulos and Kyriakos E. Kypreos
    Citation: Molecular Medicine 2012 18:18610421
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2012 18:Art1

  4. Maraviroc (MVC) is the first licensed antiretroviral therapeutic agent to target a host cell surface molecule, and successful HIV-1 entry blockade by this C-C chemokine receptor type 5 (CCR5)-antagonist potent...

    Authors: Samantha J. Westrop, Graeme Moyle, Akil Jackson, Mark Nelson, Sundhiya Mandalia and Nesrina Imami
    Citation: Molecular Medicine 2012 18:18081240
    Content type: Research Article Published on:

  5. Ovarian cancers are heterogeneous and contain stemlike cells that are able to self-renew and are responsible for sustained tumor growth. Metastasis in the peritoneal cavity occurs more frequently in ovarian ca...

    Authors: Hua Jiang, Xiaolong Lin, Yingtao Liu, Wenjia Gong, Xiaoling Ma, Yinhua Yu, Yi Xie, Xiaoxi Sun, Youji Feng, Viktor Janzen and Tong Chen
    Citation: Molecular Medicine 2012 18:18081197
    Content type: Research Article Published on:

  6. Inflammation contributes to the pathogenesis of chronic kidney disease (CKD). Molecules released by the inflamed injured tissue can activate toll-like receptors (TLRs), thereby modulating macrophage and CD4+ T-ce...

    Authors: Tarcio Teodoro Braga, Matheus Correa-Costa, Yuri Felipe Souza Guise, Angela Castoldi, Cassiano Donizetti de Oliveira, Meire Ioshie Hyane, Marcos Antonio Cenedeze, Simone Aparecida Teixeira, Marcelo Nicolas Muscara, Katia Regina Perez, Iolanda Midea Cuccovia, Alvaro Pacheco-Silva, Giselle Martins Gonçalves and Niels Olsen Saraiva Camara
    Citation: Molecular Medicine 2012 18:18081231
    Content type: Research Article Published on:

  7. Human immunodeficiency virus type 1 (HIV-1) infection enhances the expression of inhibitory molecules on T cells, leading to T-cell impairment. The signaling pathways underlying the regulation of inhibitory mo...

    Authors: Karlhans Fru Che, Esaki Muthu Shankar, Sundaram Muthu, Sasan Zandi, Mikael Sigvardsson, Jorma Hinkula, Davorka Messmer and Marie Larsson
    Citation: Molecular Medicine 2012 18:18081169
    Content type: Research Article Published on:

  9. Pneumonia is a common cause of morbidity and mortality and the most frequent source of sepsis. Bacteria that try to invade normally sterile body sites are recognized by innate immune cells through pattern reco...

    Authors: Jacobien J. Hoogerwerf, Gerritje J. W. van der Windt, Dana C. Blok, Arie J. Hoogendijk, Alex F. de Vos, Cornelis van’t Veer, Sandrine Florquin, Koichi S. Kobayashi, Richard A. Flavell and Tom van der Poll
    Citation: Molecular Medicine 2012 18:18071067
    Content type: Research Article Published on:

  10. Aquaporin-4 (AQP-4), the most important water channel in the brain, is expressed by astrocyte end feet abutting microvessels. Altered expression levels of AQP-4 and redistribution of the protein throughout the...

    Authors: Gianluca Isoardo, Isabella Morra, Giulia Chiarle, Valentina Audrito, Silvia Deaglio, Antonio Melcarne, Carola Junemann, Michele Naddeo, Maurizio Cogoni, Maria Consuelo Valentini, Andrea Limberti, Federico Faccani, Fabio Malavasi and Giuliano Faccani
    Citation: Molecular Medicine 2012 18:18071147
    Content type: Research Article Published on:

  11. Isocorydine (ICD), an anticancer agent under current evaluation, decreased the percentage of side population (SP) cells significantly in hepatocellular carcinoma (HCC) cell lines. ICD treatment sensitized canc...

    Authors: Ping Lu, Hefen Sun, Lixing Zhang, Helei Hou, Lin Zhang, Fangyu Zhao, Chao Ge, Ming Yao, Tingpu Wang and Jinjun Li
    Citation: Molecular Medicine 2012 18:18071136
    Content type: Research Article Published on:

  12. Flurbiprofen acts as a nonselective inhibitor for cyclooxygenases (COX-1 and COX-2), but its impact on hepatic ischemia/reperfusion (I/R) injury remains unclear. Mice were randomized into sham, I/R and flurbip...

    Authors: Hailong Fu, Huan Chen, Chengcai Wang, Haitao Xu, Fang Liu, Meng Guo, Quanxing Wang and Xueyin Shi
    Citation: Molecular Medicine 2012 18:18071128
    Content type: Research Article Published on:

  13. The CD44hi compartment in human breast cancer is enriched in tumor-initiating cells; however, the functional heterogeneity within this subpopulation remains poorly defined. We used a triple-negative breast cancer...

    Authors: Rikke Leth-Larsen, Mikkel G. Terp, Anne G. Christensen, Daniel Elias, Thorsten Kühlwein, Ole N. Jensen, Ole W. Petersen and Henrik J. Ditzel
    Citation: Molecular Medicine 2012 18:18071109
    Content type: Research Article Published on:

  15. Bacterial pneumonia remains associated with high morbidity and mortality. The gram-positive pathogen Streptococcus pneumoniae is the most common cause of community-acquired pneumonia. Lipoteichoic acid (LTA) is a...

    Authors: Arie J. Hoogendijk, Joris J. T. H. Roelofs, JanWillem Duitman, Miriam H. P. van Lieshout, Dana C. Blok, Tom van der Poll and Catharina W. Wieland
    Citation: Molecular Medicine 2012 18:18071086
    Content type: Research Article Published on:

  16. Erythropoietin (EPO) improves cognitive performance in clinical studies and rodent experiments. We hypothesized that an intrinsic role of EPO for cognition exists, with particular relevance in situations of co...

    Authors: Anne Kästner, Sabrina Grube, Ahmed El-Kordi, Beata Stepniak, Heidi Friedrichs, Derya Sargin, Judith Schwitulla, Martin Begemann, Ina Giegling, Kamilla W Miskowiak, Swetlana Sperling, Kathrin Hannke, Anna Ramin, Ralf Heinrich, Olaf Gefeller, Klaus-Armin Nave…
    Citation: Molecular Medicine 2012 18:1861029
    Content type: Research Article Published on:

  17. Heat shock proteins (HSP) have long been considered intracellular chaperones that possess housekeeping and cytoprotective functions. Consequently, HSP overexpression was proposed as a potential therapy for neu...

    Authors: María José Mansilla, Xavier Montalban and Carmen Espejo
    Citation: Molecular Medicine 2012 18:1861018
    Content type: Review Article Published on:

  18. Spinal muscular atrophy (SMA) is an inherited neurodegenerative disorder and the first genetic cause of death in childhood. SMA is caused by low levels of survival motor neuron (SMN) protein that induce select...

    Authors: Michela Murdocca, Arianna Malgieri, Andrea Luchetti, Luciano Saieva, Gabriella Dobrowolny, Elvira de Leonibus, Antonio Filareto, Maria Chiara Quitadamo, Giuseppe Novelli, Antonio Musarò and Federica Sangiuolo
    Citation: Molecular Medicine 2012 18:18071076
    Content type: Research Article Published on:

  19. Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the eme...

    Authors: Ian M. Copple, Amy E. Mercer, James Firman, Gail Donegan, Bram Herpers, Michael H. L. Wong, James Chadwick, Andreia D. Bringela, Maria L. S. Cristiano, Bob van de Water, Stephen A. Ward, Paul M. O’Neill and B. Kevin Park
    Citation: Molecular Medicine 2012 18:18071045
    Content type: Research Article Published on:

  20. CXC chemokine receptor (CXCR)-4 agonists have been shown to attenuate inflammation and organ injury in various disease models, including trauma/hemorrhage. The pathophysiological role of CXCR4 during the early...

    Authors: Harold H. Bach IV, Vikas Saini, Todd A. Baker, Abhishek Tripathi, Richard L. Gamelli and Matthias Majetschak
    Citation: Molecular Medicine 2012 18:18071056
    Content type: Research Article Published on:

  22. Severe sepsis, a syndrome that complicates infection and injury, affects 750,000 annually in the United States. The acute mortality rate is approximately 30%, but, strikingly, sepsis survivors have a significa...

    Authors: Sangeeta S Chavan, Patricio T Huerta, Sergio Robbiati, S I Valdes-Ferrer, Mahendar Ochani, Meghan Dancho, Maya Frankfurt, Bruce T Volpe, Kevin J Tracey and Betty Diamond
    Citation: Molecular Medicine 2012 18:1806930
    Content type: Research Article Published on:

  24. Fibroblast-like synoviocyte (FLS) invasiveness correlates with articular damage in rheumatoid arthritis (RA), yet little is known about its regulation. In this study we aimed to determine the role of the nucle...

    Authors: Teresina Laragione and Pércio S Gulko
    Citation: Molecular Medicine 2012 18:1861009
    Content type: Research Article Published on:

  25. Recent studies indicate that toll-like receptors (TLRs) are expressed on T cells and that these receptors directly or indirectly activate the adaptive immune system. We have shown previously that acute alcohol...

    Authors: Xiaoling Li, Juan L Rendon, Suhail Akhtar and Mashkoor A Choudhry
    Citation: Molecular Medicine 2012 18:1806982
    Content type: Research Article Published on:

  26. Cardiac hypertrophy is the heart’s response to a variety of extrinsic and intrinsic stimuli, some of which might finally lead up to a maladaptive state. An integral part of the pathogenesis of the hypertrophic...

    Authors: Valentina Sala, Simona Gallo, Christian Leo, Stefano Gatti, Bruce D Gelb and Tiziana Crepaldi
    Citation: Molecular Medicine 2012 18:1806938
    Content type: Review Article Published on:

  27. Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL). We investigated the involvement of apoA-I in diet-induced accumulation of triglycerides in hepatocytes and its potential role ...

    Authors: Eleni A Karavia, Dionysios J Papachristou, Kassiani Liopeta, Irene-Eva Triantaphyllidou, Odyssefs Dimitrakopoulos and Kyriakos E. Kypreos
    Citation: Molecular Medicine 2012 18:1806901
    Content type: Research Article Published on:

  28. Hyperglycemia and inflammation are hallmarks of burn injury. In this study, we used a rat model of hyperglycemia and burn injury to investigate the effects of hyperglycemia on inflammatory responses in the liv...

    Authors: Gabriela A Kulp, Ronald G. Tilton, David N Herndon and Marc G Jeschke
    Citation: Molecular Medicine 2012 18:1806948
    Content type: Research Article Published on:

  29. Sustained inflammatory reactions are common pathological events associated with neuron loss in neurodegenerative diseases. Reported evidence suggests that Toll-like receptor 4 (TLR4) is a key player of neuroin...

    Authors: Massimiliano De Paola, Alessandro Mariani, Paolo Bigini, Marco Peviani, Giovanni Ferrara, Monica Molteni, Sabrina Gemma, Pietro Veglianese, Valeria Castellaneta, Valentina Boldrin, Carlo Rossetti, Chiara Chiabrando, Gianluigi Forloni, Tiziana Mennini and Roberto Fanelli
    Citation: Molecular Medicine 2012 18:1806971
    Content type: Research Article Published on:

  30. Antiestrogen therapy resistance remains a huge stumbling block in the treatment of breast cancer. We have found significant elevation of O6 methylguanine DNA methyl transferase (MGMT) expression in a small sample...

    Authors: George C Bobustuc, Joshua S Smith, Sreeram Maddipatla, Sheila Jeudy, Arati Limaye, Beth Isley, Maria-Lourdes M Caparas, Susan M Constantino, Nikita Shah, Cheryl H Baker, Kalkunte S Srivenugopal, Said Baidas and Santhi D Konduri
    Citation: Molecular Medicine 2012 18:1806913
    Content type: Research Article Published on:

  31. Stemlike cells have been isolated by their ability to efflux Hoechst 33342 dye and are called the side population (SP). We evaluated the effect of axitinib on targeting cancer stemlike cells and enhancing the ...

    Authors: Fang Wang, Yan-jun Mi, Xing-Gui Chen, Xing-ping Wu, Zhenguo Liu, Shu-peng Chen, Yong-ju Liang, Chao Cheng, Kenneth Kin Wah To and Li-wu Fu
    Citation: Molecular Medicine 2012 18:1805887
    Content type: Research Article Published on:

  32. Complement factor B plays a critical role in ischemic tissue injury and autoimmunity. Factor B is dynamically synthesized and released by cells outside of the liver, but the molecules that trigger local factor...

    Authors: David J. Kaczorowski, Melanie J. Scott, John P. Pibris, Amin Afrazi, Atsunori Nakao, Rebecca D. Edmonds, Sodam Kim, Joon H. Kwak, Yujian Liu, Jie Fan and Timothy R. Billiar
    Citation: Molecular Medicine 2012 18:1805851
    Content type: Research Article Published on:

  33. Macrophage migration inhibitory factor (MIF) is an inflammatory cytokine that exerts protective effects during myocardial ischemia/reperfusion injury. We hypothesized that elevated MIF levels in the early post...

    Authors: Christian Stoppe, Gerrit Grieb, Rolf Rossaint, David Simons, Mark Coburn, Andreas Götzenich, Tim Strüssmann, Norbert Pallua, Jürgen Bernhagen and Steffen Rex
    Citation: Molecular Medicine 2012 18:1805843
    Content type: Research Article Published on:

  34. Fibrosis affects an extensive range of organs and is increasingly acknowledged as a major component of many chronic disorders. It is now well accepted that the elevated expression of certain inflammatory cell-...

    Authors: Eun Hye H. Shin, M. Albert Basson, Michael L. Robinson, John W. McAvoy and Frank J. Lovicu
    Citation: Molecular Medicine 2012 18:1805861
    Content type: Research Article Published on:

  35. The uptake and clearance of apoptotic cells by macrophages and other phagocytic cells, a process called efferocytosis, is a major component in the resolution of inflammation. Increased concentrations of extrac...

    Authors: Arnaud Friggeri, Sami Banerjee, Na Xie, Huachun Cui, Andressa de Freitas, Mourad Zerfaoui, Hervé Dupont, Edward Abraham and Gang Liu
    Citation: Molecular Medicine 2012 18:1805825
    Content type: Research Article Published on:

  36. Indoleamine 2,3-dioxygenase (IDO), a metabolic enzyme that catalyzes tryptophan conversion into kynurenines, is a crucial regulator of immunity. Altered IDO activity is often associated with pathology, includi...

    Authors: Ciriana Orabona, Maria Teresa Pallotta and Ursula Grohmann
    Citation: Molecular Medicine 2012 18:1805834
    Content type: Invited Review Article Published on:

  37. Despite some advances in the understanding of amyotrophic lateral sclerosis (ALS) pathogenesis, significant achievements in treating this disease are still lacking. Mesenchymal stromal (stem) cells (MSCs) have...

    Authors: Antonio Uccelli, Marco Milanese, Maria Cristina Principato, Sara Morando, Tiziana Bonifacino, Laura Vergani, Debora Giunti, Adriana Voci, Enrico Carminati, Francesco Giribaldi, Claudia Caponnetto and Giambattista Bonanno
    Citation: Molecular Medicine 2012 18:1805794
    Content type: Research Article Published on:

  38. This study was performed to determine whether murine alternatively spliced tissue factor (masTF) acts analogously to human alternatively spliced tissue factor (hasTF) in promoting neovascularization via integr...

    Authors: Richard C. Godby, Yascha W. van den Berg, Ramprasad Srinivasan, Robert Sturm, David Y. Hui, Stephen F. Konieczny, Bruce J. Aronow, Evgeny Ozhegov, Wolfram Ruf, Henri H. Versteeg and Vladimir Y. Bogdanov
    Citation: Molecular Medicine 2012 18:1805771
    Content type: Research Article Published on:

  39. Basal and adaptive β-cell regeneration capacity declines with old age, but the underlying molecular mechanisms remain incompletely understood. Poly (adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP-1) is...

    Authors: Lei Gong, Fu-qiang Liu, Ying Wang, Xin-guo Hou, Wei Zhang, Wei-dong Qin, Yun Zhang, Li Chen and Ming-Xiang Zhang
    Citation: Molecular Medicine 2012 18:1805816
    Content type: Research Article Published on:

  40. Mutations affecting mobile domains of antithrombin induce conformational instability resulting in protein polymerization that associates with a severe clinical phenotype, probably by an unknown gain of functio...

    Authors: Irene Martínez-Martínez, José Navarro-Fernández, Sonia Águila, Antonia Miñano, Nataliya Bohdan, María Eugenia de la Morena-Barrio, Adriana Ordóñez, Constantino Martínez, Vicente Vicente and Javier Corral
    Citation: Molecular Medicine 2012 18:1805762
    Content type: Research Article Published on:

  41. Resistance to docetaxel (DTX) usually occurs in patients with lung adenocarcinoma. To better elucidate the underlying molecular mechanisms involved in resistance to DTX-based chemotherapy, we established a DTX...

    Authors: Rui Wang, Jiayuan Huang, Bing Feng, Wei De and Longbang Chen
    Citation: Molecular Medicine 2012 18:1805874
    Content type: Research Article Published on:

  42. The soluble ectodomain of fibroblast growth factor receptor-IIIc (sFGFR2c) is able to bind to fibroblast growth factor (FGF) ligands and block the activation of the FGF-signaling pathway. In this study, sFGFR2...

    Authors: Wang Ju, Yu Zhihong, Zhou Zhiyou, Huang Qin, Wang Dingding, Sun Li, Zhu Baowei, Wei Xing, He Ying and Hong An
    Citation: Molecular Medicine 2012 18:1806992
    Content type: Research Article Published on:

  43. We investigated whether AMP-activated protein kinase (AMPK), a multifunctional regulator of energy homeostasis, is involved in transient receptor potential vanilloid type 1 (TRPV1)-mediated activation of endot...

    Authors: Li-Chieh Ching, Chien-Yu Chen, Kuo-Hui Su, Hsin-Han Hou, Song-Kun Shyue, Yu Ru Kou and Tzong-Shyuan Lee
    Citation: Molecular Medicine 2012 18:1805805
    Content type: Research Article Published on:

  44. Fabry disease is a panethnic, X-linked, inborn error of glycosphingolipid metabolism resulting from mutations in the α-galactosidase A gene (GLA) that lead to the deficient activity of the lysosomal enzyme, α-gal...

    Authors: Yin-Hsiu Chien, Ni-Chung Lee, Shu-Chuan Chiang, Robert J. Desnick and Wuh-Liang Hwu
    Citation: Molecular Medicine 2012 18:1805780
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2012 18:Art7

  45. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) has been characterized as an important mediator of endogenous cytoprotection in the heart. This study was designed to examine the role of ALDH2 knockout (KO) in t...

    Authors: Jianquan Liao, Aijun Sun, Yeqing Xie, Toyoshi Isse, Toshihiro Kawamoto, Yunzeng Zou and Junbo Ge
    Citation: Molecular Medicine 2012 18:1805785
    Content type: Research Article Published on:

  46. Crohn’s disease (CD) is characterized by the activation of Th1 and Th17 cells and deficiency of regulatory T cells (Tregs), leading to intestine tissue injury and destruction. As a novel cytokine of the interl...

    Authors: Lihua Duan, Jie Chen, Hongwei Zhang, Heng Yang, Ping Zhu, Ali Xiong, Quansong Xia, Fang Zheng, Zheng Tan, Feili Gong and Min Fang
    Citation: Molecular Medicine 2012 18:1805753
    Content type: Research Article Published on:

  47. The mechanism underlying the dysregulation of cholesterol metabolism and inflammation in atherogenesis is not understood fully. Glycine N-methyltransferase (GNMT) has been implicated in hepatic lipid metabolism a...

    Authors: Chien-Yu Chen, Li-Chieh Ching, Yi-Jen Liao, Yuan-Bin Yu, Chia-Yuan Tsou, Song-Kun Shyue, Yi-Ming Arthur Chen and Tzong-Shyuan Lee
    Citation: Molecular Medicine 2012 18:1805744
    Content type: Research Article Published on:

  48. Nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS) is a potent vasodilator and signaling molecule that plays essential roles in neovascularization. During limb ischemia, decreased NO bioav...

    Authors: Jinglian Yan, Guodong Tie and Louis M. Messina
    Citation: Molecular Medicine 2012 18:18081221
    Content type: Research Article Published on:

  49. The major cause for plaque instability in atherosclerotic disease is neoangiogenic revascularization, but the factors controlling this process remain only partly understood. Hedgehog (HH) is a morphogen with i...

    Authors: Karla C. S. Queiroz, Maarten F. Bijlsma, René A. Tio, Clark J. Zeebregts, Marina Dunaeva, Carmen V. Ferreira, Gwenny M. Fuhler, Ernst J. Kuipers, Maria M. Alves, Farhad Rezaee, C. Arnold Spek and Maikel P. Peppelenbosch
    Citation: Molecular Medicine 2012 18:18071122
    Content type: Research Article Published on:

  50. Transplanted individuals in operational tolerance (OT) maintain long-term stable graft function after completely stopping immunosuppression. Understanding the mechanisms involved in OT can provide valuable inf...

    Authors: Hernandez M. Silva, Maisa C. S. Takenaka, Pedro M. M. Moraes-Vieira, Sandra M. Monteiro, Maristela O. Hernandez, Wahiba Chaara, Adrien Six, Fabiana Agena, Patrícia Sesterheim, Florencia Maria Barbé-Tuana, David Saitovitch, Francine Lemos, Jorge Kalil and Verônica Coelho
    Citation: Molecular Medicine 2012 18:1805733
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658