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  1. Jed E Rose, Frédérique M Behm, Tomas Drgon, Catherine Johnson, and George R Uhl (2010) Personalized Smoking Cessation: Interactions between Nicotine Dose, Dependence and Quit-Success Genotype Score.

    Authors: Jed E. Rose, Frédérique M. Behm, Tomas Drgon, Catherine Johnson and George R. Uhl
    Citation: Molecular Medicine 2012 18:1804729
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2010 16:Art2

  2. The author Sang-Kyou Lee has indicated that the two items below need to be corrected for this paper: Yu-Mee Wee, Monica Young Choi, Choong-Hoon Kang, Yang-Hee Kim, Jin-Hee Kim, Sang-Kyou Lee, Seung-Young Yu, S...

    Authors: Yu-Mee Wee, Monica Young Choi, Choong-Hoon Kang, Yang-Hee Kim, Jin-Hee Kim, Sang-Kyou Lee, Seung-Young Yu, Song-Cheol Kim and Duck-Jong Han
    Citation: Molecular Medicine 2012 18:1802321
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2010 16:Art8

  3. Chia-Hung Yen, Yao-Cheng Lu, Chung-Hsien Li, Cheng-Ming Lee, Chia-Yen Chen, Ming-Yuan Cheng, Shiu-Feng Huang, Kuen-Feng Chen, Ann-Lii Cheng, Li-Ying Liao, Yan-Hwa Wu Lee, and Yi-Ming Arthur Chen. (2012) Functi...

    Authors: Chia-Hung Yen, Yao-Cheng Lu, Chung-Hsien Li, Cheng-Ming Lee, Chia-Yen Chen, Ming-Yuan Cheng, Shiu-Feng Huang, Kuen-Feng Chen, Ann-Lii Cheng, Li-Ying Liao, Yan-Hwa Wu Lee and Yi-Ming Arthur Chen
    Citation: Molecular Medicine 2012 18:1803546
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2011 18:Art16

  4. Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J Tracey, and Daniel J Antoine. (2012) Redox Modification of Cysteine ...

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine
    Citation: Molecular Medicine 2012 18:1803545
    Content type: Erratum Published on:

    The original article was published in Molecular Medicine 2011 18:Art13

  5. All-trans retinoic acid, controlled by cytochrome P450, family 26 (CYP26) enzymes, potentially has beneficial effects in atherosclerosis treatment. This study investigates CYP26 subfamily B, polypeptide 1 (CYP26B...

    Authors: Olesya Krivospitskaya, Ali Ateia Elmabsout, Eva Sundman, Leif Å Söderström, Olga Ovchinnikova, Andreas C. Gidlöf, Nikolai Scherbak, Giuseppe Danilo Norata, Ann Samnegård, Hans Törmä, Samy M. Abdel-Halim, Jan-Håkan Jansson, Per Eriksson, Allan Sirsjö and Peder S. Olofsson
    Citation: Molecular Medicine 2012 18:1804712
    Content type: Research Article Published on:

  6. In preclinical studies, erythropoietin (EPO) reduces ischemia-reperfusion-associated tissue injury (for example, stroke, myocardial infarction, acute kidney injury, hemorrhagic shock and liver ischemia). It ha...

    Authors: Nimesh S. A. Patel, Hannah L. Kerr-Peterson, Michael Brines, Massimo Collino, Mara Rogazzo, Roberto Fantozzi, Elizabeth G. Wood, Florence L. Johnson, Muhammad M. Yaqoob, Anthony Cerami and Christoph Thiemermann
    Citation: Molecular Medicine 2012 18:1804719
    Content type: Research Article Published on:

  7. Despite the potent antiinflammatory effects of pharmacologically induced adenosine 5′-monophosphate kinase (AMPK) activation on Toll-like receptor 4 (TLR4)-induced cellular activation, there is little evidence...

    Authors: Jean-Marc Tadie, Hong-Beom Bae, Jessy S. Deshane, Celeste P. Bell, Eduardo R. Lazarowski, David D. Chaplin, Victor J. Thannickal, Edward Abraham and Jaroslaw W. Zmijewski
    Citation: Molecular Medicine 2012 18:1804659
    Content type: Research Article Published on:

  8. Severe burn injury is associated with induction of the hepatic endoplasmic reticulum (ER) stress response. ER stress leads to activation of c-Jun N-terminal kinase (JNK), suppression of insulin receptor signal...

    Authors: Natasha C. Brooks, Juquan Song, Darren Boehning, Robert Kraft, Celeste C. Finnerty, David N. Herndon and Marc G. Jeschke
    Citation: Molecular Medicine 2012 18:1804707
    Content type: Research Article Published on:

  9. Like all cells, neurons adapt to stress by transient alterations in phenotype, an epigenetic response that forms the basis for preconditioning against acute ischemic injury in the central nervous system. We re...

    Authors: Yanli Zhu, Lihong Zhang, Jimena F. Schmidt and Jeffrey M. Gidday
    Citation: Molecular Medicine 2012 18:1804697
    Content type: Research Article Published on:

  10. Numerous human diseases arise because of defects in protein folding, leading to their degradation in the endoplasmic reticulum. Among them is cystic fibrosis (CF), caused by mutations in the gene encoding the ...

    Authors: John P. Holleran, Matthew L. Glover, Kathryn W. Peters, Carol A. Bertrand, Simon C. Watkins, Jonathan W. Jarvik and Raymond A. Frizzell
    Citation: Molecular Medicine 2012 18:1804685
    Content type: Research Article Published on:

  11. To prevent the global spread of tuberculosis (TB) infection, a novel vaccine that triggers potent and long-lived immunity is urgently required. A plasmid-based vaccine has been developed to enhance activation ...

    Authors: Sayma Rahman, Isabelle Magalhaes, Jubayer Rahman, Raija K. Ahmed, Donata R. Sizemore, Charles A. Scanga, Frank Weichold, Frank Verreck, Ivanela Kondova, Jerry Sadoff, Rigmor Thorstensson, Mats Spångberg, Mattias Svensson, Jan Andersson, Markus Maeurer and Susanna Brighenti
    Citation: Molecular Medicine 2012 18:1804647
    Content type: Research Article Published on:

  12. Erythropoietin (EPO) reduces symptoms of experimental autoimmune encephalomyelitis in rodents and shows neuroregenerative effects in chronic progressive multiple sclerosis. The mechanisms of action of EPO in t...

    Authors: Nora Hagemeyer, Susann Boretius, Christoph Ott, Axel von Streitberg, Henrike Welpinghus, Swetlana Sperling, Jens Frahm, Mikael Simons, Pietro Ghezzi and Hannelore Ehrenreich
    Citation: Molecular Medicine 2012 18:1804628
    Content type: Research Article Published on:

  13. Chronic stress is associated with negative health outcomes and is linked with neuroendocrine changes, deleterious effects on innate and adaptive immunity, and central nervous system neuropathology. Although st...

    Authors: Blake T. Gurfein, Andrew W. Stamm, Peter Bacchetti, Mary F. Dallman, Nachiket A. Nadkarni, Jeffrey M. Milush, Chadi Touma, Rupert Palme, Charles Pozzo Di Borgo, Gilles Fromentin, Rachel Lown-Hecht, Jan Pieter Konsman, Michael Acree, Mary Premenko-Lanier, Nicolas Darcel, Frederick M. Hecht…
    Citation: Molecular Medicine 2012 18:1804606
    Content type: Research Article Published on:

  14. Nitric oxide (NO) derived from endothelial nitric oxide synthase (eNOS) is a potent vasodilator and signaling molecule that plays an essential role in vascular remodeling of collateral arteries and perfusion r...

    Authors: Jinglian Yan, Guodong Tie and Louis M. Messina
    Citation: Molecular Medicine 2012 18:1804676
    Content type: Research Article Published on:

  15. Classic risk factors, including age, smoking, serum cholesterol, diabetes and blood pressure, constitute the basis of present risk prediction models but fail to identify all individuals at risk. The objective ...

    Authors: Lasse Folkersen, Jonas Persson, Johan Ekstrand, Hanna E. Agardh, Göran K. Hansson, Anders Gabrielsen, Ulf Hedin and Gabrielle Paulsson-Berne
    Citation: Molecular Medicine 2012 18:1804669
    Content type: Research Article Published on:

  16. Tumor necrosis factor receptor (TNFR) signaling may result in survival, apoptosis or programmed necrosis. The latter is called necroptosis if the receptor-interacting protein 1 (RIP1) inhibitor necrostatin-1 (...

    Authors: Andreas Linkermann, Jan H. Bräsen, Federica De Zen, Ricardo Weinlich, Reto A. Schwendener, Douglas R. Green, Ulrich Kunzendorf and Stefan Krautwald
    Citation: Molecular Medicine 2012 18:1804577
    Content type: Research Article Published on:

  17. Protein A (SpA) of Staphylococcus aureus is known to target the paratope of immunoglobulins expressing VH3 genes, and to delete marginal zone B cells and B-1a in vivo. We have discovered that SpA endows S. aureus

    Authors: Gwenoline Borhis, Muriel Viau, Gamal Badr, Yolande Richard and Moncef Zouali
    Citation: Molecular Medicine 2012 18:1804636
    Content type: Research Article Published on:

  18. Pharmacological targeting of individual ErbB receptors elicits antitumor activity, but is frequently compromised by resistance leading to therapeutic failure. Here, we describe an immunotherapeutic approach th...

    Authors: David M. Davies, Julie Foster, Sjoukje J. C. van der Stegen, Ana C. Parente-Pereira, Laura Chiapero-Stanke, George J. Delinassios, Sophie E. Burbridge, Vincent Kao, Zhe Liu, Leticia Bosshard-Carter, May C. I. van Schalkwyk, Carol Box, Suzanne A. Eccles, Stephen J. Mather, Scott Wilkie and John Maher
    Citation: Molecular Medicine 2012 18:1804565
    Content type: Research Article Published on:

  19. Entry of blood-borne pathogens into the spleen elicits a series of changes in cellular architecture that culminates in the systemic release of protective antibodies. Despite an abundance of work that has chara...

    Authors: Paola Mina-Osorio, Mauricio Rosas-Ballina, Sergio I. Valdes-Ferrer, Yousef Al-Abed, Kevin J. Tracey and Betty Diamond
    Citation: Molecular Medicine 2012 18:1804618
    Content type: Research Article Published on:

  20. CD4+CD25+ regulatory T cells (Tregs) mediate immune suppression and prevent autoimmune disorders. Recently, Tregs were found to present in atherosclerotic lesions and play an important role in the progression of ...

    Authors: Xiao Meng, Kai Zhang, Jingjing Li, Mei Dong, Jianmin Yang, Guipeng An, Weidong Qin, Fei Gao, Cheng Zhang and Yun Zhang
    Citation: Molecular Medicine 2012 18:1804598
    Content type: Research Article Published on:

  21. The nuclear factor (NF)-κB family of transcription factors regulates diverse cellular functions, including inflammation, oncogenesis and apoptosis. It was reported that A20 plays a critical role in the termina...

    Authors: Tadasuke Tsukiyama, Mayuko Matsuda-Tsukiyama, Miyuki Bohgaki, Sayuri Terai, Shinya Tanaka and Shigetsugu Hatakeyama
    Citation: Molecular Medicine 2012 18:1804587
    Content type: Research Article Published on:

  22. The molecular mechanisms determining magnitude and duration of inflammatory pain are still unclear. We assessed the contribution of G protein-coupled receptor kinase (GRK)-6 to inflammatory hyperalgesia in mic...

    Authors: Niels Eijkelkamp, Cobi J. Heijnen, Anibal Garza Carbajal, Hanneke L. D. M. Willemen, Huijing Wang, Michael S. Minett, John N. Wood, Manfred Schedlowski, Robert Dantzer, Keith W. Kelley and Annemieke Kavelaars
    Citation: Molecular Medicine 2012 18:1804556
    Content type: Research Article Published on:

  23. Pulmonary infection with Pseudomonas aeruginosa and neutrophilic lung inflammation significantly contribute to morbidity and mortality in cystic fibrosis (CF). High-mobility group box 1 protein (HMGB1), a ubiquit...

    Authors: Maria Entezari, Daniel J Weiss, Ravikumar Sitapara, Laurie Whittaker, Matthew J Wargo, JianHua Li, Haichao Wang, Huan Yang, Lokesh Sharma, Binh D Phan, Mohammad Javdan, Sangeeta S Chavan, Edmund J Miller, Kevin J Tracey and Lin L Mantell
    Citation: Molecular Medicine 2012 18:1803477
    Content type: Research Article Published on:

  24. Glioblastoma multiforme is a deadly cancer for which current treatment options are limited. The ability of glioblastoma tumor cells to infiltrate the surrounding brain parenchyma critically limits the effectiv...

    Authors: Salvatore J Coniglio, Eliseo Eugenin, Kostantin Dobrenis, E Richard Stanley, Brian L West, Marc H Symons and Jeffrey E Segall
    Citation: Molecular Medicine 2012 18:1803519
    Content type: Research Article Published on:

  25. Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex multifactorial pathogenesis. T lymphocytes play a critical role in disease pathogenesis and display abnormal gene expression and poor ...

    Authors: Vaishali R. Moulton, Dana R. Holcomb, Melissa C. Zajdel and George C. Tsokos
    Citation: Molecular Medicine 2012 18:1803370
    Content type: Research Article Published on:

  26. It has been shown that bridging integrator 1 (BIN1) can interact with c-myelocytomatosis (c-Myc) oncoprotein in cancer. However, the role of BIN1 in hepatocellular carcinoma (HCC) is not clear. In the present stu...

    Authors: Ke Pan, Xiao-ting Liang, Hua-kun Zhang, Jing-jing Zhao, Dan-dan Wang, Jian-jun Li, Qizhou Lian, Alfred E Chang, Qiao Li and Jian-chuan Xia
    Citation: Molecular Medicine 2012 18:1803507
    Content type: Research Article Published on:

  27. The high recurrence rate of secondary cataract (SC) is caused by the intrinsic differentiation activity of residual lens epithelial cells after extra-capsular lens removal. The objective of this study was to i...

    Authors: Andrea Hoffmann, Yusen Huang, Rinako Suetsugu-Maki, Carol S Ringelberg, Craig R Tomlinson, Katia Del Rio-Tsonis and Panagiotis A Tsonis
    Citation: Molecular Medicine 2012 18:1803528
    Content type: Research Article Published on:

  28. Rhodopsin is the G protein-coupled receptor in charge of initiating signal transduction in rod photoreceptor cells upon the arrival of the photon. D190N (RhoD190n), a missense mutation in rhodopsin, causes autoso...

    Authors: Javier Sancho-Pelluz, Joaquin Tosi, Chun-Wei Hsu, Frances Lee, Kyle Wolpert, Mirela R. Tabacaru, Jonathan P. Greenberg, Stephen H. Tsang and Chyuan-Sheng Lin
    Citation: Molecular Medicine 2012 18:1804549
    Content type: Research Article Published on:

  30. α-1 Antitrypsin (A1AT) is a serpin with a major protective effect against cigarette smoke-induced emphysema development, and patients with mutations of the A1AT gene display a markedly increased risk for devel...

    Authors: Angelia D Lockett, Mary Van Demark, Yuan Gu, Kelly S Schweitzer, Ninotchka Sigua, Krzysztof Kamocki, Iwona Fijalkowska, Jana Garrison, Amanda J Fisher, Karina Serban, Robert A Wise, Terence R Flotte, Christian Mueller, Robert G Presson Jr., Horia I Petrache, Rubin M Tuder…
    Citation: Molecular Medicine 2012 18:1803445
    Content type: Research Article Published on:

  31. Gene therapy studies for Duchenne muscular dystrophy (DMD) have focused on viral vector-mediated gene transfer to provide therapeutic protein expression or treatment with drugs to limit dystrophic changes in m...

    Authors: Daniel P Reay, Gabriela A Niizawa, Jon F Watchko, Molly Daood, Ja’Nean C Reay, Eugene Raggi and Paula R Clemens
    Citation: Molecular Medicine 2012 18:1803466
    Content type: Research Article Published on:

  32. The aim was to expand recently published information regarding the significance of the interleukin (IL)-8/p-STAT-3 (signal transducer and activator of transcription) pathway in astrocytomas, focusing on the IL...

    Authors: Penelope Korkolopoulou, Georgia Levidou, Elias A. El-Habr, Christos Adamopoulos, Vassilis Samaras, Athanasios Zisakis, Nikolaos Kavantzas, Efstathios Boviatsis, Paraskevi Fragkou, Athanasios G. Papavassiliou, Efstratios Patsouris and Christina Piperi
    Citation: Molecular Medicine 2012 18:1803379
    Content type: Research Article Published on:

  33. Phagocytosis of apoptotic cells by macrophages, known as efferocytosis, is a critical process in the resolution of inflammation. High mobility group box 1 (HMGB1) protein was first described as a nuclear nonhi...

    Authors: Kasey Davis, Sami Banerjee, Arnaud Friggeri, Celeste Bell, Edward Abraham and Mourad Zerfaoui
    Citation: Molecular Medicine 2011 18:1803359
    Content type: Research Article Published on:

  34. Milk fat globule-epidermal growth factor 8 (MFG-E8) plays an important role in maintaining intestinal barrier homeostasis and accelerating intestinal restitution. However, studies of MFG-E8 expression in human...

    Authors: Qiu-jie Zhao, Yan-bo Yu, Xiu-li Zuo, Yan-yan Dong and Yan-qing Li
    Citation: Molecular Medicine 2011 18:1803497
    Content type: Research Article Published on:

  36. The immune response to infection or injury coordinates host defense and tissue repair, but also has the capacity to damage host tissues. Recent advances in understanding protective mechanisms have found neural...

    Authors: Peder S Olofsson, David A Katz, Mauricio Rosas-Ballina, Yaakov A Levine, Mahendar Ochani, Sergio I Valdés-Ferrer, Valentin A Pavlov, Kevin J Tracey and Sangeeta S Chavan
    Citation: Molecular Medicine 2011 18:1803539
    Content type: Research Article Published on:

  37. Tissue injury, hypoxia and significant metabolic stress activate innate immune responses driven by tumor necrosis factor (TNF)-α and other proinflammatory cytokines that typically increase damage surrounding a...

    Authors: Michael Brines and Anthony Cerami
    Citation: Molecular Medicine 2011 18:1803486
    Content type: Review Article Published on:

  38. Nonalcoholic fatty liver disease (NAFLD) is associated with the development of metabolic syndromes and hepatocellular carcinoma (HCC). Cholesterol accumulation is related to NAFLD, whereas its detailed mechani...

    Authors: Yi-Jen Liao, Tzu-Lang Chen, Tzong-Shyuan Lee, Hsiang-An Wang, Chung-Kwe Wang, Li-Ying Liao, Ren-Shyan Liu, Shiu-Feng Huang and Yi-Ming Arthur Chen
    Citation: Molecular Medicine 2011 18:1803412
    Content type: Research Article Published on:

  39. Administration of therapeutic genes to human osteoarthritic (OA) cartilage is a potential approach to generate effective, durable treatments against this slow, progressive disorder. Here, we tested the ability...

    Authors: Anja Weimer, Henning Madry, Jagadeesh K. Venkatesan, Gertrud Schmitt, Janina Frisch, Anna Wezel, Jochen Jung, Dieter Kohn, Ernest F Terwilliger, Stephen B. Trippel and Magali Cucchiarini
    Citation: Molecular Medicine 2011 18:1803346
    Content type: Research Article Published on:

  40. Homeobox D10 (HoxD10) gene plays a critical role in cell differentiation and morphogenesis during development. However, the function of HoxD10 in tumor progression remains largely unknown. We demonstrate that the...

    Authors: Liangjing Wang, Shujie Chen, Meng Xue, Jing Zhong, Xian Wang, Lihong Gan, Emily K. Y. Lam, Xin Liu, Jianbin Zhang, Tianhua Zhou, Jun Yu, Hongchuan Jin and Jianmin Si
    Citation: Molecular Medicine 2011 18:1803389
    Content type: Research Article Published on:

  41. Prostaglandin I2 (PGI2) analog is regarded as a potential candidate for treating asthma. Human myeloid dendritic cells (mDCs) play a critical role in the pathogenesis of asthma. However, the effects of PGI2 analo...

    Authors: Chang-Hung Kuo, Ching-Hsiung Lin, San-Nan Yang, Ming-Yii Huang, Hsiu-Lin Chen, Po-Lin Kuo, Ya-Ling Hsu, Shau-Ku Huang, Yuh-Jyh Jong, Wan-Ju Wei, Yi-Pin Chen and Chih-Hsing Hung
    Citation: Molecular Medicine 2011 18:1803433
    Content type: Research Article Published on:

  42. The fragile X mental retardation protein (FMRP) plays a key role for neurotransmitter-mediated signaling upstream of neuronal protein synthesis. Functional loss of FMRP causes the inherited intellectual disabi...

    Authors: Christina Gross and Gary J. Bassell
    Citation: Molecular Medicine 2011 18:1803336
    Content type: Research Article Published on:

  43. Delayed neutrophil apoptosis and overshooting neutrophil activity contribute to organ dysfunction and subsequent organ failure in sepsis. Here, we investigated apoptotic signaling pathways that are involved in...

    Authors: Adnana Paunel-Görgülü, Tamara Kirichevska, Tim Lögters, Joachim Windolf and Sascha Flohé
    Citation: Molecular Medicine 2011 18:1803325
    Content type: Invited Research Article Published on:

  45. Recurrent respiratory papillomatosis (RRP) is caused by human papillomaviruses (HPVs), primarily types 6 and 11. The disease is characterized by multiple recurrences of airway papillomas, resulting in high lev...

    Authors: Alexandra V. Lucs, Rong Wu, Virginia Mullooly, Allan L. Abramson and Bettie M. Steinberg
    Citation: Molecular Medicine 2011 18:1802244
    Content type: Research Article Published on:

  46. Mitochondria play a critical role in metabolic homeostasis of a cell. Our recent studies, based on the reported interrelationship between c-Myc and Sirt1 (mammalian orthologue of yeast sir2 [silent information...

    Authors: Bixi Jian, Shaolong Yang, Irshad H. Chaudry and Raghavan Raju
    Citation: Molecular Medicine 2011 18:1802209
    Content type: Research Article Published on:

  47. Mesenchymal stem cell (MSC) therapy is considered one of the most promising approaches for treating different neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). We previously character...

    Authors: Laura Canzi, Valeria Castellaneta, Stefania Navone, Sara Nava, Marta Dossena, Ileana Zucca, Tiziana Mennini, Paolo Bigini and Eugenio A Parati
    Citation: Molecular Medicine 2011 18:1803401
    Content type: Research Article Published on:

  48. The nuclear protein high mobility group box protein 1 (HMGB1) promotes inflammation upon extracellular release. HMGB1 induces proinflammatory cytokine production in macrophages via Toll-like receptor (TLR)-4 s...

    Authors: Hulda Sigridur Hreggvidsdóttir, Anna M. Lundberg, Ann-Charlotte Aveberger, Lena Klevenvall, Ulf Andersson and Helena Erlandsson Harris
    Citation: Molecular Medicine 2011 18:1802224
    Content type: Research Article Published on:

  49. Serum levels of vitamin D levels are commonly reduced in patients with rheumatoid arthritis (RA) and have been implicated in disease pathogenesis. We recently identified a new vitamin D receptor transcriptiona...

    Authors: Teresina Laragione, Anish Shah and Pércio S. Gulko
    Citation: Molecular Medicine 2011 18:1802194
    Content type: Research Article Published on:

  50. The fundamental mechanisms that underlie platelet activation in atherothrombosis are still obscure. Oxidative stress is involved in central features of atherosclerosis. Platelet-derived microvesicles (PMVs) co...

    Authors: Hua Wang, Zhi-Hao Wang, Jing Kong, Meng-Yun Yang, Gui-Hua Jiang, Xu-Ping Wang, Ming Zhong, Yun Zhang, Jing-Ti Deng and Wei Zhang
    Citation: Molecular Medicine 2011 18:1802159
    Content type: Research Article Published on:
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ISSN: 1528-3658