Skip to main content

Advertisement

We're creating a new version of this page. See preview

  • Erratum
  • Open Access

Erratum to: Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1)

  • 1,
  • 2,
  • 2,
  • 2,
  • 3,
  • 3,
  • 4,
  • 2,
  • 1 and
  • 5Email author
Molecular Medicine201218:1803545

https://doi.org/10.2119/molmed.2012.00002.erratum

  • Published:

The original article was published in Molecular Medicine 2011 18:1802250

Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J Tracey, and Daniel J Antoine. (2012) Redox Modification of Cysteine Residues Regulates the Cytokine Activity of High Mobility Group Box-1 (HMGB1). Mol. Med. 18(2):250–259.

In Table 2 of this paper, the second through fifth lines of the “Histological findings” entry was presented incorrectly and should have been shifted one column to the right; below is what was published:

Histological findings

No abnormalities detected necrosis with mild inflammatory cell infiltration

Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling)

Centrilobular hepatocyte detected

No abnormalities

Below is corrected Table 2.
Table 2

Overview of hepatic histological changes (extent of hepatic damage determined by serum ALT activity) induced by acetaminophen over time in mice and corresponding serum HMGB1 redox status.

Time post-APAP treatmenta

0 h

5 h

15 h

24 h

Histological findings

No abnormalities detected

Centrilobular hepatocyte necrosis with mild inflammatory cell infiltration

Centrilobular hepatocyte necrosis with moderate inflammatory cell infiltration (including neutrophil rolling)

No abnormalities detected

Serum ALT (U/L)b

31 ± 10

2641 ± 1,024c

3,015 ± 801c

3,811 ± 1,514c

Serum HMGB1 cysteine redox status identified

Molecule A

Molecule A + D

Molecule A + D

Molecule D

aThe corresponding LC-MS/MS characterized redox status of each cysteine within circulating HMGB1 also is given for each time point.

bData are presented as mean ± SEM with six animals per group.

cP < 0.01 versus 0 h.

Notes

Authors’ Affiliations

(1)
Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, Manhasset, New York, USA
(2)
Departments of Women’s and Children’s Health, Medicine and Rheumatology Research Laboratory, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
(3)
San Raffaele University and Scientific Institute, Milan, Italy
(4)
Department of Medicinal Chemistry, The Feinstein Institute for Medical Research, Manhasset, New York, USA
(5)
MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK, L69 3GE

Copyright

© The Author(s) 2012

Advertisement