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Page 28 of 37

  1. Traumatic brain injury (TBI) and hemorrhagic shock often occur concomitantly due to multiple injuries. Gastrointestinal dysfunction occurs frequently in patients with TBI. However, whether alterations in the g...

    Authors: Lei Qi, Xiaoxuan Cui, Weifeng Dong, Rafael Barrera, Jeffrey Nicastro, Gene F. Coppa, Ping Wang and Rongqian Wu
    Citation: Molecular Medicine 2011 18:1802186
  2. Glycine N-methyltransferase (GNMT) is a tumor suppressor for hepatocellular carcinoma (HCC). High rates of Gnmt knockout mice developed HCC. Epigenetic alteration and dysregulation of several pathways including w...

    Authors: Chia-Hung Yen, Yao-Cheng Lu, Chung-Hsien Li, Cheng-Ming Lee, Chia-Yen Chen, Ming-Yuan Cheng, Shiu-Feng Huang, Kuen-Feng Chen, Ann-Lii Cheng, Li-Ying Liao, Yan-Hwa Wu Lee and Yi-Ming Arthur Chen
    Citation: Molecular Medicine 2011 18:1802286

    The Erratum to this article has been published in Molecular Medicine 2012 18:Art23

  3. The insulin receptor substrate (IRS) proteins are key mediators of insulin and insulinlike growth factor 1 (IGF-1) signaling. Protein tyrosine phosphatase (PTP)-1B dephosphorylates and inactivates both insulin...

    Authors: Silvia Murillo-Cuesta, Guadalupe Camarero, Águeda González-Rodriguez, Lourdes Rodríguez-de la Rosa, Deborah J. Burks, Carlos Avendaño, Ángela M. Valverde and Isabel Varela-Nieto
    Citation: Molecular Medicine 2011 18:1802260
  4. Hereditary cerebral hemorrhage with amyloidosis-Dutch type is a disorder associated with a missense mutation (E693Q) in the β-amyloid (Aβ)-coding region of the amyloid precursor protein (APP). This familial di...

    Authors: Alexandra M. Nicholson, Lindsey A. Wold, Dominic M. Walsh and Adriana Ferreira
    Citation: Molecular Medicine 2011 18:1802178
  5. Monocytes emigrate from bone marrow, can infiltrate into brain, differentiate into microglia and clear amyloid β (Aβ) from the brain of mouse models of Alzheimer’s disease (AD). Here we show that these mechani...

    Authors: Gaëlle Naert and Serge Rivest
    Citation: Molecular Medicine 2011 18:1802297
  6. Antenatal stimulation of lung growth is a reasonable approach to treat congenital diaphragmatic hernia (CDH), a disease characterized by pulmonary hypoplasia and hypertension. Several evidences from the litera...

    Authors: Cristina Nogueira-Silva, Emanuel Carvalho-Dias, Paulina Piairo, Susana Nunes, Maria J. Baptista, Rute S. Moura and Jorge Correia-Pinto
    Citation: Molecular Medicine 2011 18:1802231
  7. Pulmonary hypertension (PH) is a devastating disease leading to progressive hypoxemia, right ventricular failure, and death. Hypoxia can play a pivotal role in PH etiology, inducing pulmonary vessel constricti...

    Authors: Yinzhong Zhang, Arunabh Talwar, Donna Tsang, Annette Bruchfeld, Ali Sadoughi, Maowen Hu, Kennedy Omonuwa, Kai Fan Cheng, Yousef Al-Abed and Edmund J. Miller
    Citation: Molecular Medicine 2011 18:1802215
  8. The Met receptor tyrosine kinase is overexpressed and/or activated in variety of human malignancies. Previously we have shown that c-Met is overexpressed in Middle Eastern papillary thyroid carcinoma (PTC) and...

    Authors: Rong Bu, Shahab Uddin, Maqbool Ahmed, Azhar R. Hussain, Saif Alsobhi, Tarek Amin, Abdurahman Al-Nuaim, Fouad Al-Dayel, Jehad Abubaker, Prashant Bavi and Khawla S. Al-Kuraya
    Citation: Molecular Medicine 2011 18:1802167
  9. Common dietary components including vitamins A and D, omega-3 and probiotics are now widely accepted to be essential to protect against many diseases with an inflammatory nature. On the other hand, high-fat di...

    Authors: Shohreh Issazadeh-Navikas, Roman Teimer and Robert Bockermann
    Citation: Molecular Medicine 2011 18:1801095
  10. Natural killer (NK) cells were first described as immune leukocytes that could kill tumor cells and soon after were reported to kill virus-infected cells. In the mid-1980s, 10 years after their discovery, NK c...

    Authors: Fernando Souza-Fonseca-Guimaraes, Minou Adib-Conquy and Jean-Marc Cavaillon
    Citation: Molecular Medicine 2011 18:1802270
  11. The pathogenesis of sepsis is complex and, unfortunately, poorly understood. The cellular process of autophagy is believed to play a protective role in sepsis; however, the mechanisms responsible for its regul...

    Authors: Lemeng Zhang, Jon S. Cardinal, Runalia Bahar, John Evankovich, Hai Huang, Gary Nace, Timothy R. Billiar, Matthew R. Rosengart, Pinhua Pan and Allan Tsung
    Citation: Molecular Medicine 2011 18:1802201
  12. High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is released passively during cell injury and necrosis, and secreted actively by immune cells. HMGB1 ...

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine
    Citation: Molecular Medicine 2011 18:1802250

    The Retraction Note to this article has been published in Molecular Medicine 2020 26:133

    The Erratum to this article has been published in Molecular Medicine 2012 18:Art22

    The Expression of Concern to this article has been published in Molecular Medicine 2020 26:18

  13. Although rapidly becoming a valuable tool for gene silencing, regulation or editing in vitro, the direct transfer of small interfering ribonucleic acids (siRNAs) into cells is still an unsolved problem for in viv...

    Authors: Wilfried Posch, Stefan Piper, Thomas Lindhorst, Birgit Werner, Adam Fletcher, Holger Bock, Cornelia Lass-Flörl, Heribert Stoiber and Doris Wilflingseder
    Citation: Molecular Medicine 2011 18:1801111
  14. Reverse cholesterol transport (RCT) has been characterized as a crucial step for antiatherosclerosis, which is initiated by ATP-binding cassette A1 (ABCA1) to mediate the efflux of cellular phospholipids and c...

    Authors: Guo-Jun Zhao, Kai Yin, Yu-chang Fu and Chao-Ke Tang
    Citation: Molecular Medicine 2011 18:1802149
  15. Hypoxia leads to free radical production, which has a pivotal role in the pathophysiology of pulmonary hypertension (PH). We hypothesized that treatment with extracellular superoxide dismutase (EC-SOD) could a...

    Authors: Mohamed N. Ahmed, Yinzhong Zhang, Champa Codipilly, Nahla Zaghloul, Dhara Patel, Michael Wolin and Edmund J. Miller
    Citation: Molecular Medicine 2011 18:1801038
  16. Suppression of the immune system after the resolution of infection or inflammation is an important process that limits immune-mediated pathogenesis and autoimmunity. Several mechanisms of immune suppression ha...

    Authors: Matthew W. Klinker and Steven K. Lundy
    Citation: Molecular Medicine 2011 18:1801123
  17. To economically produce recombinant human a-galactosidase A (GLA) with a cell culture system that does not require bovine serum, we chose methylotrophic yeast cells with the OCH1 gene, which encodes α-l,6-mannosy...

    Authors: Takahiro Tsukimura, Ikuo Kawashima, Tadayasu Togawa, Takashi Kodama, Toshihiro Suzuki, Toru Watanabe, Yasunori Chiba, Yoshifumi Jigami, Tomoko Fukushige, Takuro Kanekura and Hitoshi Sakuraba
    Citation: Molecular Medicine 2011 18:1801076
  18. Topoisomerase I is a privileged target for widely used anticancer agents such as irinotecan. Although these drugs are classically considered to be DNA-damaging agents, increasing evidence suggests that they mi...

    Authors: Eric Guérin, Wolfgang Raffelsberger, Erwan Pencreach, Armin Maier, Agnès Neuville, Anne Schneider, Philippe Bachellier, Serge Rohr, Amélie Petitprez, Olivier Poch, Dino Moras, Pierre Oudet, Annette K. Larsen, Marie-Pierre Gaub and Dominique Guenot
    Citation: Molecular Medicine 2011 18:1801083
  19. Many tumors present with increased activation of the phosphatidylinositol 3-kinase (PI3K)-PtdIns(3,4,5)P3-protein kinase B (PKB/Akt) signaling pathway. It has long been thought that the lipid phosphatases SH2 dom...

    Authors: Gwenny M. Fuhler, Robert Brooks, Bonnie Toms, Sonia Iyer, Elizabeth A. Gengo, Mi-Young Park, Matthew Gumbleton, Dennis R. Viernes, John D. Chisholm and William G. Kerr
    Citation: Molecular Medicine 2011 18:1801065
  20. Remote ischemic preconditioning (RIPC) can be induced by transient occlusion of blood flow to a limb with a blood pressure cuff and exerts multiorgan protection from ischemia/reperfusion injury. Ischemia/reper...

    Authors: Karina Zitta, Patrick Meybohm, Berthold Bein, Christin Heinrich, Jochen Renner, Jochen Cremer, Markus Steinfath, Jens Scholz and Martin Albrecht
    Citation: Molecular Medicine 2011 18:1801029
  21. Pulmonary fibrosis develops in Hermansky-Pudlak syndrome (HPS) types 1 and 4. Limited information is available about lung disease in HPS type 2 (HPS-2), which is characterized by abnormal function of the adapt...

    Authors: Bernadette R. Gochuico, Marjan Huizing, Gretchen A. Golas, Charles D. Scher, Maria Tsokos, Stacey D. Denver, Melissa J. Frei-Jones and William A. Gahl
    Citation: Molecular Medicine 2011 18:1801056
  22. Ocular angiogenesis, characterized by the formation of new blood vessels in the avascular area in eyes, is a highly coordinated process involved in retinal vasculature formation and several ocular diseases suc...

    Authors: Guo-Rui Dou, Lin Wang, Yu-Sheng Wang and Hua Han
    Citation: Molecular Medicine 2011 18:1801047
  23. The role of histamine as a newly recognized sympathetic neurotransmitter has been presented previously, and its postsynaptic effects greatly depended on the activities of sympathetic nerves. Cardiac sympatheti...

    Authors: Gonghao He, Jing Hu, Teng Li, Xue Ma, Jingru Meng, Min Jia, Jun Lu, Hiroshi Ohtsu, Zhong Chen and Xiaoxing Luo
    Citation: Molecular Medicine 2011 18:1801001
  24. We have previously shown that sorafenib, a multikinase inhibitor, exhibits cytotoxic effects on chronic lymphocytic leukemia (CLL) cells. Because the cellular microenvironment can protect CLL cells from drug-i...

    Authors: Jessie-F. Fecteau, Ila S. Bharati, Morgan O’Hayre, Tracy M. Handel, Thomas J. Kipps and Davorka Messmer
    Citation: Molecular Medicine 2011 18:1801019
  25. Leptin, a key hormone in regulating energy homeostasis, is mainly produced by adipocytes. Cogent evidence indicates a unique role of leptin in the promotion of liver fibrosis. Hepatic stellate cell (HSC) activ...

    Authors: Kunfeng Yan, Xiong Deng, Xuguang Zhai, Mingming Zhou, Xin Jia, Lin Luo, Minghui Niu, Huixia Zhu, Hui Qiang and Yajun Zhou
    Citation: Molecular Medicine 2011 18:1801010
  26. Thoracic aortic aneurysm (TAA) is a common complication in patients with a bicuspid aortic valve (BAV), the most frequent congenital heart disorder. For unknown reasons TAA occurs at a younger age, with a high...

    Authors: Lasse Folkersen, Dick Wågsäter, Valentina Paloschi, Veronica Jackson, Johan Petrini, Sanela Kurtovic, Shohreh Maleki, Maria J. Eriksson, Kenneth Caidahl, Anders Hamsten, Jean-Baptiste Michel, Jan Liska, Anders Gabrielsen, Anders Franco-Cereceda and Per Eriksson
    Citation: Molecular Medicine 2011 17:17111365
  27. The frequent occurrence of stereotyped heavy complementarity-determining region 3 (VH CDR3) sequences among unrelated cases with chronic lymphocytic leukemia (CLL) is widely taken as evidence for antigen selec...

    Authors: Eugenia Tsakou, Andreas Agathagelidis, Myriam Boudjoghra, Thorsten Raff, Antonis Dagklis, Maria Chatzouli, Tatjana Smilevska, George Bourikas, Helene Merle-Beral, Eleni Manioudaki-Kavallieratou, Achilles Anagnostopoulos, Monika Brüggemann, Frederic Davi, Kostas Stamatopoulos and Chrysoula Belessi
    Citation: Molecular Medicine 2011 18:1801138

    The Erratum to this article has been published in Molecular Medicine 2013 19:Art41

  28. The failure of chemotherapeutic regimens to eradicate cancers often results from the outgrowth of minor subclones with more dangerous genomic abnormalities or with self-renewing capacity. To explore such intra...

    Authors: Carlo Calissano, Rajendra N. Damle, Sonia Marsilio, Xiao-Jie Yan, Sophia Yancopoulos, Gregory Hayes, Claire Emson, Elizabeth J. Murphy, Marc K. Hellerstein, Cristina Sison, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, Ivana Ivanovic, Igor M. Dozmorov…
    Citation: Molecular Medicine 2011 17:17111374

    The Correction to this article has been published in Molecular Medicine 2022 28:35

  29. Although serum amyloid A (SAA) is an excellent marker for coronary artery disease, its direct effect on atherogenesis in vivo is obscure. In this study we investigated the direct effect of SAA on promoting the fo...

    Authors: Zhe Dong, Tingting Wu, Weidong Qin, Chuankai An, Zhihao Wang, Mingxiang Zhang, Yun Zhang, Cheng Zhang and Fengshuang An
    Citation: Molecular Medicine 2011 17:17111357
  30. The mediators of tissue damage in systemic lupus erythematosus (SLE) such as antibodies, cytokines and activated immune cells have direct access to most organs in the body but must penetrate the blood-brain ba...

    Authors: Meggan Mackay, Mathew P. Bussa, Cynthia Aranow, Aziz M. Uluğ, Bruce T. Volpe, Patricio T. Huerta, Miklos Argyelan, Arthur Mandel, Joy Hirsch, Betty Diamond and David Eidelberg
    Citation: Molecular Medicine 2011 17:17111349
  31. Various biomarkers currently used for the diagnosis of intestinal mucosal injury (IMI) in patients with acute intestinal obstruction have low sensitivity and specificity. In the present study, IMI, as indicate...

    Authors: Jian-Jun Yang, Yan-Lei Ma, Peng Zhang, Hong-Qi Chen, Zhi-Hua Liu and Huan-Long Qin
    Citation: Molecular Medicine 2011 17:17111323
  32. It has long been shown that many of the presently used anticancer drugs exert their effects partly through modulating the activity of vital transcription factors. The intricacy of transcriptional regulation st...

    Authors: Michalis V. Karamouzis and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2011 17:17111133
  33. The German Multicenter EPO Stroke Trial, which investigated safety and efficacy of erythropoietin (EPO) treatment in ischemic stroke, was formally declared a negative study. Exploratory subgroup analysis, howe...

    Authors: Hannelore Ehrenreich, Anne Kästner, Karin Weissenborn, Jackson Streeter, Swetlana Sperling, Kevin K. Wang, Hans Worthmann, Ronald L. Hayes, Nico von Ahsen, Andreas Kastrup, Andreas Jeromin and Manfred Herrmann
    Citation: Molecular Medicine 2011 17:17111306
  34. Endoplasmic reticulum (ER) stress-associated apoptosis plays a role in organ remodeling after insult. The effect of ER stress on renal tubular damage and fibrosis remains controversial. This study aims to inve...

    Authors: Chih-Kang Chiang, Shih-Ping Hsu, Cheng-Tien Wu, Jenq-Wen Huang, Hui-Teng Cheng, Yi-Wen Chang, Kuan-Yu Hung, Kuan-Dun Wu and Shing-Hwa Liu
    Citation: Molecular Medicine 2011 17:17111295
  35. Ovarian cancer is the number one cause of death from gynecologic malignancy. A defective p53 pathway is a hallmark of ovarian carcinoma. The p53 mutation correlates significantly with resistance to platinum-ba...

    Authors: Zhu Yuan, Kang Cao, Chao Lin, Lei Li, Huan-yi Liu, Xin-yu Zhao, Lei Liu, Hong-xin Deng, Jiong Li, Chun-lai Nie and Yu-quan Wei
    Citation: Molecular Medicine 2011 17:17111262
  36. Mounting evidence suggests that the blueprint of chronic renal disease is established during early development by environmental cues that dictate alterations in differentiation programming. Here we show that a...

    Authors: M. Hadi Falahatpisheh, Adrian Nanez and Kenneth S. Ramos
    Citation: Molecular Medicine 2011 17:17111275
  37. Mutations in the CLN3 gene lead to juvenile neuronal ceroid lipofuscinosis, a pediatric neurodegenerative disorder characterized by visual loss, epilepsy and psychomotor deterioration. Although most CLN3 patients...

    Authors: Anne-Hélène Lebrun, Parisa Moll-Khosrawi, Sandra Pohl, Georgia Makrypidi, Stephan Storch, Dirk Kilian, Thomas Streichert, Benjamin Otto, Sara E. Mole, Kurt Ullrich, Susan Cotman, Alfried Kohlschütter, Thomas Braulke and Angela Schulz
    Citation: Molecular Medicine 2011 17:17111253
  38. Dysregulated release of neutrophil azurophilic granules causes increased tissue damage and amplified inflammation during autoimmune disease. Antineutrophil cytoplasmic antibodies (ANCAs) are implicated in the ...

    Authors: Neil J. Holden, Caroline O. S. Savage, Stephen P. Young, Michael J. Wakelam, Lorraine Harper and Julie M. Williams
    Citation: Molecular Medicine 2011 17:17111242
  39. Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In t...

    Authors: Ning Wang, Nan Shen, Timothy J. Vyse, Vidya Anand, Iva Gunnarson, Gunnar Sturfelt, Solbritt Rantapää-Dahlqvist, Kerstin Elvin, Lennart Truedsson, Bengt A. Andersson, Charlotte Dahle, Eva Örtqvist, Peter K. Gregersen, Timothy W. Behrens and Lennart Hammarström
    Citation: Molecular Medicine 2011 17:17111383
  40. MicroRNAs (miRNAs) play an important regulatory role in breast tumorigenesis. Previously, we found that let-7 miRNAs were downregulated significantly in formalin-fixed paraffin-embedded (FFPE) breast cancer tissu...

    Authors: Yingchun Zhao, Caishu Deng, Weida Lu, Jing Xiao, Danjun Ma, Mingxi Guo, Robert R. Recker, Zoran Gatalica, Zhaoyi Wang and Gary Guishan Xiao
    Citation: Molecular Medicine 2011 17:17111233
  41. Several cases of T-cell leukemia caused by gammaretroviral insertional mutagenesis in children treated for x-linked severe combined immunodeficiency (SCID) by transplantation of autologous gene-modified stem c...

    Authors: Sebastian Newrzela, Kerstin Cornils, Tim Heinrich, Julia Schläger, Ji-Hee Yi, Olga Lysenko, Janine Kimpel, Boris Fehse and Dorothee von Laer
    Citation: Molecular Medicine 2011 17:17111223
  42. New drug-eluting stent (DES) methods have recently been demonstrated to improve outcomes of intravascular interventions. A novel technique is the design of gene-silencing stents that elute specific small-inter...

    Authors: Andrea Nolte, Tobias Walker, Martina Schneider, Oya Kray, Meltem Avci-Adali, Gerhard Ziemer and Hans Peter Wendel
    Citation: Molecular Medicine 2011 17:17111213
  43. B-cell chronic lymphocytic leukemia (CLL) patients display leukemic clones bearing either germline or somatically mutated immunoglobulin heavy variable (IGHV) genes. Most information on CLL immunoglobulins (Igs),...

    Authors: Fabio Ghiotto, Paolo Marcatili, Claudya Tenca, Maria Grazia Calevo, Xiao-Jie Yan, Emilia Albesiano, Davide Bagnara, Monica Colombo, Giovanna Cutrona, Charles C. Chu, Fortunato Morabito, Silvia Bruno, Manlio Ferrarini, Anna Tramontano, Franco Fais and Nicholas Chiorazzi
    Citation: Molecular Medicine 2011 17:17111188
  44. The present study was designed to investigate the cardiac benefits of M3 muscarinic receptor (M3-mAChR) overexpression and whether these effects are related to the regulation of the inward rectifying K+ channel b...

    Authors: Yan Liu, Lihua Sun, Zhenwei Pan, Yunlong Bai, Ning Wang, Jinlong Zhao, Chaoqian Xu, Zhi Li, Baoxin Li, Zhimin Du, Yanjie Lu, Xu Gao and Baofeng Yang
    Citation: Molecular Medicine 2011 17:17111179
  45. Chronic hepatitis C (CHC) is generally a slowly progressive disease, but some factors associated with rapid progression have been identified. Steatosis, independently of its metabolic or viral origin, leads to...

    Authors: Michał Kukla, Włodzimierz Mazur, Rafał J. Bułdak and Krystyna Żwirska-Korczala
    Citation: Molecular Medicine 2011 17:17111397
  46. Calprotectin has been recently described as a novel marker of obesity. The aim of this study was to determine the circulating concentrations and expression levels of calprotectin subunits (S100A8 and S100A9) i...

    Authors: Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Fernando Rotellar, Victor Valentí, Camilo Silva, María J. Gil, José Manuel Fernández-Real, Javier Salvador and Gema Frühbeck
    Citation: Molecular Medicine 2011 17:17111157
  47. Septic shock is a frequent and costly problem among patients in the pediatric intensive care unit (PICU) and is associated with high mortality and devastating survivor morbidity. Genome-wide expression pattern...

    Authors: James L. Wynn, Natalie Z. Cvijanovich, Geoffrey L. Allen, Neal J. Thomas, Robert J. Freishtat, Nick Anas, Keith Meyer, Paul A. Checchia, Richard Lin, Thomas P. Shanley, Michael T. Bigham, Sharon Banschbach, Eileen Beckman and Hector R. Wong
    Citation: Molecular Medicine 2011 17:17111146
  48. Trimethylation of lysine 27 on histone H3 (H3K27me3) is an epigenetic change which plays a critical role in tumor development and/or progression. However, the molecular status of H3K27me3 and its clinicopathol...

    Authors: Mu-Yan Cai, Zhu-Ting Tong, Wei Zhu, Zhu-Zhi Wen, Hui-Lan Rao, Ling-Ling Kong, Xin-Yuan Guan, Hsiang-Fu Kung, Yi-Xin Zeng and Dan Xie
    Citation: Molecular Medicine 2011 17:17111137

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