Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 38 of 39

  1. Recurrent respiratory papillomas are epithelial tumors of the airway caused by human papillomaviruses. We previously reported that the epidermal growth factor receptor (EGFR) is overexpressed in papilloma cell...

    Authors: Rong Wu, Salvatore J. Coniglio, Amanda Chan, Marc H. Symons and Bettie M. Steinberg
    Citation: Molecular Medicine 2007 13:130030143
    Content type: Research Article Published on:

  2. Many strategies for redirecting the tropism of murine Moloney leukemia virus (MMLV) have been described. Preformed virion-liposome complexes, termed virosomes, have been reported to be relatively stable. Viros...

    Authors: Peng H. Tan, Shao-An Xue, Bin Wei, Angelika Holler, Ralf-Holger Voss and Andrew J. T. George
    Citation: Molecular Medicine 2007 13:130030216
    Content type: Research Article Published on:

  3. High Mobility Group Box-1 (HMGB1) is a cytokine implicated in the pathogenesis of rheumatoid arthritis (RA) and other inflammatory diseases. The cholinergic anti-inflammatory pathway, a vagus nerve-dependent m...

    Authors: Richard S. Goldstein, Annette Bruchfeld, Lihong Yang, Abdul R. Qureshi, Margot Gallowitsch-Puerta, Nirav B. Patel, Brett J. Huston, Sangeeta Chavan, Mauricio Rosas-Ballina, Peter K. Gregersen, Christopher J. Czura, Richard P. Sloan, Andrew E. Sama and Kevin J. Tracey
    Citation: Molecular Medicine 2007 13:130030210
    Content type: Research Article Published on:

  4. Macrophage migration inhibitory factor (MIF) is a ubiquitous cytokine that functions in reproduction and plays an important role in sperm maturation and motility. Here we reveal a correlation between MIF level...

    Authors: Bayan Aljabari, Aldo E. Calogero, Anna Perdichizzi, Enzo Vicari, Raja Karaki, Tarek Lahloub, Rashed Zatari, Khaleel El-Abed, Ferdinando Nicoletti, Edmund J. Miller, Valentin A. Pavlov and Yousef Al-Abed
    Citation: Molecular Medicine 2007 13:130030199
    Content type: Research Article Published on:

  5. Prions are composed solely of the disease-causing prion protein (PrPSc) that is formed from the cellular isoform PrPC by a post-translational process. Here we report that short phosphorothioate DNA (PS-DNA) oligo...

    Authors: Marcela V. Karpuj, Kurt Giles, Sagit Gelibter-Niv, Michael R. Scott, Vishwanath R. Lingappa, Francis C. Szoka, David Peretz, Wilfred Denetclaw and Stanley B. Prusiner
    Citation: Molecular Medicine 2007 13:130030190
    Content type: Research Article Published on:

  6. Advanced glycation end products (AGEs) and their receptor (RAGE) play an important role in accelerated atherosclerosis in diabetes. We have recently found that the soluble form of RAGE (sRAGE) levels are signi...

    Authors: Kazuo Nakamura, Sho-ichi Yamagishi, Hisashi Adachi, Yayoi Kurita-Nakamura, Takanori Matsui, Takafumi Yoshida and Tsutomu Imaizumi
    Citation: Molecular Medicine 2007 13:130030185
    Content type: Research Article Published on:

  7. Recent evidence reveals that the immune system is under the direct control of the vagus nerve via the “cholinergic anti-inflammatory pathway.” Stimulation of vagus nerve activity significantly inhibits cytokin...

    Authors: Richard P. Sloan, Heather McCreath, Kevin J. Tracey, Stephen Sidney, Kiang Liu and Teresa Seeman
    Citation: Molecular Medicine 2007 13:130030178
    Content type: Research Article Published on:

  8. Tuberous Sclerosis Complex (TSC) is a tumor suppressor gene disorder with mutations of TSC1/TSC2 genes. This leads to the development of hamartomas that most frequently affect central nervous system, kidney, a...

    Authors: Stephana Carelli, Elena Lesma, Simona Paratore, Vera Grande, Giorgia Zadra, Silvano Bosari, Anna Maria Di Giulio and Alfredo Gorio
    Citation: Molecular Medicine 2007 13:130030166
    Content type: Research Article Published on:

  9. Angiomyolipomas are benign tumors of the kidney which express phenotypes of smooth muscle, fat, and melanocytes. These tumors appear with increased frequency in the autosomal dominant disorder tuberous scleros...

    Authors: So Dug Lim, William Stallcup, Benjamin Lefkove, Baskaran Govindarajan, Kit Sing Au, Hope Northrup, Deborah Lang, David E. Fisher, Avani Patel, Mahul B. Amin and Jack L. Arbiser
    Citation: Molecular Medicine 2007 13:130030160
    Content type: Research Article Published on:

  10. Phosphatase of regenerating liver-3 (PRL-3) has been proposed to promote the invasion of tumor cells to metastasis sites. However, the effect of PRL-3 on spontaneous metastasis has not been clearly demonstrate...

    Authors: Feng Qian, Yu-Pei Li, Xia Sheng, Zi-Chao Zhang, Ran Song, Wei Dong, Shao-Xian Cao, Zi-Chun Hua and Qiang Xu
    Citation: Molecular Medicine 2007 13:130030151
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2007 13:Art11

  11. Leukocyte infiltration is viewed as a pharmacological target in cerebral ischemia. We previously reported that reparixin, a CXCL8 receptor blocker that inhibits neutrophil infiltration, and related molecules c...

    Authors: Pia Villa, Sara Triulzi, Barbara Cavalieri, Rosa Di Bitondo, Riccardo Bertini, Sara Barbera, Paolo Bigini, Tiziana Mennini, Paolo Gelosa, Elena Tremoli, Luigi Sironi and Pietro Ghezzi
    Citation: Molecular Medicine 2007 13:130030125
    Content type: Research Article Published on:

  12. It has been demonstrated recently that coagulation factor XIII (FXIII) plays an extraordinary role in myocardial healing after infarction, improving survival in a mouse model. Common FXIII gene variants (i.e. ...

    Authors: Donato Gemmati, Federica Federici, Gianluca Campo, Silvia Tognazzo, Maria L. Serino, Monica De Mattei, Marco Valgimigli, Patrizia Malagutti, Gabriele Guardigli, Paolo Ferraresi, Francesco Bernardi, Roberto Ferrari, Gian L. Scapoli and Linda Catozzi
    Citation: Molecular Medicine 2007 13:1301112
    Content type: Research Article Published on:

  13. In animal models of conotruncal heart defects, an abnormal calcium sensitivity of the contractile apparatus and a depressed L-type calcium current have been described. Sarcoplasmic reticulum (SR) Ca2+ ATPase (SER...

    Authors: Simona Vittorini, Simona Storti, Maria Serena Parri, Alfredo Giuseppe Cerillo and Aldo Clerico
    Citation: Molecular Medicine 2007 13:1301105
    Content type: Research Article Published on:

  14. Patients with chronic hepatitis C frequently have serum and hepatic iron overload, but the mechanism is unknown. Recently identified hepcidin, exclusively synthesized in the liver, is thought to be a key regul...

    Authors: Naoki Fujita, Ryosuke Sugimoto, Masaki Takeo, Naohito Urawa, Rumi Mifuji, Hideaki Tanaka, Yoshinao Kobayashi, Motoh Iwasa, Shozo Watanabe, Yukihiko Adachi and Masahiko Kaito
    Citation: Molecular Medicine 2007 13:1301097
    Content type: Research Article Published on:

  15. APE1/Ref-1, normally localized in the nucleus, is a regulator of the cellular response to oxidative stress. Cytoplasmic localization has been observed in several tumors and correlates with a poor prognosis. Be...

    Authors: Vittorio Di Maso, Claudio Avellini, Lory Saveria Crocè, Natalia Rosso, Franco Quadrifoglio, Laura Cesaratto, Erika Codarin, Giorgio Bedogni, Carlo Alberto Beltrami, Gianluca Tell and Claudio Tiribelli
    Citation: Molecular Medicine 2007 13:1301089
    Content type: Research Article Published on:

  16. Several markers have been used to detect circulating tumor cells (CTC) in the peripheral blood of patients with breast cancer. However, analysis of activated signaling kinases in CTC implicated in cellular tra...

    Authors: Galatea Kallergi, Dimitris Mavroudis, Vassilis Georgoulias and Christos Stournaras
    Citation: Molecular Medicine 2007 13:1301079
    Content type: Research Article Published on:

  17. Diindolylmethane (DIM), a biologically active congener of indole-3-carbinol (I3C) derived from cruciferous vegetables, is a promising agent for the prevention of estrogen-sensitive cancers. Both DIM and estrog...

    Authors: Laura Mulvey, Alamelu Chandrasekaran, Kai Liu, Sarah Lombardi, Xue-Ping Wang, Karen J. Auborn and Leslie Goodwin
    Citation: Molecular Medicine 2007 13:1301069
    Content type: Research Article Published on:

  18. Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed ...

    Authors: Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery, Ward A. Ortmann, Karl J. Espe, Jill Novitzke, Steven R. Ytterberg, Peter K. Gregersen, Timothy W. Behrens and Ann M. Reed
    Citation: Molecular Medicine 2007 13:1301059
    Content type: Research Article Published on:

  19. Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor prognosis are not always reliable. Gene expression in RA may...

    Authors: Christopher J. Edwards, Jeffrey L. Feldman, Jonathan Beech, Kathleen M. Shields, Jennifer A. Stover, William L. Trepicchio, Glenn Larsen, Brian M. J. Foxwell, Fionula M. Brennan, Marc Feldmann and Debra D. Pittman
    Citation: Molecular Medicine 2007 13:1301040
    Content type: Research Article Published on:

  20. Chronic wounds, such as venous ulcers, are characterized by physiological impairments manifested by delays in healing, resulting in severe morbidity. Surgical debridement is routinely performed on chronic woun...

    Authors: Harold Brem, Olivera Stojadinovic, Robert F. Diegelmann, Hyacinth Entero, Brian Lee, Irena Pastar, Michael Golinko, Harvey Rosenberg and Marjana Tomic-Canic
    Citation: Molecular Medicine 2007 13:1301030
    Content type: Research Article Published on:

  21. It has recently been shown that nitrosyl complexes of hemoglobin (NO-Hb) are sensitive to low-level blue laser irradiation, suggesting that laser irradiation can facilitate the release of biologically active n...

    Authors: Rainer Mittermayr, Anatoly Osipov, Christina Piskernik, Susanne Haindl, Peter Dungel, Carina Weber, Yuri A. Vladimirov, Heinz Redl and Andrey V. Kozlov
    Citation: Molecular Medicine 2007 13:1301022
    Content type: Research Article Published on:

  22. Tyroserleutide (YSL) is an active, low-molecular-weight polypeptide, comprised of three amino acids, that has shown antitumor effects on human hepatocarcinoma BEL-7402 in vitro and in vivo. In this study, we e...

    Authors: Zhi Yao, Xu-chun Che, Rong Lu, Min-na Zheng, Zhi-feng Zhu, Jin-ping Li, Xu Jian, Lin-xi Shi, Jun-yan Liu and Wen-yuan Gao
    Citation: Molecular Medicine 2007 13:1301014
    Content type: Research Article Published on:

  23. Patients with temporal lobe epilepsy (TLE) often have a shrunken hippocampus that is known to be the location in which seizures originate. The role of the sclerotic hippocampus in the causation and maintenance...

    Authors: Tih-Shih Lee, Shrikant Mane, Tore Eid, Hongyu Zhao, Aiping Lin, Zhong Guan, Jung H. Kim, Jeffrey Schweitzer, David King-Stevens, Peter Weber, Susan S. Spencer, Dennis D. Spencer and Nihal C. de Lanerolle
    Citation: Molecular Medicine 2007 13:1301001
    Content type: Research Article Published on:

  24. The cytochrome P-450 (CYP) isoenzymes, a superfamily of heme proteins which are the terminal oxidases of the mixed function oxidases system, metabolize more than 70% of all clinically approved drugs. The highl...

    Authors: Jimena V. Lavandera, Victoria E. Parera, Alcira Batlle and Ana María Buzaleh
    Citation: Molecular Medicine 2006 12:1209259
    Content type: Research Article Published on:

  25. Multiple older studies report that immunoglobulin directed to rough mutant bacteria, such as E. coli J5, provides broad protection against challenge with heterologous strains of Gram-negative bacteria. This prote...

    Authors: Catherine H. Valentine, Judith Hellman, Laura K. Beasley-Topliffe, Aranya Bagchi and H. Shaw Warren
    Citation: Molecular Medicine 2006 12:1209252
    Content type: Research Article Published on:

  26. Lesch-Nyhan syndrome (LNS) is an X-linked genetic disorder resulting in hyperuricemia, choreoathetosis, mental retardation, and self-injurious behavior. It is caused by loss of activity of the ubiquitous enzym...

    Authors: Cristina Lapucci, Diego Pomarè Montin, Massimo Pandolfo and Matteo Bertelli
    Citation: Molecular Medicine 2006 12:1209246
    Content type: Research Article Published on:

  27. During embryogenesis, a complex interplay between extracellular matrix (ECM) molecules, regulatory molecules, and growth factors mediates morphogenetic processes involved in palatogenesis. Transforming growth ...

    Authors: Tiziano Baroni, Catia Bellucci, Cinzia Lilli, Furio Pezzetti, Francesco Carinci, Ennio Becchetti, Paolo Carinci, Giordano Stabellini, Mario Calvitti, Eleonora Lumare and Maria Bodo
    Citation: Molecular Medicine 2006 12:1209237
    Content type: Research Article Published on:

  28. A new chimeric IgG1 antibody hCAb which could be specifically directed against a cell surface-associated glycoprotein of colorectal cancer cells was prepared by genetic engineering technology in our lab. In th...

    Authors: Hua Xiong, Ling Li, Qin-Chuan Liang, Hui-Jie Bian, Juan Tang, Qin Zhang, Li Mi and Zhi-Nan Chen
    Citation: Molecular Medicine 2006 12:1209229
    Content type: Research Article Published on:

  29. Reactive free radical and oxidant production leads to DNA damage during myocardial Ischemia/reperfusion. Consequent overactivation of poly(ADP-ribose) polymerase (PARP) promotes cellular energy deficit and nec...

    Authors: Emese Tóth-Zsámboki, Eszter Horváth, Katarina Vargova, Eszter Pankotai, Kanneganti Murthy, Zsuzsanna Zsengellér, Tamás Bárány, Tamás Pék, Katalin Fekete, Róbert Gábor Kiss, István Préda, Zsombor Lacza, Domokos Gerö and Csaba Szabó
    Citation: Molecular Medicine 2006 12:1209221
    Content type: Research Article Published on:

  30. Our previous study showed that CD151 promotes neovascularization and improves blood perfusion in a rat hindlimb ischemia model. In this study, we investigated whether CD151 promotes neovascularization and impr...

    Authors: Zhenzhong Zheng and Zhengxiang Liu
    Citation: Molecular Medicine 2006 12:1209214
    Content type: Research Article Published on:

  31. Chemokines activate and recruit specific leukocyte subpopulations. We sought to determine whether neutrophil migration, which can contribute to the development of ischemia-reperfusion injury, correlates with l...

    Authors: Shin Hirayama, Takeshi Shiraishi, Takayuki Shirakusa, Takao Higuchi and Edmund J. Miller
    Citation: Molecular Medicine 2006 12:1209208
    Content type: Research Article Published on:

  32. The adenoviral transfer of therapeutic genes into epidermal and dermal cells is an interesting approach to treat skin diseases and to promote wound healing. The aim of this study was to assess the in vitro and...

    Authors: Tobias Hirsch, Sebastian von Peter, Grzegorz Dubin, Dominik Mittler, Frank Jacobsen, Markus Lehnhardt, Elof Eriksson, Hans-Ulrich Steinau and Lars Steinstraesser
    Citation: Molecular Medicine 2006 12:1209199
    Content type: Research Article Published on:

  33. Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world. Liver transplantation (LT) represents a curative treatment for “small” HCC. Preoperative staging is critical in selecting optimal ca...

    Authors: Valeria R. Mas, Daniel G. Maluf, Kellie J. Archer, Kenneth Yanek, Bridgette Williams and Robert A. Fisher
    Citation: Molecular Medicine 2006 12:12040097
    Content type: Research Article Published on:

  34. Gamma knife radiosurgery is an attractive noninvasive treatment of brain tumors and vascular malformations that minimizes collateral tissue damage. However, exposure of normal tissue to even low-dose radiation...

    Authors: Serhat Erbayraktar, Nihal de Lanerolle, Alain de Lotbinière, Jonathan P. S. Knisely, Zubeyde Erbayraktar, Osman Yilmaz, Anthony Cerami, Thomas R. Coleman and Michael Brines
    Citation: Molecular Medicine 2006 12:12040074
    Content type: Research Article Published on:

  35. ADAMs (a disintegrin and metalloprotease) constitute a family of cell surface proteins containing disintegrin and metalloprotease domains which associate features of adhesion molecules and proteases. ADAMTSs (a d

    Authors: Geneviève Paulissen, Natacha Rocks, Florence Quesada-Calvo, Philippe Gosset, Jean-Michel Foidart, Agnès Noel, Renaud Louis and Didier D. Cataldo
    Citation: Molecular Medicine 2006 12:1207171
    Content type: Research Article Published on:

  36. The use of quantitative gene expression analysis for the diagnosis, prognosis, and monitoring of disease requires the ability to distinguish pathophysiological changes from natural variations. To characterize ...

    Authors: Kevin McLoughlin, Ken Turteltaub, Danute Bankaitis-Davis, Richard Gerren, Lisa Siconolfi, Kathleen Storm, John Cheronis, David Trollinger, Dennis Macejak, Victor Tryon and Michael Bevilacqua
    Citation: Molecular Medicine 2006 12:1207185
    Content type: Research Article Published on:

  37. Advanced glycation end products (AGEs) are senescent macroprotein derivatives that are formed at an accelerated rate in patients with chronic renal failure (CRF). AGE formation and accumulation in plasma and v...

    Authors: Seiji Ueda, Sho-ichi Yamagishi, Masayoshi Takeuchi, Keisuke Kohno, Ryo Shibata, Yuriko Matsumoto, Utako Kaneyuki, Toshiko Fujimura, Ayako Hayashida and Seiya Okuda
    Citation: Molecular Medicine 2006 12:1207180
    Content type: Research Article Published on:

  38. The brain is a common metastatic site for various types of cancers, especially lung cancer. Patients with brain metastases have a poor prognosis in spite of radiotherapy and/or chemotherapy. It is postulated t...

    Authors: Bei Ping He, Jian Jun Wang, Xian Zhang, Yan Wu, Miao Wang, Boon-Huat Bay and Alex Yuang-Chi Chang
    Citation: Molecular Medicine 2006 12:1207161
    Content type: Research Article Published on:

  39. Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal...

    Authors: Tiziana Mennini, Massimiliano De Paola, Paolo Bigini, Cristina Mastrotto, Elena Fumagalli, Sara Barbera, Manuela Mengozzi, Barbara Viviani, Emanuela Corsini, Marina Marinovich, Lars Torup, Johan Van Beek, Marcel Leist, Michael Brines, Antony Cerami and Pietro Ghezzi
    Citation: Molecular Medicine 2006 12:1207153
    Content type: Research Article Published on:

  40. Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the present study was to investigate PARP activa...

    Authors: Andrea Molnár, Attila Tóth, Zsolt Bagi, Zoltán Papp, István Édes, Miklós Vaszily, Zoltán Galajda, Julius Gy. Papp, András Varró, Viktória Szüts, Zsombor Lacza, Domokos Gerö and Csaba Szabó
    Citation: Molecular Medicine 2006 12:1207143
    Content type: Research Article Published on:

  41. Missense mutations reduce protein levels through several molecular mechanisms. Among them, altered targeting to endoplasmic reticulum (ER) and its relationship with clinical phenotypes in patients have been po...

    Authors: Lara Rizzotto, Mirko Pinotti, Paolo Pinton, Rosario Rizzuto and Francesco Bernardi
    Citation: Molecular Medicine 2006 12:1207137
    Content type: Research Article Published on:

  42. Vascular endothelial growth factor (VEGF) plays an important role in normal and pathological angiogenesis. VEGF receptors (VEGFRs, including VEGFR-1, VEGFR-2, and VEGFR-3) and neuropilins (NRPs, including NRP-...

    Authors: Xiao-Yong Man, Xiao-Hong Yang, Sui-Qing Cai, Yong-Gang Yao and Min Zheng
    Citation: Molecular Medicine 2006 12:1207127
    Content type: Research Article Published on:

  43. Hepatitis B virus (HBV) is one of the major etiological factors responsible for the development of hepatocellular carcinoma (HCC). We used a transgenic mouse, containing HBV sequences, as a model system to unr...

    Authors: Michele Barone, Daniela Spano, Maria D’Apolito, Marta Centra, Carla Lasalandra, Mario Capasso, Alfredo Di Leo, Stefano Volinia, Diego Arcelli, Natalia Rosso, Antonio Franavilla, Claudio Tiribelli and Achille Iolascon
    Citation: Molecular Medicine 2006 12:12040115
    Content type: Research Article Published on:

  44. Intestinal barrier dysfunction occurs following hemorrhagic shock and resuscitation (HS/R). High-mobility group B1 (HMGB1) has been shown to increase the permeability of Caco-2 human enterocyte-like epithelial...

    Authors: Runkuan Yang, Tomoyuki Harada, Kevin P. Mollen, Jose M. Prince, Ryan M. Levy, Joshua A. Englert, Margot Gallowitsch-Puerta, LiHong Yang, Huan Yang, Kevin J. Tracey, Brian G. Harbrecht, Timothy R. Billiar and Mitchell P. Fink
    Citation: Molecular Medicine 2006 12:12040105
    Content type: Research Article Published on:

  45. The inflammatory phenotype of genetically modified mice is complex, and the role of Gram-negative lipopolysaccharide (LPS) In acute inflammation induced by surgical cannulation trauma, alone or in combination ...

    Authors: Jose M. Prince, Ryan M. Levy, John Bartels, Arie Baratt, John M. Kane III, Claudio Lagoa, Jonathan Rubin, Judy Day, Joyce Wei, Mitchell P. Fink, Sanna M. Goyert, Gilles Clermont, Timothy R. Billiar and Yoram Vodovotz
    Citation: Molecular Medicine 2006 12:12040088
    Content type: Research Article Published on:

  46. Hepatocellular carcinoma (HCC), one of the most common and malignant tumors worldwide, is unresponsive to any of the available therapies. Using intact HCC cells as therapeutic targets, we isolated a novel pept...

    Authors: Yong-Qiang Jiang, Hai-Rong Wang, Han-Ping Li, Huai-Jie Hao, Yu-Ling Zheng and Jun Gu
    Citation: Molecular Medicine 2006 12:12040081
    Content type: Research Article Published on:

  47. Hypoxia produces sex dimorphic immune responses in males and proestrus females. Because Kupffer cells are the major source of proinflammatory cytokines, studies were conducted to discern IL-6 production in mou...

    Authors: Rui Zheng, George Pan, Bjoern M. Thobe, Mashkoor A. Choudhry, Takeshi Matsutani, T. S. Anantha Samy, Shih-Ching Kang, Kirby I. Bland and Irshad H. Chaudry
    Citation: Molecular Medicine 2006 12:12040065
    Content type: Research Article Published on:

  48. Hepatitis C virus (HCV) core protein features many intriguing properties and plays a pivotal role in cellular immunity, cell growth, apoptosis, cell transformation, and eventually in tumor development. However...

    Authors: Chuan-ging Wu, Anuradha Budhu, Sheng Chen, Xiaoling Zhou, Nicholas C. Popescu, Kristoffer Valerie and Xin Wei Wang
    Citation: Molecular Medicine 2006 12:12010047
    Content type: Research Article Published on:

  49. The Tie receptors (Tie-1 and Tie-2/Tek) are essential for angiogenesis and vascular remodeling/integrity. Tie receptors are up-regulated in tumor-associated endothelium, and their inhibition disrupts angiogene...

    Authors: Peter W. Hewett, Emma L. Daft, Charles A. Laughton, Shakil Ahmad, Asif Ahmed and J. Clifford Murray
    Citation: Molecular Medicine 2006 12:12010008
    Content type: Research Article Published on:

  50. Matriptase is a type II transmembrane serine protease expressed in most human epithelia, where it is coexpressed with its cognate transmembrane inhibitor, hepatocyte growth factor activator inhibitor (HAI)-1. ...

    Authors: Karin List, Thomas H. Bugge and Roman Szabo
    Citation: Molecular Medicine 2006 12:12010001
    Content type: Research Article Published on:
Submit manuscript

Annual Journal Metrics

  • Annual Journal Metrics

    Citation Impact 2023
    Journal Impact Factor: 6.0
    5-year Journal Impact Factor: 6.0
    Source Normalized Impact per Paper (SNIP): 0.907
    SCImago Journal Rank (SJR): 1.446

    Speed 2023
    Submission to first editorial decision (median days): 6
    Submission to acceptance (median days): 132

    Usage 2023
    Downloads: 1,105,866
    Altmetric mentions: 1,878

Follow

Molecular Medicine

ISSN: 1528-3658