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  1. This study aimed to delineate the cell heterogeneity in the bone-implant interface and investigate the fibroblast responses to implant-associated S. aureus infection.

    Authors: Jinlong Yu, Boyong Wang, Feiyang Zhang, Zun Ren, Feng Jiang, Musha Hamushan, Mingzhang Li, Geyong Guo and Hao Shen
    Citation: Molecular Medicine 2023 29:35
    Content type: Research article Published on:

  2. The homologous to the E6-AP carboxyl terminus (HECT)-type E3 ubiquitin ligases are the selective executers in the protein ubiquitination, playing a vital role in modulation of the protein function and stabilit...

    Authors: Rui Zhang and Shaoqing Shi
    Citation: Molecular Medicine 2023 29:34
    Content type: Review Published on:

  4. Idiopathic pulmonary fibrosis (IPF) is a condition that may cause persistent pulmonary damage. The transformation of pericytes into myofibroblasts has been recognized as a key player during IPF progression. Th...

    Authors: Yichun Wang, Diyu Chen, Han Xie, Shuhua Zhou, Mingwang Jia, Xiaobo He, Feifei Guo, Yihuan Lai and Xiao Xiao Tang
    Citation: Molecular Medicine 2023 29:32
    Content type: Research article Published on:

  5. Pancreatic beta cell dysfunction and activated macrophage infiltration are early features in type 1 diabetes pathogenesis. A tricarboxylic acid cycle metabolite that can strongly activate NF-E2-related factor ...

    Authors: Sunyue He, Yuchen Zhao, Guoxing Wang, Qiaofang Ke, Nan Wu, Lusi Lu, Jiahua Wu, Shuiya Sun, Weihua Jin, Wenjing Zhang and Jiaqiang Zhou
    Citation: Molecular Medicine 2023 29:31
    Content type: Research article Published on:

  6. Accumulating evidence indicates that intervertebral disc degeneration (IDD) is associated with diabetes mellitus (DM), while the underlying mechanisms still remain elusive. Herein, the current study sought to ...

    Authors: Xiao-Jun Yu, Ying-Guang Wang, Rui Lu, Xin-Zhen Guo, Yun-Kun Qu, Shan-Xi Wang, Hao-Ran Xu, Hao Kang, Hong-Bo You and Yong Xu
    Citation: Molecular Medicine 2023 29:30
    Content type: Research article Published on:

  7. Intriguingly, liver regeneration after injury does not induce uncontrolled growth and the underlying mechanisms of such a “hepatostat” are still not clear. Endocan, a proteoglycan, was implicated in liver regener...

    Authors: Sinan Efe Yazici, Mustafa Emre Gedik, Can Berk Leblebici, Kemal Kosemehmetoglu, Gurcan Gunaydin and Ahmet Bulent Dogrul
    Citation: Molecular Medicine 2023 29:29
    Content type: Research article Published on:

  8. Vascular aging is an inevitable process with advancing age, which plays a crucial role in the pathogenesis of cardiovascular and microvascular diseases. Diabetic retinopathy (DR) and age-related macular degene...

    Authors: Bowen Zhao, Lijia Zhu, Meng Ye, Xiaotong Lou, Qianxue Mou, Yuanyuan Hu, Hong Zhang and Yin Zhao
    Citation: Molecular Medicine 2023 29:28
    Content type: Review Published on:

  10. Survivors of acute COVID-19 often suffer prolonged, diffuse symptoms post-infection, referred to as “Long-COVID”. A lack of Long-COVID biomarkers and pathophysiological mechanisms limits effective diagnosis, t...

    Authors: Maitray A. Patel, Michael J. Knauer, Michael Nicholson, Mark Daley, Logan R. Van Nynatten, Gediminas Cepinskas and Douglas D. Fraser
    Citation: Molecular Medicine 2023 29:26
    Content type: Research article Published on:

  11. Dendritic cell (DC) dysfunction plays a central role in sepsis-induced immunosuppression. Recent research has indicated that collective mitochondrial fragmentation contributes to the dysfunction of immune cell...

    Authors: You Wu, Longwang Chen, Zhimin Qiu, Xijing Zhang, Guangju Zhao and Zhongqiu Lu
    Citation: Molecular Medicine 2023 29:25
    Content type: Research article Published on:

  12. Calcific aortic valve disease (CAVD) is the second leading cause of adult heart diseases. The purpose of this study is to investigate whether miR-101-3p plays a role in the human aortic valve interstitial cell...

    Authors: Jianglei Chen, Yi Lin and Zhongjie Sun
    Citation: Molecular Medicine 2023 29:24
    Content type: Research article Published on:

  13. Gestational diabetes Mellitus (GDM) is a common pregnancy-specific disease with high morbidity, which is linked to a high risk of obesity and diabetes in offspring. N6-methyladenosine modification of RNA is em...

    Authors: Jie Fang, Xiafei Wu, Jie He, Hanwen Zhang, Xuyang Chen, Hua Zhang, Boris Novakovic, Hongbo Qi and Xinyang Yu
    Citation: Molecular Medicine 2023 29:23
    Content type: Research article Published on:

  14. Glycine receptors (GlyRs) play key roles in the processing of inflammatory pain. The use of adeno-associated virus (AAV) vectors for gene therapy in human clinical trials has shown promise, as AAV generally ca...

    Authors: Hung-Chen Wang, Kuang-I Cheng, Kuang-Yi Tseng, Aij-Lie Kwan and Lin-Li Chang
    Citation: Molecular Medicine 2023 29:22
    Content type: Research article Published on:

  15. Sepsis is caused by the dysregulated immune response due to an initial infection and results in significant morbidity and mortality in humans. Extracellular cold inducible RNA binding protein (eCIRP) is a nove...

    Authors: Timothy Borjas, Asha Jacob, Molly Kobritz, Gaifeng Ma, Chuyi Tan, Vihas Patel, Gene F. Coppa, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2023 29:21
    Content type: Research article Published on:

  16. Fibroblasts are highly heterogeneous mesenchymal stromal cells, and different fibroblast subpopulations play different roles. A subpopulation of fibroblasts expressing CD90, a 25–37 kDa glycosylphosphatidylino...

    Authors: Feng Zeng, Mengxiang Gao, Shan Liao, Zihua Zhou, Gengqiu Luo and Yanhong Zhou
    Citation: Molecular Medicine 2023 29:20
    Content type: Review Published on:

  17. With the increasing morbidity and mortality of preeclampsia (PE), it has posed a huge challenge to public health. Previous studies have reported endoplasmic reticulum (ER) stress could contribute to trophoblas...

    Authors: Yangyang Chen, Xiaoxia Liu, Lun Li, Xiyang He, Fanghui Zheng, Yang Zhang, Hui Gao, Zhishan Jin, Di Wu, Qianhua Wang, Hui Tao, Yin Zhao, Weifang Liu and Li Zou
    Citation: Molecular Medicine 2023 29:19
    Content type: Research article Published on:

  19. Osteoarthritis (OA) is a common chronic disease characterized by chronic inflammation and extracellular matrix degradation. Indole-3-propionic acid (IPA) is a tryptophan metabolite secreted by intestinal flora...

    Authors: Huangming Zhuang, Xunshan Ren, Fuze Jiang and Panghu Zhou
    Citation: Molecular Medicine 2023 29:17
    Content type: Research article Published on:

  20. Chorioamnionitis is a common cause of preterm birth and leads to serious complications in newborns. The objective of this study was to investigate the role of the Hippo signaling pathway in lung branching morp...

    Authors: Hung-Shuo Ko, Vincent Laiman, Po-Nien Tsao, Chung-Ming Chen and Hsiao-Chi Chuang
    Citation: Molecular Medicine 2023 29:16
    Content type: Research article Published on:

  21. Osteosarcoma is a malignant bone tumor that usually affects adolescents aged 15–19 y. The DNA damage response (DDR) is significantly enhanced in osteosarcoma, impairing the effect of systemic chemotherapy. Tar...

    Authors: Doudou Jing, Xuanzuo Chen, Zhenhao Zhang, Fengxia Chen, Fuhua Huang, Zhicai Zhang, Wei Wu, Zengwu Shao and Feifei Pu
    Citation: Molecular Medicine 2023 29:15
    Content type: Research article Published on:

  22. Germline mutations in cancer susceptibility genes were identified in pancreatic cancer (PanC) patients with a sporadic disease and in those unselected for family cancer history.

    Authors: Francesca Tavano, Domenica Gioffreda, Andrea Fontana, Orazio Palmieri, Annamaria Gentile, Tiziana Latiano, Anna Latiano, Tiziana Pia Latiano, Matteo Scaramuzzi, Evaristo Maiello, Francesca Bazzocchi and Francesco Perri
    Citation: Molecular Medicine 2023 29:14
    Content type: Research article Published on:

  23. Acute respiratory distress syndrome (ARDS), a life-threatening condition during critical illness, is a common complication of COVID-19. It can originate from various disease etiologies, including severe infect...

    Authors: Richa Batra, Rie Uni, Oleh M. Akchurin, Sergio Alvarez-Mulett, Luis G. Gómez-Escobar, Edwin Patino, Katherine L. Hoffman, Will Simmons, William Whalen, Kelsey Chetnik, Mustafa Buyukozkan, Elisa Benedetti, Karsten Suhre, Edward Schenck, Soo Jung Cho, Augustine M. K. Choi…
    Citation: Molecular Medicine 2023 29:13
    Content type: Short report Published on:

  24. Amyotrophic lateral sclerosis (ALS) is a rare progressive neurodegenerative disease that affects upper and lower motor neurons. As the molecular basis of the disease is still elusive, the development of high-t...

    Authors: Kyriaki Founta, Dimitra Dafou, Eirini Kanata, Theodoros Sklaviadis, Theodoros P. Zanos, Anastasios Gounaris and Konstantinos Xanthopoulos
    Citation: Molecular Medicine 2023 29:12
    Content type: Research article Published on:

  26. Evading apoptosis by overexpression of anti-apoptotic Bcl-2 family proteins is a hallmark of cancer cells and the Bcl-2 selective inhibitor venetoclax is widely used in the treatment of hematologic malignancie...

    Authors: Tianming Zhao, Qiang He, Shurong Xie, Huien Zhan, Cheng Jiang, Shengbin Lin, Fangshu Liu, Cong Wang, Guo Chen and Hui Zeng
    Citation: Molecular Medicine 2023 29:10
    Content type: Research article Published on:

  27. Retinal ganglion cells (RGCs) apoptosis is a vital manifestation of retinal ischemia/reperfusion (I/R) injury, yet the underlying mechanisms are not well understood. The contribution of long noncoding RNAs (ln...

    Authors: Yuqing Feng, Jinfang Lu, Xujun Peng, Yanni Ge, Ran Zhang and Huiling Li
    Citation: Molecular Medicine 2023 29:9
    Content type: Research Article Published on:

  28. Inflammation, the physiological response to infection and injury, is coordinated by the immune and nervous systems. Interleukin-1β (IL-1β) and other cytokines produced during inflammatory responses activate se...

    Authors: Harold A. Silverman, Aisling Tynan, Tyler D. Hepler, Eric H. Chang, Manojkumar Gunasekaran, Jian Hua Li, Tomás S. Huerta, Tea Tsaava, Qing Chang, Meghan E. Addorisio, Adrian C. Chen, Dane A. Thompson, Valentin A. Pavlov, Michael Brines, Kevin J. Tracey and Sangeeta S. Chavan
    Citation: Molecular Medicine 2023 29:4
    Content type: Research article Published on:

  29. Autism spectrum disorder (ASD) is a neurodevelopmental disorder that impairs normal brain development and socio-cognitive abilities. The pathogenesis of this condition points out the involvement of genetic and...

    Authors: Amin Ravaei, Marco Emanuele, Giovanni Nazzaro, Luciano Fadiga and Michele Rubini
    Citation: Molecular Medicine 2023 29:8
    Content type: Mini-review Published on:

  30. Bladder cancer (BCa) is the most common malignant tumor of the urinary system, with transitional cell carcinoma (TCC) being the predominant type. EP300 encodes a lysine acetyltransferase that regulates a large su...

    Authors: Mayao Luo, Yifan Zhang, Zhuofan Xu, Shidong Lv, Qiang Wei and Qiang Dang
    Citation: Molecular Medicine 2023 29:7
    Content type: Research article Published on:

  31. Activated Cdc42-associated kinase 1 (ACK1) is a promising druggable target for cancer, but its inhibitors only showed moderate effects in clinical trials. The study aimed to investigate the underlying mechanis...

    Authors: Jinhong Zhu, Kui Cao, Meng Zhao, Keru Ma, Xiangyu Jiang, Yuwen Bai, Xiaodong Ling and Jianqun Ma
    Citation: Molecular Medicine 2023 29:6
    Content type: Research article Published on:

  32. Diarrheal irritable bowel syndrome (IBS-D) is a common chronic functional gastrointestinal disorder, and the underlying pathogenic mechanism is still unclear. Animal models that mimic the pathological state of...

    Authors: Qian Chen, Hua Zhang, Chang-Yue Sun, Qing-Ying He, Rui-Rong Zhang, Bin-Fei Luo, Zi-Hao Zhou and Xiao-Fan Chen
    Citation: Molecular Medicine 2023 29:5
    Content type: Research Article Published on:

  33. Cerebral ischemia/reperfusion (I/R) is a pathological process that occurs in ischemic stroke. Bone marrow mesenchymal stem cell-derived exosomes (BMSC-Exos) have been verified to relieve cerebral I/R-induced i...

    Authors: Xiaowei Xie, Yu Cao, Liangping Dai and Dingzhou Zhou
    Citation: Molecular Medicine 2023 29:3
    Content type: Research Article Published on:

  35. Long intergenic non-coding RNA 00963 (LINC00963) is an oncogenic lncRNA in human cancers. However, little is known on how it impacts the pathogenesis of lung adenocarcinoma (LUAD).

    Authors: Ronghang Hu, Baobin Xu, Jiajun Ma, Linfeng Li, Liming Zhang, Li Wang, Jiebo Zhu, Tao Guo, Heng Zhang and Shaoqiang Wang
    Citation: Molecular Medicine 2023 29:1
    Content type: Research article Published on:

  36. Recurrent spontaneous abortion (RSA), is a dangerous pregnancy-related condition and is a subject of debate in the gynaecology and obstetrics communities. The objective of this study was to determine the funct...

    Authors: Yuhan Duan, Huijia Fu, Jiayu Huang, Nanlin Yin, Linhong Liu and Xiru Liu
    Citation: Molecular Medicine 2022 28:165
    Content type: Research Article Published on:

  37. High mobility group box 1 (HMGB1) is a damage-associated molecular pattern (DAMP) molecule that plays a central role in innate immunity. HMGB1 acts as a late mediator of inflammation when actively secreted in ...

    Authors: Jaemin Shin, Young Hun Kim, Bin Lee, Jae Ho Chang, Hee Youn Choi, Hoojung Lee, Ki Chan Song, Man Sup Kwak, Ji Eun Choi and Jeon-Soo Shin
    Citation: Molecular Medicine 2022 28:164
    Content type: Research Article Published on:

  38. Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear. Here, we report ...

    Authors: Ying-Ya Cao, Yuan Zhang, Wuyun Gerile, Yan Guo, Li-Na Wu, Li-Li Wu, Kai Song, Wei-Hua Lu and Jian-Bo Yu
    Citation: Molecular Medicine 2022 28:163
    Content type: Research Article Published on:

  39. Randall’s plaques (RP) are identified as anchored sites for kidney calcium oxalate stones, but the mechanism remains unclear. Given the importance of osteogenic-like cells in RP formation and OCT4 in reprogram...

    Authors: Zewu Zhu, Fang Huang, Yingcheng Jiang, Shuhao Ruan, Minghui Liu, Youjie Zhang, Yongchao Li, Jinbo Chen, Yu Cui, Zhiyong Chen, Hequn Chen and Feng Zeng
    Citation: Molecular Medicine 2022 28:162
    Content type: Research article Published on:

  40. Gut microbiota plays a critical role in the maintenance of host health. As a low-cost and genetically tractable vertebrate model, zebrafish have been widely used for biological research. Zebrafish and humans s...

    Authors: Hui Xia, Huimin Chen, Xue Cheng, Mingzhu Yin, Xiaowei Yao, Jun Ma, Mengzhen Huang, Gang Chen and Hongtao Liu
    Citation: Molecular Medicine 2022 28:161
    Content type: Review Published on:

  42. This study aims to explore the protective role of ethanol extract from Chimonanthus nitens Oliv. leaf (COE) in hyperlipidemia via the leptin/Janus kinase 2 (JAK2)/signal transducer and activator of transcription ...

    Authors: Jianping Pan, Xilin Ouyang, Qi Jin, Wei Wang, Jiali Xie, Baoming Yu, Zhijie Ling, Qizhen Wu and Baoping Zheng
    Citation: Molecular Medicine 2022 28:159
    Content type: Research article Published on:

  43. Acute thoracic aortic dissection (ATAD) is a fatal condition characterized by tear of intima, formation of false lumen and rupture of aorta. However, the subpopulations of normal and dissected aorta remain les...

    Authors: Yu-bin He, Hai-zhen Jin, Jin-long Zhao, Chong Wang, Wen-rui Ma, Jie Xing, Xiao-bin Zhang, Yang-yang Zhang, Huang-dong Dai, Nai-shi Zhao, Jian-feng Zhang, Guan-xin Zhang and Jing Zhang
    Citation: Molecular Medicine 2022 28:158
    Content type: Research article Published on:

  44. Sepsis is a syndrome where the dysregulated host response to infection threatens the life of the patient. The isoform of the cholesteryl-ester transfer protein (CETPI) is synthesized in the small intestine, an...

    Authors: Eréndira G. Pérez-Hernández, Víctor De la Puente-Díaz de León, Ismael Luna-Reyes, Blanca Delgado-Coello, José Sifuentes-Osornio and Jaime Mas-Oliva
    Citation: Molecular Medicine 2022 28:157
    Content type: Research article Published on:

  45. The use of doxorubicin is associated with an increased risk of acute and long-term cardiomyopathy. Despite the constantly growing number of cancer survivors, little is known about the transcriptional mechanism...

    Authors: Justyna Totoń-Żurańska, Joanna Sulicka-Grodzicka, Michał T. Seweryn, Ewelina Pitera, Przemysław Kapusta, Paweł Konieczny, Leszek Drabik, Maria Kołton-Wróż, Bernadeta Chyrchel, Ewelina Nowak, Andrzej Surdacki, Tomasz Grodzicki and Paweł P. Wołkow
    Citation: Molecular Medicine 2022 28:156
    Content type: Research article Published on:

  46. Exenatide is a stable analogue of glucagon-like peptide 1 that can reduce postprandial hyperglycemia and has been utilized as adjunctive therapy for type 1 diabetes mellitus (T1DM). The human umbilical cord is...

    Authors: Wei Wang, Yahao Wang, Jingwei Chi, Xiaojun Tan, Jianxia Hu, Xiaolong Ma, Xiaofang Sun, Kui Che, Wenshan Lv and Yangang Wang
    Citation: Molecular Medicine 2022 28:155
    Content type: Research article Published on:

  47. Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as a hyper inflammatory proce...

    Authors: Cíntia Barros Santos-Rebouças, Rafael Mina Piergiorge, Cristina dos Santos Ferreira, Raquel de Seixas Zeitel, Alexandra Lehmkuhl Gerber, Marta Cristine Felix Rodrigues, Ana Paula de Campos Guimarães, Rodrigo Moulin Silva, Adriana Rodrigues Fonseca, Rangel Celso Souza, Ana Tereza Antunes Monteiro de Souza, Átila Duque Rossi, Luís Cristóvão de Moraes Sobrino Porto, Cynthia Chester Cardoso and Ana Tereza Ribeiro de Vasconcelos
    Citation: Molecular Medicine 2022 28:153
    Content type: Research article Published on:

  48. Acute renal injury (AKI) secondary to ischemia reperfusion (IR) injury continues to be a significant perioperative problem and there is no effective treatment. Mindin belongs to the mindin/F-spondin family and...

    Authors: Tao Bai, Xiong Wang, Cong Qin, Kang Yang, Zhiguo Duan, Zhixiu Cao, Jiaqian Liang, Lei Wang, Jingdong Yuan and Pengcheng Luo
    Citation: Molecular Medicine 2022 28:152
    Content type: Research article Published on:

  49. Endometriosis (EMS) is a “tumour-like” gynaecological disease with distant metastasis, and studies have shown that EMS can induce distant metastasis through vascular vessels, but the driving factors and their ...

    Authors: Caiqi Ma, Wei Huang, Hui Wang, Wenxia Yao, Min Liang, Guifang Yu and Xinke Zhou
    Citation: Molecular Medicine 2022 28:151
    Content type: Research article Published on:

  50. Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are lacking. Alveolar macrophages are central in the progression of these diseases by releasing proinflammatory cy...

    Authors: Daniel Weidinger, Kaschin Jamal Jameel, Desiree Alisch, Julian Jacobsen, Paul Bürger, Matthias Ruhe, Faisal Yusuf, Simon Rohde, Klemens Störtkuhl, Peter Kaufmann, Juliane Kronsbein, Marcus Peters, Hanns Hatt, Nikolaos Giannakis and Jürgen Knobloch
    Citation: Molecular Medicine 2022 28:150
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658