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  1. A new population of peripheral helper T (Tph) cells has been identified and contributed to various autoimmune diseases. Tph cells can secrete interleukin-21 (IL-21), interferon (IFN) and C-X-C motif chemokine ...

    Authors: Junyi Ren, Kuai Ma, Xiangheng Lu, Haoyu Peng, Jia Wang, Moussa Ide Nasser and Chi Liu
    Citation: Molecular Medicine 2024 30:174
    Content type: Review Published on:

  2. The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury. Previous studies have shown that deple...

    Authors: Jiejie Zhang, Shan Wang, Haitao Zhang, Xiaotong Yang, Xin Ren, Lei Wang, Yihan Yang, Yi Yang and Ya Wen
    Citation: Molecular Medicine 2024 30:173
    Content type: Research Published on:

  3. The role of ELAVL1 in the progression of various tumors has been demonstrated. Our research aims to investigate how ELAVL1 controls the glycolytic process in nasopharyngeal carcinoma cells through the HMGB3/β-...

    Authors: Yi Cui, Haojie Wen, Jinyong Tang, Jiawen Chen, Juan Zhou, Minghua Hou, Xiaohan Rong, Yuanzhao Lan and Qiong Wu
    Citation: Molecular Medicine 2024 30:172
    Content type: Research article Published on:

  4. Aging-related strength decline contributes to physiological deterioration and is a good predictor of poor prognosis. However, the mechanisms underlying neuromuscular junction disorders affecting contraction in...

    Authors: Yanling Zhao, Han Yan, Ke Liu, Jiangping Ma, Wenlan Sun, Hejin Lai, Hongli Li, Jianbang Gu and He Huang
    Citation: Molecular Medicine 2024 30:171
    Content type: Research Published on:

  5. Rheumatoid arthritis, a chronic autoimmune disease, is characterized by synovial hyperplasia and cartilage erosion. Here, we investigated the potential mechanism of action of quercetin, the main component of f...

    Authors: FengQi Zhang, YiYang Zhang, JiaWang Zhou, Ying Cai, ZhiYu Li, Jing Sun, ZhiJun Xie and GuiFeng Hao
    Citation: Molecular Medicine 2024 30:170
    Content type: Research Published on:

  7. A spinal cord injury (SCI) can result in severe impairment and fatality as well as significant motor and sensory abnormalities. Exosomes produced from IPSCs have demonstrated therapeutic promise for accelerati...

    Authors: Azar Abbas, Xiaosheng Huang, Aftab Ullah, Lishi Luo, Wenqun Xi, Yuanjiao Qiao and Kun Zeng
    Citation: Molecular Medicine 2024 30:168
    Content type: Research Published on:

  8. Glucocorticoid-associated osteonecrosis of the femoral head (GA-ONFH) is a progressive bone disorder which frequently results in femoral head collapse and hip joint dysfunction. Sclerostin (SOST) is principall...

    Authors: Junming Huang, Tianle Ma, Chenzhong Wang, Zhe Wang, Xinyuan Wang, Bingxuan Hua, Chang Jiang and Zuoqin Yan
    Citation: Molecular Medicine 2024 30:167
    Content type: Research article Published on:

  9. Nomilin is a limonoid compound known for its multiple biological activities, but its role in triple negative breast cancer (TNBC) remains unclear. This study aims to uncover the potential therapeutic effect of...

    Authors: Zhixuan Wu, Haoyi Xiang, Xiaowu Wang, Rongrong Zhang, Yangyang Guo, Liangchen Qu, Jingyao Zhou and Yanyi Xiao
    Citation: Molecular Medicine 2024 30:166
    Content type: Research Published on:

  12. Fibrosis cataract occurs in patients receiving cataract extraction. Still, no medication that can cure the disease exists in clinical. This study aims to investigate the effects and mechanisms of Entrectinib o...

    Authors: Xuefei Ding, Xiaohe Li, Rui Fang, Peilin Yue, Yuxuan Jia, Enjie Li, Yayue Hu, Honggang Zhou and Xudong Song
    Citation: Molecular Medicine 2024 30:163
    Content type: Research Published on:

  13. During wound healing, fibroblast to myofibroblast transition is required for wound contraction and remodeling. While hypoxia is an important biophysical factor in wound microenvironment, the exact regulatory m...

    Authors: Wanqi Huang, Ze Zhang, Xin Li, Qingqing Zheng, Chao Wu, Luojia Liu, Ying Chen, Jiaping Zhang and Xupin Jiang
    Citation: Molecular Medicine 2024 30:162
    Content type: Research article Published on:

  14. The pathophysiological mechanisms of cardiovascular disease and microvascular complications in diabetes have been extensively studied, but effective methods of prevention and treatment are still lacking. In re...

    Authors: Giulia Damiano, Raffaella Rinaldi, Angela Raucci, Chiara Molinari, Annalisa Sforza, Sergio Pirola, Francesco Paneni, Stefano Genovese, Giulio Pompilio and Maria Cristina Vinci
    Citation: Molecular Medicine 2024 30:161
    Content type: Review Published on:

  15. The cGAS-STING pathway is an important component of the innate immune system and plays significant role in acetaminophen-induced liver injury (AILI). Pentagalloylglucose (PGG) is a natural polyphenolic compoun...

    Authors: Congyang Zheng, Yuanyuan Chen, Tingting He, Ye Xiu, Xu Dong, Xianling Wang, Xinru Wen, Chengwei Li, Qing Yao, Simin Chen, Xiaoyan Zhan, Lili Gao and Zhaofang Bai
    Citation: Molecular Medicine 2024 30:160
    Content type: Research article Published on:

  16. Retinal ischemia/reperfusion (IR) injury is a common pathological process in many ophthalmic diseases. Interleukin-1β (IL-1β) is an important inflammatory factor involved in the pathology of retinal IR injury,...

    Authors: Yong Wan, Jiayu Li, Jialei Pu, Jing Yang, Cheng Pei and Yun Qi
    Citation: Molecular Medicine 2024 30:159
    Content type: Research article Published on:

  17. Huntington’s disease (HD) is a progressive neurodegenerative disease that causes motor, cognitive, and psychiatric abnormalities, with no satisfying disease-modifying therapy so far. 3-nitropropionic acid (3NP...

    Authors: Mona E. Noureldeen, Nancy N. Shahin, Hebat Allah A. Amin, Maha M. El-Sawalhi and Heba R. Ghaiad
    Citation: Molecular Medicine 2024 30:158
    Content type: Research article Published on:

  18. Noncoding RNAs play pivotal roles in the process of autoimmune diseases. However, the definite contributions of these molecules to Behçet’s disease (BD) are still unknown. This study aimed to explore the clini...

    Authors: Asmaa A. ElMonier, Olfat G. Shaker and Shimaa O. Ali
    Citation: Molecular Medicine 2024 30:157
    Content type: Research Published on:

  19. Necrotizing enterocolitis (NEC) is a severe gastrointestinal disease characterized by intestinal inflammation and injury, with high mortality risk. Extracellular cold-inducible RNA-binding protein (eCIRP) is a...

    Authors: Colleen P. Nofi, Jose M. Prince, Mariana R. Brewer, Monowar Aziz and Ping Wang
    Citation: Molecular Medicine 2024 30:156
    Content type: Research article Published on:

  21. Thoracic aortic dissection (TAD) is an irreversible cardiovascular disorder with high mortality and morbidity. However, the molecular mechanisms remain elusive. Thus, identifying an effective therapeutic targe...

    Authors: Liqing Jiang, Linhe Lu, Chao Xue, He Sun, Kai Ren, Liyun Zhang, Hanzhao Zhu, Bin Zhang, Xiaoya Wang, Xinan Qiao, Xiangyan Peng, Jincheng Liu and Weixun Duan
    Citation: Molecular Medicine 2024 30:154
    Content type: Research Published on:

  22. Specialized pro-resolving mediators (SPMs) promote resolution of inflammation, clear infections and stimulate tissue regeneration. These include resolvins, protectins, and maresins. During self-resolving acute...

    Authors: Charles N. Serhan, Nan Chiang and Robert Nshimiyimana
    Citation: Molecular Medicine 2024 30:153
    Content type: Research article Published on:

  23. VEXAS syndrome, an uncommon yet severe autoimmune disorder stemming from a mutation in the UBA1 gene, is the focus of this paper. The overview encompasses its discovery, epidemiological traits, genetic underpi...

    Authors: Xiao Xiao Li, Wen Hui Huang, Xiao Bin Yang, Qi Lin Yang, Yu Zheng, Yong Bao Huo, Ting Ting Xie, Cheng Hui Huang and Shui Lian Yu
    Citation: Molecular Medicine 2024 30:152
    Content type: Mini-review Published on:

  24. Erythropoietin (EPO), expressed in red blood progenitor cells, primarily regulates erythropoiesis by binding to its receptor. Besides anemia, recent studies have identified new therapeutic indications for EPO ...

    Authors: Xiao Liu, Mengxue Zhou, Yifan Wu, Xiang Gao, Lei Zhai, Liang Liu and Huan Geng
    Citation: Molecular Medicine 2024 30:151
    Content type: Research article Published on:

  25. Cis-dichlorodiammineplatinum(II) (CDDP), while widely utilized in tumor therapy, results in toxic side effects that patients find intolerable. The specific mechanism by which CDDP inflicts ovarian damage remai...

    Authors: Lu Zhang, Zhe Dong, Fan Jiang, Huaju Huang, Hui Ding and Meimei Liu
    Citation: Molecular Medicine 2024 30:150
    Content type: Research article Published on:

  26. Obesity is a global epidemic, and the low-grade chronic inflammation of adipose tissue in obese individuals can lead to insulin resistance and type 2 diabetes. Adipose tissue macrophages (ATMs) are the main so...

    Authors: Huaying Huang, Heye Chen, Yu Yao and Xueyong Lou
    Citation: Molecular Medicine 2024 30:149
    Content type: Research article Published on:

  27. Ventilator-induced lung injury (VILI) is one of the severe complications in the clinic concerning mechanical ventilation (MV). Capsaicin (CAP) has anti-inflammatory and inhibitory effects on oxidative stress, ...

    Authors: Jinyuan Lin, Huajin Ou, Bijun Luo, Maoyao Ling, Fei Lin, Liming Cen, Zhaokun Hu, Liu Ye and Linghui Pan
    Citation: Molecular Medicine 2024 30:148
    Content type: Research article Published on:

  28. The complex interplay between Sirtuin 1 (SIRT1) and FOXO3 in endometrial cancer (EC) remains understudied. This research aims to unravel the interactions of deacetylase SIRT1 and transcription factor FOXO3 in ...

    Authors: Xuehua Wei, Xiangpeng Xiong, Pingping Wang, Shufang Zhang and Dongxian Peng
    Citation: Molecular Medicine 2024 30:147
    Content type: Research article Published on:

  29. At present, hepatic ischemia-reperfusion injury (IRI) is an important complication of partial hepatectomy and liver transplantation, and it is an important cause of poor prognosis. Spleen tyrosine kinase(SYK) ...

    Authors: Xuejiao Chen, Chuanwei Jiang, Minhao Chen, Xiangdong Li, Wenjie Yu, Aigang Qiu, Linfeng Sun, Liyong Pu and Yuhua Shi
    Citation: Molecular Medicine 2024 30:146
    Content type: Research Published on:

  30. Ionizing radiation (IR), including radiotherapy, can exert lasting harm on living organisms. While liposaccharide (LPS) offers resistance to radiation damage, it also induces toxic responses. Thankfully, an LP...

    Authors: Zhihua Li, Yatong Wu, Jicong Du, Wen Qian, Sinian Wang, Fengsheng Li, Suhe Dong and Shunchang Jiao
    Citation: Molecular Medicine 2024 30:145
    Content type: Research Published on:

  31. Idiopathic pulmonary fibrosis (IPF) is a special kind of chronic interstitial lung disease with insidious onset. Previous studies have revealed that mutations in ZCCHC8 may lead to IPF. The aim of this study i...

    Authors: Chen-Yu Wang, Si-Hua Chang, Cheng-Feng Hu, Yi-Qiao Hu, Hong Luo, Lv Liu and Liang-Liang Fan
    Citation: Molecular Medicine 2024 30:144
    Content type: Short report Published on:

  32. Targeting the tumor microenvironment represents an emerging therapeutic strategy for cancer. Macrophages are an essential part of the tumor microenvironment. Macrophage polarization is modulated by mitochondri...

    Authors: Sung Woo Lee, Soyoon Kim, Bokyung Kim, Jung Bae Seong, Young-Ho Park, Hong Jun Lee, Dong Kyu Choi, Eunbyul Yeom and Dong-Seok Lee
    Citation: Molecular Medicine 2024 30:143
    Content type: Research article Published on:

  33. Oxidative damage to human retinal pigment epithelial (RPE) cells is the main cause of age-related macular degeneration (AMD), in our previous work, we showed that ghrelin has an antioxidative effect on human l...

    Authors: Jie Bai, Yanqing Wang, Yanze Li, Yan Liu and Shan Wang
    Citation: Molecular Medicine 2024 30:142
    Content type: Research article Published on:

  34. Advanced glycation end products (AGEs) are a diverse range of compounds that are formed when free amino groups of proteins, lipids, and nucleic acids are carbonylated by reactive carbonyl species or glycosylat...

    Authors: Yanchi Chen, Zihan Meng, Yong Li, Shibo Liu, Pei Hu and En Luo
    Citation: Molecular Medicine 2024 30:141
    Content type: Review Published on:

  35. Sepsis-induced pulmonary injury (SPI) is a common complication of sepsis with a high rate of mortality. N4-acetylcytidine (ac4C) is mediated by the ac4C “writer”, N-acetyltransferase (NAT)10, to regulate the stab...

    Authors: Pengcheng Xing, Minjie Zhou, Jian Sun, Donglian Wang, Weipeng Huang and Peng An
    Citation: Molecular Medicine 2024 30:140
    Content type: Research article Published on:

  36. Myocardial ischemia/reperfusion (I/R) injury is a common pathological process in clinical practice. Developing effective therapeutic strategies to reduce or prevent this injury is crucial. The article aimed to...

    Authors: Haibin Dong, Wenjuan Jia, Chunxiao Wang, Da Teng, Bowen Xu, Xiaoning Ding, Jun Yang, Lin Zhong and Lei Gong
    Citation: Molecular Medicine 2024 30:139
    Content type: Research article Published on:

  37. Premature rupture of the membranes (PROM) is a key cause of preterm birth and represents a major cause of neonatal mortality and morbidity. Natural products N-acetyl-d-galactosamine (GalNAc), which are basic b...

    Authors: Jia-Le Chen, Lou Liu, Xin-Rui Peng, Yan Wang, Xiang Xiang, Yu Chen, De-Xiang Xu and Dao-Zhen Chen
    Citation: Molecular Medicine 2024 30:138
    Content type: Research article Published on:

  41. Epidermal remodeling and hypertrophy are hallmarks of skin fibrotic disorders, and keratinocyte to mesenchymal (EMT)-like transformations drive epidermis alteration in skin fibrosis such as keloids and hypertr...

    Authors: Javier Milara, Pilar Ribera, Severiano Marín, Paula Montero, Inés Roger and Julio Cortijo
    Citation: Molecular Medicine 2024 30:134
    Content type: Research article Published on:

  42. Renal ischemia/reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), which is associated with high incidence and mortality. AST-120 is an oral carbonaceous adsorbent that can alleviate kidney...

    Authors: Jinmeng Zhou, Jinbao Zhang, Feng Xu, Haijin Gao, Lei Wang, Yutong Zhao and Ke Li
    Citation: Molecular Medicine 2024 30:133
    Content type: Research article Published on:

  43. Cell-based therapeutic strategies have been proposed as an alternative for brain and blood vessels repair after stroke, but their clinical application is hampered by potential adverse effects. We therefore tes...

    Authors: Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Mazurek and Fabien Gosselet
    Citation: Molecular Medicine 2024 30:132
    Content type: Research article Published on:

  44. The severe course of COVID-19 causes cardiovascular injuries, although the mechanisms involved are still not fully recognized, linked, and understood. Their characterization is of great importance with the est...

    Authors: Maciej Suski, Agnieszka Olszanecka, Aneta Stachowicz, Anna Kiepura, Michał Terlecki, Józef Madej, Marek Rajzer and Rafał Olszanecki
    Citation: Molecular Medicine 2024 30:131
    Content type: Research Published on:

  45. Vascular calcification is a common vascular lesion associated with high morbidity and mortality from cardiovascular events. Antibiotics can disrupt the gut microbiota (GM) and have been shown to exacerbate or ...

    Authors: Shi-Yu Zeng, Yi-Fu Liu, Zhao-Lin Zeng, Zhi-Bo Zhao, Xi-Lin Yan, Jie Zheng, Wen-Hang Chen, Zhen-Xing Wang, Hui Xie and Jiang-Hua Liu
    Citation: Molecular Medicine 2024 30:130
    Content type: Research article Published on:

  46. Mitochondria, responsible for cellular energy synthesis and signal transduction, intricately regulate diverse metabolic processes, mediating fundamental biological phenomena such as cell growth, aging, and apo...

    Authors: Quanling Zhou, Tingping Cao, Fujun Li, Ming Zhang, Xiaohui Li, Hailong Zhao and Ya Zhou
    Citation: Molecular Medicine 2024 30:129
    Content type: Review Published on:

  48. Cognitive dysfunction caused by infection frequently emerges as a complication in sepsis survivor patients. However, a comprehensive understanding of its pathogenesis remains elusive.

    Authors: Ni Liang, Yi Li, Chuang Yuan, Xiaoli Zhong, Yanliang Yang, Fang Liang, Kai Zhao, Fangfang Yuan, Jian Shi, Erhua Wang, Yanjun Zhong, Guixiang Tian, Ben Lu and Yiting Tang
    Citation: Molecular Medicine 2024 30:127
    Content type: Research article Published on:

  49. Bone marrow mesenchymal stem cells (BMMSCs) are commonly used for cell transplantation to treat refractory diseases. However, the presence of inflammatory factors, such as tumour necrosis factor-alpha (TNF-α),...

    Authors: Xudong Wang, Yong Liu, Shiyong Zhang, Linli Zheng, Yunze Kang, Puyi Sheng and Ziji Zhang
    Citation: Molecular Medicine 2024 30:126
    Content type: Research article Published on:

  50. Epimedin A (EA) has been shown to suppress extensive osteoclastogenesis and bone resorption, but the effects of EA remain incompletely understood. The aim of our study was to investigate the effects of EA on o...

    Authors: Jun Li, Jia J. Wei, Cen H. Wu, Tao Zou, Hong Zhao, Tian Q. Huo, Cheng J. Wei and Ting Yang
    Citation: Molecular Medicine 2024 30:125
    Content type: Research article Published on:
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    Citation Impact 2023
    Journal Impact Factor: 6.0
    5-year Journal Impact Factor: 6.0
    Source Normalized Impact per Paper (SNIP): 0.907
    SCImago Journal Rank (SJR): 1.446

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Molecular Medicine

ISSN: 1528-3658