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Page 29 of 37

  1. Obesity, a serious and growing health threat, is associated with low-grade inflammation that plays a role in mediating its adverse consequences. Previously, we have discovered a role for neural cholinergic sig...

    Authors: Sanjaya K Satapathy, Mahendar Ochani, Meghan Dancho, LaQueta K Hudson, Mauricio Rosas-Ballina, Sergio I Valdes-Ferrer, Peder S Olofsson, Yael Tobi Harris, Jesse Roth, Sangeeta Chavan, Kevin J Tracey and Valentin A Pavlov
    Citation: Molecular Medicine 2011 17:1707599
    Content type: Research Article Published on:

  2. Cerebral malaria (CM) Is associated with excessive Inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, infl...

    Authors: Constance A M Finney, Cheryl A Hawkes, Dylan C Kain, Aggrey Dhabangi, Charles Musoke, Christine Cserti-Gazdewich, Tamas Oravecz, W Conrad Liles and Kevin C Kain
    Citation: Molecular Medicine 2011 17:1707717
    Content type: Research Article Published on:

  3. This issue of Molecular Medicine contains 14 original research reports and state-of-the-art reviews on histone deacetylase inhibitors (HDACi’s), which are being studied in models of a broad range of diseases not ...

    Authors: Charles A. Dinarello, Gianluca Fossati and Paolo Mascagni
    Citation: Molecular Medicine 2011 17:1705333
    Content type: Review Article Published on:

  4. The mutational status of the immunoglobulin heavy-chain variable region (IGHV) genes utilized by chronic lymphocytic leukemia (CLL) clones defines two disease subgroups. Patients with unmutated IGHV have a mor...

    Authors: Monica Colombo, Giovanna Cutrona, Daniele Reverberi, Sonia Fabris, Antonino Neri, Marina Fabbi, Giovanni Quintana, Giovanni Quarta, Fabio Ghiotto, Franco Fais and Manlio Ferrarini
    Citation: Molecular Medicine 2011 17:1707834
    Content type: Research Article Published on:

  5. Multiple myeloma (MM) is a neoplasm of plasma cell origin that is largely confined to the bone marrow (BM). Chromosomal translocations and other genetic events are known to contribute to deregulation of signal...

    Authors: Gwenny Manel Fuhler, Sander Henricus Diks, Maikel Petrus Peppelenbosch and William Garrow Kerr
    Citation: Molecular Medicine 2011 17:1707790
    Content type: Research Article Published on:

  6. Pulmonary infection is a major cause of mortality and morbidity, and the magnitude of the lung inflammatory response correlates with patient survival. Previously, we have shown that neutrophil migration into j...

    Authors: Yinzhong Zhang, Xinchun Lin, Kiyokazu Koga, Koichiro Takahashi, Helena M Linge, Adriana Mello, Teresina Laragione, Percio S Gulko and Edmund J Miller
    Citation: Molecular Medicine 2011 17:1707780
    Content type: Research Article Published on:

  7. Deficits In social behavior In mice lacking the CD38 gene have been attributed to Impaired secretion of oxytocin. In humans, similar deficits in social behavior are associated with autistic spectrum disorder (ASD...

    Authors: Mathias Riebold, David Mankuta, Elad Lerer, Salomon Israel, Songfa Zhong, Luba Nemanov, Mikhail V Monakhov, Shlomit Levi, Nurit Yirmiya, Maya Yaari, Fabio Malavasi and Richard P Ebstein
    Citation: Molecular Medicine 2011 17:1707799
    Content type: Research Article Published on:

  8. Acute cellular rejection (ACR) and hepatitis C virus (HCV) recurrence (HCVrec) are common complications after liver transplantation (LT) in HCV patients, who share common clinical and histological features, ma...

    Authors: Ricardo Gehrau, Daniel Maluf, Kellie Archer, Richard Stravitz, Jihee Suh, Ngoc Le and Valeria Mas
    Citation: Molecular Medicine 2011 17:1707824
    Content type: Research Article Published on:

  9. Chronic lymphocytic leukemia (CLL) cells feature a pronounced apoptotic resistance. The vascular endothelial growth factor (VEGF) possesses a role in this apoptotic block, although underlying functional mechan...

    Authors: Iris Gehrke, Rajesh Kumar Gandhirajan, Simon Jonas Poll-Wolbeck, Michael Hallek and Karl-Anton Kreuzer
    Citation: Molecular Medicine 2011 17:1707619
    Content type: Research Article Published on:

  10. Stroke is the third leading cause of death in the United States with high rates of morbidity among survivors. The search to fill the unequivocal need for new therapeutic approaches would benefit from unbiased ...

    Authors: Agnes Bergerat, Julius Decano, Chang-Jiun Wu, Hyungwon Choi, Alexey I Nesvizhskii, Ann Marie Moran, Nelson Ruiz-Opazo, Martin Steffen and Victoria L M Herrera
    Citation: Molecular Medicine 2011 17:1707588
    Content type: Research Article Published on:

  11. Regulatory T (Treg) cells play an important role in the resolution of crescentic glomerulonephritis, where a T helper 1 (Th1)-predominant immune response promotes crescent formation. Therefore, agents that inc...

    Authors: Yoshitsugu Takabatake, Xiao-Kang Li, Masayuki Mizui, Kenro Miyasato, Isao Matsui, Noritaka Kawada, Enyu Imai, Thomas Hünig, Shiro Takahara, Takashi Wada, Kengo Furuichi, Hiromi Rakugi and Yoshitaka Isaka
    Citation: Molecular Medicine 2011 17:1707686
    Content type: Research Article Published on:

  12. Cytological analysis of body fluids is currently used for detecting cancer. The objective of this study was to determine if the herpes virus carrying an enhanced green fluorescent protein (EGFP) could detect r...

    Authors: Prasad S. Adusumilli, Sepideh Gholami, Yun Shin Chun, Michael Mullerad, Mei Ki Chan, Zhenkun Yu, Leah Ben-Porat, Valerie W Rusch and Yuman Fong
    Citation: Molecular Medicine 2011 17:1707628
    Content type: Research Article Published on:

  13. Impaired regulation of the transforming growth factor-β (TGFβ) signaling pathway has been linked to thoracic aortic aneurysm (TAA). Previous work has indicated that differential splicing is a common phenomenon...

    Authors: Sanela Kurtovic, Valentina Paloschi, Lasse Folkersen, Johan Gottfries, Anders Franco-Cereceda and Per Eriksson
    Citation: Molecular Medicine 2011 17:1707665
    Content type: Research Article Published on:

  14. Diabetes mellitus is characterized by elevated plasma glucose and increased rates of skin infections. Altered immune responses have been suggested to contribute to this prevalent complication, which involves m...

    Authors: Cheng-Che E. Lan, Ching-Shuang Wu, Shu-Mei Huang, Hsuan-Yu Kuo, I.-Hui Wu, Chien-Hui Wen, Chee-Yin Chai, Ai-Hui Fang and Gwo-Shing Chen
    Citation: Molecular Medicine 2011 17:1707771
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2011 17:Art28

  16. Fatty acid synthase (FASN), the enzyme responsible for de novo synthesis of fatty acids, has been shown to be deregulated in several cancers, including epithelial ovarian carcinoma (EOC). In this study, we invest...

    Authors: Shahab Uddin, Zeenath Jehan, Maqbool Ahmed, Aisha Alyan, Fouad Al-Dayel, Azhar Hussain, Prashant Bavi and Khawla S Al-Kuraya
    Citation: Molecular Medicine 2011 17:1707635
    Content type: Research Article Published on:

  17. Endogenous opioid peptides are substances involved in cell communication. They are present in various organs and tissues of the male and female reproductive tract, suggesting that they may regulate some of the...

    Authors: Nerea Subirán, Luis Casis and Jon Irazusta
    Citation: Molecular Medicine 2011 17:1707846
    Content type: Research Article Published on:

  19. The hereditary forms of breast cancer identified by BRCA1 and BRCA2 genes have a defect in homologous DNA repair and demonstrate a dependence on alternate DNA repair processes by base excision repair, which requi...

    Authors: Mary Leung, David Rosen, Scott Fields, Alessandra Cesano and Daniel R Budman
    Citation: Molecular Medicine 2011 17:1707854
    Content type: Research Article Published on:

  20. Interleukin (IL)-12 and IL-23 both share the p40 subunit and are key cytokines in the pathogenesis of Crohn’s disease. Previously, we have developed and identified three mouse p40 peptide-based and virus-like ...

    Authors: Qingdong Guan, Yanbing Ma, China-Li Hillman, Gefei Qing, Allan G Ma, Carolyn R Weiss, Gang Zhou, Aiping Bai, Richard J Warrington, Charles N Bernstein and Zhikang Peng
    Citation: Molecular Medicine 2011 17:1707646
    Content type: Research Article Published on:

  21. Mesenchymal stromal cells (MSCs), also called mesenchymal stem cells, migrate and function as stromal cells in tumor tissues. The effects of MSCs on tumor growth are controversial. In this study, we showed tha...

    Authors: Kazuhiro Suzuki, Ruowen Sun, Makoto Origuchi, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Akihiro Umezawa, Hiroshi Kijima, Shinsaku Fukuda and Yasuo Saijo
    Citation: Molecular Medicine 2011 17:1707579
    Content type: Research Article Published on:

  22. High mobility group protein B1 (HMGB1) has been implicated as an important mediator in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). However, the expression of HMGB1 in plasma an...

    Authors: Changchun Hou, Haijin Zhao, Laiyu Liu, Wenjun Li, Xiaoting Zhou, Yanhua Lv, Xiangbo Shen, Zhenyu Liang, Shaoxi Cai and Fei Zou
    Citation: Molecular Medicine 2011 17:1707807
    Content type: Research Article Published on:

  23. Morbid obesity is associated with a state of chronic inflammation. Interleukin-1 family (IL-1F) cytokine members are produced by human adipose tissue in obesity. Whereas certain IL-1F members such as IL-1β or ...

    Authors: Alexander R Moschen, Clemens Molnar, Barbara Enrich, Sabine Geiger, Christoph F Ebenbichler and Herbert Tilg
    Citation: Molecular Medicine 2011 17:1707840
    Content type: Research Article Published on:

  24. The IC53 gene was reported to be upregulated In the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarc...

    Authors: Jingzhou Chen, Yi Shi, Ziyu Li, Hui Yu, Yu Han, Xiaojian Wang, Kai Sun, Tao Yang, Kejia Lou, Yan Song, Yinhui Zhang, Yisong Zhen, Guiguo Zhang, Ying Hu, Jiafu Ji and Rutai Hui
    Citation: Molecular Medicine 2011 17:1707607
    Content type: Research Article Published on:

  25. Congenital erythropoietic porphyria (CEP) is an autosomal recessive disorder due to the deficient activity of uroporphyrinogen III synthase (UROS). Knock-in mouse models were generated for the common, hematolo...

    Authors: David F Bishop, Sonia Clavero, Narla Mohandas and Robert J Desnick
    Citation: Molecular Medicine 2011 17:1707748
    Content type: Research Article Published on:

  26. Mesenchymal stem cells (MSCs) are suggested to be immune modulators because of their therapeutic potential in transplantation. In the present study, we evaluated the therapeutic potential of autologous MSCs fo...

    Authors: Yang-Hee Kim, Yu-Mee Wee, Monica-Y Choi, Dong-Gyun Lim, Song-Cheol Kim and Duck-Jong Han
    Citation: Molecular Medicine 2011 17:1707697
    Content type: Research Article Published on:

  28. Considerable levels of testosterone and dihydrotestosterone (DHT) are found In prostate cancer (PCa) tissue after androgen deprivation therapy. Treatment of surviving cancer-initiating cells and the ability to...

    Authors: Minja J Pfeiffer, Frank P Smit, John P M Sedelaar and Jack A Schalken
    Citation: Molecular Medicine 2011 17:1707657
    Content type: Research Article Published on:

  30. Inhibition of histone deacetylases (HDAC) has been shown to modulate gene expression and cytokine production after stimulation with several stimuli. In the present study, the antiinflammatory effect of a poten...

    Authors: Leo A B Joosten, Flavio Leoni, Sajeda Meghji and Paolo Mascagni
    Citation: Molecular Medicine 2011 17:1705391
    Content type: Review Article Published on:

  31. Small sputum macrophages represent highly active cells that Increase In the airways of patients with Inflammatory diseases such as chronic obstructive pulmonary disease (COPD). It has been reported often that ...

    Authors: Marion Frankenberger, Christiane Eder, Thomas P J Hofer, Irene Heimbeck, Kerstin Skokann, Gudrun Kaßner, Norbert Weber, Winfried Möller and Loems Ziegler-Heitbrock
    Citation: Molecular Medicine 2011 17:1707762
    Content type: Research Article Published on:

  32. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to tumorigenesis by acting as oncogenes or tumor suppressor genes and may be important in the diagnosis, prognosis and treatment of cancer. Many miRN...

    Authors: Walter Pavicic, Esa Perkiö, Sippy Kaur and Päivi Peltomäki
    Citation: Molecular Medicine 2011 17:1707726
    Content type: Research Article Published on:

  33. S100P was recently found to be overexpressed In a variety of cancers and Is considered a potential target for cancer therapy, but the functional role or mechanism of action of S100P in colon cancer is not full...

    Authors: Lei Jiang, Yiu-Kay Lai, Jinfang Zhang, Hua Wang, Marie C M Lin, Ming-liang He and Hsiang-fu Kung
    Citation: Molecular Medicine 2011 17:1707709
    Content type: Research Article Published on:

  34. Milk fat globule-EGF factor 8 (MFG-E8) has been shown to play an important role in maintaining the integrity of the intestinal mucosa and to accelerate healing of the mucosa in septic mice. Herein, we (a) anal...

    Authors: Ashish Chogle, Heng-Fu Bu, Xiao Wang, Jeffrey B Brown, Pauline M Chou and Xiao-Di Tan
    Citation: Molecular Medicine 2011 17:1705502
    Content type: Research Article Published on:

  35. There are no reliable criteria to handle disease progression of muscle invasive bladder cancer (MIBC), which strongly influences patient survival. Therefore, an accurate predicting method to identify progressi...

    Authors: Wun-Jae Kim, Seon-Kyu Kim, Pildu Jeong, Seok-Joong Yun, In-Chang Cho, Isaac Yi Kim, Sung-Kwon Moon, Hong-Duck Um and Yung Hyun Choi
    Citation: Molecular Medicine 2011 17:1705478
    Content type: Research Article Published on:

  36. Single nucleotide polymorphisms (SNPs) have been associated with prostate cancer (PCa) risk and tumor aggressiveness in retrospective studies. To assess the value of genotyping in a clinical setting, we evalua...

    Authors: Jean-Nicolas Cornu, Sarah Drouin, Géraldine Cancel-Tassin, Pierre Bigot, Abdel-Rahmène Azzouzi, Nicolas Koutlidis, Luc Cormier, Cécile Gaffory, Morgan Rouprêt, Philippe Sèbe, Marc-Olivier Bitker, François Haab and Olivier Cussenot
    Citation: Molecular Medicine 2011 17:1705473
    Content type: Research Article Published on:

  39. Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β-cell failure. In addition to impro...

    Authors: Dan P Christensen, Mattias Dahllöf, Morten Lundh, Daniel N Rasmussen, Mette D Nielsen, Nils Billestrup, Lars G Grunnet and Thomas Mandrup-Poulsen
    Citation: Molecular Medicine 2011 17:1705378
    Content type: Review Article Published on:

  41. Obesity is an important risk factor for cardiovascular disease, diabetes and certain cancers. The fat mass- and obesity-associated (FTO) gene is tightly associated with the pathophysiology of obesity, whereas the...

    Authors: Pei Wang, Feng-Jiao Yang, Hui Du, Yun-Feng Guan, Tian-Ying Xu, Xue-Wen Xu, Ding-Feng Su and Chao-Yu Miao
    Citation: Molecular Medicine 2011 17:1705523
    Content type: Research Article Published on:

  43. Burn injury causes hepatic dysfunction associated with endoplasmic reticulum (ER) stress and induction of the unfolded protein response (UPR). ER stress/UPR leads to hepatic apoptosis and activation of the Jun...

    Authors: Marc G Jeschke, Robert Kraft, Juquan Song, Gerd G Gauglitz, Robert A Cox, Natasha C Brooks, Celeste C Finnerty, Gabriela A Kulp, David N Herndon and Darren Boehning
    Citation: Molecular Medicine 2011 17:1705516
    Content type: Research Article Published on:

  44. In coronary artery disease (CAD), endothelin-1 (ET-1) is released by activated macrophages and thereby contributes to coronary plaque rupture and triggered cardiac events. The multifactorial regulation of ET-1...

    Authors: Matthew M Burg, Aaron Soufer, Rachel Lampert, Dorothea Collins and Robert Soufer
    Citation: Molecular Medicine 2011 17:1705495
    Content type: Research Article Published on:

  45. Mutations in the gap junction β2 (GJB2) gene, encoding the connexin26 (CX26) protein, are the most common cause of nonsyndromic hearing loss (HL) in many populations. In the East Asian population, two variants, p...

    Authors: Soo-Young Choi, Kyu Yup Lee, Hyun-Jin Kim, Hyo-Kyeong Kim, Qing Chang, Hong-Joon Park, Chang-Jin Jeon, Xi Lin, Jinwoong Bok and Un-Kyung Kim
    Citation: Molecular Medicine 2011 17:1705550
    Content type: Research Article Published on:

  46. Histone deacetylase (HDAC) inhibitors are currently used clinically as anticancer drugs. Recent data have demonstrated that some of these drugs have potent antiinflammatory or immunomodulatory effects at noncy...

    Authors: Sung Choi and Pavan Reddy
    Citation: Molecular Medicine 2011 17:1705404
    Content type: Review Article Published on:

  47. Coagulation is fundamental for the confinement of infection and/or the inflammatory response to a limited area. Under pathological inflammatory conditions such as arthritis, multiple sclerosis or sepsis, an un...

    Authors: Carla Jennewein, Nguyen Tran, Patrick Paulus, Peter Ellinghaus, Johannes Andreas Eble and Kai Zacharowski
    Citation: Molecular Medicine 2011 17:1705568
    Content type: Review Article Published on:

  48. Glycine N-methyltransferase (GNMT) is a major hepatic enzyme that converts S-adenosylmethionine to S-adenosylhomocys-teine while generating sarcosine from glycine, hence it can regulate mediating methyl group ava...

    Authors: Yi-Cheng Wang, Yi-Ming Chen, Yan-Jun Lin, Shih-Ping Liu and En-Pei Isabel Chiang
    Citation: Molecular Medicine 2011 17:1705486
    Content type: Research Article Published on:

  49. In type 1 diabetes, inflammatory and immunocompetent cells enter the islet and produce proinflammatory cytokines such as interleukin-1 β (IL-1β), IL-12, tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ); ...

    Authors: Eli C Lewis, Lykke Blaabjerg, Joachim Størling, Sif G Ronn, Paolo Mascagni, Charles A Dinarello and Thomas Mandrup-Poulsen
    Citation: Molecular Medicine 2011 17:1705369
    Content type: Research Article Published on:

  50. Cardiac dysfunction and mortality associated with trauma and sepsis increase with age. Mitochondria play a critical role in the energy demand of cardiac muscles, and thereby on the function of the heart. Speci...

    Authors: Bixi Jian, Shaolong Yang, Dongquan Chen, Luyun Zou, John C Chatham, Irshad Chaudry and Raghavan Raju
    Citation: Molecular Medicine 2010 17:1705542
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658