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Page 31 of 36

  1. Age-related macular degeneration (AMD) can be classified into two main categories: the atrophic, dry form and the exudative, wet form. The crucial difference between dry and wet AMD is the development of choro...

    Authors: Antero Salminen, Anu Kauppinen, Juha M. T. Hyttinen, Elisa Toropainen and Kai Kaarniranta
    Citation: Molecular Medicine 2010 16:1611535
    Content type: Review Article Published on:

  2. Abilities to successfully quit smoking display substantial evidence for heritability in classic and molecular genetic studies. Genomewide association (GWA) studies have demonstrated single-nucleotide polymorph...

    Authors: George R. Uhl, Tomas Drgon, Catherine Johnson, Marco F. Ramoni, Frederique M. Behm and Jed E. Rose
    Citation: Molecular Medicine 2010 16:1611513
    Content type: Research Article Published on:

  4. Hyperbilirubinemia may lead to neurotoxicity and neuronal death. Although the mechanisms of nerve cell damage by unconjugated bilirubin (UCB) appear to involve a disruption of the redox status and excitotoxici...

    Authors: Maria A. Brito, Ana R. Vaz, Sandra L. Silva, Ana S. Falcão, Adelaide Fernandes, Rui F. M. Silva and Dora Brites
    Citation: Molecular Medicine 2010 16:1609372
    Content type: Research Article Published on:

  5. Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) play crucial roles in diabetic angiopathy. In vivo, however, the following facts remain unknown: whether COX-2 and iNOS bind, how peroxynitrite-...

    Authors: Yanning Li, Jinsheng Qi, Kun Liu, Bin Li, Hui Wang and Jinhai Jia
    Citation: Molecular Medicine 2010 16:1609335
    Content type: Research Article Published on:

  6. We recently analyzed the hypermethylation status of the p16INK4a (p16) gene promoter in normal-appearing mucosa obtained from patients with colorectal cancer. Hypermethylation of p16 was associated with reduced s...

    Authors: Yvonne Wettergren, Elisabeth Odin, Göran Carlsson and Bengt Gustavsson
    Citation: Molecular Medicine 2010 16:1609425
    Content type: Research Article Published on:

  8. The role of common APOE variants on plasma lipids, particularly low density lipoprotein (LDL) levels, and coronary heart disease (CHD) risk is well known; the influence of variation in the other nearby apolipopro...

    Authors: Gie Ken-Dror, Philippa J. Talmud, Steve E. Humphries and Fotios Drenos
    Citation: Molecular Medicine 2010 16:1609389
    Content type: Research Article Published on:

  9. Airway remodeling is the process of airway structural change that occurs in patients with asthma in response to persistent inflammation and leads to increasing disease severity. Drugs that decrease this persis...

    Authors: Pei-Fen Chen, Ya-ling Luo, Wei Wang, Jiang-xin Wang, Wen-yan Lai, Si-ming Hu, Kai Fan Cheng and Yousef Al-Abed
    Citation: Molecular Medicine 2010 16:1609400
    Content type: Research Article Published on:

  10. Atherosclerosis is characterized by a chronic inflammatory condition that involves numerous cellular and molecular inflammatory components. A wide array of inflammatory mediators, such as cytokines and protein...

    Authors: Kai Yin, Duan-fang Liao and Chao-ke Tang
    Citation: Molecular Medicine 2010 16:1609438
    Content type: Review Article Published on:

  11. The first feline model of human congenital erythropoietic porphyria (CEP) due to deficient uroporphyrinogen III synthase (URO-synthase) activity was identified by its characteristic clinical phenotype, and con...

    Authors: Sonia Clavero, David F. Bishop, Urs Giger, Mark E. Haskins and Robert J. Desnick
    Citation: Molecular Medicine 2010 16:1609381
    Content type: Research Article Published on:

  13. Most immunosuppressive drugs that support successful allograft survival act by inhibiting or depleting T lymphocytes. Tautomycetin (TMC) is a specific inhibitor of protein phosphatase 1, which has a role in ce...

    Authors: Yu-Mee Wee, Monica Young Choi, Choong-Hoon Kang, Yang-Hee Kim, Jin-Hee Kim, Sang-Kyou Lee, Seung-Young Yu, Song-Cheol Kim and Duck-Jong Han
    Citation: Molecular Medicine 2010 16:1607298
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2012 18:Art19

  14. Endogenous hydrogen sulfide (H2S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-β-synthase and cystathionine-γ-lyase (CSE). H2S has been dem...

    Authors: Jing Zhang, Selena Wei Shan Sio, Shabbir Moochhala and Madhav Bhatia
    Citation: Molecular Medicine 2010 16:1609417
    Content type: Research Article Published on:

  15. To date there is no diagnostic biomarker for mild stroke, although elevation of inflammatory biomarkers has been reported at early stages. Previous studies implicated acetylcholinesterase (AChE) involvement in...

    Authors: Einor Ben Assayag, Shani Shenhar-Tsarfaty, Keren Ofek, Lilach Soreq, Irena Bova, Ludmila Shopin, Ronan M. G. Berg, Shlomo Berliner, Itzhak Shapira, Natan M. Bornstein and Hermona Soreq
    Citation: Molecular Medicine 2010 16:1607278
    Content type: Research Article Published on:

  16. MicroRNAs are small noncoding RNAs that are produced endogenously and have emerged as important regulators in pathophysiological conditions such as development and tumorigenesis. Very little is known about the...

    Authors: Kirti Bhatt, Li Zhou, Qing-Sheng Mi, Shuang Huang, Jin-Xiong She and Zheng Dong
    Citation: Molecular Medicine 2010 16:1609409
    Content type: Research Article Published on:

  17. Several HMGBl-specific antagonists have provided beneficial results in multiple models of inflammatory disease-preclinical trials including arthritis. Since no HMGB1-specific targeted therapy has yet reached t...

    Authors: Hanna Schierbeck, Heidi Wähämaa, Ulf Andersson and Helena Erlandsson Harris
    Citation: Molecular Medicine 2010 16:1609343
    Content type: Research Article Published on:

  18. ST-segment elevation is the major clinical criterion for committing patients with chest pain to have emergent coronary revascularizations; however, the mechanism responsible for ST-segment elevation is unknown...

    Authors: Ming Long, Lei Yang, Genya Huang, Liping Liu, Yugang Dong, Zhimin Du, Anli Tang, Chenghen Hu, Ruimin Gu, Xiuren Gao and Lilong Tang
    Citation: Molecular Medicine 2010 16:1607322
    Content type: Research Article Published on:

  19. Types A and B Niemann-Pick disease (NPD) result from the deficient activity of acid sphingomyelinase (ASM), due to mutations in the sphingomyelin phosphodiesterase 1 (SMPD1) gene. Here we report the identificatio...

    Authors: Jonathan P. Desnick, Jungmin Kim, Xingxuan He, Melissa P. Wasserstein, Calogera M. Simonaro and Edward H. Schuchman
    Citation: Molecular Medicine 2010 16:1607316
    Content type: Research Article Published on:

  20. The mechanisms by which alcohol consumption accelerates liver disease in patients with chronic hepatitis C virus (HCV) are not well understood. To identify the characteristics of molecular pathways affected by...

    Authors: Valeria R. Mas, Ryan Fassnacht, Kellie J. Archer and Daniel Maluf
    Citation: Molecular Medicine 2010 16:1607287
    Content type: Research Article Published on:

  21. The Hedgehog (Hh) signaling pathway has an important role during embryogenesis and in adult life, regulating proliferation, angiogenesis, matrix remodeling and stem-cell renewal. Deregulation of the Hh pathway...

    Authors: Ingrid Laurendeau, Marcela Ferrer, Delia Garrido, Nicky D’Haene, Patricia Ciavarelli, Armando Basso, Michel Vidaud, Ivan Bieche, Isabelle Salmon and Irene Szijan
    Citation: Molecular Medicine 2010 16:1607262
    Content type: Research Article Published on:

  22. Type 2 diabetes (T2D) is strongly linked to obesity and an adipose tissue unresponsive to insulin. The insulin resistance is due to defective insulin signaling, but details remain largely unknown. We examined ...

    Authors: Anita Öst, Kristoffer Svensson, Iida Ruishalme, Cecilia Brännmark, Niclas Franck, Hans Krook, Per Sandström, Preben Kjolhede and Peter Strålfors
    Citation: Molecular Medicine 2010 16:1607235
    Content type: Research Article Published on:

  23. We and others have reported that Rho-kinase plays an important role in the pathogenesis of heart ischemia/reperfusion (I/R) injury. Studies have also demonstrated that the activation of Rho-kinase is reversed ...

    Authors: Juan-Zhang, Hong-Jun Bian, Xiao-Xing Li, Xiao-Bo Liu, Jun-Ping Sun, Na-Li, Yun-Zhang and Xiao-Ping Ji
    Citation: Molecular Medicine 2010 16:1607307
    Content type: Research Article Published on:

  24. Hereditary colorectal cancer develops through a series of well-defined genetic and histological changes. However, elucidation of the canonical pathway based on hereditary colorectal cancer has not provided a c...

    Authors: Dong-Hyung Cho, Yoon Kyung Jo, Seon Ae Roh, Young-Soon Na, Tae Won Kim, Se Jin Jang, Yong Sung Kim and Jin Cheon Kim
    Citation: Molecular Medicine 2010 16:1607271
    Content type: Research Article Published on:

  25. Trauma-hemorrhage (T-H) is known to impair tissue perfusion, leading to tissue hypoxia, and thus affecting mitochondria, the organelles with the highest oxygen demand. In a model of T-H and prolonged hypotensi...

    Authors: Andrey V. Kozlov, J. Catharina Duvigneau, Tanya C. Hyatt, Raghavan Raju, Tricia Behling, Romana T. Hartl, Katrin Staniek, Ingrid Miller, Wolfgang Gregor, Heinz Redl and Irshad H. Chaudry
    Citation: Molecular Medicine 2010 16:1607254
    Content type: Research Article Published on:

  26. Improving and targeting nicotine replacement therapy (NRT) are cost-effective strategies for reducing adverse health consequences for smokers. Treatment studies document the efficacy of precessation NRT and su...

    Authors: Jed E. Rose, Frédérique M. Behm, Tomas Drgon, Catherine Johnson and George R. Uhl
    Citation: Molecular Medicine 2010 16:1607247
    Content type: Research Article Published on:

  27. Celiac disease (CD) is an immune-mediated disorder triggered by the ingestion of wheat gliadin and related proteins in genetically predisposed individuals. To find a proteomic CD diagnostic signature and to ga...

    Authors: Maria Paola Simula, Renato Cannizzaro, Vincenzo Canzonieri, Alessandro Pavan, Stefania Maiero, Giuseppe Toffoli and Valli De Re
    Citation: Molecular Medicine 2010 16:1605199
    Content type: Research Article Published on:

  28. Previous studies have shown that amyloid β protein (Aβ), the essential molecule for the formation of toxic oligomers and, subsequently, Alzheimer plaques, has been associated in vivo with the immune modulator, ma...

    Authors: Michael Bacher, Oliver Deuster, Bayan Aljabari, Rupert Egensperger, Frauke Neff, Frank Jessen, Julius Popp, Carmen Noelker, Jens Peter Reese, Yousef Al-Abed and Richard Dodel
    Citation: Molecular Medicine 2010 16:1603116
    Content type: Research Article Published on:

  29. The protein transduction domain from human immunodeficiency virus (HIV) Tat allows proteins to penetrate the cell membrane. Enhanced cellular uptake of therapeutic proteins could benefit a number of disorders....

    Authors: Koji Higuchi, Makoto Yoshimitsu, Xin Fan, Xiaoxin Guo, Vanessa I. Rasaiah, Jennifer Yen, Chuwa Tei, Toshihiro Takenaka and Jeffrey A. Medin
    Citation: Molecular Medicine 2010 16:1605216
    Content type: Research Article Published on:

  30. Skin keratinocytes express tissue factor (TF) and are highly associated with skin wound healing. Although it has been demonstrated that perivascular TF expression in granulation tissue formed after dermal inju...

    Authors: Zhi Xu, Haifeng Xu, Victoria A. Ploplis and Francis J. Castellino
    Citation: Molecular Medicine 2010 16:1605167
    Content type: Research Article Published on:

  31. Deletion of mouse preprotachykinin-A (PPTA), which encodes mainly for neuropeptide substance P, has been shown to protect against lung injury and mortality in sepsis. This study explored microarray-based differen...

    Authors: Akhil Hegde, Ramasamy Tamizhselvi, Jayapal Manikandan, Alirio J. Melendez, Shabbir M. Moochhala and Madhav Bhatia
    Citation: Molecular Medicine 2010 16:1605188
    Content type: Research Article Published on:

  32. Interferon γ (IFN-γ) has recently been implicated in cancer immunosurveillance. Among the most abundant proteins induced by IFN-γ are guanylate binding proteins (GBPs), which belong to the superfamily of large...

    Authors: Karoline Lipnik, Elisabeth Naschberger, Nathalie Gonin-Laurent, Petra Kodajova, Helga Petznek, Stefanie Rungaldier, Simonetta Astigiano, Silvano Ferrini, Michael Stürzl and Christine Hohenadl
    Citation: Molecular Medicine 2010 16:1605177
    Content type: Research Article Published on:

  33. Endocytosis is the process by which cells take up macromolecules from the surrounding medium. The best-characterized process is the so-called clathrin-dependent endocytosis, although much is also currently kno...

    Authors: Jennifer E. Ziello, Yan Huang and Ion S. Jovin
    Citation: Molecular Medicine 2010 16:1605222
    Content type: Review Article Published on:

  34. The aim of the present study was to test the hypothesis that the activation of the angiotensin-converting enzyme (ACE)2/angiotensin-(1–7)/Mas receptor axis by use of a novel ACE2 activator (XNT) would protect aga...

    Authors: Rodrigo A. Fraga-Silva, Brian S. Sorg, Mamta Wankhede, Casey deDeugd, Joo Y. Jun, Matthew B. Baker, Yan Li, Ronald K. Castellano, Michael J. Katovich, Mohan K. Raizada and Anderson J. Ferreira
    Citation: Molecular Medicine 2010 16:1605210
    Content type: Research Article Published on:

  35. Cystic fibrosis (CF) is a lethal genetic disorder characterized by airway remodeling and inflammation, leading to premature death. Recent evidence suggests the importance of protease activity in CF pathogenesi...

    Authors: Patricia L. Jackson, Xin Xu, Landon Wilson, Nathaniel M. Weathington, John Paul Clancy, James Edwin Blalock and Amit Gaggar
    Citation: Molecular Medicine 2010 16:1605159
    Content type: Research Article Published on:

  37. The threat of nuclear terrorism has led to growing worldwide concern about exposure to radiation. Acute radiation syndrome, or radiation sickness, develops after whole-body or a partial-body irradiation with a...

    Authors: Asha Jacob, Kavin G. Shah, Rongqian Wu and Ping Wang
    Citation: Molecular Medicine 2010 16:1603137
    Content type: Review Article Published on:

  38. Transforming growth factor β (TGFβ) is important in inflammation, angiogenesis, reepithelialization and connective tissue regeneration during wound healing. We analyzed components of TGFβ signaling pathway in ...

    Authors: Irena Pastar, Olivera Stojadinovic, Agata Krzyzanowska, Stephan Barrientos, Christina Stuelten, Karen Zimmerman, Miroslav Blumenberg, Harold Brem and Marjana Tomic-Canic
    Citation: Molecular Medicine 2010 16:1603092
    Content type: Research Article Published on:

  40. Juvenile idiopathic arthritis (JIA) is the most common autoimmune inflammatory disease in children; joint inflammation is the hallmark of the disease. Thirty-five children with JIA were studied, of whom 26 had...

    Authors: Riva Brik, Irit Rosen, Dana Savulescu, Iris Borovoi, Moshe Gavish and Rafael Nagler
    Citation: Molecular Medicine 2009 16:1603122
    Content type: Research Article Published on:

  41. Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elucidate hepatocellular carcinoma molecular pathogenesis, it is still not fully understood. To acquire further ...

    Authors: Daniela Spano, Roberta Russo, Vittorio Di Maso, Natalia Rosso, Luigi M. Terracciano, Massimo Roncalli, Luigi Tornillo, Mario Capasso, Claudio Tiribelli and Achille Iolascon
    Citation: Molecular Medicine 2009 16:1603102
    Content type: Research Article Published on:

  42. Polycystic ovary syndrome (PCOS) is an endocrine-metabolic disorder associated with insulin resistance and compensatory hyperinsulinemia. Scarce information is available on the expression of molecules involved...

    Authors: Romina Fornes, Paulina Ormazabal, Carlos Rosas, Fernando Gabler, David Vantman, Carmen Romero and Margarita Vega
    Citation: Molecular Medicine 2009 16:1603129
    Content type: Research Article Published on:

  43. Human CD38 is a pleiotropic glycoprotein belonging to a family of enzymes/receptors involved in the catabolism of extracellular nucleotides. CD38-receptor activities are regulated through binding to the nonsub...

    Authors: Silvia Deaglio, Semra Aydin, Maurizia Mello Grand, Tiziana Vaisitti, Luciana Bergui, Giovanni D’Arena, Giovanna Chiorino and Fabio Malavasi
    Citation: Molecular Medicine 2009 16:1603087
    Content type: Research Article Published on:

  44. The role of inflammation in malaria pathogenesis is not fully understood, although C-reactive protein (CRP) may have a negative influence on host immunity to infections. An upstream polymorphism, −286 (C > T >...

    Authors: Hayder A. Giha, Amre Nasr, Mattias Ekström, Elisabeth Israelsson, Gishanthi Arambepola, David Arnot, Thor G. Theander, Marita Troye-Blomberg, Klavs Berzins, Per Tornvall and Gehad ElGhazali
    Citation: Molecular Medicine 2009 16:16010027
    Content type: Research Article Published on:

  45. The main circulating estrogen hormone 17β-estradiol (E2) contributes to the initiation and progression of breast cancer. Estrogen receptors (ERs), as transcription factors, mediate the effects of E2. Ablation ...

    Authors: Stephanie L. Nott, Yanfang Huang, Aja Kalkanoglu, Kathryn Harper, Ming Chen, Scott F. Paoni, Bruce M. Fenton and Mesut Muyan
    Citation: Molecular Medicine 2009 16:16010010
    Content type: Research Article Published on:

  46. During the course of polymicrobial sepsis, a range of pro- and antiinflammatory cytokines are produced by the host immune system. Successful recovery from sepsis involves striking a balance between these count...

    Authors: Akhil Hegde, Mahesh Uttamchandani, Shabbir M. Moochhala and Madhav Bhatia
    Citation: Molecular Medicine 2009 16:16010045
    Content type: Research Article Published on:

  47. The present work describes a novel interaction between the human immunodeficiency virus type 1 (HIV-1) Rev protein and the cellular lens epithelium-derived growth factor p75 (LEDGF/p75) protein in vitro and in vi...

    Authors: Aviad Levin, Joseph Rosenbluh, Zvi Hayouka, Assaf Friedler and Abraham Loyter
    Citation: Molecular Medicine 2009 16:16010034
    Content type: Research Article Published on:

  48. Systemic lupus erythematosus (SLE) is characterized by the production of grouped sets of autoantibodies targeting mainly the U1 ribonucleoprotein (RNP) and/or Ro/La RNP particles. Intraparticle diversification...

    Authors: John G. Routsias, Nikolaos Kyriakidis, Michael Latreille and Athanasios G. Tzioufas
    Citation: Molecular Medicine 2009 16:16010019
    Content type: Research Article Published on:

  49. Glioblastomas, the most frequent primary brain tumors in adults, are characterized by a highly aggressive, inflammatory and angiogenic phenotype. Methylation of CpG islands in cancer-related genes may serve as...

    Authors: Christina Piperi, Marios S. Themistocleous, George A. Papavassiliou, Elena Farmaki, Georgia Levidou, Penelope Korkolopoulou, Christos Adamopoulos and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2009 16:16010001
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658