Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 23 of 37

  1. Intestinal ischemia and reperfusion (I/R) is encountered in various clinical conditions and contributes to multiorgan failure and mortality as high as 60% to 80%. Intestinal I/R not only injures the intestine,...

    Authors: Juan-Pablo Idrovo, Weng-Lang Yang, Asha Jacob, Monowar Aziz, Jeffrey Nicastro, Gene F. Coppa and Ping Wang
    Citation: Molecular Medicine 2015 20:2001676
    Content type: Research Article Published on:

  2. The process of islet transplantation for treating type 1 diabetes has been limited by the high level of graft failure. This may be overcome by locally delivering trophic factors to enhance engraftment. Regener...

    Authors: Ying Ding, Yuemei Xu, Xuanyu Shuai, Xuhui Shi, Xiang Chen, Wenbin Huang, Yun Liu, Xiubin Liang, Zhihong Zhang and Dongming Su
    Citation: Molecular Medicine 2014 20:2001548
    Content type: Research Article Published on:

  3. There is an expanding role for interleukin (IL)-1 in diseases from gout to cancer. More than any other cytokine family, the IL-1 family is closely linked to innate inflammatory and immune responses. This linka...

    Authors: Charles Anthony Dinarello
    Citation: Molecular Medicine 2014 20(Suppl 1):20001043
    Content type: Retrospective Published on:

    This article is part of a Supplement: Volume 20 Supplement 1

  4. Granulocyte colony-stimulating factor (G-CSF) is a major regulator of granulopoiesis on engagement with the G-CSF receptor (G-CSFR). The truncated, alternatively spliced, class IV G-CSFR (G-CSFRIV) has been as...

    Authors: HaiJiao Zhang, Lilia Goudeva, Stephan Immenschuh, Axel Schambach, Julia Skokowa, Britta Eiz-Vesper, Rainer Blasczyk and Constança Figueiredo
    Citation: Molecular Medicine 2014 20:2001736
    Content type: Research Article Published on:

  5. Rupture of abdominal aortic aneurysm (AAA) is a cause of significant mortality and morbidity in aging populations. Uptake of 18-fluorodeoxyglucose (FDG) detected by positron emission tomography (PET) is observ...

    Authors: Audrey Courtois, Betty V. Nusgens, Roland Hustinx, Gauthier Narnur, Pierre Gomez, Helena Kuivaniemi, Jean-Olivier Defraigne, Alain C. Colige and Natzi Sakalihasan
    Citation: Molecular Medicine 2014 20:2001697
    Content type: Research Article Published on:

  6. Pathophysiological conditions that lead to the release of the prototypic damage-associated molecular pattern molecule high mobility group box 1 (HMGB1) also result in activation of poly(ADP-ribose) polymerase ...

    Authors: Thomas D. Walko III, Valentina Di Caro, Jon Piganelli, Timothy R. Billiar, Robert S. B. Clark and Rajesh K. Aneja
    Citation: Molecular Medicine 2014 20:2001612
    Content type: Research Article Published on:

  7. Patients with chronic lymphocytic leukemia (CLL) assigned to stereotyped subset #4 express highly homologous B-cell receptor immunoglobulin (BcR IG) sequences with intense intraclonal diversification (ID) in t...

    Authors: Lesley-Ann Sutton, Giorgos Papadopoulos, Anastasia Hadzidimitriou, Stavros Papadopoulos, Efterpi Kostareli, Richard Rosenquist, Dimitrios Tzovaras and Kostas Stamatopoulos
    Citation: Molecular Medicine 2014 20:2001720
    Content type: Research Article Published on:

  8. Chronic hypoxia typically elicits pulmonary hypertension (PH) in mice with a male-dominant phenotype. There is an opposite-sex bias in human PH, with a higher prevalence in women, but greater survival (the “es...

    Authors: Yang-Ming Yang, Huijuan Yuan, John G. Edwards, Yester Skayian, Kanta Ochani, Edmund J. Miller and Pravin B. Sehgal
    Citation: Molecular Medicine 2014 20:2001625
    Content type: Research Article Published on:

  9. Although erythropoietin ameliorates experimental type 2 diabetes with neuropathy, serious side effects limit its potential clinical use. ARA 290, a nonhematopoietic peptide designed from the structure of eryth...

    Authors: Michael Brines, Ann N. Dunne, Monique van Velzen, Paolo L. Proto, Claes-Goran Ostenson, Rita I. Kirk, Ioannis N. Petropoulos, Saad Javed, Rayaz A. Malik, Anthony Cerami and Albert Dahan
    Citation: Molecular Medicine 2014 20:2001658
    Content type: Research Article Published on:

  10. Toll-like receptor 4 (TLR4) is ubiquitously expressed on parenchymal and immune cells of the liver and is the most studied TLR responsible for the activation of proinflammatory signaling cascades in liver isch...

    Authors: Kerry-Ann McDonald, Hai Huang, Samer Tohme, Patricia Loughran, Kimberly Ferrero, Timothy Billiar and Allan Tsung
    Citation: Molecular Medicine 2014 20:2001639
    Content type: Research Article Published on:

  11. Surgery and critical illness often associate with cognitive decline. Surgical trauma or infection can lead independently to learning and memory impairments via similar, but not identical, cellular signaling of...

    Authors: Niccolò Terrando, Ting Yang, Jae Kyu Ryu, Phillip T. Newton, Claudia Monaco, Marc Feldmann, Daqing Ma, Katerina Akassoglou and Mervyn Maze
    Citation: Molecular Medicine 2014 20:2001667
    Content type: Research Article Published on:

  12. Ethyl pyruvate (EP), a simple aliphatic ester of pyruvic acid, has been shown to have antiinflammatory effects and to confer protective effects in various pathological conditions. Recently, a number of studies...

    Authors: Joo-Hyun Shin, Il-Doo Kim, Seung-Woo Kim, Hye-Kyung Lee, Yinchuan Jin, Ju-Hun Park, Tae-Kyung Kim, Chang-Kook Suh, Jiyeon Kwak, Keun-Hyeung Lee, Pyung-Lim Han and Ja-Kyeong Lee
    Citation: Molecular Medicine 2014 20:2001649
    Content type: Research Article Published on:

  13. We first reported the role of 5-hydroxymethyl-2-furfural (5-HMF) against hypoxia. Here, we studied the mechanism by using oxygen-dependent degradation domain (ODD)-Luc mice, which are a useful model to probe t...

    Authors: Yun-Ling He, Ming-Ming Li, Li-Ying Wu, Tong Zhao, Yao Di, Xin Huang, Xue-Feng Ding, Kui-Wu Wu, Ming Fan and Ling-Ling Zhu
    Citation: Molecular Medicine 2014 20:2001590
    Content type: Research Article Published on:

  14. Inflammatory conditions characterized by excessive peripheral immune responses are associated with diverse alterations in brain function, and brain-derived neural pathways regulate peripheral inflammation. Imp...

    Authors: Harold A. Silverman, Meghan Dancho, Angelique Regnier-Golanov, Mansoor Nasim, Mahendar Ochani, Peder S. Olofsson, Mohamed Ahmed, Edmund J. Miller, Sangeeta S. Chavan, Eugene Golanov, Christine N. Metz, Kevin J. Tracey and Valentin A. Pavlov
    Citation: Molecular Medicine 2014 20:2001601
    Content type: Research Article Published on:

  15. Mechanical ventilation (MV) is one of the lynchpins of modern intensive-care medicine and is life saving in many critically ill patients. Continuous ventilator support, however, results in ventilation-induced ...

    Authors: Huibin Tang, Ira J. Smith, Sabah N. A. Hussain, Peter Goldberg, Myung Lee, Sista Sugiarto, Guillermo L. Godinez, Baljit K. Singh, Donald G. Payan, Thomas A. Rando, Todd M. Kinsella and Joseph B. Shrager
    Citation: Molecular Medicine 2014 20:2001579
    Content type: Research Article Published on:

  17. Macrophage activation syndrome (MAS) is a potentially fatal complication of systemic inflammation. High mobility group box 1 (HMGB1) is a nuclear protein extensively leaked extracellularly during necrotic cell...

    Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson
    Citation: Molecular Medicine 2014 20:2001538
    Content type: Research Article Published on:

    The Retraction Note to this article has been published in Molecular Medicine 2020 26:131

    The Expression of Concern to this article has been published in Molecular Medicine 2020 26:17

  19. The study was designed to explore the role and possible mechanisms of hydrogen sulfide (H2S) in the regulation of myocardial collagen remodeling in spontaneously hypertensive rats (SHRs). We treated nine-week-old...

    Authors: Lili Sun, Hongfang Jin, Lujing Sun, Siyao Chen, Yaqian Huang, Jia Liu, Zhenzhen Li, Manman Zhao, Yan Sun, Chaoshu Tang, Bin Zhao and Junbao Du
    Citation: Molecular Medicine 2014 20:2001503
    Content type: Research Article Published on:

  20. Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine to...

    Authors: Göran K. Hansson
    Citation: Molecular Medicine 2014 20:2001381
    Content type: Anthony Cerami Award in Translational Medicine Published on:

  21. Helium, a noble gas, has been used safely in humans. In animal models of regional myocardial ischemia/reperfusion (I/R) it was shown that helium conditioning reduces infarct size. Currently, it is not known ho...

    Authors: Gezina T. M. L. Oei, Michal Heger, Rowan F. van Golen, Lindy K. Alles, Moritz Flick, Allard C. van der Wal, Thomas M. van Gulik, Markus W. Hollmann, Benedikt Preckel and Nina C. Weber
    Citation: Molecular Medicine 2014 20:2001516
    Content type: Research Article Published on:

  22. Disc degeneration is the most common cause of back pain in adults and has enormous socioeconomic implications. Conservative management is ineffective in most cases, and results of surgical treatment have not y...

    Authors: Elias S. Vasiliadis, Spyros G. Pneumaticos, Demitrios S. Evangelopoulos and Athanasios G. Papavassiliou
    Citation: Molecular Medicine 2014 20:2001400
    Content type: Review Article Published on:

  23. Cell death and inflammation are key pathologic responses of acute pancreatitis (AP), the leading cause of hospital admissions for gastrointestinal disorders. It is becoming increasingly clear that damage-assoc...

    Authors: Rui Kang, Michael T. Lotze, Herbert J. Zeh, Timothy R. Billiar and Daolin Tang
    Citation: Molecular Medicine 2014 20:2001466
    Content type: Review Article Published on:

  24. Lapatinib, a tyrosine kinase inhibitor, is used in the treatment of advanced or metastatic breast cancer overexpressing human epidermal receptor 2 (HER2). Lapatinib can modulate the function of ATP-binding cas...

    Authors: Shao-lin Ma, Ya-peng Hu, Fang Wang, Zhen-cong Huang, Yi-fan Chen, Xiao-kun Wang and Li-wu Fu
    Citation: Molecular Medicine 2014 20:2001390
    Content type: Research Article Published on:

  25. Atherosclerosis is an inflammatory disease and the main cause of cardiovascular disease. Inflammation promotes plaque instability and clinical disease, such as myocardial infarction, stroke and peripheral vasc...

    Authors: Leif Å Söderström, Karl Gertow, Lasse Folkersen, Maria Sabater-Lleal, Eva Sundman, Yuri Sheikine, Anuj Goel, Damiano Baldassarre, Steve E. Humphries, Ulf de Faire, Hugh Watkins, Elena Tremoli, Fabrizio Veglia, Anders Hamsten, Göran K. Hansson and Peder S. Olofsson
    Citation: Molecular Medicine 2014 20:2001456
    Content type: Research Article Published on:

  26. Chemokine (C-X-C motif) receptor (CXCR) 4 and atypical chemokine receptor (ACKR) 3 ligands have been reported to modulate cardiovascular function in various disease models. The underlying mechanisms, however, ...

    Authors: Harold H. Bach IV, Yee M. Wong, Abhishek Tripathi, Amanda M. Nevins, Richard L. Gamelli, Brian F. Volkman, Kenneth L. Byron and Matthias Majetschak
    Citation: Molecular Medicine 2014 20:2001435
    Content type: Research Article Published on:

  27. Although androgen receptor (AR) signaling is the main molecular tool regulating growth and function of the prostate gland, estrogen receptor β (ERβ) is involved in the differentiation of prostatic epithelial c...

    Authors: Paraskevi Christoforou, Panagiotis F. Christopoulos and Michael Koutsilieris
    Citation: Molecular Medicine 2014 20:2001427
    Content type: Review Article Published on:

  28. Inadequate magnesium (Mg) intake is a widespread problem, with over 50% of women of reproductive age consuming less than the Recommended Dietary Allowance (RDA). Because pregnancy increases the requirement for...

    Authors: Madhu Gupta, Malvika H. Solanki, Prodyot K. Chatterjee, Xiangying Xue, Amanda Roman, Neeraj Desai, Burton Rochelson and Christine N. Metz
    Citation: Molecular Medicine 2014 20:2001332
    Content type: Research Article Published on:

  29. Poly(ADP-ribosyl)ation (PARylation) is a protein modification reaction regulating various diverse cellular functions ranging from metabolism, DNA repair and transcription to cell death. We set out to investiga...

    Authors: Tarek El-Hamoly, Csaba Hegedűs, Petra Lakatos, Katalin Kovács, Péter Bai, Mona A. El-Ghazaly, Ezzeddin S. El-Denshary, Éva Szabó and László Virág
    Citation: Molecular Medicine 2014 20:2001363
    Content type: Research Article Published on:

  30. Thyroid dysfunction is common in individuals with diabetes mellitus (DM) and may contribute to the associated cardiac dysfunction. However, little is known about the extent and pathophysiological consequences ...

    Authors: Nathan Y. Weltman, Kaie Ojamaa, Evelyn H. Schlenker, Yue-Feng Chen, Riccardo Zucchi, Alessandro Saba, Daria Colligiani, Viswanathan Rajagopalan, Christine J. Pol and A. Martin Gerdes
    Citation: Molecular Medicine 2014 20:2001302
    Content type: Research Article Published on:

  31. Recurrent respiratory papillomatosis (RRP) is a rare, chronic disease caused by human papillomaviruses (HPVs) types 6 and 11 that is characterized by the polarization of adaptive immune responses that support ...

    Authors: James DeVoti, Lynda Hatam, Alexandra Lucs, Ali Afzal, Allan Abramson, Bettie Steinberg and Vincent Bonagura
    Citation: Molecular Medicine 2014 20:2001372
    Content type: Research Article Published on:

  32. PDZ domain containing 1 (PDZK1) is a scaffold protein that plays a role in the fate of several proteins. Estrogen can induce PDZK1 gene expression; however, our recent report showed that PDZK1 expression in the b...

    Authors: Hogyoung Kim, Zakaria Y. Abd Elmageed, Christian Davis, Ali H. El-Bahrawy, Amarjit S. Naura, Ibrahim Ekaidi, Asim B. Abdel-Mageed and A. Hamid Boulares
    Citation: Molecular Medicine 2014 20:2001270
    Content type: Research Article Published on:

  33. Forkhead box P3 (Foxp3) is the major transcription factor controlling the development and function of regulatory T (Treg) cells. Previous studies have indicated epigenetic regulation of Foxp3 expression. Here, we...

    Authors: Michael W. Y. Chan, Chia-Bin Chang, Chien-Hsueh Tung, Justin Sun, Jau-Ling Suen and Shu-Fen Wu
    Citation: Molecular Medicine 2014 20:2001248
    Content type: Research Article Published on:

  34. Poly(ADP-ribose) polymerase-1 (PARP-1) activation is a hallmark of oxidative stress-induced cellular injury that can lead to energetic failure and necrotic cell death via depleting the cellular nicotinamide ad...

    Authors: Domokos Gerö, Petra Szoleczky, Athanasia Chatzianastasiou, Andreas Papapetropoulos and Csaba Szabo
    Citation: Molecular Medicine 2014 20:2001313
    Content type: Research Article Published on:

  35. A side effect of radiation therapy in the head and neck region is injury to surrounding healthy tissues such as irreversible impaired function of the salivary glands. Hyperbaric oxygen therapy (HBOT) is clinic...

    Authors: Linda Spiegelberg, Sigrid M. A. Swagemakers, Wilfred F. J. van Ijcken, Edwin Oole, Eppo B. Wolvius, Jeroen Essers and Joanna A. M. Braks
    Citation: Molecular Medicine 2014 20:2001257
    Content type: Research Article Published on:

  36. Interleukin 18 (IL-18) is a proinflammatory cytokine in the IL-1 family that has been implicated in a number of disease states. In animal models of acute myocardial infarction (AMI), pressure overload, and LPS...

    Authors: Laura C. O’Brien, Eleonora Mezzaroma, Benjamin W. Van Tassell, Carlo Marchetti, Salvatore Carbone, Antonio Abbate and Stefano Toldo
    Citation: Molecular Medicine 2014 20:2001221
    Content type: Review Article Published on:

  37. Chronic lymphocytic leukemia (CLL) cells survive longer in vivo than in vitro, suggesting that the tissue microenvironment provides prosurvival signals to tumor cells. Primary and secondary lymphoid tissues are i...

    Authors: Amit K. Mittal, Nagendra K. Chaturvedi, Karan J. Rai, Christine E. Gilling-Cutucache, Tara M. Nordgren, Margaret Moragues, Runqing Lu, Rene Opavsky, Greg R. Bociek, Dennis D. Weisenburger, Javeed Iqbal and Shantaram S. Joshi
    Citation: Molecular Medicine 2014 20:2001290
    Content type: Research Article Published on:

  38. Chronic stress has deleterious effects on immune function, which can lead to adverse health outcomes. However, studies investigating the impact of stress reduction interventions on immunity in clinical researc...

    Authors: Blake T. Gurfein, Olga Davidenko, Mary Premenko-Lanier, Jeffrey M. Milush, Michael Acree, Mary F. Dallman, Chadi Touma, Rupert Palme, Vanessa A. York, Gilles Fromentin, Nicolas Darcel, Douglas F. Nixon and Frederick M. Hecht
    Citation: Molecular Medicine 2014 20:2001179
    Content type: Research Article Published on:

  39. Pulmonary arterial hypertension (PAH) is characterized by a persistent elevation of pulmonary arterial pressure and pulmonary arterial remodeling with unknown etiology. Current therapeutics available for PAH a...

    Authors: Patrick Crosswhite and Zhongjie Sun
    Citation: Molecular Medicine 2014 20:2001191
    Content type: Review Article Published on:

  40. Mechanical ventilation with supraphysiological concentrations of oxygen (hyperoxia) is routinely used to treat patients with respiratory distress. However, prolonged exposure to hyperoxia compromises the abili...

    Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr., Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell
    Citation: Molecular Medicine 2014 20:2001238
    Content type: Research Article Published on:

    The Retraction Note to this article has been published in Molecular Medicine 2020 26:132

    The Expression of Concern to this article has been published in Molecular Medicine 2020 26:16

  41. The insulinlike growth factor-I (IGF-I) is an important factor which regulates a variety of cellular responses in multiple biological systems. The IGF1 gene comprises a highly conserved sequence and contains six ...

    Authors: Anastassios Philippou, Maria Maridaki, Spiros Pneumaticos and Michael Koutsilieris
    Citation: Molecular Medicine 2014 20:2001202
    Content type: Review Article Published on:

  42. Taxanes, such as docetaxel and taxol, have been used as firstline chemotherapies in advanced lung adenocarcinoma (LAD), but limited responses to chemotherapy remain a major impediment in the clinic. Treatment ...

    Authors: Jin Ren, Rui Wang, Haizhu Song, Guichun Huang and Longbang Chen
    Citation: Molecular Medicine 2014 20:2001164
    Content type: Research Article Published on:

  44. To characterize the molecular mechanisms of N-acetylaspartate (NAA) metabolism following traumatic brain injury (TBI), we measured the NAA, adenosine triphosphate (ATP) and adenosine diphosphate (ADP) concentrati...

    Authors: Valentina Di Pietro, Angela Maria Amorini, Barbara Tavazzi, Roberto Vagnozzi, Ann Logan, Giacomo Lazzarino, Stefano Signoretti, Giuseppe Lazzarino and Antonio Belli
    Citation: Molecular Medicine 2014 20:2001147
    Content type: Research Article Published on:

  45. The posttranscriptional mechanisms by which RNA binding proteins (RBPs) regulate T-cell differentiation and cytokine production in vivo remain unclear. The RBP HuR binds to labile mRNAs, usually leading to increa...

    Authors: Matthew M. Gubin, Patsharaporn Techasintana, Joseph D. Magee, Garrett M. Dahm, Robert Calaluce, Jennifer L. Martindale, Maryln S. Whitney, Craig L. Franklin, Cindy Besch-Williford, John W. Hollingsworth, Kotb Abdelmohsen, Myriam Gorospe and Ulus Atasoy
    Citation: Molecular Medicine 2014 20:2001093
    Content type: Research Article Published on:

  46. Kisspeptin is an antimetastatic agent in some cancers that has also been associated with lymphoid cell apoptosis, a phenomenon favoring metastases. Our aim was to determine the association of kisspeptin with l...

    Authors: Martha Stathaki, Athanasios Armakolas, Andreas Dimakakos, Loukas Kaklamanis, Ioannis Vlachos, Manoussos M. Konstantoulakis, George Zografos and Michael Koutsilieris
    Citation: Molecular Medicine 2013 20:2001080
    Content type: Research Article Published on:

  47. Atrophic autoimmune gastritis (AAG) is a condition of chronic inflammation and atrophy of stomach mucosa, for which development can be partially triggered by the bacterial pathogen Helicobacter pylori (HP). HP ca...

    Authors: Ombretta Repetto, Stefania Zanussi, Mariateresa Casarotto, Vincenzo Canzonieri, Paolo De Paoli, Renato Cannizzaro and Valli De Re
    Citation: Molecular Medicine 2013 20:2001057
    Content type: Research Article Published on:

  48. Hyperactivation of signal transducer and activator of transcription 3 (STAT3) has been linked to tumorigenesis in most malignancies, including head and neck squamous cell carcinoma. Intravenous delivery of a c...

    Authors: Malabika Sen, Kathleen Paul, Maria L. Freilino, Hua Li, Changyou Li, Daniel E. Johnson, Lin Wang, Julie Eiseman and Jennifer R. Grandis
    Citation: Molecular Medicine 2013 20:2001046
    Content type: Research Article Published on:

  49. Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that th...

    Authors: Zhenwei Zhang, Lei Miao, Xiaoming Xin, Jianpeng Zhang, Shengsheng Yang, Mingyong Miao, Xiangping Kong and Binghua Jiao
    Citation: Molecular Medicine 2013 20:2001017
    Content type: Research Article Published on:

  50. The endocannabinoid CB2 receptor system has been implicated in the neuropathology of Alzheimer’s disease (AD). In order to investigate the impact of the CB2 receptor system on AD pathology, a colony of mice with ...

    Authors: Jeremy Koppel, Valerie Vingtdeux, Philippe Marambaud, Cristina d’Abramo, Heidy Jimenez, Mark Stauber, Rachel Friedman and Peter Davies
    Citation: Molecular Medicine 2013 20:2001029
    Content type: Research Article Published on:
Submit manuscript

Annual Journal Metrics

  • Annual Journal Metrics

    2022 Citation Impact
    5.7 - 2-year Impact Factor
    6.3 - 5-year Impact Factor
    1.026 - SNIP (Source Normalized Impact per Paper)
    1.245 - SJR (SCImago Journal Rank)

    2023 Speed
    6 days submission to first editorial decision for all manuscripts (Median)
    132 days submission to accept (Median)

    2023 Usage
    1,105,866 downloads
    1,878 Altmetric mentions

Follow

Molecular Medicine

ISSN: 1528-3658