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  1. Cerebral malaria (CM) Is associated with excessive Inflammatory responses and endothelial activation. Sphingosine 1-phosphate (S1P) is a signaling sphingolipid implicated in regulating vascular integrity, infl...

    Authors: Constance A M Finney, Cheryl A Hawkes, Dylan C Kain, Aggrey Dhabangi, Charles Musoke, Christine Cserti-Gazdewich, Tamas Oravecz, W Conrad Liles and Kevin C Kain
    Citation: Molecular Medicine 2011 17:1707717
    Content type: Research Article Published on:

  3. Multiple myeloma (MM) is a neoplasm of plasma cell origin that is largely confined to the bone marrow (BM). Chromosomal translocations and other genetic events are known to contribute to deregulation of signal...

    Authors: Gwenny Manel Fuhler, Sander Henricus Diks, Maikel Petrus Peppelenbosch and William Garrow Kerr
    Citation: Molecular Medicine 2011 17:1707790
    Content type: Research Article Published on:

  4. Pulmonary infection is a major cause of mortality and morbidity, and the magnitude of the lung inflammatory response correlates with patient survival. Previously, we have shown that neutrophil migration into j...

    Authors: Yinzhong Zhang, Xinchun Lin, Kiyokazu Koga, Koichiro Takahashi, Helena M Linge, Adriana Mello, Teresina Laragione, Percio S Gulko and Edmund J Miller
    Citation: Molecular Medicine 2011 17:1707780
    Content type: Research Article Published on:

  5. Deficits In social behavior In mice lacking the CD38 gene have been attributed to Impaired secretion of oxytocin. In humans, similar deficits in social behavior are associated with autistic spectrum disorder (ASD...

    Authors: Mathias Riebold, David Mankuta, Elad Lerer, Salomon Israel, Songfa Zhong, Luba Nemanov, Mikhail V Monakhov, Shlomit Levi, Nurit Yirmiya, Maya Yaari, Fabio Malavasi and Richard P Ebstein
    Citation: Molecular Medicine 2011 17:1707799
    Content type: Research Article Published on:

  6. Acute cellular rejection (ACR) and hepatitis C virus (HCV) recurrence (HCVrec) are common complications after liver transplantation (LT) in HCV patients, who share common clinical and histological features, ma...

    Authors: Ricardo Gehrau, Daniel Maluf, Kellie Archer, Richard Stravitz, Jihee Suh, Ngoc Le and Valeria Mas
    Citation: Molecular Medicine 2011 17:1707824
    Content type: Research Article Published on:

  7. Chronic lymphocytic leukemia (CLL) cells feature a pronounced apoptotic resistance. The vascular endothelial growth factor (VEGF) possesses a role in this apoptotic block, although underlying functional mechan...

    Authors: Iris Gehrke, Rajesh Kumar Gandhirajan, Simon Jonas Poll-Wolbeck, Michael Hallek and Karl-Anton Kreuzer
    Citation: Molecular Medicine 2011 17:1707619
    Content type: Research Article Published on:

  8. Stroke is the third leading cause of death in the United States with high rates of morbidity among survivors. The search to fill the unequivocal need for new therapeutic approaches would benefit from unbiased ...

    Authors: Agnes Bergerat, Julius Decano, Chang-Jiun Wu, Hyungwon Choi, Alexey I Nesvizhskii, Ann Marie Moran, Nelson Ruiz-Opazo, Martin Steffen and Victoria L M Herrera
    Citation: Molecular Medicine 2011 17:1707588
    Content type: Research Article Published on:

  9. Regulatory T (Treg) cells play an important role in the resolution of crescentic glomerulonephritis, where a T helper 1 (Th1)-predominant immune response promotes crescent formation. Therefore, agents that inc...

    Authors: Yoshitsugu Takabatake, Xiao-Kang Li, Masayuki Mizui, Kenro Miyasato, Isao Matsui, Noritaka Kawada, Enyu Imai, Thomas Hünig, Shiro Takahara, Takashi Wada, Kengo Furuichi, Hiromi Rakugi and Yoshitaka Isaka
    Citation: Molecular Medicine 2011 17:1707686
    Content type: Research Article Published on:

  10. Impaired regulation of the transforming growth factor-β (TGFβ) signaling pathway has been linked to thoracic aortic aneurysm (TAA). Previous work has indicated that differential splicing is a common phenomenon...

    Authors: Sanela Kurtovic, Valentina Paloschi, Lasse Folkersen, Johan Gottfries, Anders Franco-Cereceda and Per Eriksson
    Citation: Molecular Medicine 2011 17:1707665
    Content type: Research Article Published on:

  11. Diabetes mellitus is characterized by elevated plasma glucose and increased rates of skin infections. Altered immune responses have been suggested to contribute to this prevalent complication, which involves m...

    Authors: Cheng-Che E. Lan, Ching-Shuang Wu, Shu-Mei Huang, Hsuan-Yu Kuo, I.-Hui Wu, Chien-Hui Wen, Chee-Yin Chai, Ai-Hui Fang and Gwo-Shing Chen
    Citation: Molecular Medicine 2011 17:1707771
    Content type: Research Article Published on:

    The Erratum to this article has been published in Molecular Medicine 2011 17:Art28

  13. Endogenous opioid peptides are substances involved in cell communication. They are present in various organs and tissues of the male and female reproductive tract, suggesting that they may regulate some of the...

    Authors: Nerea Subirán, Luis Casis and Jon Irazusta
    Citation: Molecular Medicine 2011 17:1707846
    Content type: Research Article Published on:

  15. Mesenchymal stromal cells (MSCs), also called mesenchymal stem cells, migrate and function as stromal cells in tumor tissues. The effects of MSCs on tumor growth are controversial. In this study, we showed tha...

    Authors: Kazuhiro Suzuki, Ruowen Sun, Makoto Origuchi, Masahiko Kanehira, Takenori Takahata, Jugoh Itoh, Akihiro Umezawa, Hiroshi Kijima, Shinsaku Fukuda and Yasuo Saijo
    Citation: Molecular Medicine 2011 17:1707579
    Content type: Research Article Published on:

  16. The IC53 gene was reported to be upregulated In the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarc...

    Authors: Jingzhou Chen, Yi Shi, Ziyu Li, Hui Yu, Yu Han, Xiaojian Wang, Kai Sun, Tao Yang, Kejia Lou, Yan Song, Yinhui Zhang, Yisong Zhen, Guiguo Zhang, Ying Hu, Jiafu Ji and Rutai Hui
    Citation: Molecular Medicine 2011 17:1707607
    Content type: Research Article Published on:

  17. Congenital erythropoietic porphyria (CEP) is an autosomal recessive disorder due to the deficient activity of uroporphyrinogen III synthase (UROS). Knock-in mouse models were generated for the common, hematolo...

    Authors: David F Bishop, Sonia Clavero, Narla Mohandas and Robert J Desnick
    Citation: Molecular Medicine 2011 17:1707748
    Content type: Research Article Published on:

  20. ITF2357 (givinostat) is a histone deacetylase inhibitor with antiinflammatory properties at low nanomolar concentrations. We report here a phase I safety and pharmacokinetics trial in healthy males administere...

    Authors: Antonio Furlan, Valmen Monzani, Leonid L Reznikov, Flavio Leoni, Gianluca Fossati, Daniela Modena, Paolo Mascagni and Charles A Dinarello
    Citation: Molecular Medicine 2011 17:1705353
    Content type: Research Article Published on:

  21. Systemic lupus erythematosus (SLE) is a prototypic autoimmune inflammatory disease characterized by the production of autoantibodies directed against nuclear antigens such as nucleosomes, DNA and histone prote...

    Authors: Christopher M Reilly, Nicole Regna and Nilamadhab Mishra
    Citation: Molecular Medicine 2011 17:1705417
    Content type: Review Article Published on:

  22. Inhibition of histone deacetylases (HDAC) has been shown to modulate gene expression and cytokine production after stimulation with several stimuli. In the present study, the antiinflammatory effect of a poten...

    Authors: Leo A B Joosten, Flavio Leoni, Sajeda Meghji and Paolo Mascagni
    Citation: Molecular Medicine 2011 17:1705391
    Content type: Review Article Published on:

  23. Small sputum macrophages represent highly active cells that Increase In the airways of patients with Inflammatory diseases such as chronic obstructive pulmonary disease (COPD). It has been reported often that ...

    Authors: Marion Frankenberger, Christiane Eder, Thomas P J Hofer, Irene Heimbeck, Kerstin Skokann, Gudrun Kaßner, Norbert Weber, Winfried Möller and Loems Ziegler-Heitbrock
    Citation: Molecular Medicine 2011 17:1707762
    Content type: Research Article Published on:

  24. MicroRNAs (miRNAs) are small noncoding RNAs that contribute to tumorigenesis by acting as oncogenes or tumor suppressor genes and may be important in the diagnosis, prognosis and treatment of cancer. Many miRN...

    Authors: Walter Pavicic, Esa Perkiö, Sippy Kaur and Päivi Peltomäki
    Citation: Molecular Medicine 2011 17:1707726
    Content type: Research Article Published on:

  25. Histone deacetylases inhibitors (HDACi) include a growing number of drugs that share the ability to inhibit the enzymatic activity of some or all the HDACs. Experimental and preclinical evidence indicates that...

    Authors: Silvia Consalvi, Valentina Saccone, Lorenzo Giordani, Giulia Minetti, Chiara Mozzetta and Pier Lorenzo Puri
    Citation: Molecular Medicine 2011 17:1705457
    Content type: Review Article Published on:

  26. Milk fat globule-EGF factor 8 (MFG-E8) has been shown to play an important role in maintaining the integrity of the intestinal mucosa and to accelerate healing of the mucosa in septic mice. Herein, we (a) anal...

    Authors: Ashish Chogle, Heng-Fu Bu, Xiao Wang, Jeffrey B Brown, Pauline M Chou and Xiao-Di Tan
    Citation: Molecular Medicine 2011 17:1705502
    Content type: Research Article Published on:

  27. There are no reliable criteria to handle disease progression of muscle invasive bladder cancer (MIBC), which strongly influences patient survival. Therefore, an accurate predicting method to identify progressi...

    Authors: Wun-Jae Kim, Seon-Kyu Kim, Pildu Jeong, Seok-Joong Yun, In-Chang Cho, Isaac Yi Kim, Sung-Kwon Moon, Hong-Duck Um and Yung Hyun Choi
    Citation: Molecular Medicine 2011 17:1705478
    Content type: Research Article Published on:

  28. Single nucleotide polymorphisms (SNPs) have been associated with prostate cancer (PCa) risk and tumor aggressiveness in retrospective studies. To assess the value of genotyping in a clinical setting, we evalua...

    Authors: Jean-Nicolas Cornu, Sarah Drouin, Géraldine Cancel-Tassin, Pierre Bigot, Abdel-Rahmène Azzouzi, Nicolas Koutlidis, Luc Cormier, Cécile Gaffory, Morgan Rouprêt, Philippe Sèbe, Marc-Olivier Bitker, François Haab and Olivier Cussenot
    Citation: Molecular Medicine 2011 17:1705473
    Content type: Research Article Published on:

  31. Both common forms of diabetes have an inflammatory pathogenesis in which immune and metabolic factors converge on interleukin-1β as a key mediator of insulin resistance and β-cell failure. In addition to impro...

    Authors: Dan P Christensen, Mattias Dahllöf, Morten Lundh, Daniel N Rasmussen, Mette D Nielsen, Nils Billestrup, Lars G Grunnet and Thomas Mandrup-Poulsen
    Citation: Molecular Medicine 2011 17:1705378
    Content type: Review Article Published on:

  33. Obesity is an important risk factor for cardiovascular disease, diabetes and certain cancers. The fat mass- and obesity-associated (FTO) gene is tightly associated with the pathophysiology of obesity, whereas the...

    Authors: Pei Wang, Feng-Jiao Yang, Hui Du, Yun-Feng Guan, Tian-Ying Xu, Xue-Wen Xu, Ding-Feng Su and Chao-Yu Miao
    Citation: Molecular Medicine 2011 17:1705523
    Content type: Research Article Published on:

  34. Deterioration of diaphragm function is one of the prominent factors that contributes to the susceptibility of serious respiratory infections and development of respiratory failure in patients with Duchenne Mus...

    Authors: Jennifer M Peterson, William Kline, Benjamin D Canan, Daniel J Ricca, Brian Kaspar, Dawn A Delfín, Kelly DiRienzo, Paula R Clemens, Paul D Robbins, Albert S Baldwin, Pat Flood, Pravin Kaumaya, Michael Freitas, Joe N Kornegay, Jerry R Mendell, Jill A Rafael-Fortney…
    Citation: Molecular Medicine 2011 17:1705508
    Content type: Research Article Published on:

  36. Burn injury causes hepatic dysfunction associated with endoplasmic reticulum (ER) stress and induction of the unfolded protein response (UPR). ER stress/UPR leads to hepatic apoptosis and activation of the Jun...

    Authors: Marc G Jeschke, Robert Kraft, Juquan Song, Gerd G Gauglitz, Robert A Cox, Natasha C Brooks, Celeste C Finnerty, Gabriela A Kulp, David N Herndon and Darren Boehning
    Citation: Molecular Medicine 2011 17:1705516
    Content type: Research Article Published on:

  37. In coronary artery disease (CAD), endothelin-1 (ET-1) is released by activated macrophages and thereby contributes to coronary plaque rupture and triggered cardiac events. The multifactorial regulation of ET-1...

    Authors: Matthew M Burg, Aaron Soufer, Rachel Lampert, Dorothea Collins and Robert Soufer
    Citation: Molecular Medicine 2011 17:1705495
    Content type: Research Article Published on:

  38. Glaucoma Is a progressive optic neuropathy, which, If left untreated, leads to blindness. The most common and most modifiable risk factor in glaucoma is elevated intraocular pressure (IOP), which can be manage...

    Authors: Li-Fong Seet, Wing Sum Lee, Roseline Su, Sharon N Finger, Jonathan G Crowston and Tina T Wong
    Citation: Molecular Medicine 2011 17:1705557
    Content type: Research Article Published on:

  39. Mutations in the gap junction β2 (GJB2) gene, encoding the connexin26 (CX26) protein, are the most common cause of nonsyndromic hearing loss (HL) in many populations. In the East Asian population, two variants, p...

    Authors: Soo-Young Choi, Kyu Yup Lee, Hyun-Jin Kim, Hyo-Kyeong Kim, Qing Chang, Hong-Joon Park, Chang-Jin Jeon, Xi Lin, Jinwoong Bok and Un-Kyung Kim
    Citation: Molecular Medicine 2011 17:1705550
    Content type: Research Article Published on:

  40. Histone deacetylase (HDAC) inhibitors are currently used clinically as anticancer drugs. Recent data have demonstrated that some of these drugs have potent antiinflammatory or immunomodulatory effects at noncy...

    Authors: Sung Choi and Pavan Reddy
    Citation: Molecular Medicine 2011 17:1705404
    Content type: Review Article Published on:

  41. Coagulation is fundamental for the confinement of infection and/or the inflammatory response to a limited area. Under pathological inflammatory conditions such as arthritis, multiple sclerosis or sepsis, an un...

    Authors: Carla Jennewein, Nguyen Tran, Patrick Paulus, Peter Ellinghaus, Johannes Andreas Eble and Kai Zacharowski
    Citation: Molecular Medicine 2011 17:1705568
    Content type: Review Article Published on:

  42. Glycine N-methyltransferase (GNMT) is a major hepatic enzyme that converts S-adenosylmethionine to S-adenosylhomocys-teine while generating sarcosine from glycine, hence it can regulate mediating methyl group ava...

    Authors: Yi-Cheng Wang, Yi-Ming Chen, Yan-Jun Lin, Shih-Ping Liu and En-Pei Isabel Chiang
    Citation: Molecular Medicine 2011 17:1705486
    Content type: Research Article Published on:

  43. In type 1 diabetes, inflammatory and immunocompetent cells enter the islet and produce proinflammatory cytokines such as interleukin-1 β (IL-1β), IL-12, tumor necrosis factor-α (TNFα) and interferon-γ (IFNγ); ...

    Authors: Eli C Lewis, Lykke Blaabjerg, Joachim Størling, Sif G Ronn, Paolo Mascagni, Charles A Dinarello and Thomas Mandrup-Poulsen
    Citation: Molecular Medicine 2011 17:1705369
    Content type: Research Article Published on:

  44. Cardiac dysfunction and mortality associated with trauma and sepsis increase with age. Mitochondria play a critical role in the energy demand of cardiac muscles, and thereby on the function of the heart. Speci...

    Authors: Bixi Jian, Shaolong Yang, Dongquan Chen, Luyun Zou, John C Chatham, Irshad Chaudry and Raghavan Raju
    Citation: Molecular Medicine 2010 17:1705542
    Content type: Research Article Published on:

  45. Strong cardioprotective properties of erythropoietin (EPO) reported over the last 10 years have been difficult to translate to clinical applications for ischemic cardioprotection owing to undesirable parallel ...

    Authors: Ismayil Ahmet, Hyun-Jin Tae, Magdalena Juhaszova, Daniel R. Riordon, Kenneth R. Boheler, Steven J. Sollott, Michael Brines, Anthony Cerami, Edward G. Lakatta and Mark I. Talan
    Citation: Molecular Medicine 2010 17:17030194
    Content type: Research Article Published on:

  46. Standard coagulation tests have a low specificity and sensitivity for diagnosing disseminated intravascular coagulation. The aim of this study was to determine whether whole blood thromboelastometry (TEM) dete...

    Authors: Herbert Schöchl, Cristina Solomon, Arthur Schulz, Wolfgang Voelckel, Alexander Hanke, Martijn van Griensven, Heinz Redl and Soheyl Bahrami
    Citation: Molecular Medicine 2010 17:17030266
    Content type: Research Article Published on:

  47. Total cellular RNA level is stable usually, although it may increase gradually during growth or decrease gradually under certain stressors. However, we found that mammal cell RNAs could be doubled within 24 h ...

    Authors: Zhong-Wei Zhang, Jian Cheng, Fei Xu, Ming Yuan, Jun-Bo Du, Jing Shang, Yong Wang, Lei Du, Zi-Lin Li and Shu Yuan
    Citation: Molecular Medicine 2010 17:1705533
    Content type: Research Article Published on:

  48. The possible contribution of tumor necrosis factor-α (TNF-α) to the development of obesity-associated insulin resistance in humans is still controversial. Our study investigated the effect of TNF-α neutralizat...

    Authors: Thomas C. Wascher, Jan H. N. Lindeman, Harald Sourij, Teake Kooistra, Giovanni Pacini and Michael Roden
    Citation: Molecular Medicine 2010 17:17030189
    Content type: Research Article Published on:

  49. Human leukocyte antigen (HLA)-G exhibits immunotolerogenicity and is related to allograft acceptance. Qa-2 is the murine homolog of HLA-G; it has structure and functions similar to those of HLA-G. We investiga...

    Authors: Nan Lu, Chuanxin Wang, Xiaojing Yang, Shengmei Zhao, Xiangdong Li, Xiaoli Li, Hong Jiang, Jinbo Feng, Yi Zhang and Xiong Zou
    Citation: Molecular Medicine 2010 17:17030248
    Content type: Research Article Published on:

  50. Porphyria cutanea tarda (PCT) is a cutaneous porphyria with sporadic (type 1) and familial (type 2) subtypes, both resulting from decreased hepatic uroporphyrinogen decarboxylase (UROD) activity. Environmental...

    Authors: Jeffrey K. Wickliffe, Sherif Z. Abdel-Rahman, Chul Lee, Csilla Kormos-Hallberg, Gagan Sood, Catherine M. Rondelli, James J. Grady, Robert J. Desnick and Karl E. Anderson
    Citation: Molecular Medicine 2010 17:17030241
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658