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  1. Propofol is an intravenous anesthetic agent that commonly induces significant neuroapoptosis. MicroRNAs (miRNAs) have been reported to participate in the regulation of propofol exposure-mediated neurotoxicity....

    Authors: Fang Tang, Lili Zhao, Qi Yu, Tianyin Liu, Hongyan Gong, Zhiyi Liu and Qing Li
    Citation: Molecular Medicine 2020 26:38
    Content type: Research article Published on:

  2. Selective intrauterine fetal growth restriction (sIUGR) in monochorionic diamniotic twins, especially types 2&3 with abnormal umbilical artery Doppler, results in increased risk of fetal/perinatal mortality an...

    Authors: Jing Yang, Yuan Wei, Hongbo Qi, Nanlin Yin, Yang Yang, Zailing Li, Lili Xu, Xueju Wang, Pengbo Yuan, Luyao Li, Ting-Li Han and Yangyu Zhao
    Citation: Molecular Medicine 2020 26:37
    Content type: Research article Published on:

  3. HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression. To determine it, we ...

    Authors: Lilan Gao, Shengchun Li, Xiaochun Wei, Guoqing Du, Dennis Wei and Lei Wei
    Citation: Molecular Medicine 2020 26:36
    Content type: Research article Published on:

  4. Human respiratory syncytial virus (hRSV) is the most important etiological agent causing hospitalizations associated with respiratory diseases in children under 5 years of age as well as the elderly, newborns ...

    Authors: Jorge A. Soto, Nicolás M. S. Gálvez, Gaspar A. Pacheco, Susan M. Bueno and Alexis M. Kalergis
    Citation: Molecular Medicine 2020 26:35
    Content type: Review Published on:

  5. Macrophage Migration Inhibitory Factor (MIF) is a potent proinflammatory cytokine that promotes the production of other immune mediators. MIF is produced by most cell types in the brain including microglia, as...

    Authors: Elham Nasiri, Roman Sankowski, Henriette Dietrich, Aikaterini Oikonomidi, Patricio T. Huerta, Julius Popp, Yousef Al-Abed and Michael Bacher
    Citation: Molecular Medicine 2020 26:34
    Content type: Research article Published on:

  7. Vitamin D deficiency increases the risk of developing multiple sclerosis (MS) but it is unclear whether vitamin D supplementation improves the clinical course of MS, and there is uncertainty about the dose and...

    Authors: Manuela Mengozzi, Andrew Hesketh, Giselda Bucca, Pietro Ghezzi and Colin P. Smith
    Citation: Molecular Medicine 2020 26:32
    Content type: Research article Published on:

  8. Accumulating evidence has implicated the regulation of microRNAs (miRs) in ischemia stroke. The current study aimed to elucidate the role of microRNA-195 (miR-195) in neuronal apoptosis and brain plasticity in...

    Authors: Lisha Chang, Wan Zhang, Songxin Shi, Yanbo Peng, Dali Wang, Li Zhang and Jiang Zhang
    Citation: Molecular Medicine 2020 26:31
    Content type: Research article Published on:

  9. Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with high mortality, which threats peoples’ health. Unfortunately, the pathogenesis of PDAC remains unclear. Recent studies have indicated th...

    Authors: Jing Wang, Lei Zhao, Kun Shang, Fang Liu, Juanjuan Che, Huihui Li and Bangwei Cao
    Citation: Molecular Medicine 2020 26:30
    Content type: Review Published on:

  10. Glioma has the characteristics of high incidence and mortality, and is a common malignant tumor of the central nervous system. Circular RNAs (circRNAs) have been reported to play vital roles in progression of ...

    Authors: Long-Wei Huo, Ya-Fei Wang, Xiao-Bin Bai, Hu-Lin Zheng and Mao-De Wang
    Citation: Molecular Medicine 2020 26:29
    Content type: Research article Published on:

  11. The development of paclitaxel-resistance led to the tumor relapse and treatment failure of non-small cell lung cancer. Shikonin has been demonstrated to show anti-cancer activity in many cancer types. The pres...

    Authors: Farong Zang, Yuanquan Rao, Xinhai Zhu, Zhibing Wu and Hao Jiang
    Citation: Molecular Medicine 2020 26:28
    Content type: Research article Published on:

  12. Tissue factor pathway inhibitor 2 (TFPI2) participates in carcinogenesis of various tumors, and is associated with poor survival of breast cancer patients. However, the effect and underlying mechanism of TFPI2...

    Authors: Danyi Zhao, Jingjing Qiao, Hongmei He, Jincheng Song, Shanshan Zhao and Jing Yu
    Citation: Molecular Medicine 2020 26:27
    Content type: Research article Published on:

  13. Osteosarcoma is a malignancy that normally affects children, adolescents, and young adults. Although accumulating evidence has demonstrated the importance of HULC in osteosarcoma, little is reported about its ...

    Authors: Yong Li, Jing-Jing Liu, Jia-Hui Zhou, Rui Chen and Chao-Qun Cen
    Citation: Molecular Medicine 2020 26:26
    Content type: Research article Published on:

  14. B cell receptor Immunoglobulin (BcR IG) repertoire of Chronic Lymphocytic Leukemia (CLL) is characterized by the expression of quasi-identical BcR IG. These are observed in approximately 30% of patients, defin...

    Authors: Monica Colombo, Davide Bagnara, Daniele Reverberi, Serena Matis, Martina Cardillo, Rosanna Massara, Luca Mastracci, Jean Louis Ravetti, Luca Agnelli, Antonino Neri, Michela Mazzocco, Margherita Squillario, Andrea Nicola Mazzarello, Giovanna Cutrona, Andreas Agathangelidis, Kostas Stamatopoulos…
    Citation: Molecular Medicine 2020 26:25
    Content type: Research article Published on:

  15. TFAP2D is a transcription factor important for modulating gene expression in embryogenesis. Its expression and prognostic role in prostate cancer has not been evaluated.

    Authors: Christoph Fraune, Luisa Harms, Franziska Büscheck, Doris Höflmayer, Maria Christina Tsourlakis, Till S. Clauditz, Ronald Simon, Katharina Möller, Andreas M. Luebke, Christina Möller-Koop, Stefan Steurer, Claudia Hube-Magg, Guido Sauter, Sören Weidemann, Patrick Lebok, David Dum…
    Citation: Molecular Medicine 2020 26:24
    Content type: Research article Published on:

  16. Breast cancer (BC) is a major health concern and better understanding of its biology might improve treatment decisions and patient outcomes. Histone3 Lysine27 tri-methylation (H3K27me3) is a post-translational...

    Authors: Mário Fontes-Sousa, João Lobo, Silvana Lobo, Sofia Salta, Maria Amorim, Paula Lopes, Luís Antunes, Susana Palma de Sousa, Rui Henrique and Carmen Jerónimo
    Citation: Molecular Medicine 2020 26:22
    Content type: Research article Published on:

  19. The serine protease KLK12 belongs to the human fifteen-member family of kallikrein-related peptidases. Differential expression accompanied by either increased or decreased enzymatic activity has been linked to...

    Authors: Weiwei Gong, Yueyang Liu, Sarah Preis, Xiaocong Geng, Agnes Petit-Courty, Marion Kiechle, Alexander Muckenhuber, Tobias Dreyer, Julia Dorn, Yves Courty and Viktor Magdolen
    Citation: Molecular Medicine 2020 26:19
    Content type: Research article Published on:

  20. Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine
    Citation: Molecular Medicine 2020 26:18
    Content type: Expression of Concern Published on:

    The Research Article to this article has been published in Molecular Medicine 2011 18:Art13

  21. Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson
    Citation: Molecular Medicine 2020 26:17
    Content type: Expression of Concern Published on:

    The Research Article to this article has been published in Molecular Medicine 2014 20:Art57

  22. The Editors-in-Chief would like to alert readers that this article (Sitapara et al. 2014) is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the...

    Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr, Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:16
    Content type: Expression of Concern Published on:

    The Research Article to this article has been published in Molecular Medicine 2014 20:Art25

  23. Sca-1+ cardiac stem cells and their limited proliferative potential were major limiting factors for use in various studies.

    Authors: Han Saem Jeong, Chi-Yeon Park, Jong-Ho Kim, Hyung Joon Joo, Seung-Cheol Choi, Ji-Hyun Choi, I-Rang Lim, Jae Hyoung Park, Soon Jun Hong and Do-Sun Lim
    Citation: Molecular Medicine 2020 26:15
    Content type: Research article Published on:

  24. Aspirin, as a non-steroidal anti-inflammatory drug, can improve the survival rate of patients with colorectal cancer, while aspirin is effective in patients with PIK3CA mutant colorectal cancer (CRC). However,...

    Authors: Zhihang Chen, Chun Wang, Hao Dong, Xing Wang, Feng Gao, Sen Zhang and Xiaolong Zhang
    Citation: Molecular Medicine 2020 26:14
    Content type: Research article Published on:

  25. The Editors-in-Chief would like to alert readers that this article [1] is part of an investigation being conducted by the journal following the conclusions of an institutional enquiry at the University of Live...

    Authors: Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty and B. Kevin Park
    Citation: Molecular Medicine 2020 26:13
    Content type: Expression of Concern Published on:

    The Research Article to this article has been published in Molecular Medicine 2010 16:Art4

  26. Neural growth factor (NGF) is a neurotrophin that can interact with the p75NTR receptor and initiate a cascade of reactions that determines cell survival or death, and both are associated with the physiology of l...

    Authors: Leonn Mendes Soares Pereira, Ednelza da Silva Graça Amoras, Simone Regina Souza da Silva Conde, Sâmia Demachki, Eduardo José Melo dos Santos, Sandra Souza Lima, Ricardo Ishak and Antonio Carlos Rosário Vallinoto
    Citation: Molecular Medicine 2020 26:12
    Content type: Research article Published on:

  27. Genetic variants play a critical role in the development of breast cancer. This investigation aimed to explore the association between CASC16 polymorphisms and breast cancer susceptibility.

    Authors: Xiaoxiao Zuo, Huanhuan Wang, Yin Mi, Yue Zhang, Xiaofei Wang, Ya Yang and Suna Zhai
    Citation: Molecular Medicine 2020 26:11
    Content type: Research article Published on:

  29. asthma, chronic obstructive pulmonary disease (COPD), and idiopathic pulmonary fibrosis (IPF) are three serious pulmonary diseases that contain common and unique characteristics. Therefore, the identification ...

    Authors: Mazaher Maghsoudloo, Sadegh Azimzadeh Jamalkandi, Ali Najafi and Ali Masoudi-Nejad
    Citation: Molecular Medicine 2020 26:9
    Content type: Research article Published on:

  30. Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of biochemis...

    Authors: Urszula Wasik, Agnieszka Kempinska-Podhorodecka, Dimitrios P. Bogdanos, Piotr Milkiewicz and Malgorzata Milkiewicz
    Citation: Molecular Medicine 2020 26:8
    Content type: Research article Published on:

  31. Previous studies have found ischemic stroke is associated with atrial fibrillation. However, the causal association between ischemic stroke and atrial fibrillation is not clear. Furthermore, the network relati...

    Authors: Lei Hou, Mingqing Xu, Yuanyuan Yu, Xiaoru Sun, Xinhui Liu, Lu Liu, Yunxia Li, Tonghui Yuan, Wenchao Li, Hongkai Li and Fuzhong Xue
    Citation: Molecular Medicine 2020 26:7
    Content type: Research article Published on:

  32. The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patt...

    Authors: Zachary Mostel, Abraham Perl, Matthew Marck, Syed F. Mehdi, Barbara Lowell, Sagar Bathija, Ramchandani Santosh, Valentin A. Pavlov, Sangeeta S. Chavan and Jesse Roth
    Citation: Molecular Medicine 2019 26:6
    Content type: Review Published on:

  33. HMGB1 is a mediator of systemic inflammation in sepsis and trauma, and a promising biomarker in many diseases. There is currently no standard operating procedure for pre-analytical handling of HMGB1 samples, d...

    Authors: William Ottestad, Ingrid N. Rognes, Erlend Skaga, Cassandra Frisvoll, Guttorm Haraldsen, Torsten Eken and Peter Lundbäck
    Citation: Molecular Medicine 2019 26:5
    Content type: Research article Published on:

  35. The main features of bronchopulmonary dysplasia (BPD) are alveolar simplification, pulmonary growth arrest, and abnormal lung function. Multiple studies have highlighted microRNA-29 (miR-29) as a potential bio...

    Authors: Yu Hu, Liang Xie, Jing Yu, Hongling Fu, Dan Zhou and Hanmin Liu
    Citation: Molecular Medicine 2019 26:3
    Content type: Research article Published on:

  36. In mammalians, serotonin (5-HT) has critical roles in the central nervous system (CNS), including mood stability, pain tolerance, or sleep patterns. However, the vast majority of serotonin is produced by intes...

    Authors: Alejandro Quintero-Villegas and Sergio Iván Valdés-Ferrer
    Citation: Molecular Medicine 2019 26:2
    Content type: Mini-review Published on:

  37. Mutations in pre-mRNA splicing factor PRPF31 can lead to retinitis pigmentosa (RP). Although the exact disease mechanism remains unknown, it has been hypothesized that haploinsufficiency might be involved in the ...

    Authors: Lourdes Valdés-Sánchez, Sofia M. Calado, Berta de la Cerda, Ana Aramburu, Ana Belén García-Delgado, Simone Massalini, Adoración Montero-Sánchez, Vaibhav Bhatia, Eduardo Rodríguez-Bocanegra, Andrea Diez-Lloret, Daniel Rodríguez-Martínez, Christina Chakarova, Shom S. Bhattacharya and Francisco J. Díaz-Corrales
    Citation: Molecular Medicine 2019 26:1
    Content type: Research article Published on:

  38. The incidence and mortality of strokes have increased over the past three decades in China. Ischemic strokes can cause a sequence of detrimental events in patients, including increased permeability and dysfunc...

    Authors: Zili Feng, Qian Sun, Wang Chen, Yu Bai, Daihua Hu and Xin Xie
    Citation: Molecular Medicine 2019 25:57
    Content type: Review Published on:

  39. There are two isoforms of sphingomyelin synthase (SMS): SMS1 and SMS2. SMS1 is located in the Golgi apparatus only while SMS2 is located in both the plasma membrane and the Golgi apparatus. SMS1 and SMS2 act s...

    Authors: Goichi Matsumoto, Chieko Hashizume, Ken Watanabe, Makoto Taniguchi and Toshiro Okazaki
    Citation: Molecular Medicine 2019 25:56
    Content type: Research article Published on:

  40. Pancreatic cancer (PC) is a type of malignant gastrointestinal tumor. Long non-coding RNA MCM3AP antisense RNA 1 (MCM3AP-AS1) has been reported to stimulate proliferation, migration and invasion in several typ...

    Authors: Ming Yang, Shijuan Sun, Yao Guo, Junjie Qin and Guangming Liu
    Citation: Molecular Medicine 2019 25:55
    Content type: Research article Published on:

  41. Intestinal mucosa barrier dysfunction after burn injury is an important factor for causing mortality of burn patients. The current study established a burn model in rats and used a free radical scavenger edara...

    Authors: Jiaxiang Ke, Xi Bian, Hu Liu, Bei Li and Ran Huo
    Citation: Molecular Medicine 2019 25:54
    Content type: Research article Published on:

  42. Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adv...

    Authors: Shimin An, Nimra Gilani, Yuan Huang, Adam Muncan, Youhua Zhang, Yi-Da Tang, A. Martin Gerdes and Kaie Ojamaa
    Citation: Molecular Medicine 2019 25:53
    Content type: Research article Published on:

  43. Alcohol intake predisposes to infections and sepsis. Alcohol and sepsis inhibit the expression of milk fat globule epidermal growth factor-factor VIII (MFG-E8), a glycoprotein essential for optimal efferocytos...

    Authors: Wayne W. Chaung, Max Brenner, Hao-Ting Yen, Mahendar L. Ochani, Asha Jacob and Ping Wang
    Citation: Molecular Medicine 2019 25:52
    Content type: Research article Published on:

  44. This study aimed to investigate the differences in the serum levels of glucose, lipid, and thyroid function markers between unipolar and bipolar depressed patients, as well as the effect of anhedonia and suici...

    Authors: Meilei Su, Enze Li, Chong Tang, Yongzhi Zhao, Ruqing Liu and Keming Gao
    Citation: Molecular Medicine 2019 25:51
    Content type: Research article Published on:

  46. Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulat...

    Authors: Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria and Nhan L. Tran
    Citation: Molecular Medicine 2019 25:49
    Content type: Research article Published on:

  47. To study the association of radiation risk in the 2nd –3rd generations with polymorphisms in the genes CYP1A1, CYP2E1, GSTP1 and changes in the thyroid.

    Authors: Meruyert Massabayeva, Nailya Chaizhunusova, Nurlan Aukenov, Tolkyn Bulegenov, Bakytbek Apsalikov, Aigerim Shapihanova and Yersin Zhunussov
    Citation: Molecular Medicine 2019 25:48
    Content type: Research article Published on:

  48. The hunt for the molecular markers with specificity and sensitivity has been a hot area for the tumor treatment. Due to the poor diagnosis and prognosis of pancreatic cancer (PC), the excision rate is often lo...

    Authors: Yang-Yang Zhou, Li-Ping Chen, Yi Zhang, Sun-Kuan Hu, Zhao-Jun Dong, Ming Wu, Qiu-Xiang Chen, Zhi-Zhi Zhuang and Xiao-Jing Du
    Citation: Molecular Medicine 2019 25:47
    Content type: Research article Published on:

  49. Since its discovery almost three decades ago, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway has paved the road for understanding inflammatory and immunity processes rel...

    Authors: Wai Hoong Chang and Alvina G. Lai
    Citation: Molecular Medicine 2019 25:46
    Content type: Research article Published on:

  50. Club Cell protein (CC)16 correlates with lung injury and respiratory complications, which are in part triggered by polymorphonuclear leukocytes (PMNL) in severely traumatized patients (TP). CC16 exerts anti-in...

    Authors: Baolin Xu, Andrea Janicova, Jan Tilmann Vollrath, Philipp Störmann, Lukas Martin, Ingo Marzi, Sebastian Wutzler, Frank Hildebrand, Sabrina Ehnert and Borna Relja
    Citation: Molecular Medicine 2019 25:45
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658