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  1. Effects of ARA290 on glucose homeostasis were studied in type 2 diabetic Goto-Kakizaki (GK) rats. In GK rats receiving ARA290 daily for up to 4 wks, plasma glucose concentrations were lower after 3 and 4 wks, ...

    Authors: Carole Muller, Kamal Yassin, Luo-Sheng Li, Magnus Palmblad, Suad Efendic, Per-Olof Berggren, Anthony Cerami, Michael Brines and Claes-Göran Östenson
    Citation: Molecular Medicine 2015 21:2101969
    Content type: Research Article Published on:

  2. Sepsis is a major cause for death worldwide. Numerous interventional trials with agents neutralizing single proinflammatory mediators have failed to improve survival in sepsis and aseptic systemic inflammatory...

    Authors: Iglika Djoumerska-Alexieva, Lubka Roumenina, Anastas Pashov, Jordan Dimitrov, Maya Hadzhieva, Sandro Lindig, Elisaveta Voynova, Petya Dimitrova, Nina Ivanovska, Clemens Bockmeyer, Zvetanka Stefanova, Catherine Fitting, Markus Bläss, Ralf Claus, Stephan von Gunten, Srini Kaveri…
    Citation: Molecular Medicine 2015 21:21011002
    Content type: Research Article Published on:

  3. The adoptive transfer of alternatively activated macrophages (AAMs) has proven to attenuate inflammation in multiple mouse models of colitis; however, the effect of cryopreservation on AAMs, the ability of pre...

    Authors: Gabriella Leung, Björn Petri, José Luis Reyes, Arthur Wang, Jordan Iannuzzi and Derek M. McKay
    Citation: Molecular Medicine 2015 21:2101924
    Content type: Research Article Published on:

  4. Alterations in metabolic and bioenergetic homeostasis contribute to sepsis-mediated organ injury. However, how AMP-activated protein kinase (AMPK), a major sensor and regulator of energy expenditure and produc...

    Authors: Zhongyu Liu, Nathaniel Bone, Shaoning Jiang, Dae Won Park, Jean-Marc Tadie, Jessy Deshane, Cilina Ann Rodriguez, Jean-Francois Pittet, Edward Abraham and Jaroslaw W. Zmijewski
    Citation: Molecular Medicine 2015 21:2101937
    Content type: Research Article Published on:

  5. Gastro-esophageal reflux disease (GERD) is one of the most common disorders in gastroenterology. Patients present with or without increased acid exposure indicating a nonuniform etiology. Thus, the common trea...

    Authors: Heba Abdel-Aziz, Mathias Schneider, Winfried Neuhuber, Abdel Meguid Kassem, Saleem Khailah, Jürgen Müller, Hadeel Gamal Eldeen, Ahmed Khairy, Mohamed T. Khayyal, Anastasiia Shcherbakova, Thomas Efferth and Gudrun Ulrich-Merzenich
    Citation: Molecular Medicine 2015 21:21011011
    Content type: Research Article Published on:

  6. Activation of transforming growth factor (TGF)-β1 signaling in the ischemia/reperfusion (I/R) injured myocardium leads to dysregulation of miR-29-30-133, favoring the profibrotic process that leads to adverse ...

    Authors: Giuseppina Nicolini, Francesca Forini, Claudia Kusmic, Letizia Pitto, Laura Mariani and Giorgio Iervasi
    Citation: Molecular Medicine 2015 21:2101900
    Content type: Research Article Published on:

  7. Peroxisome proliferator-activated receptor (PPAR)-α is a transcription factor that has been reported to inhibit gentamicin-induced apoptosis in renal tubular cells. However, the antiapoptotic mechanism of PPAR...

    Authors: Cheng-Hsien Chen, Tso-Hsiao Chen, Mei-Yi Wu, Jia-Rung Chen, Li-Yu Hong, Cai-Mei Zheng, I-Jen Chiu, Yuh-Feng Lin and Yung-Ho Hsu
    Citation: Molecular Medicine 2015 21:2101886
    Content type: Research Article Published on:

  8. Delayed wound healing is a major complication associated with diabetes and is a result of a complex interplay among diverse deregulated cellular parameters. Although several genes and pathways have been identi...

    Authors: Sushant Bhattacharya, Rangoli Aggarwal, Vijay Pal Singh, Srinivasan Ramachandran and Malabika Datta
    Citation: Molecular Medicine 2015 21:2101847
    Content type: Research Article Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:87

  9. Subarachnoid hemorrhage (SAH) following aneurysm bleeding accounts for 6% to 8% of all cerebrovascular accidents. Although an aneurysm can be effectively managed by surgery or endovascular therapy, delayed cer...

    Authors: Giovanni Grasso, Giovanni Tomasello, Marcello Noto, Concetta Alafaci and Francesco Cappello
    Citation: Molecular Medicine 2015 21:2101979
    Content type: Review Article Published on:

  10. Diagnosis of bone tumor currently relies on imaging and biopsy, and hence, the need to find less invasive ways for its accurate detection. More recently, numerous promising deoxyribonucleic acid (DNA) and prot...

    Authors: Wan I. Wan-Ibrahim, Vivek A. Singh, Onn H. Hashim and Puteri S. Abdul-Rahman
    Citation: Molecular Medicine 2015 21:2101861
    Content type: Review Article Published on:

  11. Soluble guanylyl cyclase (sGC) is activated by nitric oxide (NO) and produces cGMP, which activates cGMP-dependent protein kinases (PKG) and is hydrolyzed by specific phosphodiesterases (PDE). The vasodilatory...

    Authors: José Luis Cano-Peñalver, Mercedes Griera, Andrea García-Jerez, Marco Hatem-Vaquero, María Piedad Ruiz-Torres, Diego Rodríguez-Puyol, Sergio de Frutos and Manuel Rodríguez-Puyol
    Citation: Molecular Medicine 2015 21:2101873
    Content type: Research Article Published on:

  12. To investigate the genetics of late-onset myasthenia gravis (LOMG), we conducted a genome-wide association study imputation of >6 million single nucleotide polymorphisms (SNPs) in 532 LOMG cases (anti-acetylch...

    Authors: Michael F. Seldin, Omar K. Alkhairy, Annette T. Lee, Janine A. Lamb, Jon Sussman, Ritva Pirskanen-Matell, Fredrik Piehl, Jan J. G. M. Verschuuren, Anna Kostera-Pruszczyk, Piotr Szczudlik, David McKee, Angelina H. Maniaol, Hanne F. Harbo, Benedicte A. Lie, Arthur Melms, Henri-Jean Garchon…
    Citation: Molecular Medicine 2015 21:2101769
    Content type: Research Article Published on:

  13. Alzheimer’s disease (AD) is characterized by progressive decline in cognitive functions associated with depositions of aggregated proteins in the form of extracellular plaques and neurofibrillary tangles in th...

    Authors: Jochen Walter
    Citation: Molecular Medicine 2015 21(Suppl 1):21010041
    Content type: Invited Review Article Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  14. A nonenzymatic reaction between reducing sugars and amino groups of proteins, lipids and nucleic acids contributes to the aging of macromolecules and subsequently alters their structural integrity and function...

    Authors: Sho-ichi Yamagishi, Nobutaka Nakamura, Mika Suematsu, Kuniyoshi Kaseda and Takanori Matsui
    Citation: Molecular Medicine 2015 21(Suppl 1):21010032
    Content type: Invited Review Article Published on:

    This article is part of a Supplement: Volume 21 Supplement 1

  15. As uncontrolled cell proliferation requires nucleotide biosynthesis, inhibiting enzymes that mediate nucleotide biosynthesis constitutes a rational approach to the management of oncological diseases. In practi...

    Authors: Kan Chen, Wanlu Cao, Juan Li, Dave Sprengers, Pratika Y. Hernanda, Xiangdong Kong, Luc J. W. van der Laan, Kwan Man, Jaap Kwekkeboom, Herold J. Metselaar, Maikel P. Peppelenbosch and Qiuwei Pan
    Citation: Molecular Medicine 2015 21:2101792
    Content type: Research Article Published on:

  16. Spinocerebellar ataxia type 3 (SCA3) is a polyglutamine (polyQ) disorder caused by a CAG repeat expansion in the ataxin-3 (ATXN3) gene resulting in toxic protein aggregation. Inflammation and oxidative stress are...

    Authors: Pauline M. Snijder, Madina Baratashvili, Nicola A. Grzeschik, Henri G. D. Leuvenink, Lucas Kuijpers, Sippie Huitema, Onno Schaap, Ben N. G. Giepmans, Jeroen Kuipers, Jan Lj Miljkovic, Aleksandra Mitrovic, Eelke M. Bos, Csaba Szabó, Harm H. Kampinga, Pascale F. Dijkers, Wilfred F. A. den Dunnen…
    Citation: Molecular Medicine 2015 21:2101758
    Content type: Research Article Published on:

  17. Checkpoint kinase inhibition has been studied as a way of enhancing the effectiveness of DNA-damaging agents. More recently, histone deacetylase inhibitors have shown efficacy in several cancers, including non...

    Authors: YanGuo Kong, Gustavo A. Barisone, Ranjit S. Sidhu, Robert T. O’Donnell and Joseph M. Tuscano
    Citation: Molecular Medicine 2015 21:2101824
    Content type: Research Article Published on:

  19. MicroRNA-181a binds to the 3′ untranslated region of messenger RNA (mRNA) for renin, a rate-limiting enzyme of the renin-angiotensin system. Our objective was to determine whether this molecular interaction tr...

    Authors: Francine Z. Marques, Simon P. R. Romaine, Matthew Denniff, James Eales, John Dormer, Ingrid M. Garrelds, Lukasz Wojnar, Katarzyna Musialik, Barbara Duda-Raszewska, Bartlomiej Kiszka, Magdalena Duda, Brian J. Morris, Nilesh J. Samani, A. H. Jan Danser, Pawel Bogdanski, Ewa Zukowska-Szczechowska…
    Citation: Molecular Medicine 2015 21:2101739
    Content type: Research Article Published on:

  20. The classical role of hemoglobin in the erythrocytes is to carry oxygen from the lungs to the tissues via the circulation. However, hemoglobin also acts as a redox regulator and as a scavenger of the gaseous m...

    Authors: Attila Brunyanszki, Katalin Erdelyi, Bartosz Szczesny, Gabor Olah, Reinaldo Salomao, David N. Herndon and Csaba Szabo
    Citation: Molecular Medicine 2015 21:2101666
    Content type: Research Article Published on:

  21. Sepsis and septic shock are enormous public health problems with astronomical financial repercussions on health systems worldwide. The central nervous system (CNS) is closely intertwined in the septic process ...

    Authors: Nikhil Mulchandani, Weng-Lang Yang, Mohammad Moshahid Khan, Fangming Zhang, Philippe Marambaud, Jeffrey Nicastro, Gene F. Coppa and Ping Wang
    Citation: Molecular Medicine 2015 21:2101637
    Content type: Research Article Published on:

  22. We recently confirmed that angiotensin II (Ang II) type 1 receptor (AT1R) was overexpressed in hepatocellular carcinoma tissue using a murine hepatoma model. Angiotensin(Ang)-(1-7) has been found beneficial in am...

    Authors: Yanping Liu, Bin Li, Ximing Wang, Guishuang Li, Rui Shang, Jianmin Yang, Jiali Wang, Meng Zhang, Yuguo Chen, Yun Zhang, Cheng Zhang and Panpan Hao
    Citation: Molecular Medicine 2015 21:2101626
    Content type: Research Article Published on:

  23. Idiopathic fetal growth restriction (FGR) is frequently associated with placental insufficiency. Previous reports have provided evidence that endocrine gland-derived vascular endothelial growth factor (EG-VEGF...

    Authors: Padma Murthi, Sophie Brouillet, Anita Pratt, Anthony Borg, Bill Kalionis, Frederic Goffin, Vassilis Tsatsaris, Carine Munaut, Jean-Jacques Feige, Mohamed Benharouga, Thierry Fournier and Nadia Alfaidy
    Citation: Molecular Medicine 2015 21:2101645
    Content type: Research Article Published on:

  24. Colorectal cancer is commonly treated with 5-fluorouracil and 5-formyltetrahydrofolate (leucovorin). Metabolic action of leucovorin requires several enzymatic steps that are dependent on expression of correspo...

    Authors: Elisabeth Odin, Arvid Sondén, Bengt Gustavsson, Göran Carlsson and Yvonne Wettergren
    Citation: Molecular Medicine 2015 21:2101597
    Content type: Research Article Published on:

  25. Folate receptor (FR)-β has been identified as a promising target for antimacrophage and antiinflammatory therapies. In the present study, we investigated EC0565, a folic acid-derivative of everolimus, as a FR-...

    Authors: Yingjuan Lu, Nikki Parker, Paul J. Kleindl, Vicky A. Cross, Kristin Wollak, Elaine Westrick, Torian W. Stinnette, Mark A. Gehrke, Kevin Wang, Hari Krishna R. Santhapuram, Fei You, Spencer J. Hahn, Jeremy F. Vaughn, Patrick J. Klein, Iontcho R. Vlahov, Philip S. Low…
    Citation: Molecular Medicine 2015 21:2101584
    Content type: Research Article Published on:

  26. Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease that remains refractory to therapy. Despite increasing evidence that protease-activated receptor 2 (PAR-2) contributes to fi...

    Authors: Cong Lin, Jan von der Thüsen, Joost Daalhuisen, Marieke ten Brink, Bruno Crestani, Tom van der Poll, Keren Borensztajn and C. Arnold Spek
    Citation: Molecular Medicine 2015 21:2101576
    Content type: Research Article Published on:

  27. Natural killer T (NKT) cells are a subset of lymphocytes that reacts to glycolipids presented by CD1d. Invariant NKT cells (iNKT) correspond to >90% of the total population of NKTs and reacts to a-galactosylce...

    Authors: Cristhiane Favero Aguiar, Cristiane Naffah-de-Souza, Angela Castoldi, Matheus Corrêa-Costa, Tárcio T. Braga, Érika L. Naka, Mariane T. Amano, Débora T. R. S. Abate, Meire I. Hiyane, Marcos A. Cenedeze, Alvaro Pacheco e Silva Filho and Niels O. S. Câmara
    Citation: Molecular Medicine 2015 21:2101553
    Content type: Research Article Published on:

  28. Diabetic neuropathic pain affects a substantial number of people and represents a major public health problem. Available clinical treatments for diabetic neuropathic pain remain only partially effective and ma...

    Authors: Andrew M. Tan, Omar A. Samad, Sulayman D. Dib-Hajj and Stephen G. Waxman
    Citation: Molecular Medicine 2015 21:2101544
    Content type: Research Article Published on:

  29. Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as aspirin, reduces the risk o...

    Authors: Hyong Woo Choi, Miaoying Tian, Fei Song, Emilie Venereau, Alessandro Preti, Sang-Wook Park, Keith Hamilton, G. V. T. Swapna, Murli Manohar, Magali Moreau, Alessandra Agresti, Andrea Gorzanelli, Francesco De Marchis, Huang Wang, Marc Antonyak, Robert J. Micikas…
    Citation: Molecular Medicine 2015 21:2101526
    Content type: Research Article Published on:

  30. T-helper cells producing interleukin (IL)-17A and IL-17F cytokines (Th17 cells) are considered the source of autoimmunity in rheumatoid arthritis (RA). In this study, we characterized specific pathogenic featu...

    Authors: Karin M. E. Andersson, Nicola Filluelo Cavallini, Dan Hu, Mikael Brisslert, Ron Cialic, Hadi Valadi, Malin C. Erlandsson, Sofia Silfverswärd, Rille Pullerits, Vijay K. Kuchroo, Howard L. Weiner and Maria I. Bokarewa
    Citation: Molecular Medicine 2015 21:2101536
    Content type: Research Article Published on:

  31. Humanin and its derivatives are peptides known for their protective antiapoptotic effects against Alzheimer’s disease. Herein, we identify a novel function of the humanin-derivative AGA(C8R)-HNG17 (namely, pro...

    Authors: Aviv Cohen, Jenny Lerner-Yardeni, David Meridor, Roni Kasher, Ilana Nathan and Abraham H. Parola
    Citation: Molecular Medicine 2015 21:2101505
    Content type: Research Article Published on:

  32. Serum amyloid A (SAA) proteins are known to be surrogate markers of sepsis, but their pathogenic roles remain poorly elucidated. Here we provide evidence to support a possible role of SAA as a pathogenic media...

    Authors: Wei Li, Shu Zhu, Jianhua Li, Jason D’Amore, John D’Angelo, Huan Yang, Ping Wang, Kevin J. Tracey and Haichao Wang
    Citation: Molecular Medicine 2015 21:2101515
    Content type: Research Article Published on:

  33. Mammalian target of rapamycin (mTOR) and phosphatidylinositol 3-kinase (PI3K) are two key components of PI3K/Akt/mTOR signaling pathway. Dysregulation of these pathways have been found in many cancers, includi...

    Authors: Azhar R. Hussain, Maha Al-Romaizan, Maqbool Ahmed, Saravanan Thangavel, Fouad Al-Dayel, Shaham Beg, Shahab Uddin, Abdul K. Siraj and Khawla S. Al-Kuraya
    Citation: Molecular Medicine 2015 21:2101466
    Content type: Research Article Published on:

  34. In Duchenne muscular dystrophy (DMD) patients and the mdx mouse model of DMD, chronic activation of the classical nuclear factor-κB (NF-κB) pathway contributes to the pathogenesis that causes degeneration of musc...

    Authors: Daniel P. Reay, Sheldon I. Bastacky, Kathryn E. Wack, Donna B. Stolz, Paul D. Robbins and Paula R. Clemens
    Citation: Molecular Medicine 2015 21:2101442
    Content type: Research Article Published on:

  35. The treatment of stroke is limited by a short therapeutic window and a lack of effective clinical drugs. Methylene blue (MB) has been used in laboratories and clinics since the 1890s. Few studies have reported...

    Authors: Yao Di, Yun-Ling He, Tong Zhao, Xin Huang, Kui-Wu Wu, Shu-Hong Liu, Yong-Qi Zhao, Ming Fan, Li-Ying Wu and Ling-Ling Zhu
    Citation: Molecular Medicine 2015 21:2101420
    Content type: Research Article Published on:

  36. Piwi-interacting RNAs (piRNAs) are a distinct group of small noncoding RNAs (sncRNAs) that silence transposable genetic elements to protect genome integrity. Because of their limited expression in gonads and s...

    Authors: Yuping Li, Xiwei Wu, Hanlin Gao, Jennifer M. Jin, Arthur X. Li, Young S. Kim, Sumanta K. Pal, Rebecca A. Nelson, Clayton M. Lau, Chao Guo, Bing Mu, Jinhui Wang, Frances Wang, Jessica Wang, Yuanyin Zhao, Wengang Chen…
    Citation: Molecular Medicine 2015 21:2101381
    Content type: Research Article Published on:

  37. Piwi-like 2 (Piwil 2) belongs to the family of Argonaute genes/proteins. The expression of Piwil 2 is associated with stem cells. A role in tumorigenesis and/or tumor progression is proposed for different canc...

    Authors: Helge Taubert, Sven Wach, Rudolf Jung, Michael Pugia, Bastian Keck, Simone Bertz, Elke Nolte, Robert Stoehr, Jan Lehmann, Carsten-H. Ohlmann, Michael Stöckle, Bernd Wullich and Arndt Hartmann
    Citation: Molecular Medicine 2015 21:2101371
    Content type: Research Article Published on:

  38. Streptococcus pneumoniae (Spneu) remains the most lethal bacterial pathogen and the dominant agent of community-acquired pneumonia. Treatment has perennially focused on the use of antibiotics, albeit scrutinized ...

    Authors: Brendon P. Scicluna, Miriam H. van Lieshout, Dana C. Blok, Sandrine Florquin and Tom van der Poll
    Citation: Molecular Medicine 2015 21:2101430
    Content type: Research Article Published on:

  39. Fabry disease, an X-linked glycosphingolipid storage disorder, is caused by the deficient activity of α-galactosidase A (α-Gal A). This results in the lysosomal accumulation in various cell types of its glycol...

    Authors: Karen M. Ashe, Eva Budman, Dinesh S. Bangari, Craig S. Siegel, Jennifer B. Nietupski, Bing Wang, Robert J. Desnick, Ronald K. Scheule, John P. Leonard, Seng H. Cheng and John Marshall
    Citation: Molecular Medicine 2015 21:2101389
    Content type: Research Article Published on:

  40. On the basis of their characteristics, we presume that developmental stage-specific hepatocytes should have the ability to induce maturation of hepatoma cells. A regulatory circuit formed by hepatocyte nuclear...

    Authors: Yanning Li, Demei Liu, Yanhong Zong, Jinsheng Qi, Bin Li, Kun Liu and Hui Xiao
    Citation: Molecular Medicine 2015 21:2101285
    Content type: Research Article Published on:

  41. Uterine leiomyomas are the most common tumors of the female genital tract, affecting 50% to 70% of females by the age of 50. Despite their prevalence and enormous medical and economic impact, no effective medi...

    Authors: Mostafa A. Borahay, Ayman Al-Hendy, Gokhan S. Kilic and Darren Boehning
    Citation: Molecular Medicine 2015 21:2101242
    Content type: Review Article Published on:

  42. The human genome contains a variant form of the α7-nicotinic acetylcholine receptor (α7nAChR) gene that is uniquely human. This CHRFAM7A gene arose during human speciation and recent data suggests that its expres...

    Authors: Todd W. Costantini, Xitong Dang, Maryana V. Yurchyshyna, Raul Coimbra, Brian P. Eliceiri and Andrew Baird
    Citation: Molecular Medicine 2015 21:2101323
    Content type: Research Article Published on:

  44. Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we have shown that, despite the lack of a paternal genome, human parthenogenetic (PG...

    Authors: Jessica Schmitt, Sigrid Eckardt, Paul G. Schlegel, Anna-Leena Sirén, Valentin S. Bruttel, K. John McLaughlin, Jörg Wischhusen and Albrecht M. Müller
    Citation: Molecular Medicine 2015 21:2101185
    Content type: Research Article Published on:

  45. Although hyperglycemia is common in patients with acute myocardial infarction (MI), the underlying mechanisms are largely unknown. Insulin signaling plays a key role in the regulation of glucose homeostasis. I...

    Authors: Jiali Wang, Baoshan Liu, Hui Han, Qiuhuan Yuan, Mengyang Xue, Feng Xu and Yuguo Chen
    Citation: Molecular Medicine 2015 21:2101068
    Content type: Research Article Published on:

  46. Under high glucose conditions, endothelial cells respond by acquiring fibroblast characteristics, that is, endothelial-to-mesenchymal transition (EndMT), contributing to diabetic cardiac fibrosis. Glucagon-lik...

    Authors: Fei Yan, Guang-hao Zhang, Min Feng, Wei Zhang, Jia-ning Zhang, Wen-qian Dong, Cheng Zhang, Yun Zhang, Li Chen and Ming-Xiang Zhang
    Citation: Molecular Medicine 2015 21:2101015
    Content type: Research Article Published on:

  47. In the skin epidermis, keratinocytes undergo anchorage-dependent cornification, which gives rise to stratified multilayers, each with a distinct differentiation feature. The active formation of the cornified c...

    Authors: Nanako Kadono, Natsumi Hagiwara, Takashi Tagawa, Kenji Maekubo and Yohei Hirai
    Citation: Molecular Medicine 2015 21:2101077
    Content type: Research Article Published on:

  48. Chronic lymphocytic leukemia (CLL) development and progression are thought to be driven by unknown antigens/autoantigens through the B cell receptor (BCR) and environmental signals for survival and expansion i...

    Authors: Nino Porakishvili, Ketki Vispute, Andrew J. Steele, Nadeeka Rajakaruna, Nina Kulikova, Tamar Tsertsvadze, Amit Nathwani, Rajendra N. Damle, Edward A. Clark, Kanti R. Rai, Nicholas Chiorazzi and Peter M. Lydyard
    Citation: Molecular Medicine 2015 21:2101046
    Content type: Research Article Published on:

  49. Sirtuin 1 (SIRT1) is an evolutionary conserved NAD+-dependent histone deacetylase that is necessary for caloric restriction-related lifespan extension. SIRT1, as an intracellular energy sensor, detects the concen...

    Authors: Lili Kong, Hao Wu, Wenhua Zhou, Manyu Luo, Yi Tan, Lining Miao and Lu Cai
    Citation: Molecular Medicine 2015 21:2101087
    Content type: Review Article Published on:

  50. IGF-1 is one of the key molecules in cancer biology; however, little is known about the role of the preferential expression of the premature IGF-1 isoforms in prostate cancer. We have examined the role of the ...

    Authors: Athanasios Armakolas, Maria Kaparelou, Andreas Dimakakos, Efstathia Papageorgiou, Nikolaos Armakolas, Athanasios Antonopoulos, Constantina Petraki, Maria Lekarakou, Pavlos Lelovas, Martha Stathaki, Constantinos Psarros, Ismene Donta, Panos S. Galanos, Paul Msaouel, Vassilis G. Gorgoulis and Michael Koutsilieris
    Citation: Molecular Medicine 2015 21:2101167
    Content type: Research Article Published on:
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Molecular Medicine

ISSN: 1528-3658