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  1. Osteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has ...

    Authors: Feng Liu, De-Ye Song, Jun Huang, Hong-Qi Yang, Di You and Jiang-Dong Ni
    Citation: Molecular Medicine 2021 27:12
    Content type: Research article Published on:

  2. House dust mite (HDM) inhalation can cause airway epithelial damage which is implicated in the process of airway inflammation in asthma. High mobility group box 1 (HMGB1) is critically required for cellular da...

    Authors: Meixuan Liu, Jingjing Lu, Qian Zhang, Yunxuan Zhang and Zhongliang Guo
    Citation: Molecular Medicine 2021 27:11
    Content type: Research article Published on:

  3. LncRNA can regulate gene at various levels such as apparent genetics, alternative splicing, and regulation of mRNA degradation. However, the molecular mechanism of LncRNA in cholangiocarcinoma is still unclear...

    Authors: Hao Ji, Juan Wang, Binbin Lu, Juan Li, Jing Zhou, Li Wang, Shufen Xu, Peng Peng, Xuezhen Hu and Keming Wang
    Citation: Molecular Medicine 2021 27:10
    Content type: Research article Published on:

  4. Reprogrammed glucose metabolism of enhanced Warburg effect (or aerobic glycolysis) is considered as a hallmark of cancer. Long non-coding RNAs (lncRNAs) have been certified to play a crucial role in tumor prog...

    Authors: Peng Deng, Kai Li, Feng Gu, Tao Zhang, Wenyan Zhao, Ming Sun and Bin Hou
    Citation: Molecular Medicine 2021 27:9
    Content type: Research article Published on:

  5. Alzheimer's disease is a neurodegenerative disease. Previous study has reported that caspase-1/IL-1β is closely associated with Alzheimer's disease. However, the biological role of caspase-1/IL-1β in Alzheimer...

    Authors: Xunhu Gu, Hanjun Wu, Yuqin Xie, Lijun Xu, Xu Liu and Wei Wang
    Citation: Molecular Medicine 2021 27:8
    Content type: Research article Published on:

  6. Malignant glioma exerts a metabolic shift from oxidative phosphorylation (OXPHOs) to aerobic glycolysis, with suppressed mitochondrial functions. This phenomenon offers a proliferation advantage to tumor cells...

    Authors: Qiuyun Yuan, Wanchun Yang, Shuxin Zhang, Tengfei Li, Mingrong Zuo, Xingwang Zhou, Junhong Li, Mao Li, Xiaoqiang Xia, Mina Chen and Yanhui Liu
    Citation: Molecular Medicine 2021 27:7
    Content type: Research article Published on:

  7. Clinical data suggest that BMI and gestational weight gain (GWG) are strongly interconnected phenotypes; however, the genetic basis of the latter is rather unclear. Here we aim to find genes and genetic varian...

    Authors: Agnieszka H. Ludwig-Słomczyńska, Michał T. Seweryn, Przemysław Kapusta, Ewelina Pitera, Urszula Mantaj, Katarzyna Cyganek, Paweł Gutaj, Łucja Dobrucka, Ewa Wender-Ożegowska, Maciej T. Małecki and Paweł P. Wołkow
    Citation: Molecular Medicine 2021 27:6
    Content type: Research article Published on:

  8. Osteoarthritis (OA) is a chronic inflammatory disease that is associated with articular cartilage destruction, subchondral bone alterations, synovitis, and even joint deformity and the loss of joint function. ...

    Authors: Jinshuo Tang, Tong Liu, Xinggui Wen, Zhongsheng Zhou, Jingtong Yan, Jianpeng Gao and Jianlin Zuo
    Citation: Molecular Medicine 2021 27:5
    Content type: Review Published on:

  9. Vascular cognitive impairment (VCI) is a common cognitive disorder caused by cerebrovascular disease, ranging from mild cognitive impairment to dementia. Studies have shown that aerobic exercise might alleviat...

    Authors: Yali Niu, Chunxiao Wan, Jing Zhang, Shu Zhang, Zilong Zhao, Leshan Zhu, Xiaodong Wang, Xiaodong Ren, Jing Wang and Ping Lei
    Citation: Molecular Medicine 2021 27:4
    Content type: Research article Published on:

  10. Fetal growth restriction (FGR) is associated with increased risks for complications before, during, and after birth, in addition to risk of disease through to adulthood. Although placental insufficiency, failu...

    Authors: Giulia F. Del Gobbo, Yue Yin, Sanaa Choufani, Emma A. Butcher, John Wei, Evica Rajcan-Separovic, Hayley Bos, Peter von Dadelszen, Rosanna Weksberg, Wendy P. Robinson and Ryan K. C. Yuen
    Citation: Molecular Medicine 2021 27:3
    Content type: Research article Published on:

  11. Although large artery atherosclerosis (LAA) is the most common type of cerebral infarction, non-LAA is not uncommon. The purpose of this paper is to investigate the prognosis of patients with non-LAA and to es...

    Authors: Ya-Ying Zeng, Wen-Bo Zhang, Lin Cheng, Li Wang, Dan-Dan Geng, Wen-Jie Tang, Jin-Cai He and Bin-Bin Deng
    Citation: Molecular Medicine 2021 27:2
    Content type: Research article Published on:

  13. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00264-1

    Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson, Kevin J. Tracey and Daniel J. Antoine
    Citation: Molecular Medicine 2020 26:133
    Content type: Retraction Note Published on:

    The original article was published in Molecular Medicine 2011 18:Art13

  14. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00265-0

    Authors: Ravikumar A. Sitapara, Daniel J. Antoine, Lokesh Sharma, Vivek S. Patel, Charles R. Ashby Jr, Samir Gorasiya, Huan Yang, Michelle Zur and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:132
    Content type: Retraction Note Published on:

    The original article was published in Molecular Medicine 2014 20:Art25

  15. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00263-2

    Authors: Karin Palmblad, Hanna Schierbeck, Erik Sundberg, Anna-Carin Horne, Helena Erlandsson Harris, Jan-Inge Henter, Daniel J. Antoine and Ulf Andersson
    Citation: Molecular Medicine 2020 26:131
    Content type: Retraction Note Published on:

    The original article was published in Molecular Medicine 2014 20:Art57

  16. This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s10020-020-00262-3

    Authors: Daniel James Antoine, Dominic P. Williams, Anja Kipar, Hugh Laverty and B. Kevin Park
    Citation: Molecular Medicine 2020 26:130
    Content type: Retraction Note Published on:

    The original article was published in Molecular Medicine 2010 16:Art4

  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ahlam Fatmi, Sid Ahmed Rebiahi, Nafissa Chabni, Hanane Zerrouki, Hafsa Azzaoui, Yamina Elhabiri, Souheila Benmansour, José Santiago Ibáñez-Cabellos, Mohammed Chems-Eddine Smahi, Mourad Aribi, José Luis García-Giménez and Federico V. Pallardó
    Citation: Molecular Medicine 2020 26:129
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2020 26:94

  18. Autosomal dominant polycystic kidney disease (ADPKD) is an inherited chronic kidney disorder (CKD) that is characterized by the development of numerous fluid-filled cysts in kidneys. It is caused either due to...

    Authors: Aryendu Kumar Saini, Rakesh Saini and Shubham Singh
    Citation: Molecular Medicine 2020 26:128
    Content type: Review Published on:

  20. Innervation of adipose tissue is essential for the proper function of this critical metabolic organ. Numerous surgical and chemical denervation studies have demonstrated how maintenance of brain-adipose commun...

    Authors: Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James Godwin and Kristy L. Townsend
    Citation: Molecular Medicine 2020 26:126
    Content type: Research article Published on:

  21. Hepatocellular carcinoma (HCC) is a common malignant primary cancer with high mortality. Previous studies have demonstrated that RNA binding proteins (RBPs) are involved in the biological processes of cancers,...

    Authors: Li Wang, Na Zhou, Jialin Qu, Man Jiang and Xiaochun Zhang
    Citation: Molecular Medicine 2020 26:125
    Content type: Research article Published on:

  22. Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-re...

    Authors: Shanshan Hu, Dongmei Su, Lei Sun, Zhongying Wang, Lina Guan, Shanhe Liu, Baowen Zhao, Yong Liu, Cuige Shi, Jianbo Yu and Xu Ma
    Citation: Molecular Medicine 2020 26:124
    Content type: Research article Published on:

  23. FINCA disease is a pediatric cerebropulmonary disease caused by variants in the NHL repeat-containing 2 (NHLRC2) gene. Neurological symptoms are among the first manifestations of FINCA disease, but the consequenc...

    Authors: Anniina E. Hiltunen, Salla M. Kangas, Steffen Ohlmeier, Ilkka Pietilä, Jori Hiltunen, Heikki Tanila, Colin McKerlie, Subashika Govindan, Hannu Tuominen, Riitta Kaarteenaho, Mikko Hallman, Johanna Uusimaa and Reetta Hinttala
    Citation: Molecular Medicine 2020 26:123
    Content type: Research article Published on:

  24. As a common ocular complication of diabetes mellitus, diabetic cataract is becoming a leading cause of visual impairment. The progression of diabetic cataract progression involves epithelial-to-mesenchymal tra...

    Authors: Xin Liu, Qiaoyun Gong, Longfei Yang, Min Liu, Lingzhi Niu and Lufei Wang
    Citation: Molecular Medicine 2020 26:122
    Content type: Research article Published on:

  25. Neonatal sepsis and the associated myocardial dysfunction remain a leading cause of infant mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a ligand of triggering receptor expressed ...

    Authors: Naomi-Liza Denning, Monowar Aziz, Li Diao, Jose M. Prince and Ping Wang
    Citation: Molecular Medicine 2020 26:121
    Content type: Research article Published on:

  26. At present, the early diagnosis of femoral head necrosis mainly relies on Magnetic resonance imaging (MRI), and most early patients are difficult to make an accurate diagnosis. Therefore, to investigate the ea...

    Authors: Xiaolong Wang, Jianbo Li, Da Man, Rui Liu and Jianmin Zhao
    Citation: Molecular Medicine 2020 26:120
    Content type: Research article Published on:

  27. Increasing number of studies provide evidence that the vagus nerve stimulation (VNS) dampens inflammation in peripheral visceral organs. However, the effects of afferent fibers of the vagus nerve (AFVN) on ant...

    Authors: Byung Gon Jo, Seung-Hyung Kim and Uk Namgung
    Citation: Molecular Medicine 2020 26:119
    Content type: Research article Published on:

  29. Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnosti...

    Authors: Samantha N. Hartin, John C. Means, Joseph T. Alaimo and Scott T. Younger
    Citation: Molecular Medicine 2020 26:117
    Content type: Perspective Published on:

  30. MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cell...

    Authors: Chuan Qu, Xin Liu, Yan Guo, Yuhong Fo, Xiuhuan Chen, Jining Zhou and Bo Yang
    Citation: Molecular Medicine 2020 26:116
    Content type: Research article Published on:

  31. Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the...

    Authors: Minjie Lin, Jungke Long, Wenbo Li, Chenxuan Yang, Patricia Loughran, Robert O’Doherty, Timothy R. Billiar, Meihong Deng and Melanie J. Scott
    Citation: Molecular Medicine 2020 26:115
    Content type: Research article Published on:

  32. Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (...

    Authors: Chong Wang, Lingling Li, Mengya Li, Weiqiong Wang, Yanfang Liu and Shujuan Wang
    Citation: Molecular Medicine 2020 26:114
    Content type: Research article Published on:

  33. Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, but the mechanism of PHN is still unclear. Activation of spinal astrocytes is involved in PHN. Our study aims to explore whether l...

    Authors: Cunlong Kong, Jie Du, Huilian Bu, Chen Huang, Fuxing Xu and Huan Ren
    Citation: Molecular Medicine 2020 26:113
    Content type: Research article Published on:

  34. The oncogenic role of the newly identified lncRNA LUADT1 has been revealed in lung adenocarcinoma. It was reported that LUADT1 plays a critical role in multiple human diseases. This study was carried out to in...

    Authors: Zhimin Zhang, Mingzhu Lv, Xiang Wang, Zheng Zhao, Daolong Jiang and Lihua Wang
    Citation: Molecular Medicine 2020 26:112
    Content type: Research article Published on:

  35. Myocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeut...

    Authors: Qiuting Feng, Xing Li, Xian Qin, Cheng Yu, Yan Jin and Xiaojun Qian
    Citation: Molecular Medicine 2020 26:111
    Content type: Research article Published on:

  36. Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified poten...

    Authors: Marpe Bam, Xiaoming Yang, Brandon P. Busbee, Allison E. Aiello, Monica Uddin, Jay P. Ginsberg, Sandro Galea, Prakash S. Nagarkatti and Mitzi Nagarkatti
    Citation: Molecular Medicine 2020 26:110
    Content type: Research article Published on:

  37. Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis. ZLM-7, SP1, VEGFA and miR-212-3p were as...

    Authors: Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li and Zhi-Yong Luo
    Citation: Molecular Medicine 2020 26:109
    Content type: Research article Published on:

  38. Acute lung injury (ALI), which is induced by numerous pathogenic factors, especially sepsis, can generate alveolar damage, pulmonary edema and vascular hyper-permeability ultimately leading to severe hypoxemia...

    Authors: Xiaojun Pan, Shunyao Xu, Zhen Zhou, Fen Wang, Lingjie Mao, Hao Li, Caixia Wu, Junfeng Wang, Yueyue Huang, Dequan Li, Cong Wang and Jingye Pan
    Citation: Molecular Medicine 2020 26:108
    Content type: Research article Published on:

  39. The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored.

    Authors: Fan Ye, Shiming Tian, Huimin Hu and Zhengwen Yu
    Citation: Molecular Medicine 2020 26:107
    Content type: Research article Published on:

  40. Recent studies have demonstrated that long non-coding RNAs (LncRNAs) can influence bone cell differentiation and formation. However, it is unclear whether lncRNA HCG18 is involved in osteoporosis (OP). This st...

    Authors: Mingxue Che, Weiquan Gong, Yao Zhao and Mingxi Liu
    Citation: Molecular Medicine 2020 26:106
    Content type: Research article Published on:

  41. Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mech...

    Authors: Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang and Hongtao Li
    Citation: Molecular Medicine 2020 26:105
    Content type: Research article Published on:

  42. Neuropathic pain belongs to chronic pain and is caused by the primary dysfunction of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) have been reported to regulate neuronal functions and play s...

    Authors: Zhen Li, Aiyuan Li, Liping Yan, Tian Yang, Wei Xu and Pengju Fan
    Citation: Molecular Medicine 2020 26:104
    Content type: Research article Published on:

  43. The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune...

    Authors: Betty Diamond, Bruce T. Volpe, Sonya VanPatten and Yousef Al Abed
    Citation: Molecular Medicine 2020 26:103
    Content type: Review Published on:

  46. The most popular miRNA quantitation technique is RQ-PCR with relative gene expression method that requires an endogenous control (EC) gene for data normalization. However, there are insufficient data and selec...

    Authors: Daina Pamedytyte, Enrika Leipute, Birute Zilaitiene, Valdas Sarauskas, Dalia Dauksiene, Albertas Dauksa and Aurelija Zvirbliene
    Citation: Molecular Medicine 2020 26:100
    Content type: Short report Published on:

  47. The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone deacetylase 3 (Hdac3) has been reported to be a crucial re...

    Authors: Di Wang, Hui Hong, Xiao-Xia Li, Jing Li and Zhi-Qun Zhang
    Citation: Molecular Medicine 2020 26:99
    Content type: Research article Published on:

  48. Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged ex...

    Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby Jr. and Lin L. Mantell
    Citation: Molecular Medicine 2020 26:98
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2021 27:93

  49. COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of...

    Authors: Yu Chen, Jinglan Wang, Chenxi Liu, Longxiang Su, Dong Zhang, Junping Fan, Yanli Yang, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li and Shuyang Zhang
    Citation: Molecular Medicine 2020 26:97
    Content type: Research article Published on:

  50. Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian ca...

    Authors: Lei Du, Cong-Rong Li, Qi-Feng He, Xiao-Hua Li, Lin-Fei Yang, Yuan Zou, Zhi-Xia Yang, Dong Zhang and Xiao-Wei Xing
    Citation: Molecular Medicine 2020 26:96
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658