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Page 2 of 36

  1. Content type: Research article

    MicroRNAs (miRNAs) contribute to the progression of chronic kidney disease (CKD) by regulating renal homeostasis. This study explored the effects of miR-181a on CKD through the Toll-like receptor (TLR)/nuclear...

    Authors: Lei Liu, Xin-Lu Pang, Wen-Jun Shang, Hong-Chang Xie, Jun-Xiang Wang and Gui-Wen Feng

    Citation: Molecular Medicine 2018 24:49

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  2. Content type: Research article

    Adolescent idiopathic scoliosis (AIS) is the most common paediatric spinal deformity. The etiology and pathology of AIS remain unexplained, and have been reported to involve a combination of genetic and epigen...

    Authors: Heng Jiang, Fu Yang, Tao Lin, Wei Shao, Yichen Meng, Jun Ma, Ce Wang, Rui Gao and Xuhui Zhou

    Citation: Molecular Medicine 2018 24:48

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  3. Content type: Research article

    Sulfonylureas (SUs) are widely prescribed for the treatment of type 2 diabetes (T2DM). Sulfonylurea receptors (SURs) are their main functional receptors. These receptors are also found in kidney, especially th...

    Authors: Rui Zhang, Xiaojun Zhou, Xue Shen, Tianyue Xie, Chunmei Xu, Zhiwei Zou, Jianjun Dong and Lin Liao

    Citation: Molecular Medicine 2018 24:47

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  4. Content type: Review

    Serum amyloid A (SAA) proteins were isolated and named over 50 years ago. They are small (104 amino acids) and have a striking relationship to the acute phase response with serum levels rising as much as 1000-...

    Authors: George H. Sack Jr

    Citation: Molecular Medicine 2018 24:46

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  5. Content type: Short report

    Endothelial barrier dysfunction characterized by hyperpermeability of the vascular endothelium is a key factor in the pathogenesis of chronic inflammatory diseases and affects clinical outcomes. In states of c...

    Authors: Tom Skaria, Esther Bachli and Gabriele Schoedon

    Citation: Molecular Medicine 2018 24:45

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  6. Content type: Research article

    Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME) is a debilitating disorder that is accompanied by reduced cytotoxic activity in natural killer (NK) cells. NK cells are an essential innate immune...

    Authors: Hélène Cabanas, Katsuhiko Muraki, Natalie Eaton, Cassandra Balinas, Donald Staines and Sonya Marshall-Gradisnik

    Citation: Molecular Medicine 2018 24:44

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  7. Content type: Research article

    Type 2 diabetes mellitus (T2DM) is characterized by pancreatic β-cell failure, which arises from metabolic stress and results in β cell dedifferentiation, leading to β-cell death. Pathological activation of th...

    Authors: Hong Chen, Wenjun Zhou, Yuting Ruan, Lei Yang, Ningning Xu, Rongping Chen, Rui Yang, Jia Sun and Zhen Zhang

    Citation: Molecular Medicine 2018 24:43

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  8. Content type: Research article

    Multiple sclerosis (MS) is an inflammatory, demyelinating and degenerative disorder of the central nervous system (CNS). Several observations support interactions between vascular and neurodegenerative mechani...

    Authors: Giovanna Marchetti, Nicole Ziliotto, Silvia Meneghetti, Marcello Baroni, Barbara Lunghi, Erica Menegatti, Massimo Pedriali, Fabrizio Salvi, Ilaria Bartolomei, Sofia Straudi, Fabio Manfredini, Rebecca Voltan, Nino Basaglia, Francesco Mascoli, Paolo Zamboni and Francesco Bernardi

    Citation: Molecular Medicine 2018 24:42

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  9. Content type: Research Article

    Retinopathy of prematurity (ROP) remains a major cause of childhood blindness and current laser photocoagulation and anti-VEGF antibody treatments are associated with reduced peripheral vision and possible del...

    Authors: Rong Zhou, Shuya Zhang, Xuejiao Gu, Yuanyuan Ge, Dingjuan Zhong, Yuling Zhou, Lingyun Tang, Xiao-Ling Liu and Jiang-Fan Chen

    Citation: Molecular Medicine 2018 24:41

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  10. Content type: Research article

    This study aimed to investigate the effect of over-expressing circular RNA CEP128 (circCEP128) on cell functions and explore the molecular mechanism of which in bladder carcinoma.

    Authors: Zhun Wu, Wei Huang, Xuegang Wang, Tao Wang, Yuedong Chen, Bin Chen, Rongfu Liu, Peide Bai and Jinchun Xing

    Citation: Molecular Medicine 2018 24:40

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  11. Content type: Research article

    The protective effect of Neuregulin-1 (NRG-1) on heart failure is well established. In this study, we assessed whether NRG-1 could protect the heart by mimicking the cardioprotective effects of ischaemic postc...

    Authors: Fuhua Wang, Huan Wang, Xuejing Liu, Haiyi Yu, Bo Zuo, Zhu Song, Ning Wang, Wei Huang and Guisong Wang

    Citation: Molecular Medicine 2018 24:39

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  12. Content type: Research article

    Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic sec...

    Authors: Valentina Maria Sofia, Cecilia Surace, Vito Terlizzi, Letizia Da Sacco, Federico Alghisi, Antonella Angiolillo, Cesare Braggion, Natalia Cirilli, Carla Colombo, Antonella Di Lullo, Rita Padoan, Serena Quattrucci, Valeria Raia, Giuseppe Tuccio, Federica Zarrilli, Anna Cristina Tomaiuolo…

    Citation: Molecular Medicine 2018 24:38

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  13. Content type: Research article

    Histone deacetylases (HDACs) play a critical role in modulating myocardial protection and cardiomyocyte survivals. However, Specific HDAC isoforms in mediating myocardial ischemia/reperfusion injury remain cur...

    Authors: Ling Zhang, Hao Wang, Yu Zhao, Jianguo Wang, Patrycja M. Dubielecka, Shougang Zhuang, Gangjian Qin, Y Eugene Chin, Race L. Kao and Ting C. Zhao

    Citation: Molecular Medicine 2018 24:37

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  14. Content type: Research article

    This study was to examine the link between astrocyte elevated gene-1 (AEG-1) and hypoxia induced-chemoresistance in T-cell non-Hodgkin’s lymphoma (T-NHL), as well as the underlying molecular mechanisms.

    Authors: Jiaqin Yan, Junhui Zhang, Xudong Zhang, Xin Li, Ling Li, Zhaoming Li, Renyin Chen, Lei Zhang, Jingjing Wu, Xinhua Wang, Zhenchang Sun, Xiaorui Fu, Yu Chang, Feifei Nan, Hui Yu, Xiaolong Wu…

    Citation: Molecular Medicine 2018 24:35

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  15. Content type: Research article

    Metastatic Prostate cancer (PCa) cells have gained survival and invasive advantages. Epidermal growth factor (EGF) receptor is a receptor tyrosine kinase, which may mediate signalling to promote progression an...

    Authors: Anna Mandel, Per Larsson, Martuza Sarwar, Julius Semenas, Azharuddin Sajid Syed Khaja and Jenny L. Persson

    Citation: Molecular Medicine 2018 24:34

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  16. Content type: Review

    Histone deacetylase 6 (HDAC6), a cytoplasmic enzyme that plays important roles in many biological processes, is one isoform of a family of HDAC enzymes that catalyse the removal of functional acetyl groups fro...

    Authors: Ben Ke, Yanxia Chen, Wei Tu, Ting Ye, Xiangdong Fang and Liping Yang

    Citation: Molecular Medicine 2018 24:33

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  17. Content type: Research article

    Critically ill patients with sepsis and acute respiratory distress syndrome have severely altered physiology and immune system modifications. RNA splicing is a basic molecular mechanism influenced by physiolog...

    Authors: Sean F. Monaghan, Debasree Banerjee, Chun-Shiang Chung, Joanne Lomas-Neira, Kamil J. Cygan, Christy L. Rhine, William G. Fairbrother, Daithi S. Heffernan, Mitchell M. Levy, William G. Cioffi and Alfred Ayala

    Citation: Molecular Medicine 2018 24:32

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  18. Content type: Correction

    After publication of this article (He et al., 2018), the corresponding authors recognised an error in Scheme 1, in particular to section “A. HMGB1/TLR4/MD-2 complex formation”. Above “Step 2: B box binding to ...

    Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey and Yousef Al-Abed

    Citation: Molecular Medicine 2018 24:31

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    The original article was published in Molecular Medicine 2018 24:21

  19. Content type: Research article

    Recent identification of 10 germline variants predisposing to monoclonal gammopathy of undetermined significance (MGUS) explicates genetic dependency of this asymptomatic precursor condition with multiple myel...

    Authors: Subhayan Chattopadhyay, Hauke Thomsen, Miguel Inacio da Silva Filho, Niels Weinhold, Per Hoffmann, Markus M. Nöthen, Arendt Marina, Karl-Heinz Jöckel, Börge Schmidt, Sonali Pechlivanis, Christian Langer, Hartmut Goldschmidt, Kari Hemminki and Asta Försti

    Citation: Molecular Medicine 2018 24:30

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  20. Content type: Research article

    Chronic autoimmune urticaria (CAU) is a common skin disease and remains unclear understanding of pathogenesis in the vast majority of cases. In order to explore a new therapy for CAU, the current study was per...

    Authors: Xiao-Yan Luo, Qun Liu, Huan Yang, Qi Tan, Li-Qiang Gan, Fa-Liang Ren and Hua Wang

    Citation: Molecular Medicine 2018 24:28

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  21. Content type: Research article

    Systemic lupus erythematosus (SLE) is an autoimmune disease with genetic, hormonal, and environmental influences. In Western Europe and North America, individuals of West African descent have a 3–4 fold greate...

    Authors: Jyotsna Bhattacharya, Karalyn Pappas, Bahtiyar Toz, Cynthia Aranow, Meggan Mackay, Peter K. Gregersen, Ogobara Doumbo, Abdel Kader Traore, Martin L. Lesser, Maureen McMahon, Tammy Utset, Earl Silverman, Deborah Levy, William J. McCune, Meenakshi Jolly, Daniel Wallace…

    Citation: Molecular Medicine 2018 24:24

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  22. Content type: Research article

    Parathyroid glands of people with relapsing remitting multiple sclerosis (RRMS) fail to respond to low serum 25-hydroxyvitamin D (25OHD) and low serum calcium, which are stimuli for parathyroid hormone (PTH) s...

    Authors: Mark Simon Stein, Gregory John Ward, Helmut Butzkueven, Trevor John Kilpatrick and Leonard Charles Harrison

    Citation: Molecular Medicine 2018 24:27

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  23. Content type: Research article

    Sepsis morbidity and mortality are aggravated by acute lung injury (ALI) or acute respiratory distress syndrome (ARDS). Mouse B-1a cells are a phenotypically and functionally unique sub-population of B cells, ...

    Authors: Monowar Aziz, Yasumasa Ode, Mian Zhou, Mahendar Ochani, Nichol E. Holodick, Thomas L. Rothstein and Ping Wang

    Citation: Molecular Medicine 2018 24:26

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  24. Content type: Review

    Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins. Translational readthrough of PTCs induce...

    Authors: Maciej Dabrowski, Zuzanna Bukowy-Bieryllo and Ewa Zietkiewicz

    Citation: Molecular Medicine 2018 24:25

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  25. Content type: Research article

    Stratified human keratinocytes (SHKs) are an essential part of mucosal innate immune response that modulates adaptive immunity to microbes encountered in the environment. The importance of these SHKs in mucosa...

    Authors: Mohd Israr, David Rosenthal, Lidia Frejo-Navarro, James DeVoti, Craig Meyers and Vincent R. Bonagura

    Citation: Molecular Medicine 2018 24:23

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  26. Content type: Research article

    Endothelial injury is an early and enduring feature of cardiovascular disease. Inflammation and hypoxia may be responsible for this, and are often associated with the up-regulation of several transcriptional f...

    Authors: Lamia Heikal, Pietro Ghezzi, Manuela Mengozzi and Gordon Ferns

    Citation: Molecular Medicine 2018 24:22

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  27. Content type: Research article

    High Mobility Group Box 1 (HMGB1) was first identified as a nonhistone chromatin-binding protein that functions as a pro-inflammatory cytokine and a Damage-Associated Molecular Pattern molecule when released f...

    Authors: Mingzhu He, Marco E. Bianchi, Tom R. Coleman, Kevin J. Tracey and Yousef Al-Abed

    Citation: Molecular Medicine 2018 24:21

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    The Correction to this article has been published in Molecular Medicine 2018 24:31

  28. Content type: Research article

    Implant failure remains a major obstacle to successful treatment via TJA. Periprosthetic osteolysis and aseptic loosening are considered as proof of wear debris-induced disruption of local regulatory mechanism...

    Authors: Zhao Yan, Xiaoxi Tian, Jinyu Zhu, Zifan Lu, Lifeng Yu, Dawei Zhang, Yanwu Liu, Chongfei Yang, Qingsheng Zhu and Xiaorui Cao

    Citation: Molecular Medicine 2018 24:20

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  29. Content type: Research article

    High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. HMGB1 interacts with toll-like receptors (TLRs) but c...

    Authors: Hannah Aucott, Agnieszka Sowinska, Helena Erlandsson Harris and Peter Lundback

    Citation: Molecular Medicine 2018 24:19

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  30. Content type: Research article

    As a form of dementia primarily affecting the elderly, vascular dementia (VD) is characterized by changes in the supply of blood to the brain, resulting in cognitive impairment. The aim of the present study wa...

    Authors: Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu and Yuan-Lin Zheng

    Citation: Molecular Medicine 2018 24:18

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  31. Content type: Research article

    Dendritic cells (DC) induce adaptive responses against foreign antigens, and play an essential role in maintaining peripheral tolerance to self-antigens. Therefore they are involved in preventing fatal autoimm...

    Authors: Inna Tabansky, Derin B. Keskin, Deepika Watts, Cathleen Petzold, Michael Funaro, Warren Sands, Paul Wright, Edmond J. Yunis, Souhel Najjar, Betty Diamond, Yonghao Cao, David Mooney, Karsten Kretschmer and Joel N. H. Stern

    Citation: Molecular Medicine 2018 24:17

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  32. Content type: Review

    Radiotherapy remains one of the corner stones in the treatment of various malignancies and often leads to an improvement in overall survival. Nonetheless, pre-clinical evidence indicates that radiation can ent...

    Authors: Nora Sundahl, Fréderic Duprez, Piet Ost, Wilfried De Neve and Marc Mareel

    Citation: Molecular Medicine 2018 24:16

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  33. Content type: Research article

    Parathyroid hormone (PTH) is one of the principal regulators of calcium homeostasis. Although serum PTH level is mostly accounted by genetic factors, genetic background underlying PTH level is insufficiently k...

    Authors: Antonela Matana, Dubravka Brdar, Vesela Torlak, Thibaud Boutin, Marijana Popović, Ivana Gunjača, Ivana Kolčić, Vesna Boraska Perica, Ante Punda, Ozren Polašek, Maja Barbalić, Caroline Hayward and Tatijana Zemunik

    Citation: Molecular Medicine 2018 24:15

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  34. Content type: Research article

    Fetal sex determination is useful for families at risk of X-linked disorders, such as Duchenne muscular dystrophy, adrenal hypoplasia, hemophilia. At first, this could be obtained through invasive procedures s...

    Authors: Elisabetta D’Aversa, Giulia Breveglieri, Patrizia Pellegatti, Giovanni Guerra, Roberto Gambari and Monica Borgatti

    Citation: Molecular Medicine 2018 24:14

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  35. Content type: Review

    Atherosclerosis has been recognized as an inflammatory disease involving the vascular wall. MicroRNAs are a group of small noncoding RNAs to regulate gene expression at the transcriptional level through mRNA d...

    Authors: Heng Li, Xin-Ping Ouyang, Ting Jiang, Xi-Long Zheng, Ping-Ping He and Guo-Jun Zhao

    Citation: Molecular Medicine 2018 24:12

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  36. Content type: Research article

    Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular diseases (CVDs). Stachydrine (STA) is an active component in Chinese motherwort Leonurus heterophyllus sweet, which has been widely use...

    Authors: Xinya Xie, Zihui Zhang, Xinfeng Wang, Zhenyu Luo, Baochang Lai, Lei Xiao and Nanping Wang

    Citation: Molecular Medicine 2018 24:10

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  37. Content type: Research article

    Endometriosis is a chronic and underdiagnosed disease which affects 5–10% of women of childbearing age and is characterized by growth of endometrial tissue outside of the uterus, most often in the peritoneal c...

    Authors: Laura A. Warren, Andrew Shih, Susana Marquez Renteira, Tamer Seckin, Brandon Blau, Kim Simpfendorfer, Annette Lee, Christine N. Metz and Peter K. Gregersen

    Citation: Molecular Medicine 2018 24:1

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  38. Content type: Review

    Chronic lymphocytic leukemia (CLL), the most frequent type of leukemia in western countries, is characterized by the progressive accumulation in blood, bone marrow and lymphoid tissues of monoclonal B lymphocy...

    Authors: Gerardo Ferrer and Emili Montserrat

    Citation: Molecular Medicine 2018 24:9

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  39. Content type: Research article

    The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl p...

    Authors: Sujun Li, Fang Liang, Kevin Kwan, Yiting Tang, Xiangyu Wang, Youzhou Tang, Jianhua Li, Huan Yang, Sangeeta S. Chavan, Haichao Wang, Ulf Andersson, Ben Lu and Kevin J. Tracey

    Citation: Molecular Medicine 2018 24:8

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  40. Content type: Research article

    In order to retrieve episodic past events, the missing information needs to be reconstructed using information stored in semantic memory. Failures in these reconstructive processes are expressed as false memor...

    Authors: Armin Zlomuzica, Friederike Preusser, Susanna Roberts, Marcella L. Woud, Kathryn J. Lester, Ekrem Dere, Thalia C. Eley and Jürgen Margraf

    Citation: Molecular Medicine 2018 24:7

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  41. Content type: Research article

    Ec peptide (PEc), resulting from the proteolytic cleavage of the IGF-1Ec isoform, is involved in prostate cancer progression and metastasis, whereas in muscle tissue, it is associated with the mobilization of ...

    Authors: A. Armakolas, A. Dimakakos, C. Loukogiannaki, N. Armakolas, A. Antonopoulos, C. Florou, P. Tsioli, E. Papageorgiou, T. P. Alexandrou, M. Stathaki, D. Spinos, D. Pektasides, E. Patsouris and M. Koutsilieris

    Citation: Molecular Medicine 2018 24:6

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  42. Content type: Review

    Necrotizing Enterocolitis (NEC) is one of the most devastating gastrointestinal diseases in neonates, particularly among preterm infants in whom surgical NEC is the leading cause of morbidity. NEC pathophysiol...

    Authors: Naomi-Liza Denning and Jose M. Prince

    Citation: Molecular Medicine 2018 24:4

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  43. Content type: Research article

    Alterations in cardiac energy metabolism contribute to the development and severity of heart failure (HF). In severe HF, overall mitochondrial oxidative metabolism is significantly decreased resulting in a red...

    Authors: Natasha Fillmore, Jody L. Levasseur, Arata Fukushima, Cory S. Wagg, Wei Wang, Jason R. B. Dyck and Gary D. Lopaschuk

    Citation: Molecular Medicine 2018 24:3

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  44. Content type: Review

    Trisomy of chromosome 21 (TS21) is the most common autosomal aneuploidy compatible with postnatal survival with a prevalence of 1 in 700 newborns. Its phenotype is highly complex with constant features, such a...

    Authors: Antonella Izzo, Nunzia Mollo, Maria Nitti, Simona Paladino, Gaetano Calì, Rita Genesio, Ferdinando Bonfiglio, Rita Cicatiello, Maria Barbato, Viviana Sarnataro, Anna Conti and Lucio Nitsch

    Citation: Molecular Medicine 2018 24:2

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  45. Content type: Research Article

    The microtubule inhibitor vincristine is currently used to treat a variety of brain tumors, including low-grade glioma and anaplastic oligodendroglioma. Vincristine, however, does not penetrate well into brain...

    Authors: Michelle De Witt, Alexander Gamble, Derek Hanson, Daniel Markowitz, Caitlin Powell, Saleh Al Dimassi, Mark Atlas, John Boockvar, Rosamaria Ruggieri and Marc Symons

    Citation: Molecular Medicine 2017 23:2301050

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