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  1. Innervation of adipose tissue is essential for the proper function of this critical metabolic organ. Numerous surgical and chemical denervation studies have demonstrated how maintenance of brain-adipose commun...

    Authors: Magdalena Blaszkiewicz, Elizabeth Wood, Sigi Koizar, Jake Willows, Ryan Anderson, Yu-Hua Tseng, James Godwin and Kristy L. Townsend

    Citation: Molecular Medicine 2020 26:126

    Content type: Research article

    Published on:

  2. Age-related cataract (ARC) is a serious visual impairment disease, and its pathogenesis is unclear. This article aims to investigate the role of ROCK1 in the apoptosis of lens epithelial cells (LECs) in age-re...

    Authors: Shanshan Hu, Dongmei Su, Lei Sun, Zhongying Wang, Lina Guan, Shanhe Liu, Baowen Zhao, Yong Liu, Cuige Shi, Jianbo Yu and Xu Ma

    Citation: Molecular Medicine 2020 26:124

    Content type: Research article

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  3. FINCA disease is a pediatric cerebropulmonary disease caused by variants in the NHL repeat-containing 2 (NHLRC2) gene. Neurological symptoms are among the first manifestations of FINCA disease, but the consequenc...

    Authors: Anniina E. Hiltunen, Salla M. Kangas, Steffen Ohlmeier, Ilkka Pietilä, Jori Hiltunen, Heikki Tanila, Colin McKerlie, Subashika Govindan, Hannu Tuominen, Riitta Kaarteenaho, Mikko Hallman, Johanna Uusimaa and Reetta Hinttala

    Citation: Molecular Medicine 2020 26:123

    Content type: Research article

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  4. As a common ocular complication of diabetes mellitus, diabetic cataract is becoming a leading cause of visual impairment. The progression of diabetic cataract progression involves epithelial-to-mesenchymal tra...

    Authors: Xin Liu, Qiaoyun Gong, Longfei Yang, Min Liu, Lingzhi Niu and Lufei Wang

    Citation: Molecular Medicine 2020 26:122

    Content type: Research article

    Published on:

  5. Neonatal sepsis and the associated myocardial dysfunction remain a leading cause of infant mortality. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a ligand of triggering receptor expressed ...

    Authors: Naomi-Liza Denning, Monowar Aziz, Li Diao, Jose M. Prince and Ping Wang

    Citation: Molecular Medicine 2020 26:121

    Content type: Research article

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  6. At present, the early diagnosis of femoral head necrosis mainly relies on Magnetic resonance imaging (MRI), and most early patients are difficult to make an accurate diagnosis. Therefore, to investigate the ea...

    Authors: Xiaolong Wang, Jianbo Li, Da Man, Rui Liu and Jianmin Zhao

    Citation: Molecular Medicine 2020 26:120

    Content type: Research article

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  7. Increasing number of studies provide evidence that the vagus nerve stimulation (VNS) dampens inflammation in peripheral visceral organs. However, the effects of afferent fibers of the vagus nerve (AFVN) on ant...

    Authors: Byung Gon Jo, Seung-Hyung Kim and Uk Namgung

    Citation: Molecular Medicine 2020 26:119

    Content type: Research article

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  9. Approximately 400 million people throughout the world suffer from a rare disease. Although advances in whole exome and whole genome sequencing have greatly facilitated rare disease diagnosis, overall diagnosti...

    Authors: Samantha N. Hartin, John C. Means, Joseph T. Alaimo and Scott T. Younger

    Citation: Molecular Medicine 2020 26:117

    Content type: Perspective

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  10. MicroRNAs (miRNAs) have been identified as important participants in the development of atherosclerosis (AS). The present study explored the role of miR-128-3p in the dysfunction of vascular smooth muscle cell...

    Authors: Chuan Qu, Xin Liu, Yan Guo, Yuhong Fo, Xiuhuan Chen, Jining Zhou and Bo Yang

    Citation: Molecular Medicine 2020 26:116

    Content type: Research article

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  11. Circulating high-mobility group box 1 (HMGB1) plays important roles in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Intracellular HMGB1 is critical for the biology of hepatocytes. However, the...

    Authors: Minjie Lin, Jungke Long, Wenbo Li, Chenxuan Yang, Patricia Loughran, Robert O’Doherty, Timothy R. Billiar, Meihong Deng and Melanie J. Scott

    Citation: Molecular Medicine 2020 26:115

    Content type: Research article

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  12. Long non-coding RNAs (lncRNAs) are biomarkers participating in multiple disease development including acute myeloid leukemia (AML). Here, we investigated molecular mechanism of X Inactive-Specific Transcript (...

    Authors: Chong Wang, Lingling Li, Mengya Li, Weiqiong Wang, Yanfang Liu and Shujuan Wang

    Citation: Molecular Medicine 2020 26:114

    Content type: Research article

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  13. Postherpetic neuralgia (PHN) is the most common complication of herpes zoster, but the mechanism of PHN is still unclear. Activation of spinal astrocytes is involved in PHN. Our study aims to explore whether l...

    Authors: Cunlong Kong, Jie Du, Huilian Bu, Chen Huang, Fuxing Xu and Huan Ren

    Citation: Molecular Medicine 2020 26:113

    Content type: Research article

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  14. The oncogenic role of the newly identified lncRNA LUADT1 has been revealed in lung adenocarcinoma. It was reported that LUADT1 plays a critical role in multiple human diseases. This study was carried out to in...

    Authors: Zhimin Zhang, Mingzhu Lv, Xiang Wang, Zheng Zhao, Daolong Jiang and Lihua Wang

    Citation: Molecular Medicine 2020 26:112

    Content type: Research article

    Published on:

  15. Myocardial infarction (MI) is the leading cause of death from cardiovascular disease (CVD). Currently, the efficacy for MI treatment remains unsatisfactory. Therefore, it is urgent to develop a novel therapeut...

    Authors: Qiuting Feng, Xing Li, Xian Qin, Cheng Yu, Yan Jin and Xiaojun Qian

    Citation: Molecular Medicine 2020 26:111

    Content type: Research article

    Published on:

  16. Posttraumatic stress disorder (PTSD) is a psychiatric disorder accompanied by chronic peripheral inflammation. What triggers inflammation in PTSD is currently unclear. In the present study, we identified poten...

    Authors: Marpe Bam, Xiaoming Yang, Brandon P. Busbee, Allison E. Aiello, Monica Uddin, Jay P. Ginsberg, Sandro Galea, Prakash S. Nagarkatti and Mitzi Nagarkatti

    Citation: Molecular Medicine 2020 26:110

    Content type: Research article

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  17. Breast cancer (BC) is a common malignant tumor with poor prognosis. Angiogenesis is related to the growth and progression of solid tumors and associated with prognosis. ZLM-7, SP1, VEGFA and miR-212-3p were as...

    Authors: Xuan Li, Zi-Zheng Zou, Min Wen, Yuan-Zhu Xie, Kun-Jian Peng, Tiao Luo, Su-You Liu, Qin Gu, Ji-Jia Li and Zhi-Yong Luo

    Citation: Molecular Medicine 2020 26:109

    Content type: Research article

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  18. Acute lung injury (ALI), which is induced by numerous pathogenic factors, especially sepsis, can generate alveolar damage, pulmonary edema and vascular hyper-permeability ultimately leading to severe hypoxemia...

    Authors: Xiaojun Pan, Shunyao Xu, Zhen Zhou, Fen Wang, Lingjie Mao, Hao Li, Caixia Wu, Junfeng Wang, Yueyue Huang, Dequan Li, Cong Wang and Jingye Pan

    Citation: Molecular Medicine 2020 26:108

    Content type: Research article

    Published on:

  19. The expression of SIN3A is closely correlated with electroacupuncture (EA) treatment efficacy of scopolamine-induced amnesia (SIA), but its underlying mechanisms remain to be further explored.

    Authors: Fan Ye, Shiming Tian, Huimin Hu and Zhengwen Yu

    Citation: Molecular Medicine 2020 26:107

    Content type: Research article

    Published on:

  20. Recent studies have demonstrated that long non-coding RNAs (LncRNAs) can influence bone cell differentiation and formation. However, it is unclear whether lncRNA HCG18 is involved in osteoporosis (OP). This st...

    Authors: Mingxue Che, Weiquan Gong, Yao Zhao and Mingxi Liu

    Citation: Molecular Medicine 2020 26:106

    Content type: Research article

    Published on:

  21. Acupuncture treatment possesses the neuroprotection potential to attenuate cerebral ischemia–reperfusion (I/R) injury. Endoplasmic reticulum (ER) stress has been suggested to be involved in the pathogenic mech...

    Authors: Xiaowei Sun, Hao Liu, Zhongren Sun, Beng Zhang, Xinyu Wang, Tingting Liu, Tingting Pan, Ying Gao, Xicheng Jiang and Hongtao Li

    Citation: Molecular Medicine 2020 26:105

    Content type: Research article

    Published on:

  22. Neuropathic pain belongs to chronic pain and is caused by the primary dysfunction of the somatosensory nervous system. Long noncoding RNAs (lncRNAs) have been reported to regulate neuronal functions and play s...

    Authors: Zhen Li, Aiyuan Li, Liping Yan, Tian Yang, Wei Xu and Pengju Fan

    Citation: Molecular Medicine 2020 26:104

    Content type: Research article

    Published on:

  23. The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune...

    Authors: Betty Diamond, Bruce T. Volpe, Sonya VanPatten and Yousef Al Abed

    Citation: Molecular Medicine 2020 26:103

    Content type: Review

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  26. The most popular miRNA quantitation technique is RQ-PCR with relative gene expression method that requires an endogenous control (EC) gene for data normalization. However, there are insufficient data and selec...

    Authors: Daina Pamedytyte, Enrika Leipute, Birute Zilaitiene, Valdas Sarauskas, Dalia Dauksiene, Albertas Dauksa and Aurelija Zvirbliene

    Citation: Molecular Medicine 2020 26:100

    Content type: Short report

    Published on:

  27. The incidence of bronchopulmonary dysplasia (BPD), a chronic lung disease of newborns, has been paradoxically rising despite medical advances. Histone deacetylase 3 (Hdac3) has been reported to be a crucial re...

    Authors: Di Wang, Hui Hong, Xiao-Xia Li, Jing Li and Zhi-Qun Zhang

    Citation: Molecular Medicine 2020 26:99

    Content type: Research article

    Published on:

  28. Mechanical ventilation, in combination with supraphysiological concentrations of oxygen (i.e., hyperoxia), is routinely used to treat patients with respiratory distress, such as COVID-19. However, prolonged ex...

    Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby Jr. and Lin L. Mantell

    Citation: Molecular Medicine 2020 26:98

    Content type: Research article

    Published on:

  29. COVID-19 is a viral respiratory disease caused by the severe acute respiratory syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this disease may be more prone to venous or arterial thrombosis because of...

    Authors: Yu Chen, Jinglan Wang, Chenxi Liu, Longxiang Su, Dong Zhang, Junping Fan, Yanli Yang, Meng Xiao, Jing Xie, Yingchun Xu, Yongzhe Li and Shuyang Zhang

    Citation: Molecular Medicine 2020 26:97

    Content type: Research article

    Published on:

  30. Kelch repeat and BTB domain-containing protein 8, KBTBD8, has been identified as a female fertility factor. However, there have been no reports on the role of KBTBD8 in the progression of epithelial ovarian ca...

    Authors: Lei Du, Cong-Rong Li, Qi-Feng He, Xiao-Hua Li, Lin-Fei Yang, Yuan Zou, Zhi-Xia Yang, Dong Zhang and Xiao-Wei Xing

    Citation: Molecular Medicine 2020 26:96

    Content type: Research article

    Published on:

  32. Neonatal sepsis remains an important cause of morbidity and mortality. The ability to quickly and accurately diagnose neonatal sepsis based on clinical assessments and laboratory blood tests remains difficult,...

    Authors: Ahlam Fatmi, Sid Ahmed Rebiahi, Nafissa Chabni, Hanane Zerrouki, Hafsa Azzaoui, Yamina Elhabiri, Souheila Benmansour, José Santiago Ibáñez-Cabellos, Mohammed Chems-Eddine Smahi, Mourad Aribi, José Luis García-Giménez and Federico V. Pallardó

    Citation: Molecular Medicine 2020 26:94

    Content type: Short report

    Published on:

    The Correction to this article has been published in Molecular Medicine 2020 26:129

  33. Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile i...

    Authors: Teresa Płatek, Anna Polus, Joanna Góralska, Urszula Raźny, Anna Gruca, Beata Kieć-Wilk, Piotr Zabielski, Maria Kapusta, Krystyna Słowińska-Solnica, Bogdan Solnica, Małgorzata Malczewska-Malec and Aldona Dembińska-Kieć

    Citation: Molecular Medicine 2020 26:93

    Content type: Research article

    Published on:

  34. Current blood-based tests for rheumatoid arthritis (RA) have inherent limitations, necessitating the need for additional new biomarkers for its diagnosis and monitoring disease activity and responsiveness to t...

    Authors: Mohamed Taha, Olfat Gamil Shaker, Enas Abdelsalam and Noha Taha

    Citation: Molecular Medicine 2020 26:92

    Content type: Research article

    Published on:

  35. Mechanically ventilated patients with COVID-19 have a mortality of 24–53%, in part due to distal mucopurulent secretions interfering with ventilation. DNA from neutrophil extracellular traps (NETs) contribute ...

    Authors: Andrew G. Weber, Alice S. Chau, Mikala Egeblad, Betsy J. Barnes and Tobias Janowitz

    Citation: Molecular Medicine 2020 26:91

    Content type: Short report

    Published on:

  37. Hypovolemic shock and septic challenge are two major causes of acute kidney injury (AKI) in the clinic setting. Src homology 2 domain-containing phosphatase 2 (SHP2) is one of the major protein phosphatase tyr...

    Authors: Jihong Jiang, Baoji Hu, Chun-Shiang Chung, Yaping Chen, Yunhe Zhang, Elizabeth W. Tindal, Jinbao Li and Alfred Ayala

    Citation: Molecular Medicine 2020 26:89

    Content type: Research article

    Published on:

  38. Patients newly diagnosed with lung adenocarcinoma with bone metastases (LABM) have poor survival rates after treatment with conventional therapies. To improve outcomes, we retrospectively investigated whether ...

    Authors: Long Huang, Xiao-Liu Jiang, Hong-Bin Liang, Jian-Cheng Li, Li-Han Chin, Jian-Ping Wei, Rui-Ru Wang, Jing Cai, Qiang Xiong, Lien-Tu Wang, David S. Cram and An-Wen Liu

    Citation: Molecular Medicine 2020 26:88

    Content type: Research article

    Published on:

  39. Phenotypic transformation of vascular smooth muscle cells is a key element in vascular remodeling and aortic aneurysm growth. Previously, deletion of several inflammasome components decreased formation of aort...

    Authors: Markus Wortmann, Muhammad Arshad, Maani Hakimi, Dittmar Böckler and Susanne Dihlmann

    Citation: Molecular Medicine 2020 26:87

    Content type: Research article

    Published on:

  41. Exposure to ionizing radiation induces complex stress responses in cells, which can lead to adverse health effects such as cancer. Although a variety of studies investigated gene expression and affected pathwa...

    Authors: Lara Kim Brackmann, Alicia Poplawski, Caine Lucas Grandt, Heike Schwarz, Thomas Hankeln, Steffen Rapp, Sebastian Zahnreich, Danuta Galetzka, Iris Schmitt, Christian Grad, Lukas Eckhard, Johanna Mirsch, Maria Blettner, Peter Scholz-Kreisel, Moritz Hess, Harald Binder…

    Citation: Molecular Medicine 2020 26:85

    Content type: Research article

    Published on:

  43. Gender-affirming hormone therapy has been hypothesized to reduce the patient’s reproductive potential in transmen, although the exact long-term effects on future fertility are unknown.

    Authors: Julian Marschalek, Detlef Pietrowski, Sabine Dekan, Marie-Louise Marschalek, Maximilian Brandstetter and Johannes Ott

    Citation: Molecular Medicine 2020 26:83

    Content type: Research article

    Published on:

  44. Chorioamnionitis, inflammation of the chorion and amnion, which often results from intrauterine infection, is associated with premature birth and contributes to significant neonatal morbidity and mortality, in...

    Authors: C. Heymans, I. H. de Lange, K. Lenaerts, L. C. G. A. Kessels, M. Hadfoune, G. Rademakers, V. Melotte, W. Boesmans, B. W. Kramer, A. H. Jobe, M. Saito, M. W. Kemp, W. G. van Gemert and T. G. A. M. Wolfs

    Citation: Molecular Medicine 2020 26:82

    Content type: Research article

    Published on:

  45. Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. We previously demonstrated that exosomes derived from natural killer (NK) cells (NK-Exo) attenuated TGF-β1-induced HSC activ...

    Authors: Ling Wang, Yinghao Wang and Jun Quan

    Citation: Molecular Medicine 2020 26:81

    Content type: Research article

    Published on:

  48. Patients with advanced non-small cell lung cancer (NSCLC) benefit from treatment with immune checkpoint inhibitors (ICIs). Biomarkers such as programmed death-ligand 1 (PD-L1), the tumor mutational burden (TMB...

    Authors: Dantong Sun, Lu Tian, Yan Zhu, Yang Wo, Qiaoling Liu, Shihai Liu, Hong Li and Helei Hou

    Citation: Molecular Medicine 2020 26:78

    Content type: Research article

    Published on:

  49. Little is known about the correlation between the melanocortin 4 receptor gene (MC4R) single nucleotide polymorphisms (SNPs) and the risk of obesity. This research sought to test the MC4R rs17782313, rs476828 and...

    Authors: Bi-Liu Wei, Rui-Xing Yin, Chun-Xiao Liu, Guo-Xiong Deng, Yao-Zong Guan and Peng-Fei Zheng

    Citation: Molecular Medicine 2020 26:77

    Content type: Research article

    Published on:

  50. Diabetes during pregnancy affects placental mitochondrial content and function, which has the potential to impact fetal development and the long-term health of offspring. Resistin is a peptide hormone original...

    Authors: Shaoning Jiang, April M. Teague, Jeanie B. Tryggestad, Timothy J. Lyons and Steven D. Chernausek

    Citation: Molecular Medicine 2020 26:76

    Content type: Research article

    Published on:

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Molecular Medicine

ISSN: 1528-3658

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