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  1. The Multi-System Inflammatory Syndrome in Children (MIS-C) can develop several weeks after SARS-CoV-2 infection and requires a distinct treatment protocol. Distinguishing MIS-C from SARS-CoV-2 negative sepsis ...

    Authors: Maitray A. Patel, Douglas D. Fraser, Mark Daley, Gediminas Cepinskas, Noemi Veraldi and Serge Grazioli
    Citation: Molecular Medicine 2024 30:51
  2. Immune-mediated arthritis is a group of autoinflammatory diseases, where the patient’s own immune system attacks and destroys synovial joints. Sustained remission is not always achieved with available immunosu...

    Authors: Dipabarna Bhattacharya, Jason Theodoropoulos, Katariina Nurmi, Timo Juutilainen, Kari K. Eklund, Riitta Koivuniemi, Tiina Kelkka, Satu Mustjoki and Tapio Lönnberg
    Citation: Molecular Medicine 2024 30:48
  3. RASopathies are genetic syndromes affecting development and having variable cancer predisposition. These disorders are clinically related and are caused by germline mutations affecting key players and regulato...

    Authors: Giulia Fasano, Stefania Petrini, Valeria Bonavolontà, Graziamaria Paradisi, Catia Pedalino, Marco Tartaglia and Antonella Lauri
    Citation: Molecular Medicine 2024 30:47
  4. Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis dur...

    Authors: Tairan Wang, Yan Jin, Mengyao Wang, Boya Chen, Jinyu Sun, Jiaying Zhang, Hui Yang, Xinyao Deng, Xingyue Cao, Lidong Wang and Yuanyuan Tang
    Citation: Molecular Medicine 2024 30:46
  5. Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that has been implicated in multiple inflammatory and non-inflammatory diseases, including liver injury induced by acetaminophen (APAP) ov...

    Authors: Joshua Bloom, Georgios Pantouris, Mingzhu He, Bayan Aljabari, Lopa Mishra, Ramu Manjula, Andrew Parkins, Elias J. Lolis and Yousef Al-Abed
    Citation: Molecular Medicine 2024 30:43
  6. The formation and accumulation of cholesterol crystals (CC) at the lesion site is a hallmark of atherosclerosis. Although studies have shown the importance of vascular smooth muscle cells (VSMCs) in the diseas...

    Authors: Jishamol Thazhathveettil, Ashok Kumar Kumawat, Isak Demirel, Allan Sirsjö and Geena Varghese Paramel
    Citation: Molecular Medicine 2024 30:42
  7. Benign prostatic hyperplasia (BPH) is a prevalent disease affecting elderly men, with chronic inflammation being a critical factor in its development. Omentin-1, also known as intelectin-1 (ITLN-1), is an anti...

    Authors: Yi-Yi Wang, Guo-Qiang Zhu, Kun Xia, Hong-Bo Zeng, Yun-Hui He, Hui Xie, Zhen-Xing Wang and Ran Xu
    Citation: Molecular Medicine 2024 30:41
  8. The accumulation of unfolded or misfolded proteins within the endoplasmic reticulum (ER), due to genetic determinants and extrinsic environmental factors, leads to endoplasmic reticulum stress (ER stress). As ...

    Authors: Siqi Yuan, Dan She, Shangming Jiang, Nan Deng, Jiayi Peng and Ling Ma
    Citation: Molecular Medicine 2024 30:40
  9. Anesthetics have been linked to cognitive alterations, particularly in the elderly. The current research delineates how Fibroblast Growth Factor 2 (Fgf2) modulates tau protein phosphorylation, contributing to ...

    Authors: Xin Xie, Xiaomin Zhang, Songze Li and Wei Du
    Citation: Molecular Medicine 2024 30:39
  10. Macrophage-derived extracellular vesicle (macrophage-EV) is highly studied for its regulatory role in atherosclerosis (AS). Our current study tried to elucidate the possible role of macrophage-EV loaded with s...

    Authors: Weijie Liang, Ruibin Wei, Xingxing Zhu, Jinliang Li, Aiwen Lin, Jun Chen, Wen Wu and Qiang Jie
    Citation: Molecular Medicine 2024 30:38
  11. The disease-causing mutation in Huntington disease (HD) is a CAG trinucleotide expansion in the huntingtin (HTT) gene. The mutated CAG tract results in the production of a small RNA, HTT1a, coding for only exon 1...

    Authors: Franziska Hoschek, Julia Natan, Maximilian Wagner, Kirupa Sathasivam, Alshaimaa Abdelmoez, Björn von Einem, Gillian P. Bates, G. Bernhard Landwehrmeyer and Andreas Neueder
    Citation: Molecular Medicine 2024 30:36

    The Correction to this article has been published in Molecular Medicine 2024 30:49

  12. Neuronal ferroptosis plays a critical role in the pathogenesis of cognitive deficits. The present study explored whether artemisinin protected type 2 diabetes mellitus (T2DM) mice from cognitive impairments by...

    Authors: Bo Wang, Sheng Zhu, Miao Guo, Run-Dong Ma, Ya-Ling Tang, Ya-Xiong Nie and Hong-Feng Gu
    Citation: Molecular Medicine 2024 30:35
  13. Imbalance in energy regulation is a major cause of insulin resistance and diabetes. Melanocortin-4 receptor (MC4R) signaling at specific sites in the central nervous system has synergistic but non-overlapping ...

    Authors: Hengru Guo, Ying Xin, Saifei Wang, Xiaoning Zhang, Yanqi Ren, Bo Qiao, Hongjiang Li, Jing Wu, Xiao Hao, Lijun Xu, Yushan Yan and Haohao Zhang
    Citation: Molecular Medicine 2024 30:34
  14. Loss of dopaminergic neurons underlies the motor symptoms of Parkinson’s disease (PD). However stereotypical PD symptoms only manifest after approximately 80% of dopamine neurons have died making dopamine-rela...

    Authors: Anna Marie Buchanan, Sergio Mena, Iman Choukari, Aditya Vasa, Jesseca N. Crawford, Jim Fadel, Nick Maxwell, Lawrence Reagan, Allie Cruikshank, Janet Best, H. Fred Nijhout, Michael Reed and Parastoo Hashemi
    Citation: Molecular Medicine 2024 30:33
  15. Endothelial-to-Mesenchymal Transformation (EndMT) plays key roles in endothelial dysfunction during the pathological progression of atherosclerosis; however, its detailed mechanism remains unclear. Herein, we ...

    Authors: Zhiwen Zhang, Quan Guo, Chao Ma, Zhenzhou Zhao, Qingbo Shi, Haosen Yu, Lixin Rao and Muwei Li
    Citation: Molecular Medicine 2024 30:32
  16. Reperfusion is the most effective strategy for myocardial infarct, but induces additional injury. WD repeat and SOCS box containing protein 1 (WSB1) plays a protective role in ischemic cells. This study aims t...

    Authors: Lini Fang, Yang Tao, Guoying Che, Yongzi Yun, Min Ren and Yujie Liu
    Citation: Molecular Medicine 2024 30:31
  17. Sepsis is a systemic inflammatory response which is frequently associated with acute lung injury (ALI). Activating transcription factor 3 (ATF3) promotes M2 polarization, however, the biological effects of ATF...

    Authors: Wei Wang, Rongli Xu, Ping He, Yuqing Xiong, Haomiao Zhao, Xuewei Fu, Jie Lin and Lijiao Ye
    Citation: Molecular Medicine 2024 30:30
  18. The escalating challenge of Carbapenem-resistant Klebsiella pneumoniae (CRKP) in hospital-acquired pneumonia (HAP) is closely linked to the blaNDM-1 gene. This study explores the regulatory mechanisms of blaNDM-1...

    Authors: Liang Ding, Zheng Yang and Baier Sun
    Citation: Molecular Medicine 2024 30:29
  19. Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen depe...

    Authors: Jiaping Chen, Rong Zhao, Yangwei Wang, Han Xiao, Wei Lin, Mingxin Diao, Shiwen He, Peiyuan Mei and Yongde Liao
    Citation: Molecular Medicine 2024 30:28
  20. Isoorientin (ISO) is a glycosylated flavonoid with antitumor, anti-inflammatory, and antioxidant properties. However, its effects on bone metabolism remain largely unknown.

    Authors: Bo Zhang, Zechao Qu, Hua Hui, Baorong He, Dong Wang, Yong Zhang, Yiwei Zhao, Jingjun Zhang and Liang Yan
    Citation: Molecular Medicine 2024 30:27
  21. Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the o...

    Authors: Robin Baudouin, Eric Tartour, Cécile Badoual and Stéphane Hans
    Citation: Molecular Medicine 2024 30:26
  22. Scleral extracellular matrix (ECM) remodeling plays a crucial role in the development of myopia, particularly in ocular axial elongation. Thrombospondin-1 (THBS1), also known as TSP-1, is a significant cellula...

    Authors: Junhan Chen, Shin-ichi Ikeda, Yajing Yang, Yan Zhang, Ziyan Ma, Yifan Liang, Kazuno Negishi, Kazuo Tsubota and Toshihide Kurihara
    Citation: Molecular Medicine 2024 30:25
  23. Lipid peroxidation is a characteristic metabolic manifestation of diabetic retinopathy (DR) that causes inflammation, eventually leading to severe retinal vascular abnormalities. Selenium (Se) can directly or ...

    Authors: Tian Niu, Xin Shi, Xijian Liu, Haiyan Wang, Kun Liu and Yupeng Xu
    Citation: Molecular Medicine 2024 30:24
  24. Fluvoxamine is one of the selective serotonin reuptake inhibitors (SSRIs) that are regarded as the first-line drugs to manage mental disorders. It has been also recognized with the potential to treat inflammat...

    Authors: Yuan Zou, Jing Zhang, Fei Sun, Qianqian Xu, Longmin Chen, Xi Luo, Ting Wang, Qing Zhou, Shu Zhang, Fei Xiong, Wen Kong, Ping Yang, Qilin Yu, Shiwei Liu and Cong-Yi Wang
    Citation: Molecular Medicine 2024 30:23
  25. The contribution of the central nervous system to sepsis pathobiology is incompletely understood. In previous studies, administration of endotoxin to mice decreased activity of the vagus anti-inflammatory refl...

    Authors: Mabel N. Abraham, Ana Nedeljkovic-Kurepa, Tiago D. Fernandes, Omar Yaipen, Mariana R. Brewer, Daniel E. Leisman, Matthew D. Taylor and Clifford S. Deutschman
    Citation: Molecular Medicine 2024 30:22
  26. Pericytes are a vital component of the blood–brain barrier, and their involvement in acute inflammation was recently suggested. However, it remains unclear whether pericytes contribute to hypothalamic chronic ...

    Authors: Akira Okekawa, Tsutomu Wada, Yasuhiro Onogi, Yuki Takeda, Yuichiro Miyazawa, Masakiyo Sasahara, Hiroshi Tsuneki and Toshiyasu Sasaoka
    Citation: Molecular Medicine 2024 30:21
  27. Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability. The main patholo...

    Authors: Hao Zheng, Yuexuan Liu, Yasi Deng, Yunzhe Li, Shiqi Liu, Yong Yang, Yun Qiu, Bin Li, Wenbing Sheng, Jinzhi Liu, Caiyun Peng, Wei Wang and Huanghe Yu
    Citation: Molecular Medicine 2024 30:20
  28. Clinical manifestation of prostate cancer (PCa) is highly variable. Aggressive tumors require radical treatment while clinically non-significant ones may be suitable for active surveillance. We previously deve...

    Authors: Michael Rade, Markus Kreuz, Angelika Borkowetz, Ulrich Sommer, Conny Blumert, Susanne Füssel, Catharina Bertram, Dennis Löffler, Dominik J. Otto, Livia A. Wöller, Carolin Schimmelpfennig, Ulrike Köhl, Ann-Cathrin Gottschling, Pia Hönscheid, Gustavo B. Baretton, Manfred Wirth…
    Citation: Molecular Medicine 2024 30:19
  29. Ischemia–reperfusion (I/R) injury is a major cause of surgical skin flap compromise and organ dysfunction. Platelet-rich plasma (PRP) is an autologous product rich in growth factors, with tissue regenerative p...

    Authors: Linlin Su, Songtao Xie, Ting Li, Yanhui Jia and Yunchuan Wang
    Citation: Molecular Medicine 2024 30:18
  30. It is well-established that CD8+ T-cells play a critical role in graft rejection. The basic leucine zipper ATF-like transcription factor (BATF) and BATF3 are transcriptional factors expressed in T lymphocytes. He...

    Authors: Chenghao Li, Zongtao Liu, Zihao Wang, Wai Yen Yim, Yajun Huang and Yuqi Chen
    Citation: Molecular Medicine 2024 30:16
  31. In heart failure (HF), mitochondrial dysfunction and metabolic remodeling lead to a reduction in energy productivity and aggravate cardiomyocyte injury. Supplementation with α-ketoglutarate (AKG) alleviated my...

    Authors: Hao Yu, Daojing Gan, Zhen Luo, Qilin Yang, Dongqi An, Hao Zhang, Yingchun Hu, Zhuang Ma, Qingchun Zeng, Dingli Xu and Hao Ren
    Citation: Molecular Medicine 2024 30:15
  32. N6-Methyladenosine (m6A) methylation is the most prevalent post-transcriptional modification in mRNA, and plays significant roles in various diseases. Nevertheless, the precise functions of m6A modification in...

    Authors: Chenzhen Xu, Congkuan Song, Wenjie Wang, Bohao Liu, Guorui Li, Tinglv Fu, Bo Hao, Ning Li and Qing Geng
    Citation: Molecular Medicine 2024 30:14
  33. PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was a novel transcriptional regulator of PD-L1 and stimulated the trans...

    Authors: Ge Qin, Fan Bai, Huabin Hu, Jianwei Zhang, Weixiang Zhan, Zehua Wu, Jianxia Li, Yang Fu and Yanhong Deng
    Citation: Molecular Medicine 2024 30:13
  34. Molecular techniques can complement conventional spermiogram analyses to provide new information on the fertilizing potential of spermatozoa and to identify early alterations due to environmental pollution.

    Authors: Giulio Ferrero, Rosaria Festa, Laura Follia, Gennaro Lettieri, Sonia Tarallo, Tiziana Notari, Antonella Giarra, Carmela Marinaro, Barbara Pardini, Alessandra Marano, Giulia Piaggeschi, Carla Di Battista, Marco Trifuoggi, Marina Piscopo, Luigi Montano and Alessio Naccarati
    Citation: Molecular Medicine 2024 30:12
  35. Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging. However, it was unclear whether the decline...

    Authors: Di-Zheng Wu, Guo-Zheng Zhu, Kai Zhao, Jia-Wen Gao, Gui-Xing Cai, Hong-Zhou Li, Yu-Sheng Huang, Chen Tu, Jing-Shen Zhuang, Zhi-Wei Huang and Zhao-Ming Zhong
    Citation: Molecular Medicine 2024 30:10
  36. Lysine demethylase 5C (KDM5C) has been implicated in the development of several human cancers. This study aims to investigate the role of KDM5C in the progression of colorectal cancer (CRC) and explore the ass...

    Authors: Fulong Yu, Liang Li, Yimei Gu, Song Wang, Lianbang Zhou, Xiaohu Cheng, Heng Jiang, Yang Huang, Yingfeng Zhang, Wenbao Qian, Xianghua Li and Zhining Liu
    Citation: Molecular Medicine 2024 30:9
  37. Medial vascular calcification is commonly identified in chronic kidney disease (CKD) patients and seriously affects the health and life quality of patients. This study aimed to investigate the effects of prote...

    Authors: Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao and Guangyi Zhao
    Citation: Molecular Medicine 2024 30:8
  38. Intervertebral disc degeneration (IDD) is considered an important pathological basis for spinal degenerative diseases. Tissue engineering is a powerful therapeutic strategy that can effectively restore the nor...

    Authors: Tao Ma, Chen Liu, Quanlai Zhao, Yu Zhang and Liang Xiao
    Citation: Molecular Medicine 2024 30:7
  39. Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in preterm infants, characterised by compromised alveolar development and pulmonary vascular abnormalities. Emerging evidence suggests that reg...

    Authors: Ying Zhu, Langyue He, Yue Zhu, Huici Yao, Jianfeng Jiang and Hongyan Lu
    Citation: Molecular Medicine 2024 30:6
  40. Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to in...

    Authors: Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao and Haidong Liang
    Citation: Molecular Medicine 2024 30:5
  41. Lesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine–guanine phosphoribosyltransferase (HGprt), an enzyme involved in the salvage synthesis of purines. T...

    Authors: Paula Escudero-Ferruz, Neus Ontiveros, Claudia Cano-Estrada, Diane J. Sutcliffe, H. A. Jinnah, Rosa J. Torres and José M. López
    Citation: Molecular Medicine 2024 30:3
  42. Umbilical cord blood-derived therapeutics, such as serum (UCS) and platelet-rich plasma (UCPRP), are popular treatment options in clinical trials and can potentially be utilized to address a clinically unmet n...

    Authors: Ruojing Huang, Caiying Su, Na Zhang, Congying Shi, Guangming Pu, Yong Ding, Wei Wei and Jiansu Chen
    Citation: Molecular Medicine 2024 30:2
  43. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals a...

    Authors: Kaylin Huitsing, Tara Tritsch, Francisco Javier Carrera Arias, Fanny Collado, Kristina K. Aenlle, Lubov Nathason, Mary Ann Fletcher, Nancy G. Klimas and Travis J. A. Craddock
    Citation: Molecular Medicine 2024 30:1

Annual Journal Metrics

  • Annual Journal Metrics

    Citation Impact 2023
    Journal Impact Factor: 6.0
    5-year Journal Impact Factor: 6.0
    Source Normalized Impact per Paper (SNIP): 0.907
    SCImago Journal Rank (SJR): 1.446

    Speed 2023
    Submission to first editorial decision (median days): 6
    Submission to acceptance (median days): 132

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    Downloads: 1,105,866
    Altmetric mentions: 1,878