Articles

MiR-100 overexpression attenuates high fat diet induced weight gain, liver steatosis, hypertriglyceridemia and development of metabolic syndrome in mice

Diet-induced obesity can result in the development of a diverse spectrum of cardiovascular and metabolic diseases, including type 2 diabetes, dyslipidemia, non-alcoholic liver steatosis and atherosclerotic dis...

Authors: Christian Smolka, Delia Schlösser, Catherine Hohnloser, Xavier Bemtgen, Caterina Jänich, Laura Schneider, Julien Martin, Dietmar Pfeifer, Martin Moser, Peter Hasselblatt, Christoph Bode, Sebastian Grundmann and Franziska Pankratz

Reversible dysregulation of renal circadian rhythm in lupus nephritis

We have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with...

Authors: Rakesh Mishra, Ramalingam Bethunaickan, Celine C. Berthier, Zhengzi Yi, Joshua J. Strohl, Patricio T. Huerta, Weijia Zhang and Anne Davidson

Correction to: 2‑O, 3‑O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1‑compromised macrophage function

Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell

The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF/p38 MAPK axis

N-Acetylcysteine (NAC) demonstrates applications in the prevention of exacerbation of chronic obstructive pulmonary disease (COPD). COPD is often characterized by fibrosis of the small airways. This study aims .....

Authors: Lanlan Zhu, Fei Xu, Xiuhua Kang, Jing Zhou, Qinqin Yao, Yang Lin and Wei Zhang

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1

Apoptosis of chondrocyte is involved in osteoarthritis (OA) pathogenesis, and mechanical stress plays a key role in this process by activation of Piezo1. However, the negative regulation of signal conduction m...

Authors: Yi Sun, Ping Leng, Pengcheng Guo, Huanshen Gao, Yikai Liu, Chenkai Li, Zhenghui Li and Haining Zhang

The long non-coding RNA DKFZp434J0226 regulates the alternative splicing process through phosphorylation of SF3B6 in PDAC

Long noncoding RNAs (lncRNAs), a type of pervasive genes that regulates various biological processes, are differentially expressed in different types of malignant tumors. The role of lncRNAs in the carcinogene...

Authors: Jinglei Li, Hanxing Tong, Dongping Li, Qiuyu Jiang, Yong Zhang, Wenqing Tang, Dayong Jin, She Chen, Xinyu Qin, Si Zhang and Ruyi Xue

CircRNAs and their regulatory roles in cancers

Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), have a covalently closed circular structure resulting from pre-mRNA back splicing via spliceosome and ribozymes. They can be classified diffe...

Authors: Mei Tao, Ming Zheng, Yanhua Xu, Shuo Ma, Weiwei Zhang and Shaoqing Ju

Correction to: GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

Authors: Ravikumar A. Sitapara, Alex G. Gauthier, Vivek S. Patel, Mosi Lin, Michelle Zur, Charles R. Ashby Jr. and Lin L. Mantell

CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro

Nucleus pulposus cell (NPC) degeneration is widely accepted as one of the major causes of intervertebral disc (IVD) degeneration (IVDD). The pathogenesis of IVDD is complex and consists of inflammation, oxidat...

Authors: Xiaoqiang Cheng, Jiayi Lin, Zhanghuan Chen, Yubo Mao, Xiexin Wu, Congxin Xu, Jiacheng Du, Zhongchen Dong, Huilin Yang, Feng Zhou and Dechun Geng

Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3

Intervertebral disc degeneration (IVDD) is the breakdown of the discs supporting the vertebrae. It is one of the most frequent causes of back pain worldwide. Currently, the clinical interventions for IVDD are ...

Authors: Xiaoqiu Yuan, Tiefeng Li, Lei Shi, Jinhao Miao, Yongfei Guo and Yu Chen

Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis

It is known that increased gastrin concentration is negatively correlated with cardiovascular mortality, and plasma gastrin levels are increased in patients after myocardial infarction (MI). However, whether g...

Authors: Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue and Lin Cai

rAAV9‐mediated supplementation of miR-29b improve angiotensin-II induced renal fibrosis in mice

Renin–angiotensin–aldosterone system activation is the critical factor in renal remodeling and dysfunction. Our previous study suggested that miR-29b may attenuate AngII-induced renal intestinal fibrosis in vi...

Authors: Ju-hong Zhang, Jing Li, Yang Ye and Wang-qi Yu

Interleukin-22: a potential therapeutic target in atherosclerosis

Atherosclerosis is recognized as a chronic immuno-inflammatory disease that is characterized by the accumulation of immune cells and lipids in the vascular wall. In this review, we focus on the latest advance ...

Authors: Jin-Wen Luo, Yuan Hu, Jian Liu, Huan Yang and Peng Huang

Correction to: Downregulation of miRNAs during delayed wound healing in diabetes: role of Dicer

Authors: Sushant Bhattacharya, Rangoli Aggarwal, Vijay Pal Singh, Srinivasan Ramachandran and Malabika Datta

The role and mechanism of long non-coding RNA H19 in stem cell osteogenic differentiation

In recent years, H19, as one of the most well-known long non-coding RNA, has been reported to play important roles in many biological and physiological processes. H19 has been identified to regulate the osteog...

Authors: Liang Wang and Lei Qi

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metastasis (OLNM) are thought to be at risk of worse outcome. However, regu...

Authors: Bo Zhou, Yue Zhou, Ying Liu, Hailin Zhang, Huangxing Mao, Mingjing Peng, Anji Xu, Zan Li, Hui Wang, Haolei Tan, Huayi Ren, Xiao Zhou and Ying Long

Placental ¹³C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight

Fetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid metabolism. Maternal hyperglycemia and obesity associate with higher birthweigh...

Authors: Oliver C. Watkins, Preben Selvam, Reshma Appukuttan Pillai, Victoria K. B. Cracknell-Hazra, Hannah E. J. Yong, Neha Sharma, Amaury Cazenave-Gassiot, Anne K. Bendt, Keith M. Godfrey, Rohan M. Lewis, Markus R. Wenk and Shiao-Yng Chan

Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer

Heterogeneity in colorectal cancer (CRC) patients provides novel strategies in clinical decision-making. Identifying distinctive subgroups in patients can improve the screening of CRC and reduce the cost of te...

Authors: Yongqu Lu, Wendong Wang, Zhenzhen Liu, Junren Ma, Xin Zhou and Wei Fu

Up-regulation of microRNA-135 or silencing of PCSK6 attenuates inflammatory response in preeclampsia by restricting NLRP3 inflammasome

Numerous studies have confirmed the correlation of microRNAs (miRNAs) with human disease, yet few have explored the role of miR-135 in preeclampsia (PE). This study intends to discuss miR-135’s function in inf...

Authors: Xiaolan Zhao, Xun Zhang, Zhao Wu, Jie Mei, Lingling Li and Yujue Wang

A CREB1-miR-181a-5p loop regulates the pathophysiologic features of bone marrow stromal cells in fibrous dysplasia of bone

Fibrous dysplasia (FD) is a bone marrow stromal cell (BMSC) disease caused by activating mutations of guanine nucleotide-binding protein alpha-stimulating activity polypeptide (GNAS) and is characterized by in...

Authors: Yu Fu, Zhili Xin, Ziji Ling, Hanyu Xie, Tao Xiao, Xin Shen, Jialin Lin, Ling Xu and Hongbing Jiang

Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway

Osteoarthritis (OA) is the most common inflammatory disease associated with pain and cartilage destruction. Interleukin (IL)-1β is widely used to induce inflammatory response in OA models. This study aimed to ...

Authors: Zhixian Xu, Tie Ke, Yongfa Zhang, Licheng Guo, Feng Chen and Wubing He

2-O, 3-O desulfated heparin (ODSH) increases bacterial clearance and attenuates lung injury in cystic fibrosis by restoring HMGB1-compromised macrophage function

High mobility group box 1 protein (HMGB1) is an alarmin following its release by immune cells upon cellular activation or stress. High levels of extracellular HMGB1 play a critical role in impairing the cleara...

Authors: Mao Wang, Alex G. Gauthier, Thomas P. Kennedy, Haichao Wang, Uday Kiran Velagapudi, Tanaji T. Talele, Mosi Lin, Jiaqi Wu, LeeAnne Daley, Xiaojing Yang, Vivek Patel, Sung Soo Mun, Charles R. Ashby Jr. and Lin L. Mantell

Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis

Extracellular vesicles (EVs) derived from tumor cells are implicated in the progression of malignancies through the transfer of molecular cargo microRNAs (miRNAs or miRs). We aimed to explore the role of EVs d...

Authors: Chong Lu, Yu Zhao, Jing Wang, Wei Shi, Fang Dong, Yue Xin, Xiangwang Zhao and Chunping Liu

Propofol attenuates lung ischemia/reperfusion injury though the involvement of the MALAT1/microRNA-144/GSK3β axis

Propofol, an intravenous anesthetic, was proven to protect against lung ischemia/reperfusion (I/R) injury. However, the detailed mechanism of Propofol in lung I/R injury is still elusive. This study was design...

Authors: Jian-Ping Zhang, Wei-Jing Zhang, Miao Yang and Hua Fang

Anti-tuberculosis chemotherapy alters TNFR2 expression on CD4+ lymphocytes in both drug-sensitive and -resistant tuberculosis: however, only drug-resistant tuberculosis maintains a pro-inflammatory profile after a long time

Tuberculosis (TB) is an infectious disease. During TB, regulatory T cells (Treg) are related to poor prognosis. However, information about conventional and unconventional Treg (cTreg and uTreg, respectively) i...

Authors: Norma A. Téllez-Navarrete, Lucero A. Ramon-Luing, Marcela Muñoz-Torrico, Mario Preciado-García, Karen Medina-Quero, Rogelio Hernandez-Pando and Leslie Chavez-Galan

Correction to: TGF‑β‑induced α‑SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells

Authors: Hui Ding, Jinjun Chen, Jingping Qin, Ruhua Chen and Zili Yi

ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy

Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. The endothelial-to-mesenchymal transition (EndMT) of glomerular endothelial cells has been reported to play a cruci...

Authors: Lihong Lu, Ziwen Zhong, Jiahui Gu, Ke Nan, Minmin Zhu and Changhong Miao

CircMTO1 inhibits ox-LDL-stimulated vascular smooth muscle cell proliferation and migration via regulating the miR-182-5p/RASA1 axis

Circular RNAs (circRNAs) play critical roles in the development of atherosclerosis (AS). This study investigated the role of circMTO1 in the progression of AS.

Authors: Ningning Ji, Yu Wang, Xinyan Gong, Shimao Ni and Hui Zhang

MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure

Although miR-125b plays a crucial role in many human cancers. However, its function in heart failure (HF) remains unclear. Our study aimed to investigate its involvement in heart failure.

Authors: Bei Zhang, Shanyong Mao, Xingde Liu, Sha Li, Haiyan Zhou, Ying Gu, Wupeng Liu, Lei Fu, Chunyan Liao and Pengzhen Wang

LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy

Accumulating evidences have demonstrated that long non-coding RNAs (lncRNAs) are involved in the pathophysiology of diabetic nephropathy (DN). lncRNA SOX2OT plays an essential role in many diseases, including ...

Authors: Ke Chen, Bo Yu and Jie Liao

The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion

Maternally Expressed Gene 3 (MEG3) is expressed at low levels in placental villi during preeclampsia; however, its roles in unexplained recurrent spontaneous abortion (URSA) remain unclear. In this study, we aime...

Authors: Jun Zhang, Xinqiong Liu and Yali Gao

Hypoxia-induced preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway

Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) express...

Authors: Wun-Hao Cheng, Chia-Ling Chen, Jing-Yun Chen, Chien-Huang Lin and Bing-Chang Chen

Liquid biopsy as an option for predictive testing and prognosis in patients with lung cancer

The aim of this study was to investigate the clinical value of liquid biopsy as a primary source for variant analysis in lung cancer. In addition, we sought to characterize liquid biopsy variants and to correl...

Authors: Alvida Qvick, Bianca Stenmark, Jessica Carlsson, Johan Isaksson, Christina Karlsson and Gisela Helenius

MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6

This study aimed to explore the role of mesenchymal stromal cells (MSCs)-derived exosomes (MSCs-Exo) in the cerebral ischemia–reperfusion (I/R) injury.

Authors: Chang Cheng, Xiuying Chen, Yuhan Wang, Wenchao Cheng, Xuzheng Zuo, Weiju Tang and Wen Huang

Platelet-rich plasma inhibits Adriamycin-induced inflammation via blocking the NF-κB pathway in articular chondrocytes

Previous studies showed that doxorubicin could lead to osteoarthritis (OA) by inducing chondrocyte inflammation and apoptosis. Besides, it is reported that platelet-rich plasma (PRP) could suppress the activat...

Authors: Haijun Zhao, Weijie Zhu, Wude Mao and Chengkai Shen

Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response.

Authors: Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar and Yoram Vodovotz

MiR-206 regulates the Th17/Treg ratio during osteoarthritis

The present study aimed to determine the functional role of miR-206 in T helper 17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis (OA).

Authors: Xiguang Ye, Qilin Lu, Aofei Yang, Jun Rao, Wei Xie, Chengjian He, Weijun Wang, Hao Li and Zhiwen Zhang

A Journey in Science: Immersion in the search for effective cancer immunotherapies

Real innovations in medicine and science are historic and singular; the stories behind each occurrence are precious. At Molecular Medicine we have established the Anthony Cerami Award in Translational Medicine...

Authors: Steven A. Rosenberg

High expression of LAMA3/AC245041.2 gene pair associated with KRAS mutation and poor survival in pancreatic adenocarcinoma: a comprehensive TCGA analysis

Pancreatic adenocarcinoma (PAAD) is one of the most challenging cancers with high morbidity and mortality. KRAS mutations could occur as an early event in PAAD. The present study aimed to identify the differen...

Authors: Chengming Tian, Xiyao Li and Chunlin Ge

LncRNA H19 induces immune dysregulation of BMMSCs, at least partly, by inhibiting IL-2 production

Systemic lupus erythematosus (SLE) is a representative systemic autoimmune disease. LncRNA H19 has been identified to participate in various biological processes in human diseases. However, the role of H19 in ...

Authors: Xinpeng Chen, Xiuxia Luo, Yazhi Wei, Hualin Sun, Liping Dai, Yidou Tangzhou, Huijie Jin and Zhihua Yin

Transforming acidic coiled-coil protein-3: a novel marker for differential diagnosis and prognosis prediction in endocervical adenocarcinoma

Endocervical adenocarcinoma (ECA) is further classified as human papillomavirus (HPV)-associated (HPVA) or non-HPVA (NHPVA), per the International Endocervical Adenocarcinoma Criteria and Classification (IECC)...

Authors: Yan-Lin Wen, Shu-Mei Yan, Wei Wei, Xia Yang, Shi-Wen Zhang, Jing-Ping Yun, Li-Li Liu and Rong-Zhen Luo

Specific detection of high mobility group box 1 degradation product with a novel ELISA

During sepsis or sterile tissue injury, the nuclear protein high mobility group box 1 (HMGB1) can be released to the extracellular space and ultimately into systemic circulation, where it mediates systemic inf...

Authors: Takaaki Totoki, Takashi Ito, Shingo Yamada, Goichi Honda, Tsuyoshi Hattori and Ikuro Maruyama

Redox modifications of cysteine residues regulate the cytokine activity of HMGB1

High mobility group box 1 (HMGB1) is a nuclear protein with extracellular inflammatory cytokine activity. It is passively released during cell death and secreted by activated cells of many lineages. HMGB1 cont...

Authors: Huan Yang, Peter Lundbäck, Lars Ottosson, Helena Erlandsson-Harris, Emilie Venereau, Marco E. Bianchi, Yousef Al-Abed, Ulf Andersson and Kevin J. Tracey

CD36 deficiency ameliorates drug-induced acute liver injury in mice

Acetaminophen (APAP) overdose causes hepatotoxicity and even acute liver failure. Recent studies indicate that sterile inflammation and innate immune cells may play important roles in damage-induced hepatocyte...

Authors: Chen Zhang, Xiao Shi, Zhongping Su, Chao Hu, Xianmin Mu, Jinshun Pan, Mengjing Li, Fengmeng Teng, Tao Ling, Ting Zhao, Che Xu, Guozhong Ji and Qiang You

CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-β1 axis

Hyaluronan (HA) metabolism by chondrocytes is important for cartilage development and homeostasis. However, information about the function of circular RNAs (circRNAs) in HA metabolism is limited. We therefore ...

Authors: Hong-Xing Liao, Zhi-Hui Zhang, Hui-Lin Chen, Ying-Mei Huang, Zhan-Liang Liu and Jian Huang

Extracellular CIRP decreases Siglec-G expression on B-1a cells skewing them towards a pro-inflammatory phenotype in sepsis

Sepsis is a life-threatening disease syndrome caused by a dysregulated host response to infection and injury. Extracellular cold-inducible RNA-binding protein (eCIRP) acts as a damage-associated molecular patt...

Authors: William Royster, Hui Jin, Ping Wang and Monowar Aziz

Heterologous vaccine interventions: boosting immunity against future pandemics

While vaccines traditionally have been designed and used for protection against infection or disease caused by one specific pathogen, there are known off-target effects from vaccines that can impact infection ...

Authors: Daniela Marín-Hernández, Douglas F. Nixon and Nathaniel Hupert

Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway

Chronic obstructive pulmonary disease (COPD) is characterized by airway obstruction and progressive lung inflammation. As the primary ingredient of a traditional Chinese medical herb, Baicalin has been previou...

Authors: Dexun Hao, Yanshuang Li, Jiang Shi and Junguang Jiang

Overexpressed XRCC2 as an independent risk factor for poor prognosis in glioma patients

XRCC2, a homologous recombination-related gene, has been reported to be associated with a variety of cancers. However, its role in glioma has not been reported. This study aimed to find out the role of XRCC2 in g...

Authors: Zhendong Liu, Wang Zhang, Xingbo Cheng, Hongbo Wang, Lu Bian, Jialin Wang, Zhibin Han, Yanbiao Wang, Xiaoyu Lian, Binfeng Liu, Zhishuai Ren, Bo Zhang, Zhenfeng Jiang, Zhiguo Lin and Yanzheng Gao

Role of long noncoding RNA taurine‐upregulated gene 1 in cancers

Long non-coding RNAs (lncRNAs) are a group of non-protein coding RNAs with a length of more than 200 bp. The lncRNA taurine up-regulated gene 1 (TUG1) is abnormally expressed in many human malignant cancers, wher...

Authors: Miao Da, Jing Zhuang, Yani Zhou, Quan Qi and Shuwen Han