Skip to main content

Articles

Thank you for your interest in Molecular Medicine. The journal has recently switched publishers to BMC, who will host all back content. If you notice any missing content, please reach out to us.

Page 2 of 36

  1. Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to in...

    Authors: Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao and Haidong Liang
    Citation: Molecular Medicine 2024 30:5
    Content type: Research article Published on:

  2. Autophagic defects are involved in Methamphetamine (Meth)-induced neurotoxicity. Syntaxin 17 (Stx17), a member of the SNARE protein family, participating in several stages of autophagy, including autophagosome...

    Authors: Xi Wang, Miaoyang Hu, Jingrong Chen, Xinyu Lou, Hongchao Zhang, Muhan Li, Jie Cheng, Tengfei Ma, Jianping Xiong, Rong Gao, Xufeng Chen and Jun Wang
    Citation: Molecular Medicine 2024 30:4
    Content type: Research article Published on:

  3. Lesch-Nyhan disease (LND) is a severe neurological disorder caused by the genetic deficiency of hypoxanthine–guanine phosphoribosyltransferase (HGprt), an enzyme involved in the salvage synthesis of purines. T...

    Authors: Paula Escudero-Ferruz, Neus Ontiveros, Claudia Cano-Estrada, Diane J. Sutcliffe, H. A. Jinnah, Rosa J. Torres and José M. López
    Citation: Molecular Medicine 2024 30:3
    Content type: Research article Published on:

  4. Umbilical cord blood-derived therapeutics, such as serum (UCS) and platelet-rich plasma (UCPRP), are popular treatment options in clinical trials and can potentially be utilized to address a clinically unmet n...

    Authors: Ruojing Huang, Caiying Su, Na Zhang, Congying Shi, Guangming Pu, Yong Ding, Wei Wei and Jiansu Chen
    Citation: Molecular Medicine 2024 30:2
    Content type: Research article Published on:

  5. Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals a...

    Authors: Kaylin Huitsing, Tara Tritsch, Francisco Javier Carrera Arias, Fanny Collado, Kristina K. Aenlle, Lubov Nathason, Mary Ann Fletcher, Nancy G. Klimas and Travis J. A. Craddock
    Citation: Molecular Medicine 2024 30:1
    Content type: Hypothesis Published on:

  6. Sepsis is a severe syndrome of organ dysfunction that often leads to cardiac dysfunction and endangers life. The role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) in LPS-induced myocardial injury is uncle...

    Authors: Haoran Liu, Qin Hu, Ke Ren, Pengxin Wu, Yang Wang and Chuanzhu Lv
    Citation: Molecular Medicine 2023 29:171
    Content type: Research article Published on:

  7. T cell immunoglobulin and mucin domain-containing molecule-3 (TIM-3) initially discovered on the surface of Th1 cells, negatively regulates immune responses and mediates apoptosis of Th1 cells. An increasing n...

    Authors: Wei Tian, Min Liu, Yuqiu Liu, Qingfeng Lv, HuaFeng Cheng, Yanling Gu and Mingjiang Li
    Citation: Molecular Medicine 2023 29:170
    Content type: Research article Published on:

  8. The aberrant formation of neutrophil extracellular traps (NETs) has been implicated in ulcerative colitis (UC), a chronic recurrent intestinal inflammation. Cyclosporine A (CsA) is now applied as rescue therap...

    Authors: Chenjing Xu, Ziping Ye, Wenyu Jiang, Shu Wang and Hongjie Zhang
    Citation: Molecular Medicine 2023 29:169
    Content type: Research article Published on:

  9. Shenqi Compound (SQC) has been used in clinic for several decades in the prevention and treatment of diabetes and its complications. But this is merely a heritage of experience. The primary aim of this study i...

    Authors: Chan Yang, Ziyan Xie, Hanyu Liu, Xueru Wang, Zehua Zhang, Lian Du and Chunguang Xie
    Citation: Molecular Medicine 2023 29:168
    Content type: Research article Published on:

  10. The cGAS-STING signaling pathway is an essential section of the natural immune system. In recent years, an increasing number of studies have shown a strong link between abnormal activation of the cGAS-STING si...

    Authors: Jincai Wen, Wenqing Mu, Hui Li, Yulu Yan, Xiaoyan Zhan, Wei Luo, Zhongxia Wang, Wen Kan, Jia Zhao, Siwen Hui, Ping He, Shuanglin Qin, Yingjie Xu, Ping Zhang, Xiaohe Xiao, Guang Xu…
    Citation: Molecular Medicine 2023 29:167
    Content type: Research article Published on:

  12. Disruption of the BBB is a harmful event after intracranial hemorrhage (ICH), and this disruption contributes to a series of secondary injuries. We hypothesized that FGF21 may have protective effects after int...

    Authors: Runfeng Wang, Jin Wang, Zhiguo Zhang, Bo Ma, Shukai Sun, Li Gao and Guodong Gao
    Citation: Molecular Medicine 2023 29:165
    Content type: Research article Published on:

  13. Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be rel...

    Authors: Ziyue Zhang, Xingbing Li, Jingwen Guo, Bo He, Lianpan Wu, Rongpei Yang, Xingyue Li, Dandong Fang, XiaoLi Yang, Donghai Yang, Fengxian Wang, Ming Tang, Yu Han, Pedro A. Jose, Hongyong Wang and Chunyu Zeng
    Citation: Molecular Medicine 2023 29:164
    Content type: Research article Published on:

  14. Acute kidney injury (AKI) due to ischemia-reperfusion (IR) is a serious and frequent complication in clinical settings, and mortality rates remain high. There are well established sex differences in renal IR, ...

    Authors: Riyaz Mohamed and Jennifer C. Sullivan
    Citation: Molecular Medicine 2023 29:163
    Content type: Research article Published on:

  16. Liver aging, marked by cellular senescence and low-grade inflammation, heightens susceptibility to chronic liver disease and worsens its prognosis. Insulin-like growth factor 2 (IGF2) has been implicated in nu...

    Authors: Xiaohai Zhou, Bowen Tan, Weiwei Gui, Caiping Zhou, Hanxin Zhao, Xihua Lin and Hong Li
    Citation: Molecular Medicine 2023 29:161
    Content type: Research article Published on:

  17. Anxiety and depression-like behaviors in allergic rhinitis (AR) are attracting attention, while the precise mechanism has not been clearly elucidated. Recent evidence shows that neuroinflammation in anterior c...

    Authors: Ziang Gao, Hao Lv, Yunfei Wang, Yulie Xie, Mengting Guan and Yu Xu
    Citation: Molecular Medicine 2023 29:160
    Content type: Research article Published on:

  18. Delay in type II alveolar epithelial cell (AECII) regeneration has been linked to higher mortality in patients with acute respiratory distress syndrome (ARDS). However, the interaction between Doublecortin-lik...

    Authors: Xiao-Yue Chen, Ching Kao, Syue-Wei Peng, Jer-Hwa Chang, Yueh-Lun Lee, Vincent Laiman, Kian Fan Chung, Pankaj K. Bhavsar, Didik Setyo Heriyanto, Kai-Jen Chuang and Hsiao-Chi Chuang
    Citation: Molecular Medicine 2023 29:159
    Content type: Research article Published on:

  19. Maresin1 (MaR1) is a potent lipid mediator that exhibits significant anti-inflammatory activity in the context of several inflammatory diseases. A previous study reported that MaR1 could suppress MSU crystal-i...

    Authors: Hui Jiang, DianZe Song, Xiaoqin Zhou, Feng Chen, Qingqing Yu, Long Ren, Qian Dai and Mei Zeng
    Citation: Molecular Medicine 2023 29:158
    Content type: Research article Published on:

  20. Inflammation plays an important role in the pathogenesis of atrial fibrillation (AF) after myocardial infarction (MI). The role of USP38, a member of the ubiquitin-specific protease family, on MI-induced atria...

    Authors: Yang Gong, Tingting Yu, Wei Shuai, Tao Chen, Jingjing Zhang and He Huang
    Citation: Molecular Medicine 2023 29:157
    Content type: Research article Published on:

  21. Krüppel-like factor 10 (KLF10) is involved in a positive feedback loop that regulates transforming growth factor β (TGFβ) signaling, and TGFβ plays an important role in the pathogenesis of liver disease. Here,...

    Authors: Sung Hwan Yoo, Ji Hae Nahm, Woon Kyu Lee, Hyun Woong Lee, Hye Young Chang and Jung Il Lee
    Citation: Molecular Medicine 2023 29:156
    Content type: Research article Published on:

  22. Colorectal cancer (CRC) is the third frequently diagnosed cancer with high incidence and mortality rate worldwide. Our previous report has demonstrated that circCOL1A1 (hsa_circ_0044556) functions as an oncoge...

    Authors: Gui Hu, Changwei Lin, Kai Gao, Miao Chen, Fei Long and Buning Tian
    Citation: Molecular Medicine 2023 29:155
    Content type: Research article Published on:

  23. Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. ...

    Authors: Wei Li, Lu Xue, Changsi Peng, Ping Zhao, Yongbo Peng, Weiwei Chen, Wenyi Wang and Jinhua Shen
    Citation: Molecular Medicine 2023 29:154
    Content type: Research article Published on:

  24. The MeltPro TB assay (MeltPro) is a molecular rapid diagnostic test designed for detecting resistance to antituberculosis drugs. However, the performance of MeltPro as an initial diagnostic test for simultaneo...

    Authors: Zhi-bin Liu, Li-ping Cheng, Hong-qiu Pan, Xiao-cui Wu, Fu-hui Lu, Jie Cao, Lei Wang, Wei Wei, Hong-yu Chen, Wei Sha and Qin Sun
    Citation: Molecular Medicine 2023 29:153
    Content type: Research article Published on:

  25. Caveolin-1 (Cav-1) is a pivotal protein in the plasma membrane. Studies on homozygous Cav-1 deficient mice revealed that Cav-1 is essential for endothelial function and angiogenesis in the retina. However, whe...

    Authors: Yixin Wang, Mahmoud Halawa, Anupriya Chatterjee, Rachana Eshwaran, Yi Qiu, Yohanes Cakrapradipta Wibowo, Jianyuan Pan, Thomas Wieland and Yuxi Feng
    Citation: Molecular Medicine 2023 29:152
    Content type: Research article Published on:

  26. 5α-Hydroxycostic acid is a eudemane sesquiterpene that is isolated from the natural plant, Laggera alata. It exerts anti-inflammatory and anti-angiogenic effects on human breast cancer cells, but its role and und...

    Authors: Wulong Lei, Huan Xu, Hao Yao, Lanjiao Li, Menglei Wang, Xiyuan Zhou and Xueqin Liu
    Citation: Molecular Medicine 2023 29:151
    Content type: Research article Published on:

  27. Recent findings elucidated hepatic PPARγ functions as a steatogenic-inducer gene that activates de novo lipogenesis, and is involved in regulation of glucose homeostasis, lipid accumulation, and inflammation resp...

    Authors: Yong Zhang, Jie Xu, Di Zhou, Tingting Ye, Puqing Zhou, Zuofeng Liu, Xinyuan Liu, Zinan Wang, Tianmiao Hua, Zhenghao Zhang and Qingyan Sun
    Citation: Molecular Medicine 2023 29:150
    Content type: Research article Published on:

  28. Acute pancreatitis is a common and serious inflammatory condition currently lacking disease modifying therapy. The cholinergic anti-inflammatory pathway (CAP) is a potent protective anti-inflammatory response ...

    Authors: Dane A. Thompson, Tea Tsaava, Arvind Rishi, Sam J. George, Tyler D. Hepler, Daniel Hide, Valentin A. Pavlov, Michael Brines, Sangeeta S. Chavan and Kevin J. Tracey
    Citation: Molecular Medicine 2023 29:149
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2024 30:45

  29. Diabetic kidney disease (DKD), has become the main cause of end-stage renal disease (ESRD) worldwide. Lately, it has been shown that the onset and advancement of DKD are linked to imbalances of gut microbiota ...

    Authors: Leilei Ma, Li Zhang, Jing Li, Xiaotian Zhang, Yiran Xie, Xiaochen Li, Bo Yang and Hongtao Yang
    Citation: Molecular Medicine 2023 29:148
    Content type: Review Published on:

  30. Chronic kidney disease (CKD) involves a variety of pathological processes, and ferroptosis plays a vital role in CKD progression. Targeting ferroptosis is a promising strategy for the treatment of CKD. However...

    Authors: Jiayu Song, Hongri Wang, Jingyi Sheng, Wen Zhang, Juan Lei, Weihua Gan, Fangfang Cai and Yunwen Yang
    Citation: Molecular Medicine 2023 29:147
    Content type: Research article Published on:

  31. Epithelial–mesenchymal transition (EMT) plays a key role in tubulointerstitial fibrosis, which is a hallmark of diabetic kidney disease (DKD). Our previous studies showed that CRTC2 can simultaneously regulate...

    Authors: Yujie Li, Yufeng Zhang, Hongshuo Shi, Xuemei Liu, Zifa Li, Jiayi Zhang, Xiuge Wang, Wenbo Wang and Xiaolin Tong
    Citation: Molecular Medicine 2023 29:146
    Content type: Research article Published on:

  32. Disulfidptosis is a recently discovered programmed cell death pathway. However, the exact molecular mechanism of disulfidptosis in cutaneous melanoma remains unclear.

    Authors: Yi Zhao, Yanjun Wei, Lingjia Fan, Yuanliu Nie, Jianan Li, Renya Zeng, Jixian Li, Xiang Zhan, Lingli Lei, Zhichao Kang, Jiaxin Li, Wentao Zhang and Zhe Yang
    Citation: Molecular Medicine 2023 29:145
    Content type: Research article Published on:

  33. Ferroptosis plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). Meteorin-like/Meteorin-β (Metrnβ) is a protein secreted by skeletal muscle and adipose tissue and plays a role i...

    Authors: Zhen Chen, Jun Li, Huan Peng, Mengli Zhang, Xian Wu, Feng Gui, Wei Li, Fen Ai, Bo Yu and Yijue Liu
    Citation: Molecular Medicine 2023 29:144
    Content type: Research article Published on:

  34. High doses of oral thiamine improve clinical fatigue scores in patients with quiescent inflammatory bowel disease (IBD) and chronic fatigue. In this study we analysed plasma samples obtained in a randomised cl...

    Authors: Palle Bager, Christian Lodberg Hvas, Mette Mejlby Hansen, Per Ueland and Jens Frederik Dahlerup
    Citation: Molecular Medicine 2023 29:143
    Content type: Short report Published on:

  35. Autophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for degradation and elimination. The mechanistic target of rapamyc...

    Authors: Naif H. Ali, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Saud A. Alnaaim, Athanasios Alexiou, Marios Papadakis, Hebatallah M. Saad and Gaber El-Saber Batiha
    Citation: Molecular Medicine 2023 29:142
    Content type: Review Published on:

  36. Diabetes mellitus (DM) is a major disease threatening human health and its incidence is increasing year on year. As a chronic complication of DM, hearing loss mostly occurs undetectably. However, the mechanism...

    Authors: Yuxin Deng, Sen Chen and Jun Hu
    Citation: Molecular Medicine 2023 29:141
    Content type: Review Published on:

  37. It is widely acknowledged that cisplatin-induced nephrotoxicity hinders its efficacy during clinical therapy. Effective pharmaceutical interventions for cisplatin-induced acute kidney injury (Cis-AKI) are curr...

    Authors: Qiming Gong, Tengfang Lai, Liudan Liang, Yan Jiang and Fahui Liu
    Citation: Molecular Medicine 2023 29:140
    Content type: Research article Published on:

  38. The pathogenesis of benign prostatic hyperplasia (BPH) has not been fully elucidated. Ras homology family member A (RhoA) plays an important role in regulating cell cytoskeleton, growth and fibrosis. The role ...

    Authors: Shidong Shan, Min Su, Yan Li, Zhen Wang, Daoquan Liu, Yongying Zhou, Xun Fu, Shu Yang, Junchao Zhang, Jizhang Qiu, Huan Liu, Guang Zeng, Ping Chen, Xinghuan Wang, Michael E. DiSanto, Yuming Guo…
    Citation: Molecular Medicine 2023 29:139
    Content type: Research article Published on:

  39. Non-alcoholic fatty liver disease (NAFLD), the primary hepatic consequence of obesity, is affecting about 25% of the global adult population. The aim of this study was to examine the in vivo role of STE20-type...

    Authors: Ying Xia, Emma Andersson, Mara Caputo, Emmelie Cansby, Francesca Sedda, Ferran Font-Gironès, Johan Ruud, Yeshwant Kurhe, Bengt Hallberg, Hanns-Ulrich Marschall, Ingrid Wernstedt Asterholm, Stefano Romeo, Matthias Blüher and Margit Mahlapuu
    Citation: Molecular Medicine 2023 29:138
    Content type: Research article Published on:

  40. Intestinal ischemia-reperfusion injury occurs in acute intestinal obstruction, intussusception, acute mesenteric artery embolism, and other diseases and can lead to local intestinal n...

    Authors: Xingjie Wang, Tianli Shen, Jie Lian, Kai Deng, Chao Qu, Enmeng Li, Gan Li, Yiwei Ren, Zijun Wang, Zhengdong Jiang, Xuejun Sun and Xuqi Li
    Citation: Molecular Medicine 2023 29:137
    Content type: Research article Published on:

  41. Hepatocellular carcinoma (HCC) is the most common primary liver cancer. It is characterized by occult onset resulting in most patients being diagnosed at advanced stages and with poor prognosis. Exosomes are n...

    Authors: Meijin Liu, Zhonghong Lai, Xiaoying Yuan, Qing Jin, Haibin Shen, Dingyu Rao and Defa Huang
    Citation: Molecular Medicine 2023 29:136
    Content type: Review Published on:

  42. Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, and renal failure. The injury and ...

    Authors: Can Yang, Zhen Zhang, Jieting Liu, Peijian Chen, Jialing Li, Haiying Shu, Yanhui Chu and Luxin Li
    Citation: Molecular Medicine 2023 29:135
    Content type: Review Published on:

  43. Positive human epidermal growth factor receptor 2 (HER2) expression is associated with an increased risk of metastases especially those to the brain in patients with advanced breast cancer (BC). Neratinib as a...

    Authors: Liting Guo, Weiwei Shao, Chenfei Zhou, Hui Yang, Liu Yang, Qu Cai, Junqing Wang, Yan Shi, Lei Huang and Jun Zhang
    Citation: Molecular Medicine 2023 29:134
    Content type: Review Published on:

  44. Rab-interacting lysosomal protein (RILP) contains an alpha-helical coil with an unexplored biological function in osteosarcoma. This study investigated the expression of RILP in osteosarcoma cells and tissues ...

    Authors: Zhun Wei, Kezhou Xia, Di Zheng, Changtian Gong and Weichun Guo
    Citation: Molecular Medicine 2023 29:133
    Content type: Research article Published on:

  45. Non-alcoholic fatty liver disease (NAFLD) is one of the most common complications of type 2 diabetes mellitus (T2DM). The pathogenesis of NAFLD involves multiple biological changes, including insulin resistanc...

    Authors: Tingli Guo, Wenhui Yan, Xin Cui, Na Liu, Xiaotong Wei, Yuzhuo Sun, KeXin Fan, Jieyun Liu, Yuanyuan Zhu, Zhuanzhuan Wang, Yilei Zhang and Lina Chen
    Citation: Molecular Medicine 2023 29:132
    Content type: Research article Published on:

  46. Traumatic encephalopathy syndrome (TES) is used to describe the clinical manifestations of chronic traumatic encephalopathy (CTE). However, effective treatment and prevention strategies are lacking. Increasing...

    Authors: Yin-qiong Huang, Zhe Wu, Shu Lin and Xiang-rong Chen
    Citation: Molecular Medicine 2023 29:131
    Content type: Review Published on:

  47. It has been documented that aerobic exercise (AE) has a positive effect on improving cognitive function in type 2 diabetes (T2DM) patients. Here, we tried to explore how AE regulates the expression of long non...

    Authors: Mingzhu Wang, Kangling Xie, Shengnan Zhao, Nan Jia, Yujiao Zong, Wenping Gu and Ying Cai
    Citation: Molecular Medicine 2023 29:130
    Content type: Research article Published on:

  50. Sexual dimorphism in placental physiology affects the functionality of placental adaptation during adverse pregnancy. Defects of placental function compromise fetal programming, affecting the offspring’s adult...

    Authors: Da Som Jeong, Ji-Yeon Lee, Myoung Hee Kim and Ji Hoon Oh
    Citation: Molecular Medicine 2023 29:114
    Content type: Research article Published on:
Submit manuscript

Annual Journal Metrics

  • Annual Journal Metrics

    2022 Citation Impact
    5.7 - 2-year Impact Factor
    6.3 - 5-year Impact Factor
    1.026 - SNIP (Source Normalized Impact per Paper)
    1.245 - SJR (SCImago Journal Rank)

    2023 Speed
    6 days submission to first editorial decision for all manuscripts (Median)
    132 days submission to accept (Median)

    2023 Usage
    1,105,866 downloads
    1,878 Altmetric mentions

Follow

Molecular Medicine

ISSN: 1528-3658