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  1. Phosphorylation modification of BCL2 is involved in receptor activator of nuclear factor-κB ligand (RANKL)-induced autophagy of osteoclast precursors (OCPs) and osteoclastogenesis. As an antiapoptotic molecule...

    Authors: Dianshan Ke, Yunlong Yu, Chenglong Li, Junyong Han and Jie Xu
    Citation: Molecular Medicine 2022 28:22
    Content type: Research article Published on:

  2. Many clinical studies have shown a correlation between proton pump inhibitors (PPIs) and osteoporosis or fractures. The purpose of this study was to establish a murine model of chronic oral PPI administration ...

    Authors: Ziping Cheng, Yangjie Liu, Mengyuan Ma, Shiyu Sun, Zengqing Ma, Yu Wang, Liyuan Yu, Xuping Qian, Luning Sun, Xuehui Zhang, Yun Liu and Yongqing Wang
    Citation: Molecular Medicine 2022 28:21
    Content type: Research article Published on:

  3. Adaptive immune responses have been studied extensively in the course of mRNA vaccination against COVID-19. Considerably fewer studies have assessed the effects on innate immune cells. Here, we characterized N...

    Authors: Angelica Cuapio, Caroline Boulouis, Iva Filipovic, David Wullimann, Tobias Kammann, Tiphaine Parrot, Puran Chen, Mira Akber, Yu Gao, Quirin Hammer, Benedikt Strunz, André Pérez Potti, Olga Rivera Ballesteros, Joshua Lange, Jagadeeswara Rao Muvva, Peter Bergman…
    Citation: Molecular Medicine 2022 28:20
    Content type: Research article Published on:

  4. Myocardial fibrosis after myocardial infarction (MI) is one of the leading causes of cardiovascular diseases. Cardiac fibroblasts (CFs) are activated and promoted by MI to undergo myofibroblast transformation ...

    Authors: Pengfei Chen, Junyu Pei, Xiaopu Wang, Shi Tai, Liang Tang and Xinqun Hu
    Citation: Molecular Medicine 2022 28:19
    Content type: Research article Published on:

  5. Although type 1 diabetes (T1D) is typically described as a T cell-mediated autoimmune disease, increasing evidence for a role of B cells has emerged. However, the pivotal disease-relevant B cell subset and its...

    Authors: Qing Ling, Lei Shen, Wei Zhang, DuoDuo Qu, Hongdong Wang, Bin Wang, Yong Liu, Jing Lu, Dalong Zhu and Yan Bi
    Citation: Molecular Medicine 2022 28:18
    Content type: Research article Published on:

  6. Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnorm...

    Authors: Jiliang Huang, Gaizhen Ru, Jiajia Sun, Luying Sun and Zhiling Li
    Citation: Molecular Medicine 2022 28:17
    Content type: Research article Published on:

  7. Hepatocellular carcinoma (HCC) remains one of the most common malignant tumors with poor survival. Pyroptosis is a kind of programmed cell death that can regulate the proliferation, invasion, and metastasis of...

    Authors: Min Deng, Shiquan Sun, Rongce Zhao, Renguo Guan, Zhen Zhang, Shaohua Li, Wei Wei and Rongping Guo
    Citation: Molecular Medicine 2022 28:16
    Content type: Research article Published on:

  8. During embryogenesis lateral symmetry is broken, giving rise to Left/Right (L/R) breast tissues with distinct identity. L/R-sided breast tumors exhibit consistently-biased incidence, gene expression, and DNA m...

    Authors: Sofía Masuelli, Sebastián Real, Emanuel Campoy, María Teresita Branham, Diego Matías Marzese, Matthew Salomon, Gerardo De Blas, Rodolfo Arias, Michael Levin and María Roqué
    Citation: Molecular Medicine 2022 28:15
    Content type: Research article Published on:

    The Correction to this article has been published in Molecular Medicine 2022 28:25

  10. Previously, we observed that hypothermia, widely used for organ preservation, elicits mitochondrial fission in different cell types. However, temperature dependence, mechanisms and consequences of this cold-in...

    Authors: Leonard Quiring, Björn Walter, Niklas Lohaus, Dhanusha Schwan, Anja Rech, Andrea Dlugos and Ursula Rauen
    Citation: Molecular Medicine 2022 28:13
    Content type: Research article Published on:

  11. The increasing incidence of non-alcoholic fatty liver disease (NAFLD) has been reported worldwide, which urges understanding of its pathogenesis and development of more effective therapeutical methods for this...

    Authors: Fei Zhao, Jinjing Ke, Wensheng Pan, Hanghai Pan and Miao Shen
    Citation: Molecular Medicine 2022 28:12
    Content type: Research article Published on:

  12. Alzheimer’s disease (AD) is the most common type of neurodegenerative disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural flavonoid compound that is mainly present in ...

    Authors: Lin Li, Wen-Jun Li, Xiang-Ru Zheng, Qing-Long Liu, Qian Du, Yu-Jie Lai and Song-Qing Liu
    Citation: Molecular Medicine 2022 28:11
    Content type: Research article Published on:

  13. Biofilm is a community of bacteria embedded in an extracellular matrix, which can colonize different human cells and tissues and subvert the host immune reactions by preventing immune detection and polarizing ...

    Authors: Rasoul Mirzaei, Niloofar Sabokroo, Yaghoub Ahmadyousefi, Hamid Motamedi and Sajad Karampoor
    Citation: Molecular Medicine 2022 28:10
    Content type: Review Published on:

  14. Sepsis is a troublesome syndrome that can cause intestinal injury and even high mortality rates. Omega-3 fatty acids (FAs) are known to protect against intestinal damage. Accordingly, the current study set out...

    Authors: You-Lian Chen, Yin-Jing Xie, Zhen-Mi Liu, Wei-Bu Chen, Ru Zhang, Hong-Xing Ye, Wei Wang, Xue-Yan Liu and Huai-Sheng Chen
    Citation: Molecular Medicine 2022 28:9
    Content type: Research article Published on:

  16. Arteriovenous fistula (AVF) is the most important vascular access for hemodialysis; however, preventive treatment to maintain the patency of AVFs has not been developed. In endothelium, β-catenin functions in ...

    Authors: Chung-Te Liu, Shih-Chang Hsu, Hui-Ling Hsieh, Cheng-Hsien Chen, Chun-You Chen, Yuh-Mou Sue, Tso-Hsiao Chen, Yung-Ho Hsu, Feng-Yen Lin, Chun-Ming Shih, Yan-Ting Shiu and Po-Hsun Huang
    Citation: Molecular Medicine 2022 28:7
    Content type: Research article Published on:

  17. Activation of brown adipose tissue (BAT) increases energy expenditure, which makes it an attractive therapeutic strategy for obesity. LncRNAs play an important role in adipocyte differentiation and regulation....

    Authors: Chunyan Wu, Shu Fang, Huijian Zhang, Xiaoqiang Li, Yuejun Du, Yudan Zhang, Xiaochun Lin, Ling Wang, Xiaoqin Ma, Yaoming Xue and Meiping Guan
    Citation: Molecular Medicine 2022 28:6
    Content type: Research article Published on:

  18. Calcific aortic valve disease (CAVD) is the most prevalent heart valve disorder in the elderly. Valvular fibrocalcification is a characteristic pathological change. In diseased valves, monocyte accumulation is...

    Authors: Peijian Zhang, Erlinda The, Zichao Luo, Yufeng Zhai, Qingzhou Yao, Lihua Ao, David A. Fullerton, Dingli Xu and Xianzhong Meng
    Citation: Molecular Medicine 2022 28:5
    Content type: Research article Published on:

  19. The unique mechanism of diabetic atherosclerosis has been a central research focus. Previous literature has reported that the inflammatory response mediated by dendritic cells (DCs) plays a vital role in the p...

    Authors: Liding Zhao, Ya Li, Tian Xu, Qingbo Lv, Xukun Bi, Xianglan Liu, Guosheng Fu, Yunzeng Zou, Junbo Ge, Zhaoyang Chen and Wenbin Zhang
    Citation: Molecular Medicine 2022 28:4
    Content type: Research article Published on:

  20. The mechanisms of chronic intermittent hypoxia (CIH)-induced cognitive deficits remain unclear. Here, our study found that about 3 months CIH treatment induced lipid droplets (LDs) accumulation in hippocampal ...

    Authors: Dongze Li, Na Xu, Yanyan Hou, Wenjing Ren, Na Zhang, Xi Wang, Yeying Sun, Wenxue Lu, Guiwu Qu, Yan Yu, Changjun Lv and Fang Han
    Citation: Molecular Medicine 2022 28:3
    Content type: Research article Published on:

  21. Although long noncoding RNA HLA complex group 18 (lncRNA HCG18) has been suggested to regulate cell growth in several tumours, the function of HCG18 in epithelial ovarian cancer (EOC) and its mechanism are sti...

    Authors: Fan Zhang, Bai-Hua Luo, Qi-Hui Wu, Qing-Ling Li and Ke-Da Yang
    Citation: Molecular Medicine 2022 28:2
    Content type: Research article Published on:

  22. Previous reports implied a possible link between PES1 and lipid metabolism. However, the role of PES1 in regulating T2DM related lipid metabolism and the effect of ketogenic diet (KD) on PES1 have not been rep...

    Authors: Jielin Zhou, Yao Lu, Yajing Jia, Jing Lu, Zhengxuan Jiang and Keyang Chen
    Citation: Molecular Medicine 2022 28:1
    Content type: Research article Published on:

  24. Similarities in the hijacking mechanisms used by SARS-CoV-2 and several types of cancer, suggest the repurposing of cancer drugs to treat Covid-19. CK2 kinase antagonists have been proposed for cancer treatmen...

    Authors: Jamilet Miranda, Ricardo Bringas, Jorge Fernandez-de-Cossio and Yasser Perera-Negrin
    Citation: Molecular Medicine 2021 27:161
    Content type: Research article Published on:

  25. COVID-19 clinical presentation differs considerably between individuals, ranging from asymptomatic, mild/moderate and severe disease which in some cases are fatal or result in long-term effects. Identifying im...

    Authors: Catherine Chen, Aisah Amelia, George W. Ashdown, Ivo Mueller, Anna K. Coussens and Emily M. Eriksson
    Citation: Molecular Medicine 2021 27:160
    Content type: Mini-review Published on:

  26. Long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) is an important lncRNA derived from the XIST gene in mammals. XIST is abnormally expressed in numerous tumors, in most of which XIST functions...

    Authors: Jun Yang, Manlong Qi, Xiang Fei, Xia Wang and Kefeng Wang
    Citation: Molecular Medicine 2021 27:159
    Content type: Review Published on:

  27. The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion. As an underlying mechanism, Rab31 is ...

    Authors: Susanne Soelch, Nathalie Beaufort, Daniela Loessner, Matthias Kotzsch, Ute Reuning, Thomas Luther, Thomas Kirchner and Viktor Magdolen
    Citation: Molecular Medicine 2021 27:158
    Content type: Research article Published on:

  28. Aberrant splicing is a common outcome in the presence of exonic or intronic variants that might hamper the intricate network of interactions defining an exon in a specific gene context. Therefore, the evaluati...

    Authors: Claudia Sacchetto, Laura Peretto, Francisco Baralle, Iva Maestri, Francesca Tassi, Francesco Bernardi, Stan F. J. van de Graaf, Franco Pagani, Mirko Pinotti and Dario Balestra
    Citation: Molecular Medicine 2021 27:157
    Content type: Research article Published on:

  29. Calcific aortic valve disease (CAVD) is the most prevalent valvular disease worldwide. However, no effective treatment could delay or prevent the progression of the disease due to the poor understanding of its...

    Authors: Qiao En, Huang Zeping, Wang Yuetang, Wang Xu and Wang Wei
    Citation: Molecular Medicine 2021 27:156
    Content type: Research article Published on:

  31. The incidence of diabetes mellitus (DM) and depression is increasing year by year around the world, bringing a serious burden to patients and their families. Jiao-tai-wan (JTW), a well-known traditional Chines...

    Authors: Yueheng Tang, Hao Su, Hongzhan Wang, Fuer Lu, Kexin Nie, Zhi Wang, Wenya Huang and Hui Dong
    Citation: Molecular Medicine 2021 27:154
    Content type: Research article Published on:

  32. Dysfunctional osteogenesis of bone marrow mesenchymal stem cells (BMSCs) plays an important role in osteoporosis occurrence and development. However, the molecular mechanisms of osteogenic differentiation rema...

    Authors: Haoran Li, Wuling Zhou, Shiwei Sun, Tianlong Zhang, Tieqi Zhang, Haitian Huang and Minghai Wang
    Citation: Molecular Medicine 2021 27:153
    Content type: Research article Published on:

  33. Bone metastasis of colorectal cancer (CRC) often indicates a poor prognosis. Osteolysis can be observed in metastatic sites, implying an aberrant activation of osteoclasts. However, how osteoclastogenesis is r...

    Authors: Qian Jin, He Yang, Zhao Jing, Wu Hong-hua, Song Ben-jing, Wang Li-ting, Ye Li-juan, Xu Wei, Kang Xia, Wu Juan and Zheng Wei
    Citation: Molecular Medicine 2021 27:152
    Content type: Research article Published on:

  34. We investigated the feasibility of two biomarkers of endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), and their association with inflammation, coagulopathy, and mortal...

    Authors: Dong Zhang, Liubing Li, Yu Chen, Jie Ma, Yanli Yang, Surita Aodeng, Qiuju Cui, Kedi Wen, Meng Xiao, Jing Xie, Yingchun Xu and Yongzhe Li
    Citation: Molecular Medicine 2021 27:151
    Content type: Research article Published on:

  35. Alzheimer’s disease (AD), the most common form of dementia, is caused by the degeneration of the central nervous system (CNS). A previous study reported that signal transducer and activator of transcription 3 ...

    Authors: Chen Li, Ruili Wang, Youyou Zhang, Chunting Hu and Qiaoya Ma
    Citation: Molecular Medicine 2021 27:150
    Content type: Research article Published on:

  36. Thrombocytopenia is one of the most common hematological disease that can be life-threatening caused by bleeding complications. However, the treatment options for thrombocytopenia remain limited.

    Authors: Jing Lin, Jing Zeng, Sha Liu, Xin Shen, Nan Jiang, Yue-Song Wu, Hong Li, Long Wang and Jian-Ming Wu
    Citation: Molecular Medicine 2021 27:149
    Content type: Research article Published on:

  37. Imatinib (IM), targeting of BCR-ABL1 tyrosine kinase, is currently one of the first-line choices in the treatment of chronic myeloid leukemia (CML). This study aims to explore the molecular mechanisms underlyi...

    Authors: Yao-hua Lu and Zhong-yi Huang
    Citation: Molecular Medicine 2021 27:148
    Content type: Research article Published on:

  38. Patients with salt-sensitive hypertension are often accompanied with severe renal damage and accelerate to end-stage renal disease, which currently lacks effective treatment. Fibroblast growth factor 21 (FGF21...

    Authors: Hua-Chun Weng, Xin-Yu Lu, Yu-Peng Xu, Yi-Hong Wang, Dan Wang, Yi-Ling Feng, Zhang Chi, Xiao-Qing Yan, Chao-Sheng Lu and Hong-Wei Wang
    Citation: Molecular Medicine 2021 27:147
    Content type: Research article Published on:

  39. Adipose-derived mesenchymal stem cells (ADSCs) are an important focus in regenerative medicine. However, the biological function of ADSCs in the wound repair of diabetic foot ulcers (DFUs) remains unclear. Thi...

    Authors: Jie Zhou, Tianhong Wei and Zhiyou He
    Citation: Molecular Medicine 2021 27:146
    Content type: Research article Published on:

  40. The alarming trend of paediatric obesity deserves our greatest awareness to hinder the early onset of metabolic complications impacting growth and functionality. Presently, insight into molecular mechanisms of...

    Authors: Margot De Spiegeleer, Ellen De Paepe, Lieven Van Meulebroek, Inge Gies, Jean De Schepper and Lynn Vanhaecke
    Citation: Molecular Medicine 2021 27:145
    Content type: Review Published on:

  42. LncRNA-ATB is a long noncoding RNA (lncRNA) activated by transforming growth factor β (TGF-β) and it has important biological functions in tumours and nontumour diseases. Meanwhile, TGF-β is the most critical ...

    Authors: Yinhui Li, Tao Ding, Haiyan Hu, Tingting Zhao, Chao Zhu, Jiarong Ding, Jihang Yuan and Zhiyong Guo
    Citation: Molecular Medicine 2021 27:143
    Content type: Research article Published on:

  43. Cardiotoxicity is a common complication following anthracycline chemotherapy and represents one of the serious adverse reactions affecting life, which severely limits the effective use of anthracyclines in can...

    Authors: Guoxing Wan, Peinan Chen, Xue Sun, Xiaojun Cai, Xiongjie Yu, Xianhe Wang and Fengjun Cao
    Citation: Molecular Medicine 2021 27:142
    Content type: Research article Published on:

  44. We aimed to investigate the functions and underlying mechanism of lncRNA SNHG1 in bone differentiation and angiogenesis in the development of osteoporosis.

    Authors: Xiao Yu, Peng-Ze Rong, Meng-Sheng Song, Ze-Wen Shi, Gong Feng, Xian-Jun Chen, Lin Shi, Cheng-Hao Wang and Qing-Jiang Pang
    Citation: Molecular Medicine 2021 27:141
    Content type: Research article Published on:

  46. Cancer-associated fibroblasts (CAFs) in the tumour microenvironment are associated with poor prognosis and chemoresistance in multiple solid tumours. However, there is a lack of universal measures of CAFs in c...

    Authors: Yu-feng Chen, Zhao-liang Yu, Min-yi Lv, Ze-rong Cai, Yi-feng Zou, Ping Lan, Xiao-jian Wu and Feng Gao
    Citation: Molecular Medicine 2021 27:139
    Content type: Research article Published on:

  48. Obesity-related nephropathy (ORN) has become one of the leading causes of end-stage renal disease and has tripled over the past decade. Previous studies have demonstrated that decreased reactive oxygen species...

    Authors: Yin-Yin Chen, Han Hong, Yu-Ting Lei, Jia Zou, Yi-Ya Yang and Li-Yu He
    Citation: Molecular Medicine 2021 27:137
    Content type: Research article Published on:

  49. Authors: Xudong Wang, Tongzhou Liang, Yuanxin Zhu, Jincheng Qiu, Xianjian Qiu, Chengjie Lian, Bo Gao, Yan Peng, Anjing Liang, Hang Zhou, Xiaoming Yang, Zhiheng Liao, Yongyong Li, Caixia Xu, Peiqiang Su and Dongsheng Huang
    Citation: Molecular Medicine 2021 27:136
    Content type: Correction Published on:

    The original article was published in Molecular Medicine 2019 25:43

  50. Cardiac arrest (CA) results in loss of blood circulation to all tissues leading to oxygen and metabolite dysfunction. Return of blood flow and oxygen during resuscitative efforts is the beginning of reperfusio...

    Authors: Muhammad Shoaib, Nancy Kim, Rishabh C. Choudhary, Tai Yin, Koichiro Shinozaki, Lance B. Becker and Junhwan Kim
    Citation: Molecular Medicine 2021 27:135
    Content type: Research article Published on:
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Molecular Medicine

ISSN: 1528-3658